Foam cell apoptosis and the development of the lipid core of human atherosclerosis

Journal of Pathology

Volumn 180, Issue 4, 1996, Pages 423-429

  Hegyi, Laszlo ^a   Skepper, Jeremy N ^a   Cary, Nat R B ^b   Mitchinson, Malcolm J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PAPWORTH HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Atherosclerosis (human); Foam cell; Lipid core; Macrophage; PCNA

Indexed keywords

CYCLINE; LOW DENSITY LIPOPROTEIN;

ADULT; AGED; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CLINICAL ARTICLE; CORONARY ARTERY; ELECTRON MICROSCOPY; FEMALE; FOAM CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; ARTERIOSCLEROSIS; DNA FRAGMENTATION; DNA NUCLEOTIDYLEXOTRANSFERASE; FEMALE; FOAM CELLS; HUMANS; LIPID METABOLISM; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MIDDLE AGED; PROLIFERATING CELL NUCLEAR ANTIGEN;

EID: 0030474490     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199612)180:4<423::AID-PATH677>3.0.CO;2-1     Document Type: Article

References (35)

1. Guyton JR, Klemp KF. Transitional features in human atherosclerosis. Intimal thickening, cholesterol clefts, and cell loss in human aortic fatty streaks. Am J Pathol 1993; 143: 1444-1457.
2. Ball RY, Stowers EC, Burton JH, Cary NRB, Skepper JN, Mitchinson MJ. Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma. Atherosclerosis 1995; 114: 45-54.
3. Geng YJ, Libby P. Evidence for apoptosis in advanced human atheroma. Am J Pathol 1995; 147: 251-266.
4. Han DKM, Haudenschild CC, Hong MK., Tinkle BT, Leon MB, Liau G. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am J Pathol 1995; 147: 267-277.
5. Cathcart MK, Morel DW, Chisolm GM. Monocytes and neutrophils oxidise low density lipoprotein making it cytotoxic. J Leukocyte Biol 1985; 38: 341-350.
6. Reid VC, Mitchinson MJ. Toxicity of oxidised low density lipoprotein towards mouse peritoneal macrophages in vitro. Atherosclerosis 1993; 98: 17-24.
7. Marchant CE, Law NS, van der Veen C, Hardwick SJ, Carpenter KLH, Mitchinson MJ. Oxidized low-density lipoprotein is cytotoxic to human monocyte-macrophages: protection with lipophilic antioxidants. FEBS Lett 1995; 358: 175-178.
8. Reid VC, Mitchinson MJ, Skepper JN. Cytotoxicity of oxidized low-density lipoprotein to mouse peritoneal macrophages: an ultrastructural study. J Pathol 1993; 171: 321-328.
9. Hardwick SJ, Hegyi L, Clare K, et al. Apoptosis in human monocyte-macrophages exposed to oxidized low density lipoprotein. J Pathol 1996; 179: 294-302.
10. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol, modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989; 320: 915-924.
11. Braesen JH, Beisiegel U, Niendorf A. Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbits. Virchows Arch 1995; 426: 179-188.
12. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
13. Gundersen HJG. Notes on the estimation of the numerical density of arbitrary profiles: the edge effect. J Microsc 1977; 111: 219-223.
14. Migheli A, Attanasio A, Schiffer D. Ultrastructural detection of DNA strand breaks in apoptotic neural cells by in situ end-labelling techniques. J Pathol 1995; 176: 27-35.
15. Montenegro MR, Eggen DA. Topography of atherosclerosis in the coronary arteries. Lab Invest 1968; 18: 586-593.
16. Faggiotto A, Ross R. Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque. Arteriosclerosis 1984; 4: 341-356.
17. Tejada C, Strong JP, Montenegro MR, Restrepo C, Solberg LA. Distribution of coronary and aortic atherosclerosis by geographic location, race, and sex. Lab Invest 1968; 18: 509-526.
18. Aqel NM, Ball RY, Waldmann H, Mitchinson MJ. Identification of macrophages and smooth muscle cells in human atherosclerosis using monoclonal antibodies. J Pathol 1985; 146: 197-204.
19. Bennett MR, Evan GI, Schwartz SM. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest 1995; 95: 2266-2274.
20. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
21. Wyllie AH, Kerr JFR, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol 1980; 68: 251-306.
22. Rubin LL, Philpott KL, Brooks SF. The cell cycle and cell death. Curr Biol 1993; 3: 391-394.
23. Evan GI, Wyllie AH, Gilbert CS, et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992; 69: 119-128.
24. Chittenden T, Harrington EA, O'Connor R, et al. Induction of apoptosis by the Bcl-2 homologue Bak. Nature 1995; 374: 733-736.
25. Christ M, Luu B, Mejia JE, Moosbrugger I, Bischoff P. Apoptosis induced by oxysterols in murine lymphoma cells and in normal thymocytes. Immunology 1993; 78: 455-460.
26. Isner JM, Kearney M, Bortman S, Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation 1995; 91: 2703-2711.
27. Gordon D, Reidy MA, Benditt EP, Schwartz SM. Cell proliferation in human coronary arteries. Proc Natl Acad Sci USA 1990; 87: 4600-4604.
28. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801-809.
29. Berges RR, Furuya Y, Remington L, English HF, Jacks T, Isaacs JT. Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation. Proc Natl Acad Sci USA 1993; 90: 8910-8914.
30. Marchant CE, van der Veen C, Law NS, et al. Oxidation of low-density lipoprotein by human monocyte-macrophages results in toxicity to the oxidising culture. Free Rad Res 1996; 24: 333-342.
31. Clare K, Hardwick SJ, Carpenter KLH, Weeratunge N, Mitchinson MJ. Toxicity of oxysterols to human monocyte-macrophages. Atherosclerosis 1995; 118: 67-75.
32. Alison MR, Sarraf CE. Apoptosis: regulation and relevance to toxicology. Hum Exp Toxicol 1995; 14: 234-247.
33. Palinski W, Rosenfeld ME, Ylä-Herttuala S, et al. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci USA 1989; 86: 1372-1376.
34. Mitchinson MJ. Macrophages, oxidised lipids and atherosclerosis. Med Hypotheses 1983; 12: 171-178.
35. Stephens NG, Parsons A, Schofield P, et al. A randomised controlled trial of vitamin E in patients with coronary disease: the Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996; 347: 781-786.