Dehydroepiandrosterone treatment attenuates reperfusion injury after testicular torsion and detorsion in rats

Journal of Pediatric Surgery

Volumn 42, Issue 10, 2007, Pages 1740-1744

  Aksoy, Hülya ^a   Yapanoglu, Turgut ^a   Aksoy, Yilmaz ^a   Özbey, Isa ^a   Turhan, Hamdullah ^a   Gursan, Nesrin ^a  

^a ATATURK UNIVERSITY   (Turkey)

Author keywords

Antioxidant enzymes; Dehydroepiandrosterone; Malondialdehyde; Testicular torsion

Indexed keywords

CATALASE; MALONALDEHYDE; PRASTERONE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; ISCHEMIA; LIPID PEROXIDATION; MALE; NONHUMAN; ORCHIECTOMY; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; TESTIS INJURY; TESTIS TORSION; TREATMENT RESPONSE;

ANIMALS; CATALASE; DEHYDROEPIANDROSTERONE; DRUG EVALUATION, PRECLINICAL; FREE RADICAL SCAVENGERS; ISCHEMIA; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SPERMATIC CORD TORSION; SUPEROXIDE DISMUTASE; TESTIS;

EID: 34848850688     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2007.05.033     Document Type: Article

References (30)

1. Can C., Tore F., Tuncel N., et al. Protective effect of vasoactive intestinal peptide on testicular torsion-detorsion injury: association with heparin-containing mast cells. Urology 63 (2004) 195-200
2. Romeo C., Antonuccio P., Esposito M., et al. Raxofelast, a hydrophilic vitamin E-like antioxidant, reduces testicular ischemia-reperfusion injury. Urol Res 32 (2004) 367-371
3. Filho D.W., Torres M.A., Bordin A.L.B., et al. Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Mol Aspects Med 25 (2004) 199-210
4. Uz E., Sogut S., and Sahin S. The protective role of caffeic acid phenethyl ester (CAPE) on testicular tissue after testicular torsion and detorsion. World J Urol 20 (2002) 264-270
5. Khalil A., Lehoux J.G., Wagner R.J., et al. Dehydroepiandrosterone protects low density lipoproteins against peroxidation by free radicals produced by gamma-radiolysis of ethanol-water mixtures. Atherosclerosis 136 (1998) 99-107
6. Li H., Klein G.M., Sun P., et al. Dehydroepiandroterone (DHEA) reduced neuronal injury in a rat model of global cerebral ischemia. Brain Res 888 (2001) 263-266
7. Aragno M., Tamagno E., Gatto V., et al. Dehydroepiandrosterone protects tissues of streptozotocin-treated rats against oxidative stress. Free Radic Biol Med 26 (1999) 1467-1474
8. Aksoy Y., Yapanoglu T., Aksoy H., et al. The effect of dehydroepiandrosterone on renal ischemia-reperfusion-induced oxidative stress in rabbits. Urol Res 32 (2004) 93-96
9. Ayhan S., Tugay C., Norton S., et al. Dehydroepiandrosterone protects the microcirculation of muscle flaps from ischemia-reperfusion injury by reducing the expression of adhesion molecules. Plast Reconstr Surg 111 (2003) 2286-2294
10. Aragno M., Parola S., Brignardello E., et al. Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats. Diabetes 49 (2000) 1924-1931
11. Turner T.T., Tung K.S., Tomomasa H., et al. Acute testicular ischemia results in germ cell-specific apoptosis in the rat. Biol Reprod 57 (1997) 1267-1274
12. Bradford M.M.A. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
13. Sun Y., Oberley L.W., and Ying L. A simple method for clinical assay of superoxide dismutase. Clin Chem 34 (1988) 497-500
14. Sinha A.K. Colorimetric assay of catalase. Anal Biochem 47 (1972) 389-394
15. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95 (1979) 351-358
16. Cosentino M.J., Nishida M., Rabinowitz R., et al. Histopathology of prepubertal rat testes subjected to various durations of spermatic cord torsion. J Androl 7 (1986) 23-31
17. Dokucu A.I., Ozturk H., Ozdemir E., et al. The protective effects of nitric oxide on the contralateral testis in prepubertal rats with unilateral testicular torsion. BJU Int 85 (2000) 767-771
18. Avlan D., Erdougan K., Cimen B., et al. The protective effect of selenium on ipsilateral and contralateral testes in testicular reperfusion injury. Pediatr Surg Int 21 (2005) 274-278
19. Tunckiran A., Cayan S., Bozlu M., et al. Protective effect of vascular endothelial growth factor on histologic changes in testicular ischemia-reperfusion injury. Fertil Steril 84 (2005) 468-473
20. Turner T.T. On unilateral testicular and epididymal torsion: no effect on the contralateral testis. J Urol 138 (1987) 1285-1290
21. Sukhotnik I., Miselevich I., Lurie M., et al. The time relationship between ipsilateral testicular ischemia and germ cell apoptosis in the contralateral testis in rat. Pediatr Surg Int 21 (2005) 512-516
22. Lysiak J.J., Turner S.D., and Turner T.T. Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis. Biol Reprod 63 (2000) 1465-1472
23. York J.P., and Drago J.R. Torsion and the contralateral testicle. J Urol 133 (1985) 294-297
24. Ozkurkcugil C., Yardimoglu M., Dalcik H., et al. Effect of insulin-like growth factor-1 on apoptosis of rat testicular germ cells induced by testicular torsion. BJU Int 93 (2004) 1094-1097
25. Greenstein A., Smith-Harrison L.I., Wakely P.E., et al. The effect of polyethylene glycol-superoxide dismutase administration on histological damage following spermatic cord torsion. J Urol 148 (1992) 639-641
26. Takahashi H., Nakajima A., and Sekihara H. Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) inhibit the apoptosis in human peripheral blood lymphocytes. J Steroid Biochem Mol Biol 88 (2004) 261-264
27. Aragno M., Brignardello E., Tamagno E., et al. Dehydroepiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats. J Endocrinol 155 (1997) 233-240
28. Mohan P., and Clearly M. Short-term effects of dehydroepiandrosterone treatment in rats on mitochondrial respiration. J Nutr 121 (1991) 240-250
29. Aragno M., Parola S., Tamagno E., et al. Oxidative derangement in rat synaptosomes induced by hyperglycaemia: restorative effect of dehydroepiandrosterone treatment. Biochem Pharmacol 60 (2000) 389-395
30. Tamagno E., Aragno M., Boccuzzi G., et al. Oxygen free radical scavenger properties of dehydroepiandrosterone. Cell Biochem Funct 16 (1998) 57-63