Novel oxadiazole analogues derived from ethacrynic acid: Design, synthesis, and structure - Activity relationships in inhibiting the activity of glutathione S-transferase P1-1 and cancer cell proliferation

Journal of Medicinal Chemistry

Volumn 53, Issue 3, 2010, Pages 1015-1022

  Yang, Xinmei ^a   Liu, Guyue ^b   Li, Hongcai ^a   Zhang, Yun ^a   Song, Dandan ^b   Li, Chunmin ^a   Wang, Rui ^c   Liu, Bo ^a   Liang, Wen ^a   Jing, Yongkui ^c   Zhao, Guisen ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [2,3 DICHLORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXYMETHYL] 3 (4 CHLOROBENZYL) 1,2,4 OXADIAZOL; 5 [2,3 DICHLORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXYMETHYL] 3 (4 FLUOROPHENYL) 1,2,4 OXADIAZOL; 5 [2,3 DICHLORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXYMETHYL] 3 (4 METHOXYPHENYL) 1,2,4 OXADIAZOL; 5 [2,3 DICHLORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXYMETHYL] 3 (4 NITROBENZYL) 1,2,4 OXADIAZOL; 5 [2,3 DICHLORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXYMETHYL] 3 (4 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOL; 5 [2,3 DICHLORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXYMETHYL] 3 METHYL 1,2,4 OXADIAZOLE; 5 [2,3 DICHLORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXYMETHYL] 3 PHENYL 1,2,4 OXADIAZOLE; 5 [2,3 DIMETHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 (4 CHLOROBENZYL) 1,2,4 OXADIAZOL; 5 [2,3 DIMETHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 (4 FLUOROPHENYL) 1,2,4 OXADIAZOL; 5 [2,3 DIMETHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 (4 HYDROXYPHENYL) 1,2,4 OXADIAZOL; 5 [2,3 DIMETHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 (4 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOL; 5 [2,3 DIMETHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 METHYL 1,2,4 OXADIAZOLE; 5 [2,3 DIMETHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 PHENYL 1,2,4 OXADIAZOLE; 5 [2,3 DIMETHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL]3 (4 NITROBENZYL) 1,2,4 OXADIAZOL; 5 [3 BROMO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 METHYL 1,2,4 OXADIAZOLE; 5 [3 BROMO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 PHENYL 1,2,4 OXADIAZOLE; 5 [3 CHLORO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 (4 FLUOROPHENYL) 1,2,4 OXADIAZOL; 5 [3 CHLORO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 (4 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOL; 5 [3 CHLORO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 METHYL 1,2,4 OXADIAZOLE; 5 [3 CHLORO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 PHENYL 1,2,4 OXADIAZOLE; 5 [3 METHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 (4 FLUOROPHENYL) 1,2,4 OXADIAZOL; 5 [3 METHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 (4 HYDROXYPHENYL) 1,2,4 OXADIAZOL; 5 [3 METHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 (4 NITROBENZYL) 1,2,4 OXADIAZOL; 5 [3 METHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 (4 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOL; 5 [3 METHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 METHYL 1,2,4 OXADIAZOLE; 5 [3 METHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXYMETHYL] 3 PHENYL 1,2,4 OXADIAZOLE; ANTINEOPLASTIC AGENT; GLUTATHIONE TRANSFERASE P1; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HL 60; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; SOLID TUMOR; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; ETHACRYNIC ACID; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; OXADIAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 77249160708     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9011565     Document Type: Article

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