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Volumn 7, Issue 3, 2008, Pages 638-647

Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CYTOTOXIC AGENT; GEMCITABINE; THROMBOSPONDIN 1;

EID: 41649115595     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-2122     Document Type: Article
Times cited : (61)

References (41)
  • 2
    • 0025325071 scopus 로고
    • Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine)
    • Hertel LW, Boder GB, Kroin JS, et al. Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine). Cancer Res 1990; 50:4417-22.
    • (1990) Cancer Res , vol.50 , pp. 4417-4422
    • Hertel, L.W.1    Boder, G.B.2    Kroin, J.S.3
  • 3
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA III, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403-13.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3
  • 4
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T, Butterfield CE, Kraling BM, et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 2000;60:1878-86.
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3
  • 5
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004;4:423-36.
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 6
    • 0242331613 scopus 로고    scopus 로고
    • Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
    • Bocci G, Francia G, Man S, Lawler J, Kerbel RS. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci U S A 2003;100:12917-22.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12917-12922
    • Bocci, G.1    Francia, G.2    Man, S.3    Lawler, J.4    Kerbel, R.S.5
  • 7
    • 0034039072 scopus 로고    scopus 로고
    • Modulation of drug cytotoxicity by reintroduction of wild-type p53 gene (Ad5CMV-p53) in human pancreatic cancer
    • Cascallo M, Calbo J, Gelpi JL, Mazo A. Modulation of drug cytotoxicity by reintroduction of wild-type p53 gene (Ad5CMV-p53) in human pancreatic cancer. Cancer Gene Ther 2000;7:545-56.
    • (2000) Cancer Gene Ther , vol.7 , pp. 545-556
    • Cascallo, M.1    Calbo, J.2    Gelpi, J.L.3    Mazo, A.4
  • 8
    • 0029774144 scopus 로고    scopus 로고
    • Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice
    • Reyes G, Villanueva A, Garcia C, et al. Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. Cancer Res 1996;56:5713-9.
    • (1996) Cancer Res , vol.56 , pp. 5713-5719
    • Reyes, G.1    Villanueva, A.2    Garcia, C.3
  • 9
    • 0032810580 scopus 로고    scopus 로고
    • Orthotopic models of human pancreatic cancer
    • Capellà G, Farre L, Villanueva A, et al. Orthotopic models of human pancreatic cancer. Ann N Y Acad Sci 1999;880:103-9.
    • (1999) Ann N Y Acad Sci , vol.880 , pp. 103-109
    • Capellà, G.1    Farre, L.2    Villanueva, A.3
  • 10
    • 0039700194 scopus 로고    scopus 로고
    • p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation
    • Viñals F, Chambard JC, Pouyssegur J. p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation. J Biol Chem 1999;274:26776-82.
    • (1999) J Biol Chem , vol.274 , pp. 26776-26782
    • Viñals, F.1    Chambard, J.C.2    Pouyssegur, J.3
  • 11
    • 0027263596 scopus 로고
    • The influence of the schedule and the dose of gemcitabine on the antitumour efficacy in experimental human cancer
    • Boven E, Schipper H, Erkelens CA, Hatty SA, Pinedo HM. The influence of the schedule and the dose of gemcitabine on the antitumour efficacy in experimental human cancer. Br J Cancer 1993;68:52-6.
    • (1993) Br J Cancer , vol.68 , pp. 52-56
    • Boven, E.1    Schipper, H.2    Erkelens, C.A.3    Hatty, S.A.4    Pinedo, H.M.5
  • 12
    • 0029593648 scopus 로고
    • Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts
    • Braakhui BJ, Ruiz van Haperen VW, Welters MJ, Peters GJ. Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts. Eur J Cancer 1995;31A:2335-40.
    • (1995) Eur J Cancer , vol.31 A , pp. 2335-2340
    • Braakhui, B.J.1    Ruiz van Haperen, V.W.2    Welters, M.J.3    Peters, G.J.4
  • 13
    • 12344312012 scopus 로고    scopus 로고
    • Antiangiogenic therapy for human pancreatic carcinoma xenografts in nude mice
    • Jia L, Zhang MH, Yuan SZ, Huang WG. Antiangiogenic therapy for human pancreatic carcinoma xenografts in nude mice. World J Gastroenterol 2005;11:447-50.
    • (2005) World J Gastroenterol , vol.11 , pp. 447-450
    • Jia, L.1    Zhang, M.H.2    Yuan, S.Z.3    Huang, W.G.4
  • 14
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 2005;23:939-52.
    • (2005) J Clin Oncol , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 16
    • 0031943257 scopus 로고    scopus 로고
    • An orthotopic model of human pancreatic cancer in severe combined immunodeficient mice: Potential application for preclinical studies
    • Mohammad RM, Al-Katib A, Pettit GR, et al. An orthotopic model of human pancreatic cancer in severe combined immunodeficient mice: potential application for preclinical studies. Clin Cancer Res 1998;4:887-94.
    • (1998) Clin Cancer Res , vol.4 , pp. 887-894
    • Mohammad, R.M.1    Al-Katib, A.2    Pettit, G.R.3
  • 18
    • 15444379311 scopus 로고    scopus 로고
    • A pilot study of individualized maximum repeatable dose (iMRD), a new dose finding system, of weekly gemcitabine for patients with metastatic pancreas cancer
    • Takahashi Y, Mai M, Sawabu N, Nishioka K. A pilot study of individualized maximum repeatable dose (iMRD), a new dose finding system, of weekly gemcitabine for patients with metastatic pancreas cancer. Pancreas 2005;30:206-10.
    • (2005) Pancreas , vol.30 , pp. 206-210
    • Takahashi, Y.1    Mai, M.2    Sawabu, N.3    Nishioka, K.4
  • 19
    • 33644514374 scopus 로고    scopus 로고
    • Comparison of standard-dose and low-dose gemcitabine regimens in pancreatic adenocarcinoma patients: A prospective randomized trial
    • Sakamoto H, Kitano M, Suetomi Y, et al. Comparison of standard-dose and low-dose gemcitabine regimens in pancreatic adenocarcinoma patients: a prospective randomized trial. J Gastroenterol 2006;41:70-6.
    • (2006) J Gastroenterol , vol.41 , pp. 70-76
    • Sakamoto, H.1    Kitano, M.2    Suetomi, Y.3
  • 20
    • 28544451083 scopus 로고    scopus 로고
    • Simultaneous inhibition of EGFR, VEGFR, platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model
    • Yokoi K, Sasaki T, Bucana CD, et al. Simultaneous inhibition of EGFR, VEGFR, platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model. Cancer Res 2005;65:10371-80.
    • (2005) Cancer Res , vol.65 , pp. 10371-10380
    • Yokoi, K.1    Sasaki, T.2    Bucana, C.D.3
  • 21
    • 26444507147 scopus 로고    scopus 로고
    • Establishment and characterization of a pancreatic carcinoma cell line derived from malignant pleural effusion
    • Starr AN, Vexler A, Marmor S, et al. Establishment and characterization of a pancreatic carcinoma cell line derived from malignant pleural effusion. Oncology 2005;69:239-45.
    • (2005) Oncology , vol.69 , pp. 239-245
    • Starr, A.N.1    Vexler, A.2    Marmor, S.3
  • 22
    • 0029117043 scopus 로고
    • Hepatocyte growth factor is a potent mitogen for normal human pancreas cells in vitro
    • Vila MR, Nakamura T, Real FX. Hepatocyte growth factor is a potent mitogen for normal human pancreas cells in vitro. Lab Invest 1995;73:409-18.
    • (1995) Lab Invest , vol.73 , pp. 409-418
    • Vila, M.R.1    Nakamura, T.2    Real, F.X.3
  • 23
    • 0027486540 scopus 로고
    • Structural analysis of a new highly metastatic cell line PaTu 8902 from a primary human pancreatic adenocarcinoma
    • Elsasser HP, Lehr U, Agricola B, Kern HF. Structural analysis of a new highly metastatic cell line PaTu 8902 from a primary human pancreatic adenocarcinoma. Virchows Arch B Cell Pathol Incl Mol Pathol 1993;64:201-7.
    • (1993) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.64 , pp. 201-207
    • Elsasser, H.P.1    Lehr, U.2    Agricola, B.3    Kern, H.F.4
  • 24
    • 0026505435 scopus 로고
    • Characterization of the cytokeratins of human colonic, pancreatic, and gastric adenocarcinoma cell lines
    • Rafiee P, Ho SB, Bresalier RS, Bloom EJ, Kim JH, Kim YS. Characterization of the cytokeratins of human colonic, pancreatic, and gastric adenocarcinoma cell lines. Pancreas 1992;7:123-31.
    • (1992) Pancreas , vol.7 , pp. 123-131
    • Rafiee, P.1    Ho, S.B.2    Bresalier, R.S.3    Bloom, E.J.4    Kim, J.H.5    Kim, Y.S.6
  • 25
    • 0033557641 scopus 로고    scopus 로고
    • Characterization of six cell lines established from human pancreatic adenocarcinomas
    • Kato M, Shimada Y, Tanaka H, et al. Characterization of six cell lines established from human pancreatic adenocarcinomas. Cancer 1999;85:832-40.
    • (1999) Cancer , vol.85 , pp. 832-840
    • Kato, M.1    Shimada, Y.2    Tanaka, H.3
  • 26
    • 0029933259 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells
    • Frazier ML, Fernandez E, de Llorens R, et al. Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells. Int J Pancreatol 1996;19:31-8.
    • (1996) Int J Pancreatol , vol.19 , pp. 31-38
    • Frazier, M.L.1    Fernandez, E.2    de Llorens, R.3
  • 27
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
    • Spratlin J, Sangha R, Glubrecht D, et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 2004;10:6956-61.
    • (2004) Clin Cancer Res , vol.10 , pp. 6956-6961
    • Spratlin, J.1    Sangha, R.2    Glubrecht, D.3
  • 28
    • 0032762952 scopus 로고    scopus 로고
    • Antiangiogenesis is produced by nontoxic doses of vinblastine
    • Vacca A, Iurlaro M, Ribatti D, et al. Antiangiogenesis is produced by nontoxic doses of vinblastine. Blood 1999;94:4143-55.
    • (1999) Blood , vol.94 , pp. 4143-4155
    • Vacca, A.1    Iurlaro, M.2    Ribatti, D.3
  • 29
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • Klement G, Baruchel S, Rak J, et al. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 2000;105:R15-24.
    • (2000) J Clin Invest , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3
  • 30
    • 0025793698 scopus 로고
    • Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: Evidence for a vascular mechanism
    • Baguley BC, Holdaway KM, Thomsen LL, Zhuang L, Zwi LJ. Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer 1991;27:482-7.
    • (1991) Eur J Cancer , vol.27 , pp. 482-487
    • Baguley, B.C.1    Holdaway, K.M.2    Thomsen, L.L.3    Zhuang, L.4    Zwi, L.J.5
  • 31
    • 0029802685 scopus 로고    scopus 로고
    • The microtubule-affecting drug paclitaxel has antiangiogenic activity
    • Belotti D, Vergani V, Drudis T, et al. The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res 1996;2:1843-9.
    • (1996) Clin Cancer Res , vol.2 , pp. 1843-1849
    • Belotti, D.1    Vergani, V.2    Drudis, T.3
  • 32
    • 0036897097 scopus 로고    scopus 로고
    • Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs
    • Bocci G, Nicolaou KC, Kerbel RS. Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res 2002;62:6938-43.
    • (2002) Cancer Res , vol.62 , pp. 6938-6943
    • Bocci, G.1    Nicolaou, K.C.2    Kerbel, R.S.3
  • 33
    • 0037268220 scopus 로고    scopus 로고
    • Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly
    • Wang J, Lou P, Lesniewski R, Henkin J. Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly. Anticancer Drugs 2003;14:13-9.
    • (2003) Anticancer Drugs , vol.14 , pp. 13-19
    • Wang, J.1    Lou, P.2    Lesniewski, R.3    Henkin, J.4
  • 34
    • 20444433198 scopus 로고    scopus 로고
    • In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: Modulation by lower-dose chemotherapy
    • Ma L, Francia G, Viloria-Petit A, et al. In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower-dose chemotherapy. Cancer Res 2005;65:5365-73.
    • (2005) Cancer Res , vol.65 , pp. 5365-5373
    • Ma, L.1    Francia, G.2    Viloria-Petit, A.3
  • 36
    • 1642368865 scopus 로고    scopus 로고
    • Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression
    • Hamano Y, Sugimoto H, Soubasakos MA, et al. Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res 2004;64:1570-4.
    • (2004) Cancer Res , vol.64 , pp. 1570-1574
    • Hamano, Y.1    Sugimoto, H.2    Soubasakos, M.A.3
  • 37
    • 0009849965 scopus 로고    scopus 로고
    • Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: Effect on human microvascular endothelial cell proliferation and angiogenesis
    • Gupta K, Gupta P, Wild R, Ramakrishnan S, Hebbel RP. Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis. Angiogenesis 1999;3:147-58.
    • (1999) Angiogenesis , vol.3 , pp. 147-158
    • Gupta, K.1    Gupta, P.2    Wild, R.3    Ramakrishnan, S.4    Hebbel, R.P.5
  • 38
    • 0036225350 scopus 로고    scopus 로고
    • Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: Antitumor activity and correlation with vascular endothelial growth factor levels
    • Colleoni M, Rocca A, Sandri MT, et al. Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels. Ann Oncol 2002;13:73-80.
    • (2002) Ann Oncol , vol.13 , pp. 73-80
    • Colleoni, M.1    Rocca, A.2    Sandri, M.T.3
  • 39
    • 27644436870 scopus 로고    scopus 로고
    • Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity
    • Shaked Y, Emmenegger U, Man S, et al. Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity. Blood 2005;106:3058-61.
    • (2005) Blood , vol.106 , pp. 3058-3061
    • Shaked, Y.1    Emmenegger, U.2    Man, S.3
  • 40
    • 0141958313 scopus 로고    scopus 로고
    • Metronomic therapy with cyclophosphamide and dexamethasone for prostate carcinoma
    • Glode LM, Barqawi A, Crighton F, Crawford ED, Kerbel RS. Metronomic therapy with cyclophosphamide and dexamethasone for prostate carcinoma. Cancer 2003;98:1643-8.
    • (2003) Cancer , vol.98 , pp. 1643-1648
    • Glode, L.M.1    Barqawi, A.2    Crighton, F.3    Crawford, E.D.4    Kerbel, R.S.5
  • 41
    • 0242526860 scopus 로고    scopus 로고
    • Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors
    • Vogt T, Hafner C, Bross K, et al. Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors. Cancer 2003;98:2251-6.
    • (2003) Cancer , vol.98 , pp. 2251-2256
    • Vogt, T.1    Hafner, C.2    Bross, K.3


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