An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: Evidence that TNFα up-regulates 5-HT 2A-mediated contraction

British Journal of Pharmacology

Volumn 137, Issue 7, 2002, Pages 971-982

  Adner, Mikael ^a   Rose, Andrew C ^b   Zhang, Yaping ^a   Swärd, Karl ^c   Benson, Mikael ^a   Uddman, Rolf ^a   Shankley, Nigel P ^b   Cardell, Lars Olaf ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c LUND UNIVERSITY   (Sweden)

Author keywords

5 HT 2A receptors; Airway hyperresponsiveness; Airway remodelling; Asthma; Contractile phenotype; DNA microarray; Organ culture; Tracheal segments; Tumour necrosis factor alpha

Indexed keywords

CARBACHOL; CYTOKINE; ISOPRENALINE; MUSCARINIC RECEPTOR; POTASSIUM CHLORIDE; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; ATROPINE; AUTACOID; MUSCARINIC RECEPTOR BLOCKING AGENT; SEROTONIN; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR AFFECTING AGENT;

ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DETERMINATION; DNA MICROARRAY; GENE EXPRESSION; INFLAMMATION; LONG TERM EXPOSURE; MALE; MEDIATOR; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; TIME; TISSUE CULTURE; TRACHEA; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION PROFILING; METABOLISM; MUSCLE CONTRACTION; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; SMOOTH MUSCLE;

ANIMALS; ATROPINE; CARBACHOL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; INFLAMMATION MEDIATORS; ISOPROTERENOL; MALE; MICE; MICE, INBRED BALB C; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN CULTURE TECHNIQUES; POTASSIUM CHLORIDE; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGENTS; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; TIME FACTORS; TRACHEA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036897810     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704928     Document Type: Article

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