Reprogramming within hours following nuclear transfer into mouse but not human zygotes

Nature Communications

Volumn 2, Issue 1, 2011, Pages

  Egli, Dieter ^a,b,c,d   Chen, Alice E ^a,b   Saphier, Genevieve ^a   Ichida, Justin ^a   Fitzgerald, Claire ^a   Go, Kathryn J ^e   Acevedo, Nicole ^e   Patel, Jay ^e   Baetscher, Manfred ^a   Kearns, William G ^f   Goland, Robin ^d   Leibel, Rudolph L ^d   Melton, Douglas A ^a,b,g   Eggan, Kevin ^a,b,g  

^a Harvard University   (United States)

^b HARVARD STEM CELL INSTITUTE   (United States)

^c New York Stem Cell Foundation Laboratory   (United States)

^d Reproductive Science Center ^*  (United States)

^e Reproductive Science Center   (United States)

^f Center for Preimplantation Genetics   (United States)

^g HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIVISION; CELL MATURATION; CELL NUCLEUS TRANSPLANTATION; CONTROLLED STUDY; HUMAN; MITOSIS; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; SOMATIC CELL; STEM CELL RESEARCH; ZYGOTE; ANIMAL; CYTOLOGY;

ANIMALS; HUMANS; MICE; MITOSIS; NUCLEAR TRANSFER TECHNIQUES; ZYGOTE;

EID: 80055047765     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1503     Document Type: Article

References (56)

1. Gurdon, J. B. Adult frogs derived from the nuclei of single somatic cells. Dev. Biol. 4, 256-273 (1962).
2. Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J. & Campbell, K. H. Viable offspring derived from fetal and adult mammalian cells. Nature 385, 810-813 (1997). (Pubitemid 27106068)
3. Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 (1998). (Pubitemid 28516247)
4. Lanza, R. P., Cibelli, J. B. & West, M. D. Prospects for the use of nuclear transfer in human transplantation. Nat. Biotechnol. 17, 1171-1174 (1999).
5. Kind, A. & Colman, A. Therapeutic cloning: needs and prospects. Semin. Cell Dev. Biol. 10, 279-286 (1999). (Pubitemid 129502421)
6. Kiskinis, E. & Eggan, K. Progress toward the clinical application of patient-specific pluripotent stem cells. J. Clin. Invest. 120, 51-59 (2010).
7. Tabar, V. et al. Therapeutic cloning in individual parkinsonian mice. Nat. Med. 14, 379-381 (2008). (Pubitemid 351499386)
8. Rideout III, W. M., Hochedlinger, K., Kyba, M., Daley, G. Q. & Jaenisch, R. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 109, 17-27 (2002). (Pubitemid 34327513)
9. Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007). (Pubitemid 350138099)
10. Dimos, J. T. et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321, 1218-1221 (2008).
11. Chin, M. H. et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell 5, 111-123 (2009).
12. Lister, R. et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 471, 68-73 (2011).
13. Deng, J. et al. Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat. Biotechnol. 27, 353-360 (2009).
14. Stadtfeld, M. et al. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature 465, 175-181 (2010).
15. Hu, B. Y. et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc. Natl Acad. Sci. USA 107, 4335-4340 (2010).
16. Kim, K. et al. Epigenetic memory in induced pluripotent stem cells. Nature 467, 285-290 (2010).
17. Stojkovic, M. et al. Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes. Reprod. Biomed. Online 11, 226-231 (2005). (Pubitemid 41086950)
18. Hall, V. J. et al. Developmental competence of human in vitro aged oocytes as host cells for nuclear transfer. Hum. Reprod. 22, 52-62 (2007). (Pubitemid 44942666)
19. French, A. J. et al. Development of human cloned blastocysts following somatic cell nuclear transfer with adult fibroblasts. Stem Cells 26, 485-493 (2008). (Pubitemid 351413608)
20. Chung, Y. et al. Reprogramming of human somatic cells using human and animal oocytes. Cloning Stem Cells 11, 213-223 (2009).
21. Cibelli, J. et al. Somatic cell nuclear transfer in humans: pronuclear and early embryonic development. J. Regener. Med. 2, 25-31 (2001). (Pubitemid 34852594)
22. Lavoir, M. C., Weier, J., Conaghan, J. & Pedersen, R. A. Poor development of human nuclear transfer embryos using failed fertilized oocytes. Reprod. Biomed. Online 11, 740-744 (2005). (Pubitemid 43009269)
23. McElroy, S. L. et al. Developmental competence of immature and failed/abnormally fertilized human oocytes in nuclear transfer. Reprod. Biomed. Online 16, 684-693 (2008).
24. Egli, D., Chen, A. E., Melton, D. & Eggan, K. Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell doi:10.1016/j.stem.2011.08.002 (2011).
25. Kennedy, D. Editorial retraction. Science 311, 335 (2006). (Pubitemid 43132637)
26. Kim, K. et al. Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer. Cell Stem Cell 1, 346-352 (2007). (Pubitemid 47355324)
27. Egli, D., Rosains, J., Birkhoff, G. & Eggan, K. Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature 447, 679-685 (2007). (Pubitemid 46889733)
28. Wong, C. C. et al. Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Nat. Biotechnol. 28, 1115-1121 (2010).
29. Mitalipov, S. M. et al. Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling. Hum. Reprod. 22, 2232-2242 (2007). (Pubitemid 47241869)
30. Kawakami, M. et al. Effect of demecolcine and nocodazole on the efficiency of chemically assisted removal of chromosomes and the developmental potential of nuclear transferred porcine oocytes. Cloning Stem Cells 5, 379-387 (2003). (Pubitemid 38031861)
31. Egli, D. & Eggan, K. Recipient cell nuclear factors are required for reprogramming by nuclear transfer. Development 137, 1953-1963 (2010).
32. Wakayama, T. & Yanagimachi, R. Effect of cytokinesis inhibitors, DMSO and the timing of oocyte activation on mouse cloning using cumulus cell nuclei. Reproduction 122, 49-60 (2001). (Pubitemid 32677148)
33. Byrne, J. A. et al. Producing primate embryonic stem cells by somatic cell nuclear transfer. Nature 450, 497-502 (2007). (Pubitemid 350190255)
34. Vassena, R. et al. Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development. Development 138, 3699-3709 (2011).
35. Braude, P., Bolton, V. & Moore, S. Human gene expression first occurs between the four- and eight-cell stages of preimplantation development. Nature 332, 459-461 (1988). (Pubitemid 18090251)
36. Boiani, M., Eckardt, S., Scholer, H. R. & McLaughlin, K. J. Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev. 16, 1209-1219 (2002). (Pubitemid 34553102)
37. Brambrink, T. et al. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2, 151-159 (2008). (Pubitemid 351168714)
38. Stadtfeld, M., Maherali, N., Breault, D. T. & Hochedlinger, K. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2, 230-240 (2008).
39. Flach, G., Johnson, M. H., Braude, P. R., Taylor, R. A. & Bolton, V. N. The transition from maternal to embryonic control in the 2-cell mouse embryo. Embo J. 1, 681-686 (1982).
40. Simerly, C. et al. Molecular correlates of primate nuclear transfer failures. Science 300, 297 (2003). (Pubitemid 36433715)
41. Van der Ven, H. H. et al. Polyspermy in in vitro fertilization of human oocytes: frequency and possible causes. Ann. N.Y. Acad. Sci. 442, 88-95 (1985). (Pubitemid 15228149)
42. Craven, L. et al. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature 465, 82-85 (2010).
43. Kola, I., Trounson, A., Dawson, G. & Rogers, P. Tripronuclear human oocytes: altered cleavage patterns and subsequent karyotypic analysis of embryos. Biol. Reprod. 37, 395-401 (1987). (Pubitemid 17166093)
44. Brambrink, T., Hochedlinger, K., Bell, G. & Jaenisch, R. ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. Proc. Natl Acad. Sci. USA 103, 933-938 (2006). (Pubitemid 43212199)
45. Polo, J. M. et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat. Biotechnol. 28, 848-855 (2010).
46. Ghosh, Z. et al. Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One 5, e8975 (2010).
47. Feng, Q. et al. Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence. Stem Cells 28, 704-712 (2010).
48. Doi, A. et al. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat. Genet. 41, 1350-1353 (2009).
49. Eggan, K. et al. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc. Natl Acad. Sci. USA 98, 6209-6214 (2001). (Pubitemid 32488218)
50. Humpherys, D. et al. Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc. Natl Acad. Sci. USA 99, 12889-12894 (2002).
51. Gao, S. et al. Somatic cell-like features of cloned mouse embryos prepared with cultured myoblast nuclei. Biol. Reprod. 69, 48-56 (2003). (Pubitemid 36806806)
52. Ng, R. K. & Gurdon, J. B. Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proc. Natl Acad. Sci. USA 102, 1957-1962 (2005). (Pubitemid 40261994)
53. Rodriguez-Osorio, N. et al. Transcriptional reprogramming of gene expression in bovine somatic cell chromatin transfer embryos. BMC Genomics 10, 190 (2009).
54. Bortvin, A. et al. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development 130, 1673-1680 (2003). (Pubitemid 36527525)
55. Egli, D. & Eggan, K. Nuclear transfer into mouse oocytes. J. Vis. Exp. 116 (2006).
56. Wakayama, T., Perry, A. C., Zuccotti, M., Johnson, K. R. & Yanagimachi, R. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature 394, 369-374 (1998). (Pubitemid 28373832)