Natural killer cells are scarce in colorectal carcinoma tissue despite high levels of chemokines and cytokines

Clinical Cancer Research

Volumn 17, Issue 4, 2011, Pages 678-689

  Halama, Niels ^a   Braun, Monika ^a,b   Kahlert, Christoph ^a   Spille, Anna ^a   Quack, Christian ^a   Rahbari, Nuh ^a   Koch, Moritz ^a   Weitz, Jürgen ^a   Kloor, Matthias ^a   Zoernig, Inka ^a   Schirmacher, Peter ^a   Brand, Karsten ^a   Grabe, Niels ^a   Falk, Christine S ^a,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD3 EPSILON ANTIGEN; CD56 ANTIGEN; CHEMOKINE; CYTOKINE; HLA ANTIGEN CLASS 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; SELECTIN; UNCLASSIFIED DRUG;

ADENOMA; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER LOCALIZATION; CANCER STAGING; CANCER TISSUE; CELL DENSITY; COLORECTAL CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; TISSUE SECTION; TUMOR MICROENVIRONMENT;

ADULT; AGED; ANTIGENS, CD56; CELL ADHESION MOLECULES; CELL MOVEMENT; CHEMOKINES; COLORECTAL NEOPLASMS; CYTOKINES; FEMALE; HUMANS; INTESTINAL MUCOSA; KILLER CELLS, NATURAL; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; SELECTINS; T-LYMPHOCYTES;

EID: 79951824956     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-2173     Document Type: Article

References (35)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2006. CA Cancer J Clin 2006;56:106-30.
2. Schwitalle Y, Kloor M, Eiermann S, et al. Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers. Gastroenterology 2008;134:988-97. (Pubitemid 351459601)
3. Koebel CM, Vermi W, Swann JB, et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 2007;450:903-7. (Pubitemid 350231320)
4. Walzer T, Jaeger S, Chaix J, Vivier E. Natural killer cells: from CD3(-) NKp46(+) to post-genomics meta-analyses. Curr Opin Immunol 2007;19:365-72. (Pubitemid 46687010)
5. Colonna M. Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells inmucosal immunity. Immunity 2009;31:15-23.
6. Vivier E, Spits H, Cupedo T. Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?Nat Rev Immunol 2009;9:229-34.
7. Pessino A, Sivori S, Bottino C, et al. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J Exp Med 1998;188:953-60. (Pubitemid 28433421)
8. Sobin LH, Gospodarowicz MK, Wittekind C. TNM classification of malignant tumours . 7th ed. Oxford: Wiley-Blackwell; 2010.
9. Tsukahara T, Kawaguchi S, Torigoe T, et al. Prognostic significance of HLA class I expression in osteosarcoma defined by antipan HLA class I monoclonal antibody, EMR8-5. Cancer Sci 2006;97:1374-80. (Pubitemid 44614990)
10. Halama N, Michel S, Kloor M, et al. The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy. Cancer Immun 2009;4:1-6.
11. Halama N, Zoernig I, Spille A, et al. Estimation of immune cell densities in immune cell conglomerates: an approach for high-throughput quantification. PLoS One 2009;4(e7847):1-6.
12. Halama N, Zoernig I, Spille A, et al. Tumor maps: quantification of prognostic immune cell markers in colorectal cancer using whole slide imaging. Anal Quant Cytol Histol 2010;32:333-341.
13. Kahlert C, Bandapalli OR, Schirmacher P, Weitz J, Brand K. Invasion front-specific overexpression of tissue inhibitor of metalloproteinase-1 in liver metastases from colorectal cancer. Anticancer Res 2008;28:1459-65. (Pubitemid 351892917)
14. Poli A, Michel T, Theresine M, Andres E, Hentges F, Zimmer J. CD56bright natural killer (NK) cells: an important NK cell subset. Immunology 2009;126:458-65.
15. Gregoire C, Chasson L, Luci C, et al. The trafficking of natural killer cells. Immunol Rev 2007;220:169-82. (Pubitemid 350045566)
16. Finn OJ. Cancer immunology. N Engl J Med 2008;358:2704-15.
17. Camus M, Tosolini M, Mlecnik B, et al. Coordination of intratumoral immune reaction and human colorectal cancer recurrence. Cancer Res 2009;69:2685-2693.
18. Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006;313:1960-1964. (Pubitemid 44498003)
19. Falk CS, Noessner E, Weiss EH, Schendel DJ. Retaliation against tumor cells showing aberrant HLA expression using lymphokine activated killer-derived T cells. Cancer Res 2002;62:480-7. (Pubitemid 34106422)
20. von Geldern M, Simm B, Braun M, Weiss EH, Schendel DJ, Falk CS. TCR-independent cytokine stimulation induces non-MHC-restricted T cell activity and is negatively regulated by HLA class I. Eur J Immunol 2006;36:2347-58. (Pubitemid 44420591)
21. Coca S, Perez-Piqueras J, Martinez D, et al. The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma. Cancer 1997;79:2320-8. (Pubitemid 27251014)
22. Schleypen JS, Baur N, Kammerer R, et al. Cytotoxic markers and frequency predict functional capacity of natural killer cells infiltrating renal cell carcinoma. Clin Cancer Res 2006;12:718-25. (Pubitemid 43259850)
23. Sandel MH, Speetjens FM, Menon AG, et al. Natural killer cells infiltrating colorectal cancer and MHC class I expression. Mol Immunol 2005;42:541-546. (Pubitemid 39655966)
24. Faveeuw C, Di Mauro ME, Price AA, Ager A. Roles of alpha(4) integrins/VCAM-1 and LFA-1/ICAM-1 in the binding and transendothelial migration of T lymphocytes and T lymphoblasts across high endothelial venules. Int Immunol 2000;12:241-51.
25. Wendel M, Galani IE, Suri-Payer E, Cerwenka A. Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands. Cancer Res 2008;68:8437-45.
26. Mlecnik B, Tosolini M, Charoentong P, et al. Biomolecular network reconstruction identifies T cell homing factors associated with survival in colorectal cancer. Gastroenterology 2009;138:1429-40.
27. Yang SK, Eckmann L, Panja A, Kagnoff MF. Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells. Gastroenterology 1997;113:1214-23.
28. Cheadle EJ, Riyad K, Subar D, et al. Eotaxin-2 and colorectal cancer: a potential target for immune therapy. Clin Cancer Res 2007;13:5719-28. (Pubitemid 47583896)
29. Doll D, Keller L, Maak M, et al. Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. Int J Colorectal Dis 2010.
30. Santoni A, Carlino C, Stabile H, Gismondi A. Mechanisms underlying recruitment and accumulation of decidual NK cells in uterus during pregnancy. Am J Reprod Immunol 2008;59:417-24. (Pubitemid 351524231)
31. Vianello F, Papeta N, Chen T, et al. Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol 2006;176:2902-14.
32. Harlin H, Meng Y, Peterson AC, et al. Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res 2009;69:3077-85.
33. Bindea G, Mlecnik B, Fridman WH, Pages F, Galon J. Natural immunity to cancer in humans. Curr Opin Immunol 2010;22:215-22.
34. Horst D, Budczies J, Brabletz T, Kirchner T, Hlubek F. Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer. Cancer 2009;115:4946-4958.
35. Shankaran V, Ikeda H, Bruce AT, et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001;410:1107-11. (Pubitemid 32391043)