Myricitrin attenuates 6-hydroxydopamine-induced mitochondrial damage and apoptosis in PC12 cells via inhibition of mitochondrial oxidation

Journal of Functional Foods

Volumn 5, Issue 1, 2013, Pages 337-345

  Wang, Yue Hua ^a   Xuan, Zhao Hong ^b   Tian, Shuo ^a   He, Guo Rong ^a   Du, Guan Hua ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Lipid peroxidation; Mitochondria; Myricitrin

Indexed keywords

MORELLA CERIFERA; MYRICACEAE; RATTUS;

EID: 84873255845     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2012.11.004     Document Type: Article

References (35)

1. Alonso M.E., Otero E., D'Regules R., Figueroa H.H. Parkinson's disease: A genetic study. Canadian Journal Neurological Science 1986, 13:248-251.
2. Anglade P., Vyas S., Javoy-Agid F., Herrero M.T., Michel P.P., Marquez J., Mouatt-Prigent A., Ruberg M., Hirsch E.C., Agid Y. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histology and Histopathology 1997, 12(1):25-31.
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976, 72:248-254.
4. Cannon J.R., Greenamyre J.T. Neurotoxic in vivo models of Parkinson's disease recent advances. Progress in Brain Research 2010, 184:17-33.
5. Eliseev R.A., Malecki J., Lester T., Zhang Y., Humphrey J., Gunter T.E. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. The Journal of Biological Chemistry 2009, 284(15):9692-9699.
6. Fernandez S.P., Nguyen M., Yow T.T., Chu C., Johnston G.A., Hanrahan J.R., Chebib M. The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research 2009, 34(10):1867-1875.
7. Gassen M., Glinka Y., Pinchasi B., Youdim M.B. Apomorphine is a highly potent free radical scavenger in rat brain mitochondrial fraction. European Journal of Pharmacology 1996, 308(2):219-225.
8. Glinka Y., Tipton K.F., Youdim M.B. Nature of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine. Journal of Neurochemistry 1996, 66:2004-2010.
9. Glinka Y., Youdim M.B. Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine. European Journal of Pharmacology 1995, 292(3-4):329-332.
10. Halliwell B. Reactive oxygen species, and the central nervous system. Journal of Neurochemistry 1992, 59:1609-1623.
11. Ham Y.M., Yoon W.J., Park S.Y., Song G.P., Jung Y.H., Jeon Y.J., Kang S.M., Kim K.N. Quercitrin protects against oxidative stress-induced injury in lung fibroblast cells via up-regulation of Bcl-xL. Journal of Functional Foods 2012, 4:253-262.
12. Henchcliffe C., Beal M.F. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nature Clinical Practice Neurology 2008, 4(11):600-609.
13. Hou L., Ju C., Zhang J., Song J., Ge Y., Yue W. Antitumor effects of Isatin on human neuroblastoma cell line (SH-SY5Y) and the related mechanism. European Journal of Pharmacology 2008, 589(1-3):27-31.
14. Kang S.M., Kim A.D., Heo S.J., Kim K.N., Lee S.H., Ko S.C., Jeon Y.J. Induction of apoptosis by diphlorethohydroxycarmalol isolated from brown alga, Ishige okamurae. Journal of Functional Foods 2012, 4:433-439.
15. Kanthasamy A., Jin H., Mehrotra S., Mishra R., Kanthasamy A., Rana A. Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: Relevance to oxidative stress and neuroinflammation in Parkinson's disease. Neurotoxicology 2010, 31(5):555-561.
16. Katyare S.S., Bangur C.S., Howland J.L. Is respiratory activity in the brain mitochondria responsive to thyroid hormone action: A critical re-evaluation. Biochemical Journal 1994, 302:857-860.
17. Kaul S., Kanthasamy A., Kitazawa M., Anantharam V., Kanthasamy A.G. Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: Relevance to oxidative stress in dopaminergic degeneration. European Journal of Neuroscience 2003, 18(6):1387-1401.
18. Lee H.J., Noh Y.H., Lee D.Y., Kim Y.S., Kim K.Y., Chung Y.H., Lee W.B., Kim S.S. Baicalein attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. European Journal of Cell Biology 2005, 84(11):897-905.
19. Levites Y., Youdim M.B., Maor G., Mandel S. Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures. Biochemistry Pharmacology 2002, 63(1):21-29.
20. Mashimo K., Ohno Y. Ethanol hyperpolarizes mitochondrial membrane potential and increases mitochondrial fraction in cultured mouse myocardial cells. Archives of Toxicology 2006, 80(7):421-428.
21. Meotti F.C., Luiz A.P., Pizzolatti M.G., Kassuya C.A., Calixto J.B., Santos A.R. Analysis of the antinociceptive effect of the flavonoid myricitrin: Evidence for a role of the l-arginine-nitric oxide and protein kinase C pathways. Journal Pharmacology and Experimental Therapeutics 2006, 316(2):789-796.
22. Meotti F.C., Missau F.C., Ferreira J., Pizzolatti M.G., Mizuzaki C., Nogueira C.W., Santos A.R. Anti-allodynic property of flavonoid myricitrin in models of persistent inflammatory and neuropathic pain in mice. Biochemical Pharmacology 2006, 72:1707-1713.
23. Moghal S., Rajput A.H., D'Arcy C., Rajput R. Prevalence of movement disorders in elderly community residents. Neuroepidemiology 1994, 13(4):175-178.
24. Moser B.R. Efficacy of myricetin as an antioxidant in methyl esters of soybean oil. European Journal of Lipid Science Technology 2008, 110:1167-1174.
25. Sauer H., Klimm B., Hescheler J., Wartenberg M. Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP. The FASEB Journal 2001, 15(13):2539-2541.
26. Skulachev V.P. Cytochrome c in the apoptotic and antioxidant cascades. FEBS Letters 1998, 423(3):275-280.
27. Slee E.A., Harte M.T., Kluck R.M., Wolf B.B., Casiano C.A., Newmeyer D.D., Wang H.G., Reed J.C., Nicholson D.W., Alnemri E.S., Green D.R., Martin S.J. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2,-3,-6,-7,-8, and -10 in a caspase-9-dependent manner. The Journal of Cell Biology 1999, 144(2):281-292.
28. Soto-Otero R., Méndez-Alvarez E., Hermida-Ameijeiras A., López-Real A.M., Labandeira-García J.L. Effects of (-)-nicotine and (-)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: Relevance for Parkinson's disease. Biochemical Pharmacology 2002, 64:125-135.
29. Soto-Otero R., Méndez-Alvarez E., Sánchez-Iglesias S., Zubkov F.I., Voskressensky L.G., Varlamov A.V., de Candia M., Altomare C. Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides. Biochemical Pharmacology 2008, 75(7):1526-1537.
30. Stadtman E.R. Protein oxidation and aging. Free Radical Research 2006, 40:1250-1258.
31. Tirmenstein M.A., Hu C.X., Scicchitano M.S., Narayanan P.K., McFarland D.C., Thomas H.C., Schwartz L.W. Effects of 6-hydroxydopamine on mitochondrial function and glutathione status in SH-SY5Y human neuroblastoma cells. Toxicology In Vitro 2005, 19(4):471-479.
32. Wang Y.H., Du G.H. Ginsenoside Rg1 inhibits beta-secretase activity in vitro and protects against Abeta-induced cytotoxicity in PC12 cells. Journal of Asian Natural Products Research 2009, 11(7):604-612.
33. Wang S.J., Tong Y., Lu S., Yang R., Liao X., Xu Y.F., Li X. Anti-inflammatory activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves. Planta Medica 2010, 76(14):1492-1496.
34. Xu R., Liu J., Chen X., Xu F., Xie Q., Yu H., Guo Q., Zhou X., Jin Y. Ribozyme-mediated inhibition of caspase-3 activity reduces apoptosis induced by 6-hydroxydopamine in PC12 cells. Brain Research 2001, 899(1-2):10-19.
35. Zunino S.J., Storms D.H., Zhang Y., Seeram N.P. Growth arrest and induction of apoptosis in high-risk leukemia cells by strawberry components in vitro. Journal of Functional Foods 2009, 1:153-160.