Endothelial function and oxidative stress in diabetes: Active profile of the long-acting nitrate pentaerythritol tetranitrate (PETN)

Clinical Research in Cardiology Supplements

Volumn 5, Issue SUPPL.1, 2010, Pages 35-41

  Schnell, Oliver ^a   Stalleicken, D ^b   Daiber, A ^c   Marx, N ^d  

^a INSTITUT FÜR DIABETESFORSCHUNG   (Germany)

^b Acatvis Deutschland GmbH   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Diabetes mellitus; Endothelial dysfunction; Endothelium; Heart; Myocardial infarction; Oxidative stress; Pentaerythritol tetranitrate

Indexed keywords

EID: 84873055338     PISSN: 18610706     EISSN: 18610714     Source Type: Journal    
DOI: 10.1007/s11789-010-0015-x     Document Type: Article

References (41)

1. Standl E, Schnell O (2000) A new look at the heart in diabetes mellitus: from ailing to failing. Diabetologia 43: 1455-1469.
2. Granger CB, Califf RM, Young S et al (1993) Outcome of patients with diabetes mellitus and acute myocardial infarction treated with thrombolytic agents. The Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group. J Am Coll Cardiol 21: 920-925.
3. Otter W, Kleybrink S, Doering W, Standl E, Schnell O (2004) Hospital outcome of acute myocardial infarction in patients with and without diabetes mellitus. Diabet Med 21: 183-187.
4. Williams B, Gallacher B, Patel H, Orme C (1997) Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro. Diabetes 46: 1497-1503.
5. Hattori N, Schnell O, Bengel FM et al (2002) Deferoxamine improves coronary vascular responses to sympathetic stimulation in patients with type 1 diabetes mellitus. Eur J Nucl Med Mol Imaging 29: 891-898.
6. Palmer RM, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524-526.
7. Wilson SH, Celermajer DS, Nakagomi A et al (1999) Vascular risk factors correlate to the extent as well as the severity of coronary atherosclerosis. Coron Artery Dis 10: 449-453.
8. Pieper GM, Gross GJ (1988) Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol 255: H825-833.
9. Di Carli MF, Tobes MC, Mangner T et al (1997) Effects of cardiac sympathetic innervation on coronary blood flow. N Engl J Med 336: 1208-1215.
10. Yokoyama I, Momomura S, Ohtake T et al (1997) Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 30: 1472-1477.
11. Kichuk MR, Seyedi N, Zhang X et al (1996) Regulation of nitric oxide production in human coronary microvessels and the contribution of local kinin formation. Circulation 94: 44-51.
12. Baumgartner-Parzer SM, Wagner L, Pettermann M, Gessl A, Waldhausl W (1995) Modulation by high glucose of adhesion molecule expression in cultured endothelial cells. Diabetologia 38: 1367-1370.
13. Lorenzi M, Cagliero E (1991) Pathobiology of endothelial and other vascular cells in diabetes mellitus. Call for data. Diabetes 40: 653-659.
14. Knight JA (1998) Free radicals: their history and current status in aging and disease. Ann Clin Lab Sci 28: 331-346.
15. Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820.
16. Kruger AL, Peterson SJ, Schwartzman ML et al (2006) Upregulation of heme oxygenase provides vascular protection in an animal model of diabetes through its anti-oxidant and anti-apoptotic effects. J Pharmacol Exp Ther 319: 1144-1152.
17. Otterbein LE, Choi AM (2000) Heme oxygenase: colors of defense against cellular stress. Am J Physiol Lung Cell Mol Physiol 279: L1029-1037.
18. Chen YH, Yet SF, Perrella MA (2003) Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function. Exp Biol Med (Maywood) 228: 447-453.
19. Vitek L, Schwertner HA (2007) The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases. Adv Clin Chem 43: 1-57.
20. Hopkins PN, Wu LL, Hunt SC et al (1996) Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease. Arterioscler Thromb Vasc Biol 16: 250-255.
21. Abraham NG, Asija A, Drummond G, Peterson S (2007) Heme oxygenase -1 gene therapy: recent advances and therapeutic applications. Curr Gene Ther 7: 89-108.
22. Schulz E, Tsilimingas N, Rinze R et al (2002) Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment. Circulation 105: 1170-1175.
23. Munzel T, Daiber A, Mulsch A (2005) Explaining the phenomenon of nitrate tolerance. Circ Res 97: 618-628.
24. Sekiya M, Sato M, Funada J et al (2005) Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis. J Cardiovasc Pharmacol 46: 63-67.
25. Thomas GR, DiFabio JM, Gori T, Parker JD (2007) Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism. J Am Coll Cardiol 49: 1289-1295.
26. Jurt U, Gori T, Ravandi A et al (2001) Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation: a human in vivo study. J Am Coll Cardiol 38: 854-859.
27. Gori T, Al-Hesayen A, Jolliffe C, Parker JD (2003) Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers. Am J Cardiol 91: 1392-1394.
28. Wenzel P, Oelze M, Coldewey M et al (2007) Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates. Arterioscler Thromb Vasc Biol 27: 1729-1735.
29. Kojda G, Hacker A, Noack E (1998) Effects of nonintermittent treatment of rabbits with pentaerythritol tetranitrate on vascular reactivity and superoxide production. Eur J Pharmacol 355: 23-31.
30. Oberle S, Schwartz P, Abate A, Schroder H (1999) The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells. Biochem Biophys Res Commun 261: 28-34.
31. Oberle S, Abate A, Grosser N et al (2003) Endothelial protection by pentaerithrityl trinitrate: bilirubin and carbon monoxide as possible mediators. Exp Biol Med (Maywood) 228: 529-534.
32. Daiber A, Wenzel P, Oelze M, Munzel T (2008) New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance. Clin Res Cardiol 97: 12-20.
33. Daiber A, Wenzel P, Oelze M et al (2009) Mitochondrial aldehyde dehydrogenase (ALDH-2)-maker of and marker for nitrate tolerance in response to nitroglycerin treatment. Chem Biol Interact 178: 40-47.
34. Chen Z, Zhang J, Stamler JS (2002) Identification of the enzymatic mechanism of nitroglycerin bioactivation. Proc Natl Acad Sci USA 99: 8306-8311.
35. Dikalov S, Fink B, Skatchkov M, Bassenge E (1999) Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C. Free Radic Biol Med 27: 170-176.
36. Schulz S, Oberle-Plümpe S, Grosser N et al (2005) Pentaerythritol tetranitrate reduces free radical formation in endothelial cells and macrophages-involvement of heme oxygenase-1. Naunyn-Schmiedberg's Arch Pharmacol 371: R40.
37. Gori T, Daiber A (2009) Non-hemodynamic effects of organic nitrates and the distinctive characteristics of pentaerithrityl tetranitrate. Am J Cardiovasc Drugs 9: 7-15.
38. Pautz A, Rauschkolb P, Schmidt N et al (2009) Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects. Physiol Genomics 38: 176-185.
39. Thum T, Fraccarollo D, Thum S et al (2007) Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress. Arterioscler Thromb Vasc Biol 27: 748-754.
40. Schnorbus B, Schiewe R, Ostad MA et al (2009) Effects of pentaerythritol tetranitrate on endothelial function in coronary artery disease: results of the PENTA study. Clin Res Cardiol 99: 115-124.
41. Schnell O, Stalleicken D, Marx N (2009) Endothelfunktion und oxidativer Stress bei Diabetes - Nutzen eines Langzeitnitrats. Diabetes, Stoffwechsel und Herz 18: 21-27.