Investigation of hypoxia-inducible factor-1α in hippocampal sclerosis: A postmortem study

Epilepsia

Volumn 53, Issue 8, 2012, Pages 1349-1359

  Feast, Alexandra ^a   Martinian, Lillian ^a   Liu, Joan ^a   Catarino, Claudia B ^a   Thom, Maria ^a   Sisodiya, Sanjay M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Epilepsy; Hippocampal sclerosis; Hypoxia inducible factor 1 ; Neuroprotection; Vascular endothelial growth factor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN;

ANTIBODY LABELING; ARTICLE; AUTOPSY; CONTROLLED STUDY; DENTATE HILUS; ENTORHINAL CORTEX; EPILEPSY; HEMISPHERE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPAL SCLEROSIS; HUMAN; NERVE CELL; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEIZURE; SEVERE MYOCLONIC EPILEPSY IN INFANCY; SUDDEN DEATH;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; EPILEPSY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MIDDLE AGED; SCLEROSIS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; YOUNG ADULT;

EID: 84865046345     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2012.03591.x     Document Type: Article

References (47)

1. Antoniou X, Gassmann M, Ogunshola OO,. (2011) Cdk5 interacts with Hif-1alpha in neurons: a new hypoxic signalling mechanism? Brain Res 1381: 1-10.
2. Ara J, Fekete S, Frank M, Golden JA, Pleasure D, Valencia I,. (2011) Hypoxic-preconditioning induces neuroprotection against hypoxia-ischemia in newborn piglet brain. Neurobiol Dis 43: 473-485.
3. Bateman LM, Li CS, Seyal M,. (2008) Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors. Brain 131: 3239-3245.
4. Blumcke I,. (2009) Neuropathology of focal epilepsies: a critical review. Epilepsy Behav 15: 34-39.
5. Blumcke I, Pauli E, Clusmann H, Schramm J, Becker A, Elger C, Merschhemke M, Meencke HJ, Lehmann T, von Deimling A, Scheiwe C, Zentner J, Volk B, Romstock J, Stefan H, Hildebrandt M,. (2007) A new clinico-pathological classification system for mesial temporal sclerosis. Acta Neuropathol 113: 235-244.
6. Boer K, Troost D, Spliet WG, van Rijen PC, Gorter JA, Aronica E,. (2008) Cellular distribution of vascular endothelial growth factor A (VEGFA) and B (VEGFB) and VEGF receptors 1 and 2 in focal cortical dysplasia type IIB. Acta Neuropathol 115: 683-696.
7. Cammalleri M, Martini D, Ristori C, Timperio AM, Bagnoli P,. (2011) Vascular endothelial growth factor up-regulation in the mouse hippocampus and its role in the control of epileptiform activity. Eur J Neurosci 33: 482-498.
8. Catarino CB, Liu JY, Liagkouras I, Gibbons VS, Labrum RW, Ellis R, Woodward C, Davis MB, Smith SJ, Cross JH, Appleton RE, Yendle SC, McMahon JM, Bellows ST, Jacques TS, Zuberi SM, Koepp MJ, Martinian L, Scheffer IE, Thom M, Sisodiya SM,. (2011) Dravet syndrome as epileptic encephalopathy: evidence from long-term course and neuropathology. Brain 134 (Pt 10): 2982-3010.
9. Croll SD, Goodman JH, Scharfman HE,. (2004) Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword. Adv Exp Med Biol 548: 57-68.
10. Dawodu S, Thom M,. (2005) Quantitative neuropathology of the entorhinal cortex region in patients with hippocampal sclerosis and temporal lobe epilepsy. Epilepsia 46: 23-30.
11. Duvernoy HM,. (2005) The human hippocampus: functional anatomy, vascularization, and serial sections with MRI. Springer, Berlin; New York.
12. Fan X, Heijnen CJ, van der Kooij MA, Groenendaal F, van Bel F,. (2009) The role and regulation of hypoxia-inducible factor-1alpha expression in brain development and neonatal hypoxic-ischemic brain injury. Brain Res Rev 62: 99-108.
13. Ferrara N,. (2001) Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol 280: C1358-C1366.
14. Ferriero DM,. (2005) Protecting neurons. Epilepsia 46 (Suppl. 7): 45-51.
15. Henshall DC,. (2007) Apoptosis signalling pathways in seizure-induced neuronal death and epilepsy. Biochem Soc Trans 35: 421-423.
16. Huang LE, Gu J, Schau M, Bunn HF,. (1998) Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95: 7987-7992.
17. Jewell UR, Kvietikova I, Scheid A, Bauer C, Wenger RH, Gassmann M,. (2001) Induction of HIF-1alpha in response to hypoxia is instantaneous. Faseb J 15: 1312-1314.
18. Jin KL, Mao XO, Greenberg DA,. (2000) Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc Natl Acad Sci USA 97: 10242-10247.
19. Kandel ER, Squire LR,. (2000) Neuroscience: breaking down scientific barriers to the study of brain and mind. Science 290: 1113-1120.
20. Kent GP, Schefft BK, Howe SR, Szaflarski JP, Yeh HS, Privitera MD,. (2006) The effects of duration of intractable epilepsy on memory function. Epilepsy Behav 9: 469-477.
21. Madri JA,. (2009) Modeling the neurovascular niche: implications for recovery from CNS injury. J Physiol Pharmacol 60 (Suppl. 4): 95-104.
22. Magloczky Z,. (2010) Sprouting in human temporal lobe epilepsy: excitatory pathways and axons of interneurons. Epilepsy Res 89: 52-59.
23. Magloczky Z, Wittner L, Borhegyi Z, Halasz P, Vajda J, Czirjak S, Freund TF,. (2000) Changes in the distribution and connectivity of interneurons in the epileptic human dentate gyrus. Neuroscience 96: 7-25.
24. Marti HJ, Bernaudin M, Bellail A, Schoch H, Euler M, Petit E, Risau W,. (2000) Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol 156: 965-976.
25. McIntyre DC, Gilby KL,. (2008) Mapping seizure pathways in the temporal lobe. Epilepsia 49 (Suppl. 3): 23-30.
26. Meencke HJ, Veith G, Lund S,. (1996) Bilateral hippocampal sclerosis and secondary epileptogenesis. Epilepsy Res Suppl 12: 335-342.
27. Moroz E, Carlin S, Dyomina K, Burke S, Thaler HT, Blasberg R, Serganova I,. (2009) Real-time imaging of HIF-1alpha stabilization and degradation. PLoS ONE 4: e5077.
28. Moseley BD, Nickels K, Britton J, Wirrell E,. (2010) How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures? Epilepsia 51: 1219-1224.
29. Nicoletti JN, Shah SK, McCloskey DP, Goodman JH, Elkady A, Atassi H, Hylton D, Rudge JS, Scharfman HE, Croll SD,. (2008) Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. Neuroscience 151: 232-241.
30. Ogunshola OO, Antoniou X,. (2009) Contribution of hypoxia to Alzheimer's disease: is HIF-1alpha a mediator of neurodegeneration? Cell Mol Life Sci 66: 3555-3563.
31. Pore N, Liu S, Shu HK, Li B, Haas-Kogan D, Stokoe D, Milanini-Mongiat J, Pages G, O'Rourke DM, Bernhard E, Maity A,. (2004) Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism. Mol Biol Cell 15: 4841-4853.
32. Ratan RR, Siddiq A, Smirnova N, Karpisheva K, Haskew-Layton R, McConoughey S, Langley B, Estevez A, Huerta PT, Volpe B, Roy S, Sen CK, Gazaryan I, Cho S, Fink M, LaManna J,. (2007) Harnessing hypoxic adaptation to prevent, treat, and repair stroke. J Mol Med 85: 1331-1338.
33. Rigau V, Morin M, Rousset MC, de Bock F, Lebrun A, Coubes P, Picot MC, Baldy-Moulinier M, Bockaert J, Crespel A, Lerner-Natoli M,. (2007) Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy. Brain 130: 1942-1956.
34. Rohwer N, Cramer T,. (2011) Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat 14: 191-201.
35. Salceda S, Caro J,. (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272: 22642-22647.
36. Semenza GL,. (2000) HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480.
37. Sen A, Thom M, Martinian L, Jacobs T, Nikolic M, Sisodiya SM,. (2006) Deregulation of cdk5 in Hippocampal sclerosis. J Neuropathol Exp Neurol 65: 55-66.
38. Stowe AM, Plautz EJ, Nguyen P, Frost SB, Eisner-Janowicz I, Barbay S, Dancause N, Sensarma A, Taylor MD, Zoubina EV, Nudo RJ,. (2008) Neuronal HIF-1 alpha protein and VEGFR-2 immunoreactivity in functionally related motor areas following a focal M1 infarct. J Cereb Blood Flow Metab 28: 612-620.
39. Thaik-Oo M, Tanaka E, Tsuchiya T, Kominato Y, Honda K, Yamazaki K, Misawa S,. (2002) Estimation of postmortem interval from hypoxic inducible levels of vascular endothelial growth factor. J Forensic Sci 47: 186-189.
40. Thom M, Zhou J, Martinian L, Sisodiya S,. (2005) Quantitative post-mortem study of the hippocampus in chronic epilepsy: seizures do not inevitably cause neuronal loss. Brain 128: 1344-1357.
41. Thom M, Eriksson S, Martinian L, Caboclo LO, McEvoy AW, Duncan JS, Sisodiya SM,. (2009) Temporal lobe sclerosis associated with hippocampal sclerosis in temporal lobe epilepsy: neuropathological features. J Neuropathol Exp Neurol 68: 928-938.
42. Thom M, Liagkouras I, Elliot KJ, Martinian L, Harkness W, McEvoy A, Caboclo LO, Sisodiya SM,. (2010) Reliability of patterns of hippocampal sclerosis as predictors of postsurgical outcome. Epilepsia 51: 1801-1808.
43. Thom M, Liu JY, Thompson P, Phadke R, Narkiewicz M, Martinian L, Marsdon D, Koepp M, Caboclo L, Catarino CB, Sisodiya SM,. (2011) Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study. Brain 134 (Pt 10): 2969-2981.
44. Yeh SH, Hung JJ, Gean PW, Chang WC,. (2008) Hypoxia-inducible factor-1alpha protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression. J Neurosci 28: 14259-14270.
45. Yeh SH, Ou LC, Gean PW, Hung JJ, Chang WC,. (2011) Selective inhibition of early-but not late-expressed HIF-1alpha is neuroprotective in rats after focal ischemic brain damage. Brain Pathol 21: 249-262.
46. Yilmazer-Hanke DM, Wolf HK, Schramm J, Elger CE, Wiestler OD, Blumcke I,. (2000) Subregional pathology of the amygdala complex and entorhinal region in surgical specimens from patients with pharmacoresistant temporal lobe epilepsy. J Neuropathol Exp Neurol 59: 907-920.
47. Zhang L, Qu Y, Yang C, Tang J, Zhang X, Mao M, Mu D, Ferriero D,. (2009) Signaling pathway involved in hypoxia-inducible factor-1alpha regulation in hypoxic-ischemic cortical neurons in vitro. Neurosci Lett 461: 1-6.