메뉴 건너뛰기




Volumn 7, Issue 1, 2013, Pages 447-455

Colocalization of quantum dots by reactive molecules carried by motor proteins on polarized microtubule arrays

Author keywords

TAS; dynein; kinesin; molecular transport; motor proteins; nanostructures

Indexed keywords

BIOCHEMICAL REACTIONS; CO-LOCALIZATIONS; COLOCALIZATION; DIRECTED TRANSPORT; DISSOCIATION METHODS; DYNEIN; GLUTATHIONE-S-TRANSFERASE; GLUTATHIONES; IN-VITRO; INTRACELLULAR TRANSPORT; KINESINS; MICROTUBULES; MOLECULAR LEVELS; MOLECULAR TRANSPORT; MOTOR PROTEINS; NANOTRANSPORT; STREPTAVIDIN; TOTAL ANALYSIS SYSTEM;

EID: 84872870252     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn3045038     Document Type: Article
Times cited : (43)

References (50)
  • 1
    • 0025207507 scopus 로고
    • Miniaturized Total Chemical Analysis Systems: A Novel Concept for Chemical Sensing
    • Manz, A.; Graber, N.; Widmer, H. M. Miniaturized Total Chemical Analysis Systems: A Novel Concept for Chemical Sensing Sens. Actuators B1 1990, 244-248
    • (1990) Sens. Actuators B1 , pp. 244-248
    • Manz, A.1    Graber, N.2    Widmer, H.M.3
  • 2
    • 0033987988 scopus 로고    scopus 로고
    • Fast Separation of Oligonucleotide and Triplet Repeat DNA on a Microfabricated Capillary Electrophoresis Device and Capillary Electrophoresis
    • Ueda, M.; Kiba, Y.; Abe, H.; Arai, A.; Nakanishi, H.; Baba, Y. Fast Separation of Oligonucleotide and Triplet Repeat DNA on a Microfabricated Capillary Electrophoresis Device and Capillary Electrophoresis Electrophoresis 2000, 21, 176-180
    • (2000) Electrophoresis , vol.21 , pp. 176-180
    • Ueda, M.1    Kiba, Y.2    Abe, H.3    Arai, A.4    Nakanishi, H.5    Baba, Y.6
  • 3
    • 0027987997 scopus 로고
    • Ultra-High-Speed DNA Fragment Separations Using Microfabricated Capillary Array Electrophoresis Chips
    • Woolley, A. T.; Mathies, R. A. Ultra-High-Speed DNA Fragment Separations Using Microfabricated Capillary Array Electrophoresis Chips Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 11348-11352
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 11348-11352
    • Woolley, A.T.1    Mathies, R.A.2
  • 5
    • 0032524099 scopus 로고    scopus 로고
    • Chemical Amplification: Continuous-Flow PCR on a Chip
    • Kopp, M. U.; Mello, A. J.; Manz, A. Chemical Amplification: Continuous-Flow PCR on a Chip Science 1998, 280, 1046-1068
    • (1998) Science , vol.280 , pp. 1046-1068
    • Kopp, M.U.1    Mello, A.J.2    Manz, A.3
  • 6
    • 33645844551 scopus 로고    scopus 로고
    • PCR Microfluidic Devices for DNA Amplification
    • Zhang, C.; Xu, J.; Ma, W.; Zheng, W. PCR Microfluidic Devices for DNA Amplification Biotechnol. Adv. 2006, 24, 243-284
    • (2006) Biotechnol. Adv. , vol.24 , pp. 243-284
    • Zhang, C.1    Xu, J.2    Ma, W.3    Zheng, W.4
  • 7
    • 0036468613 scopus 로고    scopus 로고
    • Lab-on-a-Chip: Applications in Proteomics
    • Mouradian, S. Lab-on-a-Chip: Applications In Proteomics Curr. Opin. Chem. Biol. 2002, 6, 51-56
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 51-56
    • Mouradian, S.1
  • 8
    • 0347079573 scopus 로고    scopus 로고
    • Use of Lab-on-a-Chip Technology for Protein Sizing and Quantitation
    • Kuschel, M.; Neumann, T.; Barthmaier, P.; Kratzmeier, M. Use of Lab-on-a-Chip Technology for Protein Sizing and Quantitation J. Biomol. Tech. 2002, 13, 172-178
    • (2002) J. Biomol. Tech. , vol.13 , pp. 172-178
    • Kuschel, M.1    Neumann, T.2    Barthmaier, P.3    Kratzmeier, M.4
  • 9
    • 22244458625 scopus 로고    scopus 로고
    • Applications of DNA Microarrays in Biology
    • Stoughton, R. B. Applications of DNA Microarrays in Biology Annu. Rev. Biochem. 2005, 74, 53-82
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 53-82
    • Stoughton, R.B.1
  • 10
    • 58149133504 scopus 로고    scopus 로고
    • Integrated Fluidic Systems on a Nanometer Scale and the Study on Behavior of Liquids in Small Confinement
    • Hibara, A.; Tsukahara, T.; Kitamori, T. Integrated Fluidic Systems on a Nanometer Scale and The Study on Behavior of Liquids in Small Confinement J. Chromatogr., A 2009, 1216, 673-683
    • (2009) J. Chromatogr., A , vol.1216 , pp. 673-683
    • Hibara, A.1    Tsukahara, T.2    Kitamori, T.3
  • 11
    • 49049096186 scopus 로고    scopus 로고
    • Toward Single Molecule Detection of Staphylococcal Enterotoxin B: Mobile Sandwich Immunoassay on Gliding Microtubules
    • Soto, C. M.; Martin, B. D.; Sapsford, K. E.; Blum, A. S.; Ratna, B. R. Toward Single Molecule Detection of Staphylococcal Enterotoxin B: Mobile Sandwich Immunoassay on Gliding Microtubules Anal. Chem. 2008, 80, 5433-5440
    • (2008) Anal. Chem. , vol.80 , pp. 5433-5440
    • Soto, C.M.1    Martin, B.D.2    Sapsford, K.E.3    Blum, A.S.4    Ratna, B.R.5
  • 12
    • 62649121886 scopus 로고    scopus 로고
    • Multiplex Transport and Detection of Cytokines Using Kinesin-Driven Molecular Shuttles
    • Rios, L.; Bachand, G. D. Multiplex Transport and Detection of Cytokines Using Kinesin-Driven Molecular Shuttles Lab Chip 2009, 9, 1005-1010
    • (2009) Lab Chip , vol.9 , pp. 1005-1010
    • Rios, L.1    Bachand, G.D.2
  • 13
    • 0035718896 scopus 로고    scopus 로고
    • Molecular Shuttles Based on Motor Proteins: Active Transport in Synthetic Environments
    • Hess, H.; Vogel, V. Molecular Shuttles Based on Motor Proteins: Active Transport in Synthetic Environments Rev. Mol. Biotechnol. 2001, 82, 67-85
    • (2001) Rev. Mol. Biotechnol. , vol.82 , pp. 67-85
    • Hess, H.1    Vogel, V.2
  • 14
    • 34748876488 scopus 로고    scopus 로고
    • Cargo Pick-up from Engineered Loading Stations by Kinesin Driven Molecular Shuttles
    • Brunner, C.; Wahnes, C.; Vogel, V. Cargo Pick-up from Engineered Loading Stations by Kinesin Driven Molecular Shuttles Lab Chip 2007, 7, 1263-1271
    • (2007) Lab Chip , vol.7 , pp. 1263-1271
    • Brunner, C.1    Wahnes, C.2    Vogel, V.3
  • 15
    • 66749189189 scopus 로고    scopus 로고
    • Biomolecular-Motor-Based Nano- or Microscale Particle Translocations on DNA Microarrays
    • Hiyama, S.; Gojo, R.; Shima, T.; Takeuchi, S.; Sutoh, K. Biomolecular-Motor-Based Nano- or Microscale Particle Translocations on DNA Microarrays Nano Lett. 2009, 9, 2407-2413
    • (2009) Nano Lett. , vol.9 , pp. 2407-2413
    • Hiyama, S.1    Gojo, R.2    Shima, T.3    Takeuchi, S.4    Sutoh, K.5
  • 17
    • 81855171990 scopus 로고    scopus 로고
    • Graphene-Polymer Hybrid Nanostructure-Based Bioenergy Storage Device for Real-Time Control of Biological Motor Activity
    • Byun, K.-E.; Choi, D. S.; Kim, E.; Seo, D. H.; Yang, H.; Seo, S.; Hong, S. Graphene-Polymer Hybrid Nanostructure-Based Bioenergy Storage Device for Real-Time Control of Biological Motor Activity ACS Nano 2011, 5, 8656-8664
    • (2011) ACS Nano , vol.5 , pp. 8656-8664
    • Byun, K.-E.1    Choi, D.S.2    Kim, E.3    Seo, D.H.4    Yang, H.5    Seo, S.6    Hong, S.7
  • 18
    • 0034859387 scopus 로고    scopus 로고
    • Controlling the Direction of Kinesin-Driven Microtubule Movements Along Microlithographic Tracks
    • Hiratsuka, Y.; Tada, T.; Oiwa, K.; Kanayama, T.; Uyeda, T. Q. Controlling the Direction of Kinesin-Driven Microtubule Movements Along Microlithographic Tracks Biophys. J. 2001, 81, 1555-1561
    • (2001) Biophys. J. , vol.81 , pp. 1555-1561
    • Hiratsuka, Y.1    Tada, T.2    Oiwa, K.3    Kanayama, T.4    Uyeda, T.Q.5
  • 19
    • 9644266594 scopus 로고    scopus 로고
    • Unidirectional Transport of Kinesin-Coated Beads on Microtubules Oriented in a Microfluidic Device
    • Yokokawa, R.; Takeuchi, S.; Kon, T.; Nishiura, M.; Sutoh, K.; Fujita, H. Unidirectional Transport of Kinesin-Coated Beads on Microtubules Oriented in a Microfluidic Device Nano Lett. 2004, 4, 2265-2270
    • (2004) Nano Lett. , vol.4 , pp. 2265-2270
    • Yokokawa, R.1    Takeuchi, S.2    Kon, T.3    Nishiura, M.4    Sutoh, K.5    Fujita, H.6
  • 21
    • 43849110774 scopus 로고    scopus 로고
    • Nanomechanical Model of Microtubule Translocation in the Presence of Electric Fields
    • Kim, T.; Kao, M. T.; Hasselbrink, E. F.; Meyhofer, E. Nanomechanical Model of Microtubule Translocation in the Presence of Electric Fields Biophys. J. 2008, 94, 3880-3892
    • (2008) Biophys. J. , vol.94 , pp. 3880-3892
    • Kim, T.1    Kao, M.T.2    Hasselbrink, E.F.3    Meyhofer, E.4
  • 22
    • 62349126448 scopus 로고    scopus 로고
    • A Smart Dust Biosensor Powered by Kinesin Motors
    • Fischer, T.; Agarwal, A.; Hess, H. A Smart Dust Biosensor Powered by Kinesin Motors Nat. Nanotechnol. 2009, 4, 162-166
    • (2009) Nat. Nanotechnol. , vol.4 , pp. 162-166
    • Fischer, T.1    Agarwal, A.2    Hess, H.3
  • 23
    • 0032559260 scopus 로고    scopus 로고
    • Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport
    • Hirokawa, N. Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport Science 1998, 279, 519-526
    • (1998) Science , vol.279 , pp. 519-526
    • Hirokawa, N.1
  • 25
    • 0025222347 scopus 로고
    • Bead Movement by Single Kinesin Molecules Studied with Optical Tweezers
    • Block, S. M.; Goldstein, L. S.; Schnapp, B. J. Bead Movement by Single Kinesin Molecules Studied with Optical Tweezers Nature 1990, 348, 348-352
    • (1990) Nature , vol.348 , pp. 348-352
    • Block, S.M.1    Goldstein, L.S.2    Schnapp, B.J.3
  • 26
    • 50049135632 scopus 로고    scopus 로고
    • Simultaneous and Bidirectional Transport of Kinesin-Coated Microspheres and Dynein-Coated Microspheres on Polarity-Oriented Microtubules
    • Yokokawa, R.; Tarhan, M. C.; Kon, T.; Fujita, H. Simultaneous and Bidirectional Transport of Kinesin-Coated Microspheres and Dynein-Coated Microspheres on Polarity-Oriented Microtubules Biotechnol. Bioeng. 2008, 101, 1-8
    • (2008) Biotechnol. Bioeng. , vol.101 , pp. 1-8
    • Yokokawa, R.1    Tarhan, M.C.2    Kon, T.3    Fujita, H.4
  • 27
    • 0035442309 scopus 로고    scopus 로고
    • Motor Protein-Driven Unidirectional Transport of Micrometer-Sized Cargoes Across Isopolar Microtubule Arrays
    • Bohm, K.; Stracke, R.; Muhlig, P.; Unger, E. Motor Protein-Driven Unidirectional Transport of Micrometer-Sized Cargoes Across Isopolar Microtubule Arrays Nanotechnology 2001, 12, 238-244
    • (2001) Nanotechnology , vol.12 , pp. 238-244
    • Bohm, K.1    Stracke, R.2    Muhlig, P.3    Unger, E.4
  • 28
    • 69049092882 scopus 로고    scopus 로고
    • In Vitro Capture, Transport, and Detection of Protein Analytes Using Kinesin-Based Nanoharvesters
    • Carroll-Portillo, A.; Bachand, M.; Greene, A. C.; Bachand, G. D. In Vitro Capture, Transport, and Detection of Protein Analytes Using Kinesin-Based Nanoharvesters Small 2009, 5, 1835-1840
    • (2009) Small , vol.5 , pp. 1835-1840
    • Carroll-Portillo, A.1    Bachand, M.2    Greene, A.C.3    Bachand, G.D.4
  • 30
    • 44449115225 scopus 로고    scopus 로고
    • Self-Contained, Biomolecular Motor-Driven Protein Sorting and Concentrating in an Ultrasensitive Microfluidic Chip
    • Lin, C. T.; Kao, M. T.; Kurabayashi, K.; Meyhofer, E. Self-Contained, Biomolecular Motor-Driven Protein Sorting and Concentrating in an Ultrasensitive Microfluidic Chip Nano Lett. 2008, 8, 1041-1046
    • (2008) Nano Lett. , vol.8 , pp. 1041-1046
    • Lin, C.T.1    Kao, M.T.2    Kurabayashi, K.3    Meyhofer, E.4
  • 31
    • 28844487524 scopus 로고    scopus 로고
    • Highly Efficient Guiding of Microtubule Transport with Imprinted CYTOP Nanotracks
    • Cheng, L. J.; Kao, M. T.; Meyhofer, E.; Guo, L. J. Highly Efficient Guiding of Microtubule Transport with Imprinted CYTOP Nanotracks Small 2005, 1, 409-414
    • (2005) Small , vol.1 , pp. 409-414
    • Cheng, L.J.1    Kao, M.T.2    Meyhofer, E.3    Guo, L.J.4
  • 32
    • 35748962608 scopus 로고    scopus 로고
    • Quantifying the Performance of Protein-Resisting Surfaces at Ultra-low Protein Coverages Using Kinesin Motor Proteins as Probes
    • Katira, P.; Agarwal, A.; Fischer, T.; Chen, H. Y.; Jiang, X.; Lahann, J.; Hess, H. Quantifying the Performance of Protein-Resisting Surfaces at Ultra-low Protein Coverages Using Kinesin Motor Proteins as Probes Adv. Mater. 2007, 19, 3171-3176
    • (2007) Adv. Mater. , vol.19 , pp. 3171-3176
    • Katira, P.1    Agarwal, A.2    Fischer, T.3    Chen, H.Y.4    Jiang, X.5    Lahann, J.6    Hess, H.7
  • 33
    • 0347362544 scopus 로고    scopus 로고
    • Molecular Shuttles Operating Undercover: A New Photolithographic Approach for the Fabrication of Structured Surfaces Supporting Directed Motility
    • Hess, H.; Matzke, C. M.; Doot, R. K.; Clemmens, J.; Bachand, G. D.; Bunker, B. C.; Vogel, V. Molecular Shuttles Operating Undercover: A New Photolithographic Approach for the Fabrication of Structured Surfaces Supporting Directed Motility Nano Lett. 2003, 3, 1651-1655
    • (2003) Nano Lett. , vol.3 , pp. 1651-1655
    • Hess, H.1    Matzke, C.M.2    Doot, R.K.3    Clemmens, J.4    Bachand, G.D.5    Bunker, B.C.6    Vogel, V.7
  • 34
    • 1942469927 scopus 로고    scopus 로고
    • Motor-Protein ″roundabouts″: Microtubules Moving on Kinesin-Coated Tracks through Engineered Networks
    • Clemmens, J.; Hess, H.; Doot, R.; Matzke, C. M.; Bachand, G. D.; Vogel, V. Motor-Protein ″Roundabouts″: Microtubules Moving on Kinesin-Coated Tracks through Engineered Networks Lab Chip 2004, 4, 83-86
    • (2004) Lab Chip , vol.4 , pp. 83-86
    • Clemmens, J.1    Hess, H.2    Doot, R.3    Matzke, C.M.4    Bachand, G.D.5    Vogel, V.6
  • 35
    • 32044468065 scopus 로고    scopus 로고
    • Efficient Designs for Powering Microscale Devices with Nanoscale Biomolecular Motors
    • Lin, C.-T.; Kao, M.-T.; Kurabayashi, K.; Meyhofer, E. Efficient Designs for Powering Microscale Devices with Nanoscale Biomolecular Motors Small 2006, 2, 281-287
    • (2006) Small , vol.2 , pp. 281-287
    • Lin, C.-T.1    Kao, M.-T.2    Kurabayashi, K.3    Meyhofer, E.4
  • 37
    • 52049110078 scopus 로고    scopus 로고
    • Comparing Guiding Track Requirements for Myosin- and Kinesin-Powered Molecular Shuttles
    • Nitta, T.; Tanahashi, A.; Obara, Y.; Hirano, M.; Razumova, M.; Regnier, M.; Hess, H. Comparing Guiding Track Requirements for Myosin- and Kinesin-Powered Molecular Shuttles Nano Lett. 2008, 8, 2305-2309
    • (2008) Nano Lett. , vol.8 , pp. 2305-2309
    • Nitta, T.1    Tanahashi, A.2    Obara, Y.3    Hirano, M.4    Razumova, M.5    Regnier, M.6    Hess, H.7
  • 38
    • 0025104145 scopus 로고
    • Mechanochemical Coupling in Actomyosin Energy Transduction Studied by in Vitro Movement Assay
    • Harada, Y.; Sakurada, K.; Aoki, T.; Thomas, D. D.; Yanagida, T. Mechanochemical Coupling in Actomyosin Energy Transduction Studied by in Vitro Movement Assay J. Mol. Biol. 1990, 216, 49-68
    • (1990) J. Mol. Biol. , vol.216 , pp. 49-68
    • Harada, Y.1    Sakurada, K.2    Aoki, T.3    Thomas, D.D.4    Yanagida, T.5
  • 39
    • 33645687316 scopus 로고    scopus 로고
    • Transport of Semiconductor Nanocrystals by Kinesin Molecular Motors
    • Muthukrishnan, G.; Hutchins, B. M.; Williams, M. E.; Hancock, W. O. Transport of Semiconductor Nanocrystals by Kinesin Molecular Motors Small 2006, 2, 626-630
    • (2006) Small , vol.2 , pp. 626-630
    • Muthukrishnan, G.1    Hutchins, B.M.2    Williams, M.E.3    Hancock, W.O.4
  • 40
    • 0034722373 scopus 로고    scopus 로고
    • Engineering the Processive Run Length of the Kinesin Motor
    • Thorn, K. S.; Ubersax, J. A.; Vale, R. D. Engineering the Processive Run Length of the Kinesin Motor J. Cell Biol. 2000, 151, 1093-1100
    • (2000) J. Cell Biol. , vol.151 , pp. 1093-1100
    • Thorn, K.S.1    Ubersax, J.A.2    Vale, R.D.3
  • 41
    • 84863826307 scopus 로고    scopus 로고
    • Tuning the ″roadblock″ Effect in Kinesin-Based Transport
    • Schmidt, C.; Kim, B.; Grabner, H.; Ries, J.; Kulomaa, M.; Vogel, V. Tuning the ″Roadblock″ Effect in Kinesin-Based Transport Nano Lett. 2012, 12, 3466-3471
    • (2012) Nano Lett. , vol.12 , pp. 3466-3471
    • Schmidt, C.1    Kim, B.2    Grabner, H.3    Ries, J.4    Kulomaa, M.5    Vogel, V.6
  • 42
    • 52649171011 scopus 로고    scopus 로고
    • Setting up Roadblocks for Kinesin-1: Mechanism for the Selective Speed Control of Cargo Carrying Microtubules
    • Korten, T.; Diez, S. Setting up Roadblocks for Kinesin-1: Mechanism for the Selective Speed Control of Cargo Carrying Microtubules Lab Chip 2008, 8, 1441-1447
    • (2008) Lab Chip , vol.8 , pp. 1441-1447
    • Korten, T.1    Diez, S.2
  • 44
    • 39749165656 scopus 로고    scopus 로고
    • Differential Regulation of Dynein and Kinesin Motor Proteins by Tau
    • Dixit, R.; Ross, J. L.; Goldman, Y. E.; Holzbaur, E. L. Differential Regulation of Dynein and Kinesin Motor Proteins by Tau Science 2008, 319, 1086-1089
    • (2008) Science , vol.319 , pp. 1086-1089
    • Dixit, R.1    Ross, J.L.2    Goldman, Y.E.3    Holzbaur, E.L.4
  • 45
    • 0027211908 scopus 로고
    • Kinesin Follows the Microtubule's Protofilament Axis
    • Ray, S.; Meyhöfer, E.; Milligan, R. A.; Howard, J. Kinesin Follows the Microtubule's Protofilament Axis J. Cell Biol. 1993, 121, 1083-1093
    • (1993) J. Cell Biol. , vol.121 , pp. 1083-1093
    • Ray, S.1    Meyhöfer, E.2    Milligan, R.A.3    Howard, J.4
  • 46
    • 72149121791 scopus 로고    scopus 로고
    • Glutathione-Bound Gold Nanoclusters for Selective-Binding and Detection of Glutathione S-Transferase-Fusion Proteins from Cell Lysates
    • Chen, C. T.; Chen, W. J.; Liu, C. Z.; Chang, L. Y.; Chen, Y. C. Glutathione-Bound Gold Nanoclusters for Selective-Binding and Detection of Glutathione S-Transferase-Fusion Proteins from Cell Lysates Chem. Commun. 2009, 7515-7517
    • (2009) Chem. Commun. , pp. 7515-7517
    • Chen, C.T.1    Chen, W.J.2    Liu, C.Z.3    Chang, L.Y.4    Chen, Y.C.5
  • 47
    • 34547208129 scopus 로고    scopus 로고
    • Plasmonic Detection of a Model Analyte in Serum by a Gold Nanorod Sensor
    • Marinakos, S. M.; Chen, S. H.; Chilkoti, A. Plasmonic Detection of a Model Analyte in Serum by a Gold Nanorod Sensor Anal. Chem. 2007, 79, 5278-5283
    • (2007) Anal. Chem. , vol.79 , pp. 5278-5283
    • Marinakos, S.M.1    Chen, S.H.2    Chilkoti, A.3
  • 48
    • 0020009818 scopus 로고
    • Preparation of Tubulin from Brain
    • Williams, R. C., Jr.; Lee, J. C. Preparation of Tubulin from Brain Methods Enzymol. 1982, 85 Pt B, 376-385
    • (1982) Methods Enzymol. , vol.85 , pp. 376-385
    • Williams Jr., R.C.1    Lee, J.C.2
  • 50
    • 79954448219 scopus 로고    scopus 로고
    • C-Sequence of the Dictyostelium Cytoplasmic Dynein Participates in Processivity Modulation
    • Numata, N.; Shima, T.; Ohkura, R.; Kon, T.; Sutoh, K. C-Sequence of the Dictyostelium Cytoplasmic Dynein Participates in Processivity Modulation FEBS Lett. 2011, 585, 1185-1190
    • (2011) FEBS Lett. , vol.585 , pp. 1185-1190
    • Numata, N.1    Shima, T.2    Ohkura, R.3    Kon, T.4    Sutoh, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.