Ablation of Neutral Cholesterol Ester Hydrolase 1 Accelerates Atherosclerosis

Cell Metabolism

Volumn 10, Issue 3, 2009, Pages 219-228

  Sekiya, Motohiro ^a   Osuga, Jun ichi ^a,b   Nagashima, Shuichi ^b   Ohshiro, Taichi ^b   Igarashi, Masaki ^a   Okazaki, Hiroaki ^a   Takahashi, Manabu ^b   Tazoe, Fumiko ^b   Wada, Taeko ^b   Ohta, Keisuke ^a   Takanashi, Mikio ^a   Kumagai, Masayoshi ^a   Nishi, Makiko ^a   Takase, Satoru ^a   Yahagi, Naoya ^a   Yagyu, Hiroaki ^b   Ohashi, Ken ^a   Nagai, Ryozo ^a   Kadowaki, Takashi ^a   Furukawa, Yusuke ^b   Ishibashi, Shun ^b   more..

^a UNIVERSITY OF TOKYO   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

HUMDISEASE

Indexed keywords

CARBOXYLESTERASE; CHOLESTEROL ESTER; CHOLESTEROL ESTERASE; NEUTRAL CHOLESTEROL ESTERASE 1; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEFICIENCY; FOAM CELL; HYDROLYSIS; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHOLESTEROL; CHOLESTEROL ESTERS; FOAM CELLS; GENE KNOCKDOWN TECHNIQUES; MALE; MICE; MICE, KNOCKOUT; RNA INTERFERENCE; SERINE PROTEASES; STEROL ESTERASE;

MUS;

EID: 69149107158     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2009.08.004     Document Type: Article

References (44)

1. Brown M.S., Goldstein J.L., Krieger M., Ho Y.K., and Anderson R.G. Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins. J. Cell Biol. 82 (1979) 597-613
2. Chang T.Y., Chang C.C., Lin S., Yu C., Li B.L., and Miyazaki A. Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2. Curr Opin Lipidol 12 (2001) 289-296
3. Chiang K.P., Niessen S., Saghatelian A., and Cravatt B.F. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem. Biol. 13 (2006) 1041-1050
4. Choy H.A., Wang X.P., and Schotz M.C. Reduced atherosclerosis in hormone-sensitive lipase transgenic mice overexpressing cholesterol acceptors. Biochim. Biophys. Acta 1634 (2003) 76-85
5. Escary J.L., Choy H.A., Reue K., and Schotz M.C. Hormone-sensitive lipase overexpression increases cholesteryl ester hydrolysis in macrophage foam cells. Arterioscler. Thromb. Vasc. Biol. 18 (1998) 991-998
6. Ghosh S. Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA. Physiol. Genomics 2 (2000) 1-8
7. Goldstein J.L., Ho Y.K., Basu S.K., and Brown M.S. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc. Natl. Acad. Sci. USA 76 (1979) 333-337
8. Goldstein J.L., Basu S.K., and Brown M.S. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods Enzymol. 98 (1983) 241-260
9. Havel R.J., Eder H.A., and Bragdon J.H. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34 (1955) 1345-1353
10. Heider J.G., and Boyett R.L. The picomole determination of free and total cholesterol in cells in culture. J. Lipid Res. 19 (1978) 514-518
11. Igarashi M., Osuga J.I., Isshiki M., Sekiya M., Okazaki H., Takase S., Takanashi M., Ohta K., Kumagai M., Nishi M., et al. Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence. J. Lipid Res. (2009) 10.1194/jlr.M900201-JLR200 Published online July 10, 2009
12. Ishibashi S., Brown M.S., Goldstein J.L., Gerard R.D., Hammer R.E., and Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92 (1993) 883-893
13. Ishii I., Oka M., Katto N., Shirai K., Saito Y., and Hirose S. Beta-VLDL-induced cholesterol ester deposition in macrophages may be regulated by neutral cholesterol esterase activity. Arterioscler. Thromb. 12 (1992) 1139-1145
14. Kritharides L., Christian A., Stoudt G., Morel D., and Rothblat G.H. Cholesterol metabolism and efflux in human THP-1 macrophages. Arterioscler. Thromb. Vasc. Biol. 18 (1998) 1589-1599
15. Lehner R., and Vance D.E. Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol. Biochem. J. 343 (1999) 1-10
16. Libby P. Inflammation in atherosclerosis. Nature 420 (2002) 868-874
17. Long R.M., Calabrese M.R., Martin B.M., and Pohl L.R. Cloning and sequencing of a human liver carboxylesterase isoenzyme. Life Sci. 48 (1991) PL43-PL49
18. Mignon A., Guidotti J.E., Mitchell C., Fabre M., Wernet A., De La Coste A., Soubrane O., Gilgenkrantz H., and Kahn A. Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes. Nat. Med. 4 (1998) 1185-1188
19. Munger J.S., Shi G.P., Mark E.A., Chin D.T., Gerard C., and Chapman H.A. A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases. J. Biol. Chem. 266 (1991) 18832-18838
20. Ninio E. Phospholipid mediators in the vessel wall: involvement in atherosclerosis. Curr. Opin. Clin. Nutr. Metab. Care 8 (2005) 123-131
21. Nomura D.K., Leung D., Chiang K.P., Quistad G.B., Cravatt B.F., and Casida J.E. A brain detoxifying enzyme for organophosphorus nerve poisons. Proc. Natl. Acad. Sci. USA 102 (2005) 6195-6200
22. Okazaki H., Osuga J., Tsukamoto K., Isoo N., Kitamine T., Tamura Y., Tomita S., Sekiya M., Yahagi N., Iizuka Y., et al. Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase. J. Biol. Chem. 277 (2002) 31893-31899
23. Okazaki H., Igarashi M., Nishi M., Tajima M., Sekiya M., Okazaki S., Yahagi N., Ohashi K., Tsukamoto K., Amemiya-Kudo M., et al. Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis. Diabetes 55 (2006) 2091-2097
24. Okazaki H., Igarashi M., Nishi M., Sekiya M., Tajima M., Takase S., Takanashi M., Ohta K., Tamura Y., Okazaki S., et al. Identification of neutral cholesterol ester hydrolase,a key enzyme removing cholesterol from macrophages. J. Biol. Chem. 283 (2008) 33357-33364
25. Osuga J., Ishibashi S., Oka T., Yagyu H., Tozawa R., Fujimoto A., Shionoiri F., Yahagi N., Kraemer F.B., Tsutsumi O., and Yamada N. Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Proc. Natl. Acad. Sci. USA 97 (2000) 787-792
26. Out R., Jessup W., Le Goff W., Hoekstra M., Gelissen I.C., Zhao Y., Kritharides L., Chimini G., Kuiper J., Chapman M.J., et al. Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1. Circ. Res. 102 (2008) 113-120
27. Paigen B., Morrow A., Holmes P.A., Mitchell D., and Williams R.A. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 68 (1987) 231-240
28. Perrey S., Ishibashi S., Kitamine T., Osuga J., Yagyu H., Chen Z., Shionoiri F., Iizuka Y., Yahagi N., Tamura Y., et al. The LDL receptor is the major pathway for beta-VLDL uptake by mouse peritoneal macrophages. Atherosclerosis 154 (2001) 51-60
29. Probst M.R., Beer M., Beer D., Jeno P., Meyer U.A., and Gasser R. Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. J. Biol. Chem. 269 (1994) 21650-21656
30. Roberts D.C., Miller N.E., Price S.G., Crook D., Cortese C., La Ville A., Masana L., and Lewis B. An alternative procedure for incorporating radiolabelled cholesteryl ester into human plasma lipoproteins in vitro. Biochem. J. 226 (1985) 319-322
31. Sakai M., Miyazaki A., Hakamata H., Kodama T., Suzuki H., Kobori S., Shichiri M., and Horiuchi S. The scavenger receptor serves as a route for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage proliferation. J. Biol. Chem. 271 (1996) 27346-27352
32. Sekiya M., Osuga J., Yahagi N., Okazaki H., Tamura Y., Igarashi M., Takase S., Harada K., Okazaki S., Iizuka Y., et al. Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis. J. Lipid Res. 49 (2008) 1829-1838
33. Tabas I. Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 2255-2264
34. Takahashi K., Kasai M., Ohta M., Shoji Y., Kunishiro K., Kanda M., Kurahashi K., and Shirahase H. Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid. J. Med. Chem. 51 (2008) 4823-4833
35. Tazoe F., Yagyu H., Okazaki H., Igarashi M., Eto K., Nagashima S., Inaba T., Shimano H., Osuga J., and Ishibashi S. Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages. Biochem. Biophys. Res. Commun. 376 (2008) 111-115
36. Tiwari R., Koffel R., and Schneiter R. An acetylation/deacetylation cycle controls the export of sterols and steroids from S. cerevisiae. EMBO J. 26 (2007) 5109-5119
37. Veniant M.M., Sullivan M.A., Kim S.K., Ambroziak P., Chu A., Wilson M.D., Hellerstein M.K., Rudel L.L., Walzem R.L., and Young S.G. Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100. J. Clin. Invest. 106 (2000) 1501-1510
38. Venkateswaran A., Laffitte B.A., Joseph S.B., Mak P.A., Wilpitz D.C., Edwards P.A., and Tontonoz P. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc. Natl. Acad. Sci. USA 97 (2000) 12097-12102
39. Wang X., Collins H.L., Ranalletta M., Fuki I.V., Billheimer J.T., Rothblat G.H., Tall A.R., and Rader D.J. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J. Clin. Invest. 117 (2007) 2216-2224
40. Yagyu H., Kitamine T., Osuga J., Tozawa R., Chen Z., Kaji Y., Oka T., Perrey S., Tamura Y., Ohashi K., et al. Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. J. Biol. Chem. 275 (2000) 21324-21330
41. Yeaman S.J. Hormone-sensitive lipase-new roles for an old enzyme. Biochem. J. 379 (2004) 11-22
42. Yvan-Charvet L., Ranalletta M., Wang N., Han S., Terasaka N., Li R., Welch C., and Tall A.R. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J. Clin. Invest. 117 (2007) 3900-3908
43. Zhao B., Song J., Chow W.N., St Clair R.W., Rudel L.L., and Ghosh S. Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice. J. Clin. Invest. 117 (2007) 2983-2992
44. Zimmermann R., Lass A., Haemmerle G., and Zechner R. Fate of fat: The role of adipose triglyceride lipase in lipolysis. Biochim. Biophys. Acta 1791 (2008) 494-500