-
1
-
-
0037260139
-
Cancer statistics, 2003
-
Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer statistics, 2003. CA Cancer J Clin 2003;53:5-26.
-
(2003)
CA Cancer J Clin
, vol.53
, pp. 5-26
-
-
Jemal, A.1
Murray, T.2
Samuels, A.3
Ghafoor, A.4
Ward, E.5
Thun, M.J.6
-
2
-
-
0025325071
-
Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine)
-
Hertel LW, Boder GB, Kroin JS, et al. Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine). Cancer Res 1990; 50:4417-22.
-
(1990)
Cancer Res
, vol.50
, pp. 4417-4422
-
-
Hertel, L.W.1
Boder, G.B.2
Kroin, J.S.3
-
3
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA III, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403-13.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris III, H.A.1
Moore, M.J.2
Andersen, J.3
-
4
-
-
0034032882
-
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
-
Browder T, Butterfield CE, Kraling BM, et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 2000;60:1878-86.
-
(2000)
Cancer Res
, vol.60
, pp. 1878-1886
-
-
Browder, T.1
Butterfield, C.E.2
Kraling, B.M.3
-
5
-
-
2942615257
-
The anti-angiogenic basis of metronomic chemotherapy
-
Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004;4:423-36.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 423-436
-
-
Kerbel, R.S.1
Kamen, B.A.2
-
6
-
-
0242331613
-
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
-
Bocci G, Francia G, Man S, Lawler J, Kerbel RS. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci U S A 2003;100:12917-22.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 12917-12922
-
-
Bocci, G.1
Francia, G.2
Man, S.3
Lawler, J.4
Kerbel, R.S.5
-
7
-
-
0034039072
-
Modulation of drug cytotoxicity by reintroduction of wild-type p53 gene (Ad5CMV-p53) in human pancreatic cancer
-
Cascallo M, Calbo J, Gelpi JL, Mazo A. Modulation of drug cytotoxicity by reintroduction of wild-type p53 gene (Ad5CMV-p53) in human pancreatic cancer. Cancer Gene Ther 2000;7:545-56.
-
(2000)
Cancer Gene Ther
, vol.7
, pp. 545-556
-
-
Cascallo, M.1
Calbo, J.2
Gelpi, J.L.3
Mazo, A.4
-
8
-
-
0029774144
-
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice
-
Reyes G, Villanueva A, Garcia C, et al. Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. Cancer Res 1996;56:5713-9.
-
(1996)
Cancer Res
, vol.56
, pp. 5713-5719
-
-
Reyes, G.1
Villanueva, A.2
Garcia, C.3
-
10
-
-
0039700194
-
p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation
-
Viñals F, Chambard JC, Pouyssegur J. p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation. J Biol Chem 1999;274:26776-82.
-
(1999)
J Biol Chem
, vol.274
, pp. 26776-26782
-
-
Viñals, F.1
Chambard, J.C.2
Pouyssegur, J.3
-
11
-
-
0027263596
-
The influence of the schedule and the dose of gemcitabine on the antitumour efficacy in experimental human cancer
-
Boven E, Schipper H, Erkelens CA, Hatty SA, Pinedo HM. The influence of the schedule and the dose of gemcitabine on the antitumour efficacy in experimental human cancer. Br J Cancer 1993;68:52-6.
-
(1993)
Br J Cancer
, vol.68
, pp. 52-56
-
-
Boven, E.1
Schipper, H.2
Erkelens, C.A.3
Hatty, S.A.4
Pinedo, H.M.5
-
12
-
-
0029593648
-
Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts
-
Braakhui BJ, Ruiz van Haperen VW, Welters MJ, Peters GJ. Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts. Eur J Cancer 1995;31A:2335-40.
-
(1995)
Eur J Cancer
, vol.31 A
, pp. 2335-2340
-
-
Braakhui, B.J.1
Ruiz van Haperen, V.W.2
Welters, M.J.3
Peters, G.J.4
-
13
-
-
12344312012
-
Antiangiogenic therapy for human pancreatic carcinoma xenografts in nude mice
-
Jia L, Zhang MH, Yuan SZ, Huang WG. Antiangiogenic therapy for human pancreatic carcinoma xenografts in nude mice. World J Gastroenterol 2005;11:447-50.
-
(2005)
World J Gastroenterol
, vol.11
, pp. 447-450
-
-
Jia, L.1
Zhang, M.H.2
Yuan, S.Z.3
Huang, W.G.4
-
14
-
-
14644446018
-
A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
-
Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 2005;23:939-52.
-
(2005)
J Clin Oncol
, vol.23
, pp. 939-952
-
-
Pietras, K.1
Hanahan, D.2
-
15
-
-
0028889426
-
Schedule-dependent antitumor effect of gemcitabine in in vivo model system
-
Braakhuis BJ, Ruiz van Haperen VW, Boven E, Veerman G, Peters GJ. Schedule-dependent antitumor effect of gemcitabine in in vivo model system. Semin Oncol 1995;22:42-6.
-
(1995)
Semin Oncol
, vol.22
, pp. 42-46
-
-
Braakhuis, B.J.1
Ruiz van Haperen, V.W.2
Boven, E.3
Veerman, G.4
Peters, G.J.5
-
16
-
-
0031943257
-
An orthotopic model of human pancreatic cancer in severe combined immunodeficient mice: Potential application for preclinical studies
-
Mohammad RM, Al-Katib A, Pettit GR, et al. An orthotopic model of human pancreatic cancer in severe combined immunodeficient mice: potential application for preclinical studies. Clin Cancer Res 1998;4:887-94.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 887-894
-
-
Mohammad, R.M.1
Al-Katib, A.2
Pettit, G.R.3
-
17
-
-
4644279732
-
Microregional effects of gemcitabine in HCT-116 xenografts
-
Huxham LA, Kyle AH, Baker JH, Nykilchuk LK, Minchinton AI. Microregional effects of gemcitabine in HCT-116 xenografts. Cancer Res 2004;64:6537-41.
-
(2004)
Cancer Res
, vol.64
, pp. 6537-6541
-
-
Huxham, L.A.1
Kyle, A.H.2
Baker, J.H.3
Nykilchuk, L.K.4
Minchinton, A.I.5
-
18
-
-
15444379311
-
A pilot study of individualized maximum repeatable dose (iMRD), a new dose finding system, of weekly gemcitabine for patients with metastatic pancreas cancer
-
Takahashi Y, Mai M, Sawabu N, Nishioka K. A pilot study of individualized maximum repeatable dose (iMRD), a new dose finding system, of weekly gemcitabine for patients with metastatic pancreas cancer. Pancreas 2005;30:206-10.
-
(2005)
Pancreas
, vol.30
, pp. 206-210
-
-
Takahashi, Y.1
Mai, M.2
Sawabu, N.3
Nishioka, K.4
-
19
-
-
33644514374
-
Comparison of standard-dose and low-dose gemcitabine regimens in pancreatic adenocarcinoma patients: A prospective randomized trial
-
Sakamoto H, Kitano M, Suetomi Y, et al. Comparison of standard-dose and low-dose gemcitabine regimens in pancreatic adenocarcinoma patients: a prospective randomized trial. J Gastroenterol 2006;41:70-6.
-
(2006)
J Gastroenterol
, vol.41
, pp. 70-76
-
-
Sakamoto, H.1
Kitano, M.2
Suetomi, Y.3
-
20
-
-
28544451083
-
Simultaneous inhibition of EGFR, VEGFR, platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model
-
Yokoi K, Sasaki T, Bucana CD, et al. Simultaneous inhibition of EGFR, VEGFR, platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model. Cancer Res 2005;65:10371-80.
-
(2005)
Cancer Res
, vol.65
, pp. 10371-10380
-
-
Yokoi, K.1
Sasaki, T.2
Bucana, C.D.3
-
21
-
-
26444507147
-
Establishment and characterization of a pancreatic carcinoma cell line derived from malignant pleural effusion
-
Starr AN, Vexler A, Marmor S, et al. Establishment and characterization of a pancreatic carcinoma cell line derived from malignant pleural effusion. Oncology 2005;69:239-45.
-
(2005)
Oncology
, vol.69
, pp. 239-245
-
-
Starr, A.N.1
Vexler, A.2
Marmor, S.3
-
22
-
-
0029117043
-
Hepatocyte growth factor is a potent mitogen for normal human pancreas cells in vitro
-
Vila MR, Nakamura T, Real FX. Hepatocyte growth factor is a potent mitogen for normal human pancreas cells in vitro. Lab Invest 1995;73:409-18.
-
(1995)
Lab Invest
, vol.73
, pp. 409-418
-
-
Vila, M.R.1
Nakamura, T.2
Real, F.X.3
-
23
-
-
0027486540
-
Structural analysis of a new highly metastatic cell line PaTu 8902 from a primary human pancreatic adenocarcinoma
-
Elsasser HP, Lehr U, Agricola B, Kern HF. Structural analysis of a new highly metastatic cell line PaTu 8902 from a primary human pancreatic adenocarcinoma. Virchows Arch B Cell Pathol Incl Mol Pathol 1993;64:201-7.
-
(1993)
Virchows Arch B Cell Pathol Incl Mol Pathol
, vol.64
, pp. 201-207
-
-
Elsasser, H.P.1
Lehr, U.2
Agricola, B.3
Kern, H.F.4
-
24
-
-
0026505435
-
Characterization of the cytokeratins of human colonic, pancreatic, and gastric adenocarcinoma cell lines
-
Rafiee P, Ho SB, Bresalier RS, Bloom EJ, Kim JH, Kim YS. Characterization of the cytokeratins of human colonic, pancreatic, and gastric adenocarcinoma cell lines. Pancreas 1992;7:123-31.
-
(1992)
Pancreas
, vol.7
, pp. 123-131
-
-
Rafiee, P.1
Ho, S.B.2
Bresalier, R.S.3
Bloom, E.J.4
Kim, J.H.5
Kim, Y.S.6
-
25
-
-
0033557641
-
Characterization of six cell lines established from human pancreatic adenocarcinomas
-
Kato M, Shimada Y, Tanaka H, et al. Characterization of six cell lines established from human pancreatic adenocarcinomas. Cancer 1999;85:832-40.
-
(1999)
Cancer
, vol.85
, pp. 832-840
-
-
Kato, M.1
Shimada, Y.2
Tanaka, H.3
-
26
-
-
0029933259
-
Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells
-
Frazier ML, Fernandez E, de Llorens R, et al. Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells. Int J Pancreatol 1996;19:31-8.
-
(1996)
Int J Pancreatol
, vol.19
, pp. 31-38
-
-
Frazier, M.L.1
Fernandez, E.2
de Llorens, R.3
-
27
-
-
6044267987
-
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
-
Spratlin J, Sangha R, Glubrecht D, et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 2004;10:6956-61.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6956-6961
-
-
Spratlin, J.1
Sangha, R.2
Glubrecht, D.3
-
28
-
-
0032762952
-
Antiangiogenesis is produced by nontoxic doses of vinblastine
-
Vacca A, Iurlaro M, Ribatti D, et al. Antiangiogenesis is produced by nontoxic doses of vinblastine. Blood 1999;94:4143-55.
-
(1999)
Blood
, vol.94
, pp. 4143-4155
-
-
Vacca, A.1
Iurlaro, M.2
Ribatti, D.3
-
29
-
-
0034087691
-
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
-
Klement G, Baruchel S, Rak J, et al. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 2000;105:R15-24.
-
(2000)
J Clin Invest
, vol.105
-
-
Klement, G.1
Baruchel, S.2
Rak, J.3
-
30
-
-
0025793698
-
Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: Evidence for a vascular mechanism
-
Baguley BC, Holdaway KM, Thomsen LL, Zhuang L, Zwi LJ. Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer 1991;27:482-7.
-
(1991)
Eur J Cancer
, vol.27
, pp. 482-487
-
-
Baguley, B.C.1
Holdaway, K.M.2
Thomsen, L.L.3
Zhuang, L.4
Zwi, L.J.5
-
31
-
-
0029802685
-
The microtubule-affecting drug paclitaxel has antiangiogenic activity
-
Belotti D, Vergani V, Drudis T, et al. The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res 1996;2:1843-9.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 1843-1849
-
-
Belotti, D.1
Vergani, V.2
Drudis, T.3
-
32
-
-
0036897097
-
Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs
-
Bocci G, Nicolaou KC, Kerbel RS. Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res 2002;62:6938-43.
-
(2002)
Cancer Res
, vol.62
, pp. 6938-6943
-
-
Bocci, G.1
Nicolaou, K.C.2
Kerbel, R.S.3
-
33
-
-
0037268220
-
Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly
-
Wang J, Lou P, Lesniewski R, Henkin J. Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly. Anticancer Drugs 2003;14:13-9.
-
(2003)
Anticancer Drugs
, vol.14
, pp. 13-19
-
-
Wang, J.1
Lou, P.2
Lesniewski, R.3
Henkin, J.4
-
34
-
-
20444433198
-
In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: Modulation by lower-dose chemotherapy
-
Ma L, Francia G, Viloria-Petit A, et al. In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower-dose chemotherapy. Cancer Res 2005;65:5365-73.
-
(2005)
Cancer Res
, vol.65
, pp. 5365-5373
-
-
Ma, L.1
Francia, G.2
Viloria-Petit, A.3
-
35
-
-
0030833817
-
CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells
-
Dawson DW, Pearce SF, Zhong R, Silverstein RL, Frazier WA, Bouck NP. CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol 1997;138:707-17.
-
(1997)
J Cell Biol
, vol.138
, pp. 707-717
-
-
Dawson, D.W.1
Pearce, S.F.2
Zhong, R.3
Silverstein, R.L.4
Frazier, W.A.5
Bouck, N.P.6
-
36
-
-
1642368865
-
Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression
-
Hamano Y, Sugimoto H, Soubasakos MA, et al. Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res 2004;64:1570-4.
-
(2004)
Cancer Res
, vol.64
, pp. 1570-1574
-
-
Hamano, Y.1
Sugimoto, H.2
Soubasakos, M.A.3
-
37
-
-
0009849965
-
Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: Effect on human microvascular endothelial cell proliferation and angiogenesis
-
Gupta K, Gupta P, Wild R, Ramakrishnan S, Hebbel RP. Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis. Angiogenesis 1999;3:147-58.
-
(1999)
Angiogenesis
, vol.3
, pp. 147-158
-
-
Gupta, K.1
Gupta, P.2
Wild, R.3
Ramakrishnan, S.4
Hebbel, R.P.5
-
38
-
-
0036225350
-
Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: Antitumor activity and correlation with vascular endothelial growth factor levels
-
Colleoni M, Rocca A, Sandri MT, et al. Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels. Ann Oncol 2002;13:73-80.
-
(2002)
Ann Oncol
, vol.13
, pp. 73-80
-
-
Colleoni, M.1
Rocca, A.2
Sandri, M.T.3
-
39
-
-
27644436870
-
Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity
-
Shaked Y, Emmenegger U, Man S, et al. Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity. Blood 2005;106:3058-61.
-
(2005)
Blood
, vol.106
, pp. 3058-3061
-
-
Shaked, Y.1
Emmenegger, U.2
Man, S.3
-
40
-
-
0141958313
-
Metronomic therapy with cyclophosphamide and dexamethasone for prostate carcinoma
-
Glode LM, Barqawi A, Crighton F, Crawford ED, Kerbel RS. Metronomic therapy with cyclophosphamide and dexamethasone for prostate carcinoma. Cancer 2003;98:1643-8.
-
(2003)
Cancer
, vol.98
, pp. 1643-1648
-
-
Glode, L.M.1
Barqawi, A.2
Crighton, F.3
Crawford, E.D.4
Kerbel, R.S.5
-
41
-
-
0242526860
-
Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors
-
Vogt T, Hafner C, Bross K, et al. Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors. Cancer 2003;98:2251-6.
-
(2003)
Cancer
, vol.98
, pp. 2251-2256
-
-
Vogt, T.1
Hafner, C.2
Bross, K.3
|