Propofol participates in gastric mucosal protection through inhibiting the toll-like receptor-4/nuclear factor kappa-B signaling pathway

Clinics and Research in Hepatology and Gastroenterology

Volumn 37, Issue 1, 2013, Pages

  Ye, Hui Hui ^a   Wu, Ke Jian ^a   Fei, Su Juan ^a   Zhang, Xue Wei ^a,b   Liu, He Xia ^a   Zhang, Jiao Li ^a   Zhang, Yong Mei ^a,b  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b Jiangsu Province Key Laboratory of Anesthesiology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; EOSIN; HEMATOXYLIN; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MYELOID DIFFERENTIATION FACTOR 88; PROPOFOL; PROTEIN BAX; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELISA KIT; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAINING; STOMACH MUCOSA; STOMACH MUCOSA INJURY; STOMACH PROTECTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ETHANOL; GASTRIC MUCOSA; HYPNOTICS AND SEDATIVES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PROPOFOL; SIGNAL TRANSDUCTION; STOMACH DISEASES; TOLL-LIKE RECEPTOR 4;

EID: 84873207969     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2012.03.004     Document Type: Article

References (60)

1. Mustonen H., Hietaranta A., Puolakkainen P., Kemppainen E., Paimela H., Kiviluoto T., et al. Ethanol induced NF-{kappa}B activation protects against cell injury in cultured rat gastric mucosal epithelium. Am J Physiol Gastrointest Liver Physiol 2007, 292:G1614-G1621.
2. Asai M., Kawashima D., Katagiri K., Takeuchi R., Tohnai G., Ohtsuka K. Protective effect of a molecular chaperone inducer, paeoniflorin, on the HCl- and ethanol-triggered gastric mucosal injury. Life Sci 2011, 88:350-357.
3. Zhang Y., Chen H., Yang L. Toll-like receptor 4 participates in gastric mucosal protection through Cox-2 and PGE2. Dig Liver Dis 2010, 42:472-476.
4. O'Neill L.A., Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 2007, 7:353-364.
5. Kaczorowski D.J., Nakao A., Vallabhaneni R., Mollen K.P., Sugimoto R., Kohmoto J., et al. Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart. Transplantation 2009, 87:1455-1463.
6. Watts B.R., George T., Sherwood E.R., Good D.W. Basolateral LPS inhibits NHE3 and HCO3- absorption through TLR4/MyD88-dependent ERK activation in medullary thick ascending limb. Am J Physiol Cell Physiol 2011, 301(6):C1296-C1306. [Epub 2011 Aug 31].
7. Ren W., Hu L., Hua F., Jin J., Wang Y., Zhu L. Myeloid differentiation protein 2 silencing decreases LPS-induced cytokine production and TLR4/MyD88 pathway activity in alveolar macrophages. Immunol Lett 2011, 141(1):94-101. [Epub 2011 Aug 9].
8. Yang Q.W., Xiang J., Zhou Y., Zhong Q., Li J.C. Targeting HMGB1/TLR4 signaling as a novel approach to treatment of cerebral ischemia. Front Biosci (Schol Ed) 2010, 2:1081-1091.
9. Wang L., Zhang X., Liu L., Cui L., Yang R., Li M., et al. Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Brain Res 2010, 1321:143-151.
10. Fan J., Li Y., Levy R.M., Fan J.J., Hackam D.J., Vodovotz Y., et al. Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol 2007, 178:6573-6580.
11. Loukili N., Rosenblatt-Velin N., Li J., Clerc S., Pacher P., Feihl F., et al. Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo. Cardiovasc Res 2011, 89:586-594.
12. Hans P., Deby C., Deby-Dupont G., Vrijens B., Albert A., Lamy M. Effect of propofol on in vitro lipid peroxidation induced by different free radical generating systems: a comparison with vitamin E. J Neurosurg Anesthesiol 1996, 8:154-158.
13. Aksoy H., Yapanoglu T., Aksoy Y., Ozbey I., Turhan H., Gursan N. Dehydroepiandrosterone treatment attenuates reperfusion injury after testicular torsion and detorsion in rats. J Pediatr Surg 2007, 42:1740-1744.
14. Xie L.J., Zhang J.X., Li L.F. Effects of propofol on cardiomyocytes apoptosis and its mechanism after ischemia/reperfusion injury in isolated rat hearts. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2008, 24:56-61.
15. Kim S.K., Jee D., Kim J.Y., Choi J.H. Effects of propofol on early phase of warm hepatic ischemia/reperfusion injury. Hepatogastroenterology 2007, 54:2333-2336.
16. Ergun Y., Oksuz H., Atli Y., Kilinc M., Darendeli S. Ischemia-reperfusion injury in skeletal muscle: comparison of the effects of subanesthetic doses of ketamine, propofol, and etomidate. J Surg Res 2010, 159:e1-e10.
17. Yuzbasioglu M.F., Aykas A., Kurutas E.B., Sahinkanat T. Protective effects of propofol against ischemia/reperfusion injury in rat kidneys. Ren Fail 2010, 32:578-583.
18. Arslan M., Demir M.E. Prevention of postoperative nausea and vomiting with a small dose of propofol combined with dexamethasone 4mg or dexamethasone 8mg in patients undergoing middle ear surgery: a prospective, randomized, double-blind study. Bratisl Lek Listy 2011, 112:332-336.
19. Inada T., Kubo K., Shingu K. Possible link between cyclooxygenase-inhibiting and antitumor properties of propofol. J Anesth 2011, 25:569-575.
20. Corcoran T.B., Engel A., Sakamoto H., O'Shea A., O'Callaghan-Enright S., Shorten G.D. The effects of propofol on neutrophil function, lipid peroxidation and inflammatory response during elective coronary artery bypass grafting in patients with impaired ventricular function. Br J Anaesth 2006, 97:825-831.
21. Zhao S., Xie L.J., Zhang J.X., Li L.F. Effects of propofol on the activation of nuclear factor-kappaB and cardiomyocytes apoptosis during myocardial ischemia/reperfusion injury in rats. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2010, 26:291-295.
22. Sanders R.D., Hussell T., Maze M. Sedation & immunomodulation. Crit Care Clin 2009, 25:551-570.
23. Yuki K., Soriano S.G., Shimaoka M. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg 2011, 112:830-838.
24. Vasileiou I., Kalimeris K., Nomikos T., Xanthopoulou M.N., Perrea D., Agrogiannis G., et al. Propofol prevents lung injury following intestinal ischemia-reperfusion. J Surg Res 2012, 172(1):146-152. [Epub 2010 Aug 6].
25. Yagmurdur H., Cakan T., Bayrak A., Arslan M., Baltaci B., Inan N., et al. The effects of etomidate, thiopental, and propofol in induction on hypoperfusion-reperfusion phenomenon during laparoscopic cholecystectomy. Acta Anaesthesiol Scand 2004, 48:772-777.
26. Gazzieri D., Trevisani M., Springer J., Harrison S., Cottrell G.S., Andre E., et al. Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury. Free Radic Biol Med 2007, 43:581-589.
27. Kim K.K., Kim H.B. Protein interaction network related to Helicobacter pylori infection response. World J Gastroenterol 2009, 15:4518-4528.
28. Pimentel-Nunes P., Afonso L., Lopes P., Roncon-Albuquerque R., Goncalves N., Henrique R., et al. Increased expression of toll-like receptors (TLR) 2, 4 and 5 in gastric dysplasia. Pathol Oncol Res 2011, 17:677-683.
29. Tachado S.D., Li X., Bole M., Swan K., Anandaiah A., Patel N.R. MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV+ persons. Blood 2010, 115:3606-3615.
30. Wang E.L., Qian Z.R., Nakasono M., Tanahashi T., Yoshimoto K., Bando Y., et al. High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Br J Cancer 2010, 102:908-915.
31. Ortega-Cava C.F., Ishihara S., Rumi M.A., Kawashima K., Ishimura N., Kazumori H., et al. Strategic compartmentalization of Toll-like receptor 4 in the mouse gut. J Immunol 2003, 170:3977-3985.
32. Hritz I., Mandrekar P., Velayudham A., Catalano D., Dolganiuc A., Kodys K., et al. The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 2011, 48:1224-1231.
33. Zhang Y.M., Wei E.Q., Hu X., Qiao W.L., Shi Y., Xu M., et al. The role of nuclear factor-kappaB in the effect of angiotensin II in the paraventricular nucleus in protecting the gastric mucosa from ischemia-reperfusion injury in rats. J Gastroenterol 2008, 43:687-698.
34. Lu Y.C., Yeh W.C., Ohashi P.S. LPS/TLR4 signal transduction pathway. Cytokine 2008, 42:145-151.
35. Wang J., Lu H., Hu X., Chen W., Xu Z., Li S., et al. Nuclear factor translocation and acute anterior uveitis. Mol Vis 2011, 17:170-176.
36. Dhupar R., Klune J.R., Evankovich J., Cardinal J., Zhang M., Ross M., et al. Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury. Shock 2011, 35:293-301.
37. Chang W.J., Toledo-Pereyra L.H. The role of HMGB1 and HSP72 in ischemia and reperfusion injury. J Surg Res 2011, 166:219-221.
38. Oozawa S., Mori S., Kanke T., Takahashi H., Liu K., Tomono Y., et al. Effects of HMGB1 on ischemia-reperfusion injury in the rat heart. Circ J 2008, 72:1178-1184.
39. Li J., Gong Q., Zhong S., Wang L., Guo H., Xiang Y., et al. Neutralization of the extracellular HMGB1 released by ischaemic damaged renal cells protects against renal ischaemia-reperfusion injury. Nephrol Dial Transplant 2011, 26:469-478.
40. Wang L., Zhang X., Liu L., Yang R., Cui L., Li M. Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-kappaB expression. Neurosci Lett 2010, 471:152-156.
41. Wang F., Lu Z., Hawkes M., Yang H., Kain K.C., Fas Liles W.C. (CD95) induces rapid, TLR4/IRAK4-dependent release of pro-inflammatory HMGB1 from macrophages. J Inflamm 2010, 7:30.
42. Yu M., Wang H., Ding A., Golenbock D.T., Latz E., Czura C.J. HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 2006, 26:174-179.
43. Dong N., Yao Y.M., Huang X.J., He L.X., Yu Y., Sheng Z.Y. Influence of CD14 gene polymorphism on the expression of high mobility group box-1 protein in patients with severe burn. Zhonghua Shao Shang Za Zhi 2010, 26:109-112.
44. Youn J.H., Oh Y.J., Kim E.S., Choi J.E., Shin J.S. High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes. J Immunol 2008, 180:5067-5074.
45. Pisetsky D.S., Jiang W. Role of Toll-like receptors in HMGB1 release from macrophages. Ann N Y Acad Sci 2007, 1109:58-65.
46. Dikmen B., Yagmurdur H., Akgul T., Astarci M., Ustun H., Germiyanoglu C. Preventive effects of propofol and ketamine on renal injury in unilateral ureteral obstruction. J Anesth 2010, 24:73-80.
47. Wu G.J., Chen T.L., Chang C.C., Chen R.M. Propofol suppresses tumor necrosis factor-alpha biosynthesis in lipopolysaccharide-stimulated macrophages possibly through downregulation of nuclear factor-kappa B-mediated toll-like receptor 4 gene expression. Chem Biol Interact 2009, 180:465-471.
48. Jawan B., Kao Y.H., Goto S., Pan M.C., Lin Y.C., Hsu L.W. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation. Toxicol Appl Pharmacol 2008, 229:362-373.
49. Zhang Q., Sun P., Zhang S., Tian Y., Zhang J. Effects of propofol on the mRNA expression of toll-like receptor 4 in BV-2 cells during mimic ischemia-reperfusion injury in vitro. J Huazhong Univ Sci Technolog Med Sci 2008, 28:711-713.
50. Chiu W.T., Lin Y.L., Chou C.W., Chen R.M. Propofol inhibits lipoteichoic acid-induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1/2-ERK1/2-IKK-NFkappaB. Chem Biol Interact 2009, 181:430-439.
51. Song X.M., Wang Y.L., Li J.G., Wang C.Y., Zhou Q., Zhang Z.Z. Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats. Mol Biol Rep 2009, 36:2345-2351.
52. Bao H.G., Li S. Effects of Propofol on the Outcomes of Rats with Sepsis. J Surg Res 2011, 168(1):e111-e115. [Epub 2011 Jan 22].
53. Luo X.J., Li N.S., Zhang Y.S., Liu B., Yang Z.C., Li Y.J. Vanillyl nonanoate protects rat gastric mucosa from ethanol-induced injury through a mechanism involving calcitonin gene-related peptide. Eur J Pharmacol 2011, 666(1-3):211-217. [Epub 2011 May 27].
54. Noh H.S., Shin I.W., Ha J.H., Hah Y.S., Baek S.M., Kim D.R. Propofol protects the autophagic cell death induced by the ischemia/reperfusion injury in rats. Mol Cells 2010, 30:455-460.
55. Tu S., Wang X., Yang F., Chen B., Wu S., He W. Propofol induces neuronal apoptosis in infant rat brain under hypoxic conditions. Brain Res Bull 2011, 86:29-35.
56. He X.Y., Shi X.Y., Yuan H.B., Xu H.T., Li Y.K., Zou Z. Propofol attenuates hypoxia-induced apoptosis in alveolar epithelial type II cells through down-regulating hypoxia-inducible factor-1alpha. Injury 2012, 43(3):279-283. [Epub 2011 Jun 23].
57. Liu K.X., Chen S.Q., Huang W.Q., Li Y.S., Irwin M.G., Xia Z. Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats. Anesth Analg 2008, 107:1884-1891.
58. Chen L., Xue Z., Jiang H. Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury. Acta Anaesthesiol Scand 2008, 52:413-419.
59. Shin I.W., Jang I.S., Lee S.H., Baik J.S., Park K.E., Sohn J.T. Propofol has delayed myocardial protective effects after a regional ischemia/reperfusion injury in an in vivo rat heart model. Korean J Anesthesiol 2010, 58:378-382.
60. Shibuya K., Ishiyama T., Ichikawa M., Sato H., Okuyama K., Sessler D.I. The direct effects of propofol on pial microvessels in rabbits. J Neurosurg Anesthesiol 2009, 21:40-46.