메뉴 건너뛰기




Volumn 47, Issue 2, 2013, Pages 106-111

Mucin function in inflammatory bowel disease: An update

Author keywords

ER stress; goblet cell; inflammatory bowel disease; intestinal epithelium; MUC2; mucin; mucosal barrier; unfolded protein response

Indexed keywords

ANTIBODY; BETA CATENIN; FATTY ACID SYNTHASE; GLYCOPROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 8; MUCIN; MUCIN 13; MUCIN 17; MUCIN 2; MUCIN 3; MUCIN 5AC; MUCIN 6; MUCIN ANTIBODY; NICOTINE; OLIGOSACCHARIDE; SIALOMUCIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

EID: 84872947175     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3182688e73     Document Type: Review
Times cited : (120)

References (60)
  • 1
    • 77951019810 scopus 로고    scopus 로고
    • Mucin-interacting proteins: From function to therapeutics
    • Senapati S, Das S, Batra SK. Mucin-interacting proteins: from function to therapeutics. Trends Biochem Sci. 2010;35:236-245.
    • (2010) Trends Biochem Sci. , vol.35 , pp. 236-245
    • Senapati, S.1    Das, S.2    Batra, S.K.3
  • 2
    • 36849006050 scopus 로고    scopus 로고
    • Molecular signaling in the regulation of mucins
    • Theodoropoulos G, Carraway KL. Molecular signaling in the regulation of mucins. J Cell Biochem. 2007;102:1103-1116.
    • (2007) J Cell Biochem. , vol.102 , pp. 1103-1116
    • Theodoropoulos, G.1    Carraway, K.L.2
  • 3
    • 33745177351 scopus 로고    scopus 로고
    • Regulation of mucin expression: Mechanistic aspects and implications for cancer and inflammatory diseases
    • Andrianifahanana M, Moniaux N, Batra SK. Regulation of mucin expression: mechanistic aspects and implications for cancer and inflammatory diseases. Biochim Biophys Acta. 2006;1765:189-222.
    • (2006) Biochim Biophys Acta. , vol.1765 , pp. 189-222
    • Andrianifahanana, M.1    Moniaux, N.2    Batra, S.K.3
  • 4
    • 0037479789 scopus 로고    scopus 로고
    • Mucin and Toll-like receptors in host defense against intestinal parasites
    • Moncada DM, Kammanadiminti SJ, K Chadee. Mucin and Toll-like receptors in host defense against intestinal parasites. Trends Parasitol. 2003;19:305-311.
    • (2003) Trends Parasitol. , vol.19 , pp. 305-311
    • Moncada, D.M.1    Kammanadiminti, S.J.2    Chadee, K.3
  • 5
    • 34547678389 scopus 로고    scopus 로고
    • MUC1 cell surface mucin is a critical element of the mucosal barrier to infection
    • McAuley JL, Linden SK, Png CW, et al. MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. J Clin Invest. 2007;117:2313-2324.
    • (2007) J Clin Invest. , vol.117 , pp. 2313-2324
    • McAuley, J.L.1    Linden, S.K.2    Png, C.W.3
  • 6
    • 44349189080 scopus 로고    scopus 로고
    • Innate immune response mechanisms in the intestinal epithelium: Potential roles for mast cells and goblet cells in the expulsion of adult Trichinella spiralis
    • Knight PA, Brown JK, Pemberton AD. Innate immune response mechanisms in the intestinal epithelium: potential roles for mast cells and goblet cells in the expulsion of adult Trichinella spiralis. Parasitology. 2008;135:655-670.
    • (2008) Parasitology. , vol.135 , pp. 655-670
    • Knight, P.A.1    Brown, J.K.2    Pemberton, A.D.3
  • 7
    • 77951672971 scopus 로고    scopus 로고
    • Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection
    • Hasnain SZ, Wang H, Ghia JE, et al. Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Gastroenterology. 2010;138:1763-1771.
    • (2010) Gastroenterology. , vol.138 , pp. 1763-1771
    • Hasnain, S.Z.1    Wang, H.2    Ghia, J.E.3
  • 8
    • 79956093663 scopus 로고    scopus 로고
    • Muc5ac: A critical component mediating the rejection of enteric nematodes
    • Hasnain SZ, Evans CM, Roy M, et al. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011;208:893-900.
    • (2011) J Exp Med. , vol.208 , pp. 893-900
    • Hasnain, S.Z.1    Evans, C.M.2    Roy, M.3
  • 9
    • 84861664167 scopus 로고    scopus 로고
    • Exposure to host ligands correlates with co-localization of Gal/GalNAc lectin subunits in lipid rafts and PIP2 signaling in Entamoeba histolytica
    • Goldston AM, Powell RR, Koushik AB, et al. Exposure to host ligands correlates with co-localization of Gal/GalNAc lectin subunits in lipid rafts and PIP2 signaling in Entamoeba histolytica. Eukaryot Cell. 2012;11:743-751.
    • (2012) Eukaryot Cell. , vol.11 , pp. 743-751
    • Goldston, A.M.1    Powell, R.R.2    Koushik, A.B.3
  • 10
    • 33745121509 scopus 로고    scopus 로고
    • Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel
    • Lidell ME, Moncada DM, Chadee K, et al. Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel. Proc Natl Acad Sci USA. 2006;103:9298-9303.
    • (2006) Proc Natl Acad Sci USA. , vol.103 , pp. 9298-9303
    • Lidell, M.E.1    Moncada, D.M.2    Chadee, K.3
  • 11
    • 67649231565 scopus 로고    scopus 로고
    • Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency
    • Podolsky DK, Gerken G, Eyking A, et al. Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. Gastroenterology. 2009;137:209-220.
    • (2009) Gastroenterology. , vol.137 , pp. 209-220
    • Podolsky, D.K.1    Gerken, G.2    Eyking, A.3
  • 12
    • 36749092728 scopus 로고    scopus 로고
    • MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling
    • Ahmad R, Raina D, Trivedi V, et al. MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling. Nat Cell Biol. 2007;9:1419-1427.
    • (2007) Nat Cell Biol. , vol.9 , pp. 1419-1427
    • Ahmad, R.1    Raina, D.2    Trivedi, V.3
  • 13
    • 0034664947 scopus 로고    scopus 로고
    • Identification of transient glycosylation alterations of sialylated mucin oligo-saccharides during infection by the rat intestinal parasite Nippostrongylus brasiliensis
    • Karlsson NG, Olson FJ, Jovall PA, et al. Identification of transient glycosylation alterations of sialylated mucin oligo-saccharides during infection by the rat intestinal parasite Nippostrongylus brasiliensis. Biochem J. 2000;350:805-814.
    • (2000) Biochem J. , vol.350 , pp. 805-814
    • Karlsson, N.G.1    Olson, F.J.2    Jovall, P.A.3
  • 14
    • 0028265506 scopus 로고
    • Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis
    • Pullan RD, Thomas GA, Rhodes M, et al. Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis. Gut. 1994;35:353-359.
    • (1994) Gut. , vol.35 , pp. 353-359
    • Pullan, R.D.1    Thomas, G.A.2    Rhodes, M.3
  • 16
    • 0026439259 scopus 로고
    • Sulphation of colonic mucin in ulcerative colitis and Crohn's disease
    • Raouf AH, Tsai HH, Parker N, et al. Sulphation of colonic mucin in ulcerative colitis and Crohn's disease. Clin Sci. 1992;83:623-626.
    • (1992) Clin Sci. , vol.83 , pp. 623-626
    • Raouf, A.H.1    Tsai, H.H.2    Parker, N.3
  • 17
    • 0032985868 scopus 로고    scopus 로고
    • Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis
    • Van Klinken BJ, Van der Wal JW, Einerhand AW, et al. Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis. Gut. 1999;44: 387-393.
    • (1999) Gut. , vol.44 , pp. 387-393
    • Van Klinken, B.J.1    Van Der Wal, J.W.2    Einerhand, A.W.3
  • 18
    • 80054767981 scopus 로고    scopus 로고
    • Altered O-glycosylation profile of MUC2 mucin occurs in active ulcer-ative colitis and is associated with increased inflammation
    • Larsson JM, Karlsson H, Crespo JG, et al. Altered O-glycosylation profile of MUC2 mucin occurs in active ulcer-ative colitis and is associated with increased inflammation. Inflamm Bowel Dis. 2011;17:2299-2307.
    • (2011) Inflamm Bowel Dis. , vol.17 , pp. 2299-2307
    • Larsson, J.M.1    Karlsson, H.2    Crespo, J.G.3
  • 19
    • 0028908975 scopus 로고
    • Increased rate of sialylation of colonic mucin by cultured ulcerative colitis mucosal explants
    • Parker N, Tsai HH, Ryder SD, et al. Increased rate of sialylation of colonic mucin by cultured ulcerative colitis mucosal explants. Digestion. 1995;56:52-56.
    • (1995) Digestion. , vol.56 , pp. 52-56
    • Parker, N.1    Tsai, H.H.2    Ryder, S.D.3
  • 20
  • 21
    • 33751250222 scopus 로고    scopus 로고
    • Alterations in the composition of the supramucosal defense barrier in relation to disease severity of ulcerative colitis
    • Longman RJ, Poulsom R, Corfield AP, et al. Alterations in the composition of the supramucosal defense barrier in relation to disease severity of ulcerative colitis. J Histochem Cytochem. 2006;54:1335-1348.
    • (2006) J Histochem Cytochem. , vol.54 , pp. 1335-1348
    • Longman, R.J.1    Poulsom, R.2    Corfield, A.P.3
  • 22
    • 34447101563 scopus 로고    scopus 로고
    • Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease
    • Moehle C, Ackermann N, Langmann T, et al. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J Mol Med. 2006;84:1055-1066.
    • (2006) J Mol Med. , vol.84 , pp. 1055-1066
    • Moehle, C.1    Ackermann, N.2    Langmann, T.3
  • 23
    • 34250378697 scopus 로고    scopus 로고
    • Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans
    • An G, Wei B, Xia B, et al. Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med. 2007;204:1417-1429.
    • (2007) J Exp Med. , vol.204 , pp. 1417-1429
    • An, G.1    Wei, B.2    Xia, B.3
  • 24
    • 0035114484 scopus 로고    scopus 로고
    • Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease
    • Kyo K, Muto T, Nagawa H, et al. Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease. J Hum Genet. 2001;46:5-20.
    • (2001) J Hum Genet , vol.46 , pp. 5-20
    • Kyo, K.1    Muto, T.2    Nagawa, H.3
  • 25
    • 0034823196 scopus 로고    scopus 로고
    • Mucin gene expression in intestinal epithelial cells in Crohn's disease
    • Buisine MP, Desreumaux P, Leteurtre E, et al. Mucin gene expression in intestinal epithelial cells in Crohn's disease. Gut. 2001;49:544-551.
    • (2001) Gut. , vol.49 , pp. 544-551
    • Buisine, M.P.1    Desreumaux, P.2    Leteurtre, E.3
  • 26
    • 77955722731 scopus 로고    scopus 로고
    • Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neo-plastic diseases of the colon
    • Senapati S, Ho SB, Sharma P, et al. Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neo-plastic diseases of the colon. J Clin Pathol. 2010;63:702-707.
    • (2010) J Clin Pathol. , vol.63 , pp. 702-707
    • Senapati, S.1    Ho, S.B.2    Sharma, P.3
  • 27
    • 0033984841 scopus 로고    scopus 로고
    • Circulating autoanti-bodies against purified colonic mucin in ulcerative colitis
    • Takaishi H, Ohara S, Hotta K, et al. Circulating autoanti-bodies against purified colonic mucin in ulcerative colitis. J Gastroenterol. 2000;35:20-27.
    • (2000) J Gastroenterol. , vol.35 , pp. 20-27
    • Takaishi, H.1    Ohara, S.2    Hotta, K.3
  • 28
    • 0027502888 scopus 로고
    • Detection of a circulating antibody against a peptide epitope on a mucin core protein, MUC1, in ulcerative colitis
    • Hinoda Y, Nakagawa N, Nakamura H, et al. Detection of a circulating antibody against a peptide epitope on a mucin core protein, MUC1, in ulcerative colitis. Immunol Lett. 1993;35: 163-168.
    • (1993) Immunol Lett. , vol.35 , pp. 163-168
    • Hinoda, Y.1    Nakagawa, N.2    Nakamura, H.3
  • 29
    • 78149283854 scopus 로고    scopus 로고
    • Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria
    • Png CW, Linden SK, Gilshenan KS, et al. Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. Am J Gastroenterol. 2010;105:2420-2428.
    • (2010) Am J Gastroenterol. , vol.105 , pp. 2420-2428
    • Png, C.W.1    Linden, S.K.2    Gilshenan, K.S.3
  • 30
    • 0025882613 scopus 로고
    • Characterization and heterogeneity of monoclonal antibodies directed to intestinal mucin derived from Crohn's disease small bowel
    • Prindiville M, Cantrell M, Gershwin ME. Characterization and heterogeneity of monoclonal antibodies directed to intestinal mucin derived from Crohn's disease small bowel. Hybridoma. 1991;10:269-280.
    • (1991) Hybridoma. , vol.10 , pp. 269-280
    • Prindiville, M.1    Cantrell, M.2    Gershwin, M.E.3
  • 31
    • 41049107864 scopus 로고    scopus 로고
    • Altered expression of CDX-2 PDX-1 and mucin core proteins in "ulcer-associated cell lineage (UACL)" in Crohn's disease
    • Kaneko Y, Nakamura T, Hayama M, et al. Altered expression of CDX-2, PDX-1 and mucin core proteins in "Ulcer-associated cell lineage (UACL)" in Crohn's disease. J Mol Histol. 2008;39:161-168.
    • (2008) J Mol Histol. , vol.39 , pp. 161-168
    • Kaneko, Y.1    Nakamura, T.2    Hayama, M.3
  • 32
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DP, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010;42:1118-1125.
    • (2010) Nat Genet. , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3
  • 33
    • 16044373177 scopus 로고    scopus 로고
    • Two-stage genome-wide search in inflammatory bowel disease: Evidence for susceptibility loci on chromosomes 3, 7 and 12
    • Satsangi J, Parkes M, Louis E. Two-stage genome-wide search in inflammatory bowel disease: evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet. 1996;14: 199-202.
    • (1996) Nat Genet. , vol.14 , pp. 199-202
    • Satsangi, J.1    Parkes, M.2    Louis, E.3
  • 34
    • 70349459620 scopus 로고    scopus 로고
    • Activation of innate immune antiviral responses by Nod2
    • Sabbah A, Chang TH, Harnack R, et al. Activation of innate immune antiviral responses by Nod2. Nat Immunol. 2009;10:1073-1080.
    • (2009) Nat Immunol. , vol.10 , pp. 1073-1080
    • Sabbah, A.1    Chang, T.H.2    Harnack, R.3
  • 35
    • 0001251527 scopus 로고
    • Mucin glycoprotein degradation by mucin oligosaccharide-degrading strains of human faecal bacteria. Characterisation of saccharide cleavage products and their potential role in nutritional support of larger faecal bacterial populations
    • Hoskins LC. Mucin glycoprotein degradation by mucin oligosaccharide- degrading strains of human faecal bacteria. Characterisation of saccharide cleavage products and their potential role in nutritional support of larger faecal bacterial populations. Microb Ecol Health Dis. 1992;5:193-207.
    • (1992) Microb Ecol Health Dis. , vol.5 , pp. 193-207
    • Hoskins, L.C.1
  • 36
    • 54449083567 scopus 로고    scopus 로고
    • The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
    • Johansson ME, Phillipson M, Petersson J, et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci USA. 2008;105: 15064-15069.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , pp. 15064-15069
    • Johansson, M.E.1    Phillipson, M.2    Petersson, J.3
  • 37
    • 77957906400 scopus 로고    scopus 로고
    • Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model
    • Johansson ME, Gustafsson JK, Sjoberg KE, et al. Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model. PLoS One. 2010;18:e12238.
    • (2010) PLoS One. , vol.18
    • Johansson, M.E.1    Gustafsson, J.K.2    Sjoberg, K.E.3
  • 38
    • 80052593783 scopus 로고    scopus 로고
    • On the relationship between sialomucin and sulfomucin expression and hydro-genotrophic microbes in the human colonic mucosa
    • Croix JA, Carbonero F, Nava GM, et al. On the relationship between sialomucin and sulfomucin expression and hydro-genotrophic microbes in the human colonic mucosa. PLoS One. 2011;6:e24447.
    • (2011) PLoS One. , vol.6
    • Croix, J.A.1    Carbonero, F.2    Nava, G.M.3
  • 39
    • 79953307656 scopus 로고    scopus 로고
    • Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice
    • Fu J, Wei B, Wen T, et al. Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest. 2011;121:1657-1666.
    • (2011) J Clin Invest. , vol.121 , pp. 1657-1666
    • Fu, J.1    Wei, B.2    Wen, T.3
  • 40
    • 34548224209 scopus 로고    scopus 로고
    • Abnormal expression of M1/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer
    • Forgue-Lafitte ME, Fabiani B, Levy PP, et al. Abnormal expression of M1/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer. Int J Cancer. 2007;121:1543-1549.
    • (2007) Int J Cancer. , vol.121 , pp. 1543-1549
    • Forgue-Lafitte, M.E.1    Fabiani, B.2    Levy, P.P.3
  • 41
    • 77950298959 scopus 로고    scopus 로고
    • Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    • McGovern DP, Gardet A, Torkvist L, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 2010;42:332-337.
    • (2010) Nat Genet. , vol.42 , pp. 332-337
    • McGovern, D.P.1    Gardet, A.2    Torkvist, L.3
  • 42
    • 0032924112 scopus 로고    scopus 로고
    • Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene MUC3
    • Kyo K, Parkes M, Takei Y, et al. Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3. Hum Mol Genet. 1999;8:307-311.
    • (1999) Hum Mol Genet. , vol.8 , pp. 307-311
    • Kyo, K.1    Parkes, M.2    Takei, Y.3
  • 43
    • 0032709760 scopus 로고    scopus 로고
    • Ulcerative colitis is not associated with differences in MUC2 mucin allele length
    • Swallow DM, Vinall LE, Gum JR, et al. Ulcerative colitis is not associated with differences in MUC2 mucin allele length. J Med Genet. 1999;36:859-860.
    • (1999) J Med Genet. , vol.36 , pp. 859-860
    • Swallow, D.M.1    Vinall, L.E.2    Gum, J.R.3
  • 44
    • 0028913915 scopus 로고
    • Increased faecal mucin sulphatase activity in ulcerative colitis: A potential target for treatment
    • Tsai HH, Dwarakanath AD, Hart CA, et al. Increased faecal mucin sulphatase activity in ulcerative colitis: a potential target for treatment. Gut. 1995;36:570-576.
    • (1995) Gut. , vol.36 , pp. 570-576
    • Tsai, H.H.1    Dwarakanath, A.D.2    Hart, C.A.3
  • 45
    • 84862818460 scopus 로고    scopus 로고
    • The membrane-bound mucin muc1 regulates T helper 17-cell responses and colitis in mice
    • Nishida A, Lau CW, Zhang M, et al. The membrane-bound mucin muc1 regulates T helper 17-cell responses and colitis in mice. Gastroenterology. 2012;142:865-874.
    • (2012) Gastroenterology. , vol.142 , pp. 865-874
    • Nishida, A.1    Lau, C.W.2    Zhang, M.3
  • 46
    • 0013557570 scopus 로고    scopus 로고
    • Nicotine down-regulates IL-8 production and tissue expression in inflammatory bowel disease
    • Bhatti MA, Hodgson HJF. Nicotine down-regulates IL-8 production and tissue expression in inflammatory bowel disease. Gastroenterology. 1997;112:A934.
    • (1997) Gastroenterology. , vol.112
    • Bhatti, M.A.1    Hodgson, H.J.F.2
  • 47
    • 0033174811 scopus 로고    scopus 로고
    • Transdermal nicotine decreases mucosal IL-8 expression but has no effect on mucin gene expression in ulcerative colitis
    • Louvet B, Buisine MP, Desreumaux P, et al. Transdermal nicotine decreases mucosal IL-8 expression but has no effect on mucin gene expression in ulcerative colitis. Inflamm Bowel Dis. 1999;5:174-181.
    • (1999) Inflamm Bowel Dis. , vol.5 , pp. 174-181
    • Louvet, B.1    Buisine, M.P.2    Desreumaux, P.3
  • 48
    • 0023898846 scopus 로고
    • Mucin abnormality of colonic mucosa in ulcerative colitis associated with carcinoma and/or dysplasia
    • Agawa S, Muto T, Morioka Y. Mucin abnormality of colonic mucosa in ulcerative colitis associated with carcinoma and/or dysplasia. Dis Colon Rectum. 1988;31:387-389.
    • (1988) Dis Colon Rectum. , vol.31 , pp. 387-389
    • Agawa, S.1    Muto, T.2    Morioka, Y.3
  • 49
    • 0018387835 scopus 로고
    • Failure to demonstrate specificity of the morphological and histochemical changes in mucosa adjacent to colonic carcinoma
    • Issaacson P, Attwood PRA. Failure to demonstrate specificity of the morphological and histochemical changes in mucosa adjacent to colonic carcinoma. J Clin Pathol. 1979;32:214-218.
    • (1979) J Clin Pathol. , vol.32 , pp. 214-218
    • Issaacson, P.1    Attwood, P.R.A.2
  • 50
    • 33744748618 scopus 로고    scopus 로고
    • Cytokeratin 7/20 and mucin core protein expression in ulcerative colitis-associated colorectal neoplasms
    • Tatsumi N, Kushima R, Vieth M, et al. Cytokeratin 7/20 and mucin core protein expression in ulcerative colitis-associated colorectal neoplasms. Virchows Arch. 2006;448:756-762.
    • (2006) Virchows Arch. , vol.448 , pp. 756-762
    • Tatsumi, N.1    Kushima, R.2    Vieth, M.3
  • 51
    • 34548759771 scopus 로고    scopus 로고
    • - mice accelerates inflammatory bowel disease and progression to colon cancer
    • - mice accelerates inflammatory bowel disease and progression to colon cancer. J Immunol. 2007;179:735-739.
    • (2007) J Immunol. , vol.179 , pp. 735-739
    • Beatty, P.L.1    Plevy, S.E.2    Sepulveda, A.R.3
  • 52
    • 13844262819 scopus 로고    scopus 로고
    • Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
    • Wei X, Xu H, Kufe D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell. 2005;7:167-178.
    • (2005) Cancer Cell. , vol.7 , pp. 167-178
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 53
    • 0036500996 scopus 로고    scopus 로고
    • Colorectal cancer in mice genetically deficient in the mucin Muc2
    • Velcich A, Yang W, Heyer J, et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 2002;295: 1726-1729.
    • (2002) Science. , vol.295 , pp. 1726-1729
    • Velcich, A.1    Yang, W.2    Heyer, J.3
  • 54
    • 54649084868 scopus 로고    scopus 로고
    • Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: Potential role of chronic inflammation
    • Yang K, Popova NV, Yang WC, et al. Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation. Cancer Res. 2008;68:7313-7322.
    • (2008) Cancer Res. , vol.68 , pp. 7313-7322
    • Yang, K.1    Popova, N.V.2    Yang, W.C.3
  • 55
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser A, Lee AH, Franke A, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008;134:743-756.
    • (2008) Cell. , vol.134 , pp. 743-756
    • Kaser, A.1    Lee, A.H.2    Franke, A.3
  • 56
    • 74749103667 scopus 로고    scopus 로고
    • Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2~/~ mice
    • Zhao F, Edwards R, Dizon D, et al. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2~/~ mice. Dev Biol. 2010;338270-279.
    • (2010) Dev Biol. , pp. 338270-338279
    • Zhao, F.1    Edwards, R.2    Dizon, D.3
  • 57
    • 41549092745 scopus 로고    scopus 로고
    • Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
    • Heazlewood CK, Cook MC, Eri R, et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 2008;5:e54.
    • (2008) PLoS Med. , vol.5
    • Heazlewood, C.K.1    Cook, M.C.2    Eri, R.3
  • 58
    • 84863127054 scopus 로고    scopus 로고
    • Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2
    • Wei X, Yang Z, Rey FE, et al. Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2. Cell Host Microbe. 2012;11:140-152.
    • (2012) Cell Host Microbe. , vol.11 , pp. 140-152
    • Wei, X.1    Yang, Z.2    Rey, F.E.3
  • 59
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature. 2008;456:259-263.
    • (2008) Nature. , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3
  • 60
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007;39:207-211.
    • (2007) Nat Genet. , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.