A role for GATA transcription factors in the androgen regulation of the prostate-specific antigen gene enhancer

Molecular and Cellular Endocrinology

Volumn 167, Issue 1-2, 2000, Pages 43-53

  Perez Stable, Carlos M ^a,b,c   Pozas, Alicia De Las ^a   Roos, Bernard A ^a,b,c,d  

^a Education   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI   (United States)

^d Stein Gerontological Institute   (United States)

Author keywords

Dihydrotestosterone; Electrophoretic mobility shift assay; GATA family; LNCaP; PSA enhancer; Transfection

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; HEMOGLOBIN F; LYMPHOCYTE ANTIGEN; MESSENGER RNA; PROSTATE SPECIFIC ANTIGEN; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR GATA 3;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40; TARGET CELL; TRANSGENIC MOUSE;

ANIMAL; BREAST NEOPLASMS; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENHANCER ELEMENTS (GENETICS); FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMAN; MALE; MICE; MICE, TRANSGENIC; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; UROGENITAL SYSTEM; ZINC FINGERS;

EID: 0343714601     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(00)00300-2     Document Type: Article

References (51)

1. Adler A., Danielsen M., Robins D.M. Androgen-specific gene activation via a consensus glucocorticoid response element is determined by interaction with nonreceptor factors. Proc. Natl. Acad. Sci. USA. 89:1992;11660-11663.
2. Auffray C., Rougeon F. Purification of mouse immunoglobulin heavy chain messenger RNAs from total myeloma tumor DNA. Eur. J. Biochem. 107:1980;303-314.
3. Bhatia-Gaur R., Donjacour A.A., Sciavolino P.J., Kim M., Desai N., Young P., Norton C.R., Gridley T., Cardiff R.D., Cunha G.R., Abate-Shen C., Shen M.M. Roles for Nkx3.1 in prostate cancer development and cancer. Genes Dev. 13:1999;966-977.
4. Blobel G.A., Sieff C.A., Orkin S.H. Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor. Mol. Cell. Biol. 15:1995;3147-3153.
5. Blobel G.A., Nakajima T., Eckner R., Montminy M., Orkin S.H. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc. Natl. Acad. Sci. USA. 95:1998;2061-2066.
6. Carey M. The enhanceosome and transcriptional synergy. Cell. 92:1998;5-8.
7. Chang T.-J., Scher B.M., Waxman S., Scher W. Inhibition of mouse GATA-1 function by the glucocorticoid receptor: possible mechanism of steroid inhibition of erythroleukemia cell differentiation. Mol. Endocrinol. 7:1993;528-542.
8. Cleutjens K.B.J.M., van der Korput H.A.G.M., van Eekelen C.C.E.M., van Rooij H.C.J., Faber P.W., Trapman J. An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific androgen promoter. Mol. Endocrinol. 11:1997a;148-161.
9. Cleutjens K.B.J.M., van der Korput H.A.G.M., van Eekelen C.C.E.M., Sikes R.A., Fasciana C., Chung L.W., Trapman J. A 6-kb promoter fragment mimics in transgenic mice the prostate-specific and androgen-regulated expression of the endogenous prostate-specific antigen gene in humans. Mol. Endocrinol. 11:1997b;1256-1265.
10. Cunha G.R., Donjacour A.A. Mesenchymal-epithelial interactions: technical considerations. Coffey D.S., Bruchovsky N., Gardner W.A., Resnick M.I., Karr J.P. Current Concepts and Approaches to the Study of Prostate Cancer. 1987;273-282 Alan R. Liss, New York.
11. Cunha G.R., Donjacour A.A., Cooke P.S., Mee S., Bigsby R.M., Higgins S.J., Sugimura Y. The endocrinology and developmental biology of the prostate. Endocr. Rev. 8:1987;338-362.
12. Davis D.L., Burch J.B.E. The chicken vitellogenin II gene is flanked by a GATA factor-dependent estrogen response unit. Mol. Endocrinol. 10:1996;937-944.
13. Dent C.L., Latchman D.S. The DNA mobility shift assay. Latchman D.S. Transcription Factors: A Practical Approach. 1993;1-26 Oxford University Press, New York.
14. Dorfman D.M., Wilson D.B., Bruns G.A.P., Orkin S.H. Human transcription factor GATA-2: evidence for regulation of preproendothelin-1 gene expression in endothelial cells. J. Biol. Chem. 267:1992;1279-1285.
15. Engel J.D., Tanimoto K. Looping, linking, and chromatin activity: new insights into beta-globin locus regulation. Cell. 100:2000;499-502.
16. Gordon D.F., Lewis S.R., Haugen B.R., James R.A., McDermott M.T., Wood W.M., Ridgway E.C. Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin ß-subunit promoter. J. Biol. Chem. 272:1997;24339-24347.
17. Greenberg N.M., DeMayo F.J., Sheppard P.C., Barrios R., Lebovitz R., Finegold M., Angelopoulou R., Dodd J.G., Duckworth M.L., Rosen J.M., Matusik R.J. The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice. Mol. Endocrinol. 8:1994;230-239.
18. Gu H., Marth J.D., Orban P.C., Mossmann H., Rajewsky K. Deletion of a DNA polymerase ß gene segment in T cells using cell type-specific gene targeting. Science. 265:1994;103-106.
19. Hoch R.V., Thompson D.A., Baker R.J., Weigel R.J. GATA-3 is expressed in association with estrogen receptor in breast cancer. Int. J. Cancer. 84:1999;122-128.
20. Horoszewicz J.S., Leong S.S., Kawinski E., Kerr J.P., Rosenthal H., Chu T.M., Mirand E.A., Murphy G.P. LNCaP model of human prostatic carcinoma. Cancer Res. 43:1983;1809-1818.
21. Huang W., Shostak Y., Tarr P., Sawyers C., Carey M. Cooperative assembly of androgen receptor into a nucleoprotein complex that regulates the prostate-specific antigen enhancer. J. Biol. Chem. 274:1999;25756-25768.
22. Kaighn M.E., Narayan K.S., Ohnuki Y., Lechner J.F., Jones L.W. Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest. Urol. 17:1979;16-23.
23. Kawana M., Lee M.-E., Quertermous E.E., Quertermous T. Cooperative interaction of GATA-2 and AP-1 regulates transcription of the endothelin-1 gene. Mol. Cell. Biol. 15:1995;4225-4231.
24. Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D. Murine and human T-lymphocyte GATA3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol. Cell. Biol. 11:1991;2778-2784.
25. Lakshmanan G., Lieuw K.H., Lim K.-C., Gu Y., Grosveld F., Engel J.D., Karis A. Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus. Mol. Cell. Biol. 19:1999;1558-1568.
26. Laverriere A.C., MacNeil C., Mueller C., Poelmann R.E., Burch J.B., Evans T. GATA4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut. J. Biol. Chem. 269:1994;23177-23184.
27. Lawson M.A., Whyte D.B., Mellon P.L. GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol. Cell. Biol. 16:1996;3596-3605.
28. Loop S.M., Rozansky T.A., Ostenson R.C. Human primary tumor cell line ALVA-31: a new model for studying the hormonal regulation of tumor cell growth. Prostate. 22:1993;93-108.
29. Merika M., Orkin S.H. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kruppel family proteins Sp1 and ELKF. Mol. Cell. Biol. 15:1995;2437-2447.
30. Morrisey E.E., Ip H.S., Lu M.M., Parmacek M.S. GATA6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev. Biol. 177:1996;309-322.
31. Oettgen P., Finger E., Sun Z., Akbarali Y., Thamrongsak U., Boltax J., Grall F., Dube A., Weiss A., Brown L., Quinn G., Kas K., Endress G., Kunsch C., Libermann T.A. PDEF, a novel prostate epithelium-specific Ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. J. Biol. Chem. 275:2000;1216-1225.
32. Pandolfi P.P., Roth M.E., Karis A., Leonard M.W., Dzierzak E., Grosveld F.G., Engel J.D., Lindenbaum M.H. Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nat. Genet. 11:1995;40-44.
33. Pang S., Dannull J., Kaboo R., Xie Y., Tso C.-L., Michel K., deKernion J.B., Belldegrun A.S. Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen. Cancer Res. 57:1997;495-499.
34. Perez-Stable C., Altman N.H., Brown J., Cray C., Harbison M., Roos B.A. Prostate, adrenocortical, and brown adipose tumors in fetal globin/T antigen transgenic mice. Lab. Invest. 74:1996;363-373.
35. Perez-Stable C., Altman N.H., Mehta P.P., Deftos L.J., Roos B.A. Prostate cancer progression, metastasis, and gene expression in transgenic mice. Cancer Res. 57:1997;900-906.
36. Pevny L., Simon M.C., Robertson E., Klein W.H., Tsai S.F., D'Agati V., Orkin S.H., Costantini F. Erythroid differentiation in chimeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 349:1991;257-260.
37. Schuur E.R., Henderson G.A., Kmetec L.A., Miller J.D., Lamparski H.G., Henderson D.R. Prostate-specific antigen expression is regulated by an upstream enhancer. J. Biol. Chem. 271:1996;7043-7051.
38. Simon M.C. Gotta have GATA. Nat. Genet. 11:1995;9-11.
39. Soule H.D., Vazquez J., Long A., Albert S., Brennan M. A human cell line from a pleural effusion from a breast carcinoma. J. Natl. Cancer Inst. 51:1973;1409-1416.
40. Stone K.R., Mickey D.D., Wunderli H., Mickey G.H., Paulson D.F. Isolation of a human prostate carcinoma cell line (DU 145). Int. J. Cancer. 21:1978;274-281.
41. Suzuki E., Evans T., Lowry J., Truong L., Bell D.W., Testa J.R., Walsh K. The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogenic-responsive signals. Genomics. 38:1996;283-290.
42. Tamura S., Wang X.-H., Maeda M., Futai M. Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes. Proc. Natl. Acad. Sci. USA. 90:1993;10876-10880.
43. Ting C.N., Olson M.C., Barton K.P., Leiden J.M. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature. 384:1996;474-478.
44. Tremblay J.J., Viger R.S. Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1. Mol. Endocrinol. 13:1999;1388-1401.
45. Tsai F.Y., Keller G., Kuo F.C., Weiss M., Chen J., Rosenblatt M., Alt F.W., Orkin S.H. An early hematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 371:1994;221-226.
46. Tsang A.P., Visvader J.E., Turner C.A., Fujiwara Y., Yu C., Weiss M.J., Crossley M., Orkin S.H. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakarocytic differentiation. Cell. 90:1997;109-119.
47. Weiss M.J., Orkin S.H. GATA transcription factors: key regulators of hematopoiesis. Exp. Hematol. 23:1995;99-107.
48. Yeh S., Chang C. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. USA. 93:1996;5517-5521.
49. Yu D.C., Sakamoto G.T., Henderson D.R. Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of Calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy. Cancer Res. 59:1999;1498-1504.
50. Zhang S., Murtha P.E., Young C.Y.F. Defining a functional androgen responsive element in the 5′ far upstream flanking region of the prostate-specific antigen gene. Biochem. Biophys. Res. Commun. 231:1997;784-788.
51. Zhou Y., Lim K.-C., Onodera K., Takahashi S., Ohta J., Minegishi N., Tsai F.-Y., Orkin S.H., Yamamoto M., Engel J.D. Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J. 7:1998;6689-6700.