Neuroprotective effects of valproic acid against hemin toxicity: Possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin-proteasomal pathway

Neurochemistry International

Volumn 62, Issue 3, 2013, Pages 240-250

  Kwon, Kyoung Ja ^a   Kim, Jung Nam ^a   Kim, Min Kyeong ^a   Kim, Su Young ^a   Cho, Kyu Suk ^a   Jeon, Se Jin ^a   Kim, Hahn Young ^a   Ryu, Jong Hoon ^b   Han, Sun Young ^c   Cheong, Jae Hoon ^d   Ignarro, Louis J ^e,f   Han, Seol Heui ^a   Shin, Chan Young ^a  

^a Konkuk University School of Medicine   (South Korea)

^b Kyung Hee University   (South Korea)

^c Gyeongsang National University   (South Korea)

^d Sahmyook University   (South Korea)

^e Konkuk University   (South Korea)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Heme oxygenase 1; Intracerebral hemorrhage; Neuroprotection; Stroke; Ubiquitin proteasome pathway; Valproic acid

Indexed keywords

HEME OXYGENASE 1; HEMIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UBIQUITIN; VALPROIC ACID;

ARTICLE; BRAIN CELL; BRAIN HEMORRHAGE; CELL VIABILITY; CYTOTOXICITY; DOWN REGULATION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MICROINJECTION; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TOXICITY; UBIQUITINATION;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; DOWN-REGULATION; FEMALE; HEME OXYGENASE-1; HEMIN; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MAP KINASE SIGNALING SYSTEM; NEUROPROTECTIVE AGENTS; PREGNANCY; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE INHIBITORS; UBIQUITIN; VALPROIC ACID;

RATTUS;

EID: 84873255602     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.12.019     Document Type: Article

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