Characterization of a prostanoid EP3-receptor in guinea-pig aorta: Partial agonist action of the non-prostanoid ONO-AP-324

British Journal of Pharmacology

Volumn 125, Issue 6, 1998, Pages 1288-1296

  Jones, Robert L ^a,b   Qian, Yue Ming ^a   Chan, Kam Ming ^a   Yim, Anthony P C ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Arterial smooth muscle; G(i) coupled second messenger systems; L type Ca2+ channel blockers; Non prostanoid EP3 agonists; Nonprostanoid prostacyclin mimetics; Prostaglandin E2; Prostanoid EP3 receptors; Sulprostone

Indexed keywords

CALCIUM ION; EDETIC ACID; EGTAZIC ACID; GEMEPROST; GR 63799; MISOPROSTOL; NIFEDIPINE; ONO AP 324; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; SC 46275; SULPROSTONE; UNCLASSIFIED DRUG; VERAPAMIL; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETIC ACID DERIVATIVE; BENZHYDRYL DERIVATIVE; CALCIUM; DRUG DERIVATIVE; OXYTOCIC AGENT; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN EP3 RECEPTOR; VASOCONSTRICTOR AGENT;

ANIMAL TISSUE; AORTA; ARTERY CONSTRICTION; ARTICLE; CALCIUM TRANSPORT; GUINEA PIG; ISOLATED ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; DRUG EFFECT; DRUG POTENTIATION; IN VITRO STUDY; METABOLISM; MUSCLE CONTRACTION; MUSCLE RELAXATION; PHYSIOLOGY; PULMONARY ARTERY; THORACIC AORTA; ULTRASTRUCTURE; VAS DEFERENS; VASCULAR SMOOTH MUSCLE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ACETIC ACIDS; ANIMALS; AORTA, THORACIC; BENZHYDRYL COMPOUNDS; CALCIUM; DINOPROSTONE; GUINEA PIGS; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; OXYTOCICS; PULMONARY ARTERY; RECEPTORS, PROSTAGLANDIN E; VAS DEFERENS; VASOCONSTRICTOR AGENTS;

EID: 0031593806     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702189     Document Type: Article

References (56)

1. AHLUWALIA, A., HEAD, S.A., SHELDRICK, R.L.G. & COLEMAN, R.A. (1988). Prostanoid receptors mediating contraction of rabbit renal artery. Br. J. Pharmacol., 96, 721P.
2. 2 receptor transduce both intracellular calcium and cAMP signals. Biochemistry, 33, 14496-14502.
3. ARMSTRONG, R.A., LAWRENCE, R.A., JONES, R.L., WILSON, N.H. & COLLIER, A. (1989). Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors. Br. J. Pharmacol., 97, 657-668.
4. ASANO, M. & HIDAKO, H. (1980). Potentiation of the contractile response to acetylcholine in aortic strips by low concentrations of vascular contractile agonists. Br. J. Pharmacol., 69, 639-646.
5. 2+-permeable channel activated by ATP in smooth muscle. Nature (Lond), 328, 275-278.
6. 3-receptors. Adv. Prost. Thromb. Leuk. Res., 21, 379-382.
7. CAMPS, M., CAROZZI, A., SCHNABEL, P., SCHEER, A., PARKER, P.J. & GIERSCHIK, P. (1992). Isoenzyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits. Nature, 360, 684-686.
8. 1 antagonist. Br. J. Pharmacol., 85, 273P.
9. 2- (EP) sensitive receptors in smooth muscle. Br. J. Pharmacol., 91, 323P.
10. 2-(EP) sensitive receptors in smooth muscle. Br. J. Pharmacol., 91, 407P
11. COLEMAN, R.A., GRIX, S.P., HEAD, S.A., LOUTTIT, J.B., MALLETT, A. & SHELDRICK, R.L.G. (1994a). A novel inhibitory prostanoid receptor in piglet saphenous vein. Prostaglandins, 47, 151-168.
12. COLEMAN, R.A., SMITH, W.L. & NARUMIYA, S. (1994b). VIII. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev., 46, 27-50.
13. 2+ transport by cyclopiazonic acid and thapsigargin in smooth muscle microsomes. Can. J. Physiol. Pharmacol., 74, 182-192.
14. 2+ -pump inhibitor of rat aortic muscle. Acta Pharmacol. Sin., 12, 3-58.
15. EDVINSSON, L., EKBLAD, E., HAKANSON, R. & WAHLESTEDT, C. (1984). Neuropeptide Y potentiates the effect of various constrictor agents on rabbit blood vessels. Br. J. Pharmacol., 83, 519-525.
16. 2 agonists without PG skeleton. III. Bioorg. Med. Chem. Lett., 5, 1077-1082.
17. 2 agonists without PG skeleton. I. Bioorg. Med. Chem. Lett., 5, 1065-1070.
18. HIDE, E.J. & THIEMERMANN, C. (1996). Sulprostone-induced reduction of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels. Br. J. Pharmacol., 118, 1409-1414.
19. 1 in cDNA-transfected Chinese hamster ovary cells. Biochem. Biophys. Res. Commun., 204, 303-309.
20. 3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase. Eur. J. Biochem., 217, 313-318.
21. 3 isoforms. Br. J. Pharmacol., 121, 317-323.
22. JONES, R.L., QIAN, Y.M., WISE, H., WONG, H.N.C., LAM, W.L., CHAN, H.W., YIM, A.P.C & HO, J.K.S. (1997). Relaxant actions of nonprostanoid prostacyclin mimetics on human pulmonary artery. J. Cardiovasc. Pharmacol., 29, 525-535.
23. JONES, R.L., WILSON, N.H., MARR, C.G., MUIR, G. & ARMSTRONG, R.A. (1993). Diphenylmethylazine prostanoids with prostacyclin-like actions on human platelets. J. Lipid Mediators, 6, 405-410.
24. KATZ, A., WU, D. & SIMON, M.I. (1992). Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C. Nature, 360, 686-689.
25. KENAKIN, T.P., BOND, R.A. & BONNER, T.I. (1992). Definition of pharmacological receptors. Pharmacol. Rev., 44, 351-362.
26. KONDO, K. & HAMANAKA, N. (1995). Prostacyclin mimetics with non-prostanoid structures. Folia Pharmacol. Jpn., 106, 181-191 (In Japanese).
27. KURIYAMA, H., KITAMURA, K. & NABATA, H. (1995). Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. Pharmacol. Rev., 47, 387-573.
28. LAWRENCE, R.A. & JONES, R.L. (1992). Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein. Br. J. Pharmacol., 105, 817-824.
29. LAWRENCE, R.A., JONES, R.L. & WILSON, N.H. (1992). Characterisation of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum. Br. J. Pharmacol., 105, 272-278.
30. 2+ pool in vascular smooth muscles. J. Pharmacol. Exp. Ther., 258, 1105-1113.
31. LUMLEY, P., WHITE, B.P. & HUMPHREY, P.P.A. (1989). GR 32191, a highly potent and specific thromboxane receptor blocking drug on platelets and vascular smooth muscle in vitro. Br. J. Pharmacol., 97, 783-794.
32. LYDFORD, S.J., MCKECHNIE, K.C.W. & DOUGALL, I.G. (1996). Pharmacological studies on prostanoid receptors in the rabbit isolated saphenous vein: a comparison with the rabbit isolated ear artery. Br. J. Pharmacol., 117, 13-20.
33. MACLENNAN, S.J., BOLOFO, M.L. & MARTIN, G.R. (1993). Amplifying interactions between spasmogens in vascular smooth muscle. Biochem. Soc. Trans., 21, 1145-1150.
34. MEANWELL, N.A., ROMINE, J.L. & SEILER, S.M. (1994). Non-prostanoid prostacyclin mimetics. Drugs Future, 19, 361-385.
35. MERRITT, J.E., HALLAM, T.J., BROWN, A.M., BOYFIELD, I., COOPER, D.G., HICKEY, D.M.B., JAXA-CHAMIEC, A.A., KAUMANN, A.J., KEEN, M., KELLY, E., KOZLOWSKI, U., LYNHAM, J.A., MOORES, K.E., MURRAY, K.J., MACDERMOT, J. & RINK, T.J. (1991). Octimibate, a potent non-prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor. Br. J. Pharmacol., 102, 251-259.
36. MURRAY, R.K. & KOTLIKOFF, M.I. (1991). Receptor-activated calcium influx in human airway smooth muscle cells. J. Physiol., 435, 123-144.
37. 3 determines G-protein specificity. Nature, 365, 166-170.
38. 1 and to phosphoinositide metabolism in a pertussis toxin-sensitive manner. J. Biol. Chem., 264, 3916-3923.
39. 3 subtype: different COOH-terminal domains determine sensitivity to agonist-induced desensitization. J. Biol. Chem., 268, 9517-9521.
40. 3-receptor agonists on human isolated pulmonary artery. Br. J. Pharmacol., 113, 369-374.
41. RAPOPORT, R.M. (1993). Potentiation of norepinephrine-induced contraction by primary prostaglandin receptor activation in rat aorta. Eur. J. Pharmacol., 243, 207-210.
42. 3 receptors: evidence of three variants with differing carboxyl termini. Br. J. Pharmacol., 112, 377-385.
43. 3 receptor. Prost. Leuk. Essent. Fatty Acids, 49, 939-943.
44. SEILER, S.M., BRASSARD, C.L., FEDERICI, M.E., ROMINE, J. & MEANWELL, N.A. (1997). [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding. Prostaglandins, 53, 21-35.
45. SELBIE, L.A. & HILLS, S.J. (1998). G-protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends Pharmacol. Sci., 19, 87-93.
46. i/o-coupled receptors. Biochem. J., 328, 153-158.
47. SHIMA, H. & BLAUSTEIN, M.P. (1992). Modulation of evoked contractions in rat arteries by ryanodine, thapsigargin, and cyclopiazonic acid. Circ. Res., 70, 968-977.
48. SMRCKA, A.V. & STERNWEIS, P.C. (1993). Regulation of purified subtypes of phosphatidylinositol-specific phospholipase Cβ by G protein α and βγ subunits. J. Biol. Chem., 268, 9667-9674.
49. 3-subtype. Br. J. Pharmacol., 123, 1246-1252.
50. SUMNER, M.J. & HUMPHREY, P.P.A. (1990). Sumatriptan (GR43175) inhibits cyclic-AMP accumulation in dog isolated saphenous vein. Br. J. Pharmacol., 99, 219-220.
51. SWEENEY, G., TEMPLETON, A., CLAYTON, R.A., BAIRD, M., SHERIDAN, S., JOHNSTON, E.D. & MACLEAN, M.R. (1995). Contractile responses to sumatriptan in isolated bovine pulmonary artery rings: relationship to tone and cyclic nucleotide levels. J. Cardiovasc. Pharmacol., 26, 751-760.
52. TAM, F.S.F., CHAN, K.M., BOURREAU, J.P. & JONES, R.L. (1997). The mechanisms of enhancement and inhibition of field stimulation responses of guinea-pig vas deferens by prostacyclin analogues. Br. J. Pharmacol., 121, 1413-1421.
53. TYMKEWYCZ, P.M., JONES, R.L., WILSON, N.H. & MARR, C.G. (1991). Heterogeneity of thromboxane (TP-) receptors: evidence from antagonist but not agonist potency measurements. Br. J. Pharmacol., 102, 607-614.
54. UEHATA, M., ISHIZAKI, T., SATOH, H., ONO, T., KAWAHARA, T., MORISHITA, T., TAMAKAWA, H., YAMAGAMI, K., INUI, J., MAEKAWA, M. & NARUMIYA, S. (1997). Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature, 389, 990-994.
55. 2α and three 16-aryloxy analogues on the isolated rabbit jejunum. Prostaglandins, 15, 287-296.
56. 2 by the α and β subunits of trimeric GTP-binding protein. Proc. Natl. Acad. Sci. U.S.A., 90, 5297-5301.