CXCR7 Silencing Attenuates Cell Adaptive Response to Stromal Cell Derived Factor 1α after Hypoxia

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Liu, Sufang ^a,b   Jia, Xiaofeng ^b   Li, Changsheng ^b,c   Han, Xuefei ^a   Yan, Wenhai ^a   Xing, Ying ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Department of Anesthesiology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR7; MITOGEN ACTIVATED PROTEIN KINASE 3; STROMAL CELL DERIVED FACTOR 1ALPHA;

ACTIN FILAMENT; ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL ELONGATION; CELL FUNCTION; CELL MIGRATION; CELL REGENERATION; CELL STRUCTURE; CONTROLLED STUDY; GENE SILENCING; HIPPOCAMPUS; HYPOXIA; NERVE CELL; NERVE FIBER; NERVE FIBER GROWTH; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN POLYMERIZATION; RAT; UPREGULATION;

ADAPTATION, PHYSIOLOGICAL; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CELL HYPOXIA; CHEMOKINE CXCL12; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; GENETIC VECTORS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LENTIVIRUS; NEURAL STEM CELLS; NEURITES; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CXCR; TIME FACTORS;

EID: 84873165734     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055290     Document Type: Article

References (43)

1. Feast A, Martinian L, Liu J, Catarino CB, Thom M, et al. (2012) Investigation of hypoxia-inducible factor-1alpha in hippocampal sclerosis: A postmortem study. Epilepsia 53: 1349-1359.
2. Wang Y, Huang J, Li Y, Yang GY, (2012) Roles of chemokine CXCL12 and its receptors in ischemic stroke. Curr Drug Targets 13: 166-172.
3. Timotijevic G, Mostarica Stojkovic M, Miljkovic D, (2012) CXCL12: role in neuroinflammation. Int J Biochem Cell Biol 44: 838-841.
4. Liu H, Liu S, Li Y, Wang X, Xue W, et al. (2012) The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury. PLoS One 7: e34608.
5. Hitchon C, Wong K, Ma G, Reed J, Lyttle D, et al. (2002) Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts. Arthritis Rheum 46: 2587-2597.
6. Gillard SE, Lu M, Mastracci RM, Miller RJ, (2002) Expression of functional chemokine receptors by rat cerebellar neurons. J Neuroimmunol 124: 16-28.
7. Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, et al. (1998) Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Natl Acad Sci U S A 95: 14500-14505.
8. Opatz J, Kury P, Schiwy N, Jarve A, Estrada V, et al. (2009) SDF-1 stimulates neurite growth on inhibitory CNS myelin. Mol Cell Neurosci 40: 293-300.
9. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, et al. (1998) Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A 95: 9448-9453.
10. Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, et al. (2005) The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem 280: 35760-35766.
11. Sanchez-Alcaniz JA, Haege S, Mueller W, Pla R, Mackay F, et al. (2011) Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron 69: 77-90.
12. Wang Y, Li G, Stanco A, Long JE, Crawford D, et al. (2011) CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron 69: 61-76.
13. Levoye A, Balabanian K, Baleux F, Bachelerie F, Lagane B, (2009) CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling. Blood 113: 6085-6093.
14. Rajagopal S, Kim J, Ahn S, Craig S, Lam CM, et al. (2010) Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proc Natl Acad Sci U S A 107: 628-632.
15. Kumar R, Tripathi V, Ahmad M, Nath N, Mir RA, et al. (2012) CXCR7 mediated Gialpha independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells. Cell Immunol 272: 230-241.
16. Brewer GJ, Torricelli JR, Evege EK, Price PJ, (1993) Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J Neurosci Res 35: 567-576.
17. Wang FZ, Ding AS, Liu ZW, (1995) Effect of ginsenosides against anoxic damage of hippocampal neurons in culture. Zhongguo Yao Li Xue Bao 16: 419-422.
18. Cui YF, Xu JC, Hargus G, Jakovcevski I, Schachner M, et al. (2011) Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery after spinal cord injury in mice. PLoS One 6: e17126.
19. Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, et al. (2006) Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Lab Invest 86: 1221-1232.
20. Rempel SA, Dudas S, Ge S, Gutierrez JA, (2000) Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 6: 102-111.
21. Carretero-Ortega J, Walsh CT, Hernandez-Garcia R, Reyes-Cruz G, Brown JH, et al. (2010) Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. Mol Pharmacol 77: 435-442.
22. Lazarini F, Tham TN, Casanova P, Arenzana-Seisdedos F, Dubois-Dalcq M, (2003) Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system. Glia 42: 139-148.
23. Li Q, Michaud M, Stewart W, Schwartz M, Madri JA, (2008) Modeling the neurovascular niche: murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn. J Neurosci Res 86: 1227-1242.
24. Schneider C, Krischke G, Rascher W, Gassmann M, Trollmann R, (2012) Systemic hypoxia differentially affects neurogenesis during early mouse brain maturation. Brain Dev 34: 261-273.
25. Arakawa Y, Bito H, Furuyashiki T, Tsuji T, Takemoto-Kimura S, et al. (2003) Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. J Cell Biol 161: 381-391.
26. Tanaka E, Sabry J, (1995) Making the connection: cytoskeletal rearrangements during growth cone guidance. Cell 83: 171-176.
27. Yu T, Huang H, Li HF, (2010) Stromal cell-derived factor-1 promotes migration of cells from the upper rhombic lip in cerebellar development. J Neurosci Res 88: 2775-2786.
28. Lysko DE, Putt M, Golden JA, (2011) SDF1 regulates leading process branching and speed of migrating interneurons. J Neurosci 31: 1739-1745.
29. Xu Q, Wang S, Jiang X, Zhao Y, Gao M, et al. (2007) Hypoxia-induced astrocytes promote the migration of neural progenitor cells via vascular endothelial factor, stem cell factor, stromal-derived factor-1alpha and monocyte chemoattractant protein-1 upregulation in vitro. Clin Exp Pharmacol Physiol 34: 624-631.
30. Robin AM, Zhang ZG, Wang L, Zhang RL, Katakowski M, et al. (2006) Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia. J Cereb Blood Flow Metab 26: 125-134.
31. Shimizu S, Brown M, Sengupta R, Penfold ME, Meucci O, (2011) CXCR7 protein expression in human adult brain and differentiated neurons. PLoS One 6: e20680.
32. Liu H, Xue W, Ge G, Luo X, Li Y, et al. (2010) Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1alpha in MSCs. Biochem Biophys Res Commun 401: 509-515.
33. Bakondi B, Shimada IS, Peterson BM, Spees JL, (2011) SDF-1alpha secreted by human CD133-derived multipotent stromal cells promotes neural progenitor cell survival through CXCR7. Stem Cells Dev 20: 1021-1029.
34. Schonemeier B, Kolodziej A, Schulz S, Jacobs S, Hoellt V, et al. (2008) Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain. J Comp Neurol 510: 207-220.
35. Sengupta R, Burbassi S, Shimizu S, Cappello S, Vallee RB, et al. (2009) Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. J Neurosci 29: 2534-2544.
36. Tiveron MC, Boutin C, Daou P, Moepps B, Cremer H (2010) Expression and function of CXCR7 in the mouse forebrain. J Neuroimmunol.
37. Yang K, Cao F, Sheikh AM, Malik M, Wen G, et al. (2012) Up-regulation of Ras/Raf/ERK1/2 signaling impairs cultured neuronal cell migration, neurogenesis, synapse formation, and dendritic spine development. Brain Struct Funct.
38. Ortega JA, Alcantara S, (2010) BDNF/MAPK/ERK-induced BMP7 expression in the developing cerebral cortex induces premature radial glia differentiation and impairs neuronal migration. Cereb Cortex 20: 2132-2144.
39. Reichardt LF, (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 361: 1545-1564.
40. Kremer KN, Clift IC, Miamen AG, Bamidele AO, Qian NX, et al. (2011) Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-beta3 and phospholipase C-gamma1 for distinct cellular responses. J Immunol 187: 1440-1447.
41. Lin SC, Wang CC, Wu MH, Yang SH, Li YH, et al. (2012) Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells. J Clin Endocrinol Metab 97: E1515-1523.
42. Biswas I, Garg I, Singh B, Khan GA, (2012) A key role of toll-like receptor 3 in tissue factor activation through extracellular signal regulated kinase 1/2 pathway in a murine hypoxia model. Blood Cells Mol Dis 49: 92-101.
43. Hota KB, Hota SK, Chaurasia OP, Singh SB, (2012) Acetyl-L-carnitine-mediated neuroprotection during hypoxia is attributed to ERK1/2-Nrf2-regulated mitochondrial biosynthesis. Hippocampus 22: 723-736.