Smad4 expression in hepatocellular carcinoma differs by hepatitis status

Asian Pacific Journal of Cancer Prevention

Volumn 13, Issue 4, 2012, Pages 1297-1303

  Yao, Lei ^a   Li, Fu Jun ^a   Tang, Zhi Qiang ^a   Gao, Shuang ^b   Wu, De Quan ^a  

^a THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b Heilongjiang Nursing College   (China)

Author keywords

Liver cirrhosis virology; Liver neoplasms genetics; SMAD4; Ttumor suppressor gene (TSG); Viral genetics

Indexed keywords

MESSENGER RNA; SMAD4 PROTEIN; SMAD4 PROTEIN, HUMAN;

ARTICLE; FEMALE; HEPATITIS B; HEPATITIS C; HUMAN; LIVER; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; METABOLISM; MIDDLE AGED; NONPARAMETRIC TEST; PROPORTIONAL HAZARDS MODEL; SURVIVAL RATE; TUMOR RECURRENCE; VIROLOGY;

CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATITIS B; HEPATITIS C; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROPORTIONAL HAZARDS MODELS; RNA, MESSENGER; SMAD4 PROTEIN; STATISTICS, NONPARAMETRIC; SURVIVAL RATE;

EID: 84873046105     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.4.1297     Document Type: Article

References (34)

1. Ang CW, Nedjadi T, Sheikh AA, et al (2010). Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells. Carcinogenesis, 31, 1541-51.
2. Argani P, Shaukat A, Kaushal M, et al (2001). Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts. Cancer, 91, 1332-41.
3. de Caestecker MP, Piek E, Roberts AB (2000). Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst, 92, 1388-402.
4. Feitelson MA, Lee J (2007). Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett, 252, 157-70.
5. Guo GH, Tan DM, Zhu PA, Liu F (2009). Hepatitis B virus X protein promotes proliferation and upregulates TGFbeta1 and CTGF in human hepatic stellate cell line, LX-2. Hepatobiliary Pancreat Dis Int, 8, 59-64.
6. Hahn SA, Hoque AT, Moskaluk CA, et al (1996a). Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res, 56, 490-4.
7. Hahn SA, Schutte M, Hoque AT, et al (1996b). DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science, 271, 350-3.
8. Hiwatashi K, Ueno S, Sakoda M, et al (2009). Strong Smad4 expression correlates with poor prognosis after surgery in patients with hepatocellular carcinoma. Ann Surg Oncol, 16, 3176-82.
9. Inagaki Y, Mamura M, Kanamaru Y, et al (2001). Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol, 187, 117-23.
10. Ji GZ, Wang XH, Miao L, et al (2006). Role of transforming growth factor-beta1-smad signal transduction pathway in patients with hepatocellular carcinoma. World J Gastroenterol, 12, 644-8.
11. Keasler VV, Hodgson AJ, Madden CR, Slagle BL (2007). Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo. J Virol, 81, 2656-62.
12. Lai CL, Ratziu V, Yuen MF, Poynard T (2003). Viral hepatitis B. Lancet, 362, 2089-94.
13. Lee DK, Park SH, Yi Y, et al (2001). The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis. Genes Dev, 15, 455-66.
14. Lei J, Zou TT, Shi YQ, et al (1996). Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. Oncogene, 13, 2459-62.
15. Lönn P, Morén A, Raja E, et al (2009). Regulating the stability of TGFbeta receptors and Smads. Cell Res, 19, 21-35.
16. Lu Y, Wu LQ, Li CS, et al (2008). Expression of transforming growth factors in hepatocellular carcinoma and its relations with clinicopathological parameters and prognosis. Hepatobiliary Pancreat Dis Int, 7, 174-8.
17. Maitra A, Molberg K, Albores-Saavedra J, Lindberg G (2000). Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease. Am J Pathol, 157, 1105-11.
18. Massagué J (2008). TGFbeta in Cancer. Cell, 134, 215-30.
19. Maurice D, Pierreux CE, Howell M, et al (2001). Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability. J Biol Chem, 276, 43175-81.
20. Miyaki M, Kuroki T (2003). Role of Smad4 (DPC4) inactivation in human cancer. Biochem Biophys Res Commun, 306, 799-804.
21. Ozturk M (1995). Biology of hepatocellular carcinoma. In 'Gastrointestinal Cancers: Biology, Diagnosis, and Therapy', Ed Rustgi A. Raven Press, New York pp 511-25.
22. Pardali K, Moustakas A (2007). Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta, 1775, 21-62.
23. Remmele W, Stegner HE (1987). Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe, 8, 138-40.
24. Rossmanith W, Schulte-Hermann R (2001). Biology of transforming growth factor beta in hepatocarcinogenesis. Microsc Res Tech, 52, 430-6.
25. Santiago JM, Sasako M, Osorio J (2011). TNM-7th edition 2009 (UICC/AJCC) and Japanese Classification 2010 in Gastric Cancer. Towards simplicity and standardisation in the management of gastric cancer. Cir Esp, 89, 275-81.
26. Schutte M, Hruban RH, Hedrick L, et al (1996). DPC4 gene in various tumor types. Cancer Res, 56, 2527-30.
27. Shin D, Kim SI, Kim M, Park M (2006). Efficient inhibition of hepatitis B virus replication by small interfering RNAs targeted to the viral X gene in mice. Virus Res, 119, 146-53.
28. Taylor LM, Khachigian LM (2000). Induction of platelet-derived growth factor B-chain expression by transforming growth factor-β involves transactivation by Smads.J Biol Chem, 275, 16709-16.
29. Torbenson M, Marinopoulos S, Dang DT, et al (2002). Smad4 overexpression in hepatocellular carcinoma is strongly associated with transforming growth factor beta II receptor immunolabeling. Hum Pathol, 33, 871-6.
30. Vince A (2005). Hepatitis B and C: natural course of disease. Acta Med Croatica, 59, 389-92.
31. Waite KA, Eng C (2003). From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family. Nat Rev Genet, 4, 763-73.
32. Yakicier M, Irmak M, Romano A, et al (1999). Smad2 and Smad4 gene mutations in hepatocellular carcinoma. Oncogene, 18, 4879-83.
33. Yamazaki K, Masugi Y, Sakamoto M (2011). Molecular pathogenesis of hepatocellular carcinoma: altering transforming growth factor-β signaling in hepatocarcinogenesis. Dig Dis, 29, 284-8.
34. Yang G, Yang X (2010). Smad4-mediated TGF- signaling in tumorigenesis. Int J Biol Sci, 6, 1-8.