Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells

Carcinogenesis

Volumn 31, Issue 9, 2010, Pages 1541-1551

  Ang, Chin Wee ^a   Nedjadi, Taoufik ^a   Sheikh, Adnan A ^a   Tweedle, Elizabeth M ^a   Tonack, Sarah ^a   Honap, Sailish ^a   Jenkins, Rosalind E ^b   Park, B Kevin ^b   Schwarte Waldhoff, Irmgard ^c   Khattak, Ilyas ^a   Azadeh, Bahram ^b   Dodson, Andrew ^b   Kalirai, Helen ^b   Neoptolemos, John P ^a,d   Rooney, Paul S ^d   Costello, Eithne ^a,d  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ANTINEOPLASTIC AGENT; CALGRANULIN A; CALGRANULIN B; CHEMOKINE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN;

ADJUVANT THERAPY; ADULT; AGED; ARTICLE; CANCER CELL; CANCER SURGERY; CANCER SURVIVAL; CELL COUNT; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; COLORECTAL CANCER; COLORECTAL TUMOR; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NUCLEOTIDE SEQUENCE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STROMA CELL; TUMOR CELL; TUMOR VOLUME; TWO DIMENSIONAL GEL ELECTROPHORESIS;

AGED; BLOTTING, WESTERN; CALGRANULIN A; CALGRANULIN B; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DIMERIZATION; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; MALE; MIDDLE AGED; MONOCYTES; PANCREATIC NEOPLASMS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STROMAL CELLS;

EID: 77956281058     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq137     Document Type: Article

References (30)

1. Witz,I.P. (2008) Yin-yang activities and vicious cycles in the tumor microenvironment. Cancer Res., 68, 9-13.
2. Murdoch,C. et al. (2008) The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer, 8, 618-631.
3. Joyce,J.A. et al. (2009) Microenvironmental regulation of metastasis. Nat. Rev. Cancer, 9, 239-252.
4. Sheikh,A.A. et al. (2007) The expression of S100A8 in pancreatic cancerassociated monocytes is associated with the Smad4 status of pancreatic cancer cells. Proteomics, 7, 1929-1940.
5. Derynck,R. et al. (2001) TGF-beta signaling in tumor suppression and cancer progression. Nat. Genet., 29, 117-129.
6. Odink,K. et al. (1987) Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature, 330, 80-82.
7. Roth,J. et al. (1993) Expression of calcium-binding proteins MRP8 and MRP14 is associated with distinct monocytic differentiation pathways in HL-60 cells. Biochem. Biophys. Res. Commun., 191, 565-570.
8. Foell,D. et al. (2007) S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J. Leukoc. Biol., 81, 28-37.
9. Nacken,W. et al. (2003) S100A9/S100A8: myeloid representatives of the S100 protein family as prominent players in innate immunity. Microsc. Res. Tech., 60, 569-580.
10. Striz,I. et al. (2004) Calprotectin-a pleiotropic molecule in acute and chronic inflammation. Physiol. Res., 53, 245-253.
11. Ehrchen,J.M. et al. (2009) The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J. Leukoc. Biol., 86, 557-566.
12. Turovskaya,O. et al. (2008) RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis, 29, 2035-2043.
13. Hiratsuka,S. et al. (2006) Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat. Cell Biol., 8, 1369-1375.
14. Hiratsuka,S. et al. (2008) The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat. Cell Biol., 10, 1349-1355.
15. Shekouh,A.R. et al. (2003) Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics, 3, 1988-2001.
16. Thompson,C.C. et al. (2007) Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. Gut, 56, 95-106.
17. Schwarte-Waldhoff,I. et al. (1999) DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression. Oncogene, 18, 3152-3158.
18. Muller,N. et al. (2002) Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells. Oncogene, 21, 6049-6058.
19. Jazag,A. et al. (2005) Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta. Oncogene, 24, 662-671.
20. Gebhardt,C. et al. (2008) RAGE signaling sustains inflammation and promotes tumor development. J. Exp. Med., 205, 275-285.
21. Ghavami,S. et al. (2008) S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway. J. Leukoc. Biol., 83, 1484-1492.
22. Stulik,J. et al. (1999) The analysis of S100A9 and S100A8 expression in matched sets of macroscopically normal colon mucosa and colorectal carcinoma: the S100A9 and S100A8 positive cells underlie and invade tumor mass. Electrophoresis, 20, 1047-1054.
23. Roth,J. et al. (1993) MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner. Blood, 82, 1875-1883.
24. Funada,Y. et al. (2003) Prognostic significance of CD8+ T cell and macrophage peritumoral infiltration in colorectal cancer. Oncol. Rep., 10, 309-313.
25. Khorana,A.A. et al. (2003) Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with Stage II and Stage III colon carcinoma: a role for the host response in prognosis. Cancer, 97, 960-968.
26. Forssell,J. et al. (2007) High macrophage infiltration along the tumor front correlates with improved survival in colon cancer. Clin. Cancer Res., 13, 1472-1479.
27. Miyaki,M. et al. (2003) Role of Smad4 (DPC4) inactivation in human cancer. Biochem. Biophys. Res. Commun., 306, 799-804.
28. Kitamura,T. et al. (2007) SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nat. Genet., 39, 467-475.
29. Li,J.H. et al. (2004) Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease. FASEB J., 18, 176-178.
30. Zwadlo,G. et al. (1988) Two calcium-binding proteins associated with specific stages of myeloid cell differentiation are expressed by subsets of macrophages in inflammatory tissues. Clin. Exp. Immun., 72, 510-515.