Evidence for type 2 cytokine production and lymphocyte activation in the early phases of HIV-1 infection

AIDS

Volumn 10, Issue 1, 1996, Pages 23-30

  Meroni, Luca ^a   Trabattoni, Daria ^a   Balotta, Claudia ^a   Riva, Chiara ^a   Gori, Andrea ^a   Moroni, Mauro ^a   Villa, Maria Luisa ^a   Clerici, Mario ^a   Galli, Massimo ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Cytokines; Disease progression; HIV infection; Immunology; T lymphocytes

Indexed keywords

CD38 ANTIGEN; CD4 ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; MALE; PRIORITY JOURNAL; SEROCONVERSION; T LYMPHOCYTE ACTIVATION;

EID: 0030042402     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199601000-00004     Document Type: Article

References (61)

1. Shearer GM, Clerici M: Early T-helper defects in HIV infection. AIDS 1991, 5:245-253.
2. Levy JA: HIV pathogenesis and long-term survival. AIDS 1993, 7:1401-1410.
3. Fauci AS: Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 1993, 262:1011-1018.
4. Lane HC, Depper JM, Greene WC, Whalen C, Waldmann TA, Fauci AS: Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome: evidence for a selective defect in soluble antigens recognition. N Engl J Med 1985, 313:79-84.
5. Smolen JS, Bettleheim P, Koller U, et al.: Deficiency of the autologous mixed lymphocyte reaction in patients with classic hemophilia treated with communical Factor VIII concentrate: correlation with T cell subset distribution, antibodies to lymphadenopathy-associated or human T lymphotropic virus, and analysis of the cellular basis of the deficiency. J Clin Invest 1985, 75:1828-1834.
6. Giorgi JV, Fahey JL, Smith DC, et al.: Early effects of HIV on CD4 lymphocytes in vivo. J Immunol 1987, 138:3725-3730.
7. Miedema F, Petit AJ, Terpstra FG, et al.: Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs. J Clin Invest 1988, 82:1908-1916.
8. Clerici M, Stocks NI, Zajac RA, et al.: Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, HIV seropositive individuals: independence of CD4 cell number and clinical staging. J Clin Invest 1989, 84:1892-1899.
9. Chehimi J, Trinchieri G, Frank I, et al.: IL-12 deficiency in HIV-infected patients. J Exp Med 1994, 179:1361-1366.
10. Maggi E, Macchia D, Parronchi P, et al.: Reduced production of interleukin-2 and interferon-gamma and enhanced helper activity for IgG synthesis by cloned CD4+ T-cells from patients with AIDS. Eur J Immunol 1987, 17:1685-1689.
11. Clerici M, Lucey DR, Berzofsky JA, et al.: Restoration of HIV-specific cell mediated immune responses by interleukin-12 in vitro. Science 1993, 262:1721-1724.
12. Clerici M, Hakim FT, Venzon DJ, et al.: Changes in interleukin 2 and interleukin 4 production in asymptomatic, HIV-seropositive individuals. J Clin Invest 1993, 91: 759-765.
13. Naviskas V, Link J, Warhen B, Persson C, Link H: Increased levels of interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) mRNA expressing blood mononuclear cells in human HIV infection. Clin Exp Immunol 1994, 96:59-63.
14. Meeyard L, Otto SA, Keet IPM, Van Lier RAW, Miedema F: Changes in cytokine secretion patterns of CD4+ T cell clones in HIV infection. Blood 1994, 84:4262-4270.
15. Martinez-Maza O: IL-6 in AIDS. Res Immunol 1992, 143:764-769.
16. Benjamin D, Knobloch TJ, Dayton MA: Human B-cell interleukin-10: B-cell lines derived from patients with AIDS and Burkitt lymphoma constitutively secrete large quantities of interleukin-10. Blood 1992, 80:1289-1299.
17. Clerici M, Wynn TA, Berzofsky JA, et al.: Role of interleukin-10 (IL-10) in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus (HIV-1). J Clin Invest 1994, 93:768-775.
18. Akridge RE, Oyafuso LKM, Reed SG: IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages. J Immunol 1994, 153:5782-5788.
19. Emilie D, Fior L, Llorente A, et al.: Cytokines from lymphoid organs of HIV-infected patients: production and role in the immune disequilibrium of the disease and in development of B lymphomas. Immunol Rev 1994, 140:5-35.
20. Naviskas V, Link J, Warhen B, Persson C, Link H: Increased expression of IL-6, IL-10, TNF-α and perform in blood mononuclear cells in human HIV infection. AIDS Res Hum Retroviruses (in press).
21. Clerici M, Shearer GM: A TH1→TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993, 14:107-111.
22. Erard F, Wild MT, Garciz-Sanz JA, Legros C: Switch of CD8 T cells to noncytokitic CD8-CD4- cells that make Th2 cytokines and help B cells. Science 1993, 260:1802-1805.
23. Clerici M, Shearer CM: The TH1/TH2 model of HIV infection: new insights. Immunol Today 1995, 15:575-580.
24. Barcellini W, Rizzardi CP, Borhil MO, et al.: TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients. AIDS 1994, 8:757-762.
25. Miedema F, Meyaard L, Koot M, et al.: Changing virus-host interactions in the course of HIV infection. Immunol Rev 1994, 140:35-72.
26. Maggi E, Giudizi MC, Biagiotti R, et al.: Th2-like CD8+ cells showing B cell helper function and reduced cytolytic activity in HIV-I infection. J Exp Med 1994, 180:489-495.
27. Blatt SP, Hendrix CW, Butzin CA, et al.: Delayed type hypersensitivity skin testing predicts progression to AIDS in HIV-infected patients. Ann Intern Med 1993, 119:177-184.
28. Markowits N, Hansen NI, Wilcosky TC, et al.: Tubercolin and anergy testing in HIV-seropositive and HIV-seronegative persons. Ann Intern Med 1993, 119:185-193.
29. Lucey DR, Zajac RA, Melcher GP, et al.: Serum IgE levels in 622 persons with HIV infection: IgE elevation with marked depletion of CD4+ T-cells. AIDS Res Hum Retroviruses 1990, 6:427-429.
30. Israel-Biet D, Labrousse F, Tourani JM, Sors H, Andrieu JM, Even P: Elevation of IgE in HIV-infected subjects: a marker of poor prognosis. J Allergy Clin Immunol 1992, 89:68-75.
31. Romagnani S, Del Prete C, Manetti R, et al.: Role of Th1/Th2 cytokines in HIV infection. Immunol Rev 1994, 140:73-92.
32. Vigano' A, Principi N, Crupi L, et al.: Elevation of IgE in HIV-infected children and its correlation with the progression of the disease. J Allergy Clin Immunol 1995, 95:627-632.
33. Vigano' A, Principi N, Villa ML, et al.: Immunologic characterization of children vertically infected with human immuno-deficiency virus with slow or rapid progression. J Pediatr 1995, 126:368-374.
34. Fleury-Feith J, Van Nheieu JT, Picard C, Escudier E, Bernaudin JF: Bronchoalveolar lavage eosinophilia associated with Pneumocystis carinii pneumonia in AIDS patients. Comparative study with non-AIDS patients. Chest 1992, 95:1198-1201.
35. Smith KJ, Skelton HG, Drabick JJ, et al.: Hypereosinophilia secondary to immunodysregulation in patients with HIV-1 disease. Arch Dermatol 1994, 130:119-121.
36. Caterino-de-Araujo A: HIV-1 infection and eosinophilia. Immunol Today 1994, 15:498-499.
37. Landay A, Ohlsson-Wilhelm B, Giorgi J: Application of flow cytometry on the sudy of HIV infection. AIDS 1990, 4:479-497.
38. Legac E, Autran B, Merle-Beral H, Katlama C, Debre P: CD4+CD7-CD57+ T cells: a new T lymphocyte subset expanded during HIV infection. Blood 1992, 79:1746-1753.
39. Autran B, Legac E, Blanc C, Debre P: A Th0/Th2-like function of CD4+CD7+ T helper cells from normal donors and HIV infected patients. J Immunol 1995, 154:1408-1417.
40. Prince HE, Jensen ER: Three color cytofluorimetric analysis of CD8 cell subset in HIV-1 infection. J Acquir Immume Defic Syndr 1991, 4:1227-1232
41. Levacher M, Hulstaert F, Tallet S, Ullery S, Pocidalo JJ, Bach BA: The significance of activation markers on CD8 lymphocytes in human immunodeficiency syndrome: staging and prognostic value. Clin Exp Immunol 1992, 90:376-382.
42. Kestens L, Vanham C, Gigase P, et al.: Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection. AIDS 1992, 6:793-797.
43. Giorgi JV, Ho HN, Hirji K, et al.: CD8 lymphocyte activation at human immunodeficiency type 1 seroconversion: development of HLA-DR+, CD38- CD8+ cells is associated with subsequent stable CD4 cell levels. J Infect Dis 1994, 170:775-781.
44. Gaines H, von Sydow MAE, von Stedingk LV, et al.: Immunological changes in primary HIV-1 infection. AIDS 1990, 4:995-999.
45. Pedersen C, Dickmeiss E, Gaub J, et al.: T-cell alterations and lymphocyte responsiveness to mitogens and antigen during severe primary infection with HIV: a case series of seven consecutive seroconverters. AIDS 1990, 4:523-526.
46. Daar ES, Moudgil T, Meyer RD, Ho DD: Transient high levels of viremia in patients with primary HIV-1 infection. N Engl J Med 1991, 324:961-964.
47. Sinicco A, Fora R, Sciandra M, Lucchini A, Caramello P, Gioannini P: Risk of developing AIDS after primary acute HIV-1 infection. J Acquir Immun Defic Syndr 1993, 6:575-581.
48. + lymphocyte response in acutely infected Rhesus monkeys. J Virol 1993, 67:1707-1711.
49. Keet IPM, Krijnen P, Koot M, et al.: Predictors of rapid progression to AIDS in HIV-1 seroconverters. AIDS 1993, 7:51-57.
50. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MBA: Virus-specific CD8+ T lymphocyte activity associated with control of viremia in primary HIV type-1 infection. J Virol 1994, 68:6103-1610.
51. Safrit JT, Andrews CA, Zhu T, Ho DD, Koup RA: Characterization of HIV-1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope. J Exp Med 1994, 179:463-472.
52. Koup RA, Ho DD: Shutting down HIV. Nature 1994, 370:416.
53. Reimann KA, Tenner-Racs K, Racs P: Immunopathogenic events in acute infection of Rhesus monkeys with SIV of macaques. J Virol 1994, 68:2362-2370.
54. Koup RA, Safrit JT, Cao Y, et al.: Temporal association of cellular immune responses in the initial control of HIV-1 syndrome. J Virol 1994, 68:4650-4655.
55. Terpstra FG, Bert JMA, Roos MThL, et al.: Longitudinal study of leukocyte function in homosexual men seroconverted for HIV: rapid and persistent loss of B cell function after HIV infection. Eur J Immunol 1989, 19:667-673.
56. Fiorentino DF, Bond MW, Mosmann TR: Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989, 170:2081-2089.
57. Swain S: Regulation of the development of distinct subsets of CD4+ T cells. Res Immunol 1991, 142:14-55.
58. Salk J, Bretscher PA, Salk PL, Clerici M, Shearer GM: A strategy for prophylactic vaccination against HIV. Science 1993 260:1270-1272.
59. Rheinhold U, Abken H, Kukel S, et al.: CD7- T cells represent a subset of normal human blood lymphocytes. J Immunol 1993, 150:2081-2089.
60. Legendre CM, Clarke Forbes RD, Loertscher R, Guttman RD: CD4+/Leu7- large granular lymphocytes in long-term renal allograft recipients. Transplantation 1989, 47:964-971.
61. Ho HN, Hultin LE, Mitsuyasu RT, et al.: Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens. J Immunol 1993, 150:3070-3079.