Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling

Protein Science

Volumn 22, Issue 1, 2013, Pages 65-73

  Thomaston, Jessica L ^a   Nguyen, Phuong A ^a   Brown, Emily C ^a   Upshur, Mary Alice ^a   Wang, Jun ^b   DeGrado, William F ^b   Howard, Kathleen P ^a  

^a SWARTHMORE COLLEGE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adamantane drug binding; EPR spectroscopy; Lipid bilayers; M2 protein; Membrane proteins; Nitroxide spin label

Indexed keywords

ADAMANTANE; CYSTEINE; NICKEL; PEPTIDE; PROTEIN M2;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING; ELECTRON SPIN RESONANCE; LIPID BILAYER; PH; PRIORITY JOURNAL; PROTEIN STRUCTURE; SPIN LABELING;

ADAMANTANE; ANTIVIRAL AGENTS; BINDING SITES; ELECTRON SPIN RESONANCE SPECTROSCOPY; LIPID BILAYERS; PROTEIN CONFORMATION; SPIN LABELS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL MATRIX PROTEINS;

EID: 84873050159     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2186     Document Type: Article

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