6r, a novel oxadiazole analogue of ethacrynic acid, exhibits antitumor activity both in vitro and in vivo by induction of cell apoptosis and S-phase arrest

Biomedicine and Pharmacotherapy

Volumn 67, Issue 1, 2013, Pages 58-65

  Zhang, Peng ^a   Chen, Jin Hua ^a   Dong, Xue ^a   Tang, Ming Tan ^a   Gao, Li Yan ^a   Zhao, Gui Sen ^a   Yu, Lu Gang ^b   Guo, Xiu Li ^a  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

5 2,3 Dichloro 4 (2 methylene 1 oxobutyl) phenoxymethyl 3 methyl 1,2,4 oxadiazole (6r); Apoptosis; Cell cycle; Glutathione S transferase P1 1; Human cancer cell lines

Indexed keywords

5 [2,3 DICHLORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXYMETHYL] 3 METHYL 1,2,4 OXADIAZOLE; 6R; ANTINEOPLASTIC AGENT; ETACRYNIC ACID; GLUTATHIONE TRANSFERASE P1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; COLON CANCER; CONTROLLED STUDY; DRUG SCREENING; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; LUNG CANCER; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; UTERINE CERVIX CANCER; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; OXADIAZOLES; S PHASE CELL CYCLE CHECKPOINTS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84873092123     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2012.10.011     Document Type: Article

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