Altered expression of CDX-2, PDX-1 and mucin core proteins in "Ulcer-associated cell lineage (UACL)" in Crohn's disease

Journal of Molecular Histology

Volumn 39, Issue 2, 2008, Pages 161-168

  Kaneko, Yasunori ^a   Nakamura, Takamichi ^a   Hayama, Masayoshi ^b   Hosaka, Noriko ^c   Akamatsu, Taiji ^d   Ota, Hiroyoshi ^b  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Nagano Municipal Hospital   (Japan)

^d SHINSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

CDX 2; Crohn's disease; Immunohistochemistry; Mucin core protein; PDX 1; Ulcer associated cell lineage

Indexed keywords

HOMEODOMAIN PROTEIN; MUCIN; MUCIN 5AC; MUCIN 6; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR PDX 1;

ARTICLE; CELL LINEAGE; CELL STRUCTURE; CELL SURFACE; CLINICAL ARTICLE; CROHN DISEASE; DOWN REGULATION; GASTROINTESTINAL TRACT; GOBLET CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM MUCOSA; ILEUM RESECTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTESTINE MUCOSA; INTESTINE ULCER; MUCOUS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PYLORUS; SMALL INTESTINE; STOMACH GLAND; STOMACH MUCOSA; UPREGULATION;

CROHN DISEASE; GASTRIC MUCOSA; HISTOCYTOCHEMISTRY; HOMEODOMAIN PROTEINS; HUMANS; ILEUM; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; METAPLASIA; MUCINS; TRANS-ACTIVATORS;

EID: 41049107864     PISSN: 15672379     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10735-007-9149-7     Document Type: Article

References (36)

1. Babyatsky MW, Rossiter G, Podolsky DK (1996) Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 110:975-984
2. Bai YQ, Yamamoto H, Akiyama Y et al (2002) Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett 176:47-55
3. Beck F, Chawengsaksophak K, Waring P et al (1999) Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice. Proc Natl Acad Sci USA 96:7318-7323
4. Boudreau F, Rings EH, van Wering HM et al (2002) Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem 277:31909-31917
5. Buisine MP, Desreumaux P, Debailleul V et al (1999) Abnormalities in mucin gene expression in Crohn's disease. Inflamm Bowel Dis 5:24-32
6. Buisine MP, Devisme L, Degand P et al (2000a) Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands. II. Duodenum and liver, gallbladder, and pancreas. J Histochem Cytochem 48:1667-1676
7. Buisine MP, Devisme L, Maunoury V et al (2000b) Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands. I. Stomach. A relationship to gastric carcinoma. J Histochem Cytochem 48:1657-1666
8. Buisine MP, Desreumaux P, Leteurtre E et al (2001) Mucin gene expression in intestinal epithelial cells in Crohn's disease. Gut 49:544-551
9. Chawengsaksophak K, James R, Hammond VE et al (1997) Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 386:84-87
10. Eda A, Osawa H, Yanaka I et al (2002) Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J Gastroenterol 37:94-100
11. Faller G, Dimmler A, Rau T et al (2004) Evidence for acid-induced loss of Cdx2 expression in duodenal gastric metaplasia. J Pathol 203:904-908
12. Gannon M, Gamer LW, Wright CV (2001) Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev Biol 238:185-201
13. Hanby AM, Poulsom R, Singh S et al (1993) Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. Gastroenterology 105:1110-1116
14. Ho SB, Roberton AM, Shekels LL et al (1995) Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression [comment]. Gastroenterology 109:735-747
15. Hoffmann W (2004) Trefoil factor family (TFF) peptides: regulators of mucosal regeneration and repair, and more. Peptides 25:727-730
16. Ishii K, Hosaka N, Toki T et al (1998) A new view of the so-called adenoma malignum of the uterine cervix. Virchows Arch 432:315-322
17. Kushima R, Borchard F, Hattori T (1997) A new aspect of gastric metaplasia in Crohn's disease: bidirectional (foveolar and pyloric) differentiation in so-called 'pyloric metaplasia' in the ileum. Pathol Int 47:416-419
18. Lechago J, Black C, Samloff IM (1976) Immunofluorescence studies of gastric heterotopia of the small intestine in Crohn's disease. Gastroenterology 70:429-432
19. Longman RJ, Douthwaite J, Sylvester PA et al (2000) Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. Gut 47:792-800
20. Matsuzawa K, Akamatsu T, Katsuyama T (1992) Mucin histochemistry of pancreatic duct cell carcinoma, with special reference to organoid differentiation simulating gastric pyloric mucosa. Hum Pathol 23:925-933
21. Moniaux N, Escande F, Porchet N et al (2001) Structural organization and classification of the human mucin genes. Front Biosci 6:D1192-D1206
22. Nakajima K, Ota H, Zhang MX et al (2003) Expression of gastric gland mucous cell-type mucin in normal and neoplastic human tissues. J Histochem Cytochem 51:1689-1698
23. Nomura S, Settle SH, Leys CM et al (2005) Evidence for repatterning of the gastric fundic epithelium associated with Menetrier's disease and TGFalpha overexpression. Gastroenterology 128:1292-1305
24. Ota H, Hayama M, Nakayama J et al (2001) Cell lineage specificity of newly raised monoclonal antibodies against gastric mucins in normal, metaplastic, and neoplastic human tissues and their application to pathology diagnosis. Am J Clin Pathol 115:69-79
25. Ruchaud-Sparagano MH, Westley BR, May FE (2004) The trefoil protein TFF1 is bound to MUC5AC in human gastric mucosa. Cell Mol Life Sci 61:1946-1954
26. Sakai H, Eishi Y, Li XL et al (2004) PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas. Gut 53:323-330
27. Samuel S, Naora H (2005) Homeobox gene expression in cancer: insights from developmental regulation and deregulation. Eur J Cancer 41:2428-2437
28. Shaoul R, Marcon MA, Okada Y et al (2000) Gastric metaplasia: a frequently overlooked feature of duodenal biopsy specimens in untreated celiac disease. J Pediatr Gastroenterol Nutr 30:397-403
29. Shimizu M, Kitoh K, Fujimitsu Y et al (1996) Cellular differentiation and development of pyloric mucosal metaplasia in the human gall-bladder. Pathol Int 46:261-266
30. Stoffers DA, Heller RS, Miller CP et al (1999) Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology 140:5374-5381
31. Tatematsu M, Tsukamoto T, Inada K (2003) Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia. Cancer Sci 94:135-141
32. Voutilainen M, Juhola M, Farkkila M et al (2003) Gastric metaplasia and chronic inflammation at the duodenal bulb mucosa. Dig Liver Dis 35:94-98
33. Wright CL, Riddell RH (1998) Histology of the stomach and duodenum in Crohn's disease. Am J Surg Pathol 22:383-390
34. Wright NA, Pike C, Elia G (1990) Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature 343:82-85
35. Wright NA, Poulsom R, Stamp G et al (1992) Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Scand J Gastroenterol Suppl 193:76-82
36. Yamamoto H, Bai YQ, Yuasa Y (2003) Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem Biophys Res Commun 300:813-818