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Volumn , Issue , 2005, Pages 337-395

Use of Metabonomics to Study Target Organ Toxicity

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EID: 84872864128     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b14117-12     Document Type: Chapter
Times cited : (1)

References (78)
  • 1
    • 0028817867 scopus 로고
    • Drug-induced hepatotoxicity
    • Lee WM. Drug-induced hepatotoxicity. Med Prog 1995: 1118-1127.
    • (1995) Med Prog , pp. 1118-1127
    • Lee, W.M.1
  • 7
    • 0029907687 scopus 로고    scopus 로고
    • Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations
    • Timbrell JA, Waterfield CJ. Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro. Adv Exp Med Biol 1996; 403: 233-245.
    • (1996) Studies in vivo and in vitro. Adv Exp Med Biol , vol.403 , pp. 233-245
    • Timbrell, J.A.1    Waterfield, C.J.2
  • 8
    • 0027161423 scopus 로고
    • Investigation into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats
    • Waterfield CJ, Turton JA, Scales MD, Timbrell JA. Investigation into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats. Arch Toxicol 1993; 67: 244-254.
    • (1993) Arch Toxicol , vol.67 , pp. 244-254
    • Waterfield, C.J.1    Turton, J.A.2    Scales, M.D.3    Timbrell, J.A.4
  • 10
    • 0034775361 scopus 로고    scopus 로고
    • NMR and pattern recognition studies on the time-related metabolic effects of a-naphthylisothiocyanate on liver, urine, and plasma in the rat: An integrative metabonomic approach
    • Waters NJ, Holmes E, Williams A, Waterfield CJ, Farrant RD, Nicholson JK. NMR and pattern recognition studies on the time-related metabolic effects of a-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach. Chem Res Toxicol 2001; 14: 1401-1412.
    • (2001) Chem Res Toxicol , vol.14 , pp. 1401-1412
    • Waters, N.J.1    Holmes, E.2    Williams, A.3    Waterfield, C.J.4    Farrant, R.D.5    Nicholson, J.K.6
  • 11
    • 0033795182 scopus 로고    scopus 로고
    • Metabonomics: Evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants
    • Robertson DG, Reily MD, Sigler RE, Wells DF, Paterson DA, Braden TK. Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. Toxicol Sci 2000; 57: 326-337.
    • (2000) Toxicol Sci , vol.57 , pp. 326-337
    • Robertson, D.G.1    Reily, M.D.2    Sigler, R.E.3    Wells, D.F.4    Paterson, D.A.5    Braden, T.K.6
  • 12
    • 0026744665 scopus 로고
    • Proton NMR spectroscopic studies on the metabolism and biochemical effects of hydrazine in vivo
    • Sanins SM, Timbrell JA, Elcombe C, Nicholson JK. Proton NMR spectroscopic studies on the metabolism and biochemical effects of hydrazine in vivo. Arch Toxicol 1992; 66: 489-495.
    • (1992) Arch Toxicol , vol.66 , pp. 489-495
    • Sanins, S.M.1    Timbrell, J.A.2    Elcombe, C.3    Nicholson, J.K.4
  • 13
    • 77957168192 scopus 로고
    • High-resolution proton-NMR studies of metabolism and effects of hydrazine in rat
    • Sanins SM, Timbrell JA, Nicholson JK. High-resolution proton-NMR studies of metabolism and effects of hydrazine in rat. Hum Toxicol (Suppl) 1986; 5: 123.
    • (1986) Hum Toxicol (Suppl) , vol.5 , pp. 123
    • Sanins, S.M.1    Timbrell, J.A.2    Nicholson, J.K.3
  • 14
    • 0019184171 scopus 로고
    • Sterospecificity of the gliotoxic and anti-neurotoxic actions of alpha-aminoadipate
    • Olney JW, de Gubareff T, Collins JF. Sterospecificity of the gliotoxic and anti-neurotoxic actions of alpha-aminoadipate. Neurosci Lett 1980; 19: 277-282.
    • (1980) Neurosci Lett , vol.19 , pp. 277-282
    • Olney, J.W.1    de Gubareff, T.2    Collins, J.F.3
  • 15
    • 0031057309 scopus 로고    scopus 로고
    • Cationic amphiphilic drug-induced phospholipidosis
    • Halliwell WH. Cationic amphiphilic drug-induced phospholipidosis. Toxicol Pathol 1997; 25: 53-60.
    • (1997) Toxicol Pathol , vol.25 , pp. 53-60
    • Halliwell, W.H.1
  • 16
    • 0025572278 scopus 로고
    • Cationic amphiphilic drugs and phospholipid storage disorder
    • Kodavanti UP, Mehendale HM. Cationic amphiphilic drugs and phospholipid storage disorder. Pharmacol Rev 1990; 42: 327-354.
    • (1990) Pharmacol Rev , vol.42 , pp. 327-354
    • Kodavanti, U.P.1    Mehendale, H.M.2
  • 17
    • 0034530607 scopus 로고    scopus 로고
    • A metabonomic approach to the investigation of drug-induced phospholipidosis: An NMR spectroscopy and pattern recognition study
    • Nicholls AW, Nicholson JK, Haselden JN, Waterfield CJ. A metabonomic approach to the investigation of drug-induced phospholipidosis: an NMR spectroscopy and pattern recognition study. Biomarkers 2000; 5: 410-423.
    • (2000) Biomarkers , vol.5 , pp. 410-423
    • Nicholls, A.W.1    Nicholson, J.K.2    Haselden, J.N.3    Waterfield, C.J.4
  • 21
    • 0036639485 scopus 로고    scopus 로고
    • NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate
    • Waters NJ, Holmes E, Waterfield CJ, Farrant RD, Nicholson JK. NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate. Biochem Pharmacol 2002; 64: 67-77.
    • (2002) Biochem Pharmacol , vol.64 , pp. 67-77
    • Waters, N.J.1    Holmes, E.2    Waterfield, C.J.3    Farrant, R.D.4    Nicholson, J.K.5
  • 25
    • 0035107971 scopus 로고    scopus 로고
    • Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks
    • Holmes E, Nicholson JK, Tranter G. Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks. Chem Res Toxicol 2001; 14: 182-191.
    • (2001) Chem Res Toxicol , vol.14 , pp. 182-191
    • Holmes, E.1    Nicholson, J.K.2    Tranter, G.3
  • 26
    • 0036174751 scopus 로고    scopus 로고
    • Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data
    • Azmi J, Griffin JL, Antti H, Shore RF, Johansson E, Nicholson JK, Holmes E. Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data. Analyst 2002; 127: 271-276.
    • (2002) Analyst , vol.127 , pp. 271-276
    • Azmi, J.1    Griffin, J.L.2    Antti, H.3    Shore, R.F.4    Johansson, E.5    Nicholson, J.K.6    Holmes, E.7
  • 28
    • 0034368580 scopus 로고    scopus 로고
    • Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids
    • Lindon JC, Nicholson JK, Holmes E, Everett JR. Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts Magn Reson 2000; 12(5): 289-320.
    • (2000) Concepts Magn Reson , vol.12 , Issue.5 , pp. 289-320
    • Lindon, J.C.1    Nicholson, J.K.2    Holmes, E.3    Everett, J.R.4
  • 29
    • 0027426219 scopus 로고
    • Proton nuclear magnetic resonance spectroscopy of urine and plasma in renal transplantation followup
    • Le Moyec L, Pruna A, Eugene M, Bedrossian J, Idatte JM, Huneau JF, Tomé D. Proton nuclear magnetic resonance spectroscopy of urine and plasma in renal transplantation followup. Nephron 1993; 65: 433-439.
    • (1993) Nephron , vol.65 , pp. 433-439
    • Le Moyec, L.1    Pruna, A.2    Eugene, M.3    Bedrossian, J.4    Idatte, J.M.5    Huneau, J.F.6    Tomé, D.7
  • 32
    • 0022296430 scopus 로고
    • Two-dimensional proton nuclear magnetic resonance '‘maps’' of acetaminophen metabolites in human urine
    • Bales JR, Nicholson JK, Sadler PJ. Two-dimensional proton nuclear magnetic resonance '‘maps’' of acetaminophen metabolites in human urine. Clin Chem 1985; 31: 757-762.
    • (1985) Clin Chem , vol.31 , pp. 757-762
    • Bales, J.R.1    Nicholson, J.K.2    Sadler, P.J.3
  • 34
    • 0024946615 scopus 로고
    • High resolution proton magnetic resonance spectroscopy of biological fluids
    • Nicholson JK, Wilson ID. High resolution proton magnetic resonance spectroscopy of biological fluids. Prog NMR Spectrosc 1989; 21: 444-501.
    • (1989) Prog NMR Spectrosc , vol.21 , pp. 444-501
    • Nicholson, J.K.1    Wilson, I.D.2
  • 35
    • 0022385084 scopus 로고
    • Biochemical mechanisms of nephrotoxicity
    • Hook JB, Smith JH. Biochemical mechanisms of nephrotoxicity. Transplantation Proceedings 17 (supplement 1): 41-50, 1985.
    • (1985) Transplantation Proceedings , vol.17 , pp. 41-50
    • Hook, J.B.1    Smith, J.H.2
  • 37
    • 0038854471 scopus 로고
    • Toxic responses of the kidney
    • Klaassen CD, Amdur MO, Doull J, eds, New York: Macmillan
    • Hook JB, Hewit WR. Toxic responses of the kidney. In: Klaassen CD, Amdur MO, Doull J, eds. Toxicology: The Basic Science of Poisons. New York: Macmillan, 1986: 310-329.
    • (1986) Toxicology: The Basic Science of Poisons , pp. 310-329
    • Hook, J.B.1    Hewit, W.R.2
  • 38
    • 0006568776 scopus 로고
    • Renal methods in toxicology
    • Hayes WA, ed, New York: Raven Press
    • Berndt WO. Renal methods in toxicology. In: Hayes WA, ed. Principles and Methods of Toxicology. New York: Raven Press, 1982: 447-474.
    • (1982) Principles and Methods of Toxicology , pp. 447-474
    • Berndt, W.O.1
  • 39
    • 0344144576 scopus 로고
    • Urinary enzymes, proteinuria and renal function tests in the assessment of nephrotoxicity in the rat
    • Bach PH, Lock EA, eds, Chichester, U.K.: Wiley
    • Halman J, Fowler JSL, Price RG. Urinary enzymes, proteinuria and renal function tests in the assessment of nephrotoxicity in the rat. In: Bach PH, Lock EA, eds. Renal Heterogeneity and Target Cell Toxicity. Chichester, U.K.: Wiley, 1985: 295-298.
    • (1985) Renal Heterogeneity and Target Cell Toxicity , pp. 295-298
    • Halman, J.1    Fowler, J.S.L.2    Price, R.G.3
  • 40
    • 0024580448 scopus 로고
    • Investigation into the biochemical effects of region-specific nephrotoxins
    • Gartland KPR, Bonner FW, Nicholson JK. Investigation into the biochemical effects of region-specific nephrotoxins. Mol Pharmacol 1989; 35: 242-250.
    • (1989) Mol Pharmacol , vol.35 , pp. 242-250
    • Gartland, K.P.R.1    Bonner, F.W.2    Nicholson, J.K.3
  • 41
    • 0027972888 scopus 로고
    • Studies on the comparative toxicity of S-(1, 2-dichlorovinyl)-l-cysteine and 1, 1, 2-triflchloro-3, 3, 3-fluoro-1-propene in the Fischer 344 rat
    • Anthony ML, Beddell CR, Lindon JC, Nicholson JK. Studies on the comparative toxicity of S-(1, 2-dichlorovinyl)-l-cysteine and 1, 1, 2-triflchloro-3, 3, 3-fluoro-1-propene in the Fischer 344 rat. Arch Toxicol 1994; 69: 99-110.
    • (1994) Arch Toxicol , vol.69 , pp. 99-110
    • Anthony, M.L.1    Beddell, C.R.2    Lindon, J.C.3    Nicholson, J.K.4
  • 42
    • 0032517858 scopus 로고    scopus 로고
    • The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine
    • Holmes E, Nicholson JK, Nicholls AW, Lindon JC, Connor SC, Polley S, Connelly J. The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine. Chemometrics Intell Lab Syst 1998; 44: 245-255.
    • (1998) Chemometrics Intell Lab Syst , vol.44 , pp. 245-255
    • Holmes, E.1    Nicholson, J.K.2    Nicholls, A.W.3    Lindon, J.C.4    Connor, S.C.5    Polley, S.6    Connelly, J.7
  • 46
    • 48749147628 scopus 로고
    • Renal effects of antipyretic analgesics
    • Nov 14
    • Nanra RS. Renal effects of antipyretic analgesics. Am J Med 1983; Nov 14: 70-80.
    • (1983) Am J Med , pp. 70-80
    • Nanra, R.S.1
  • 47
    • 0023971143 scopus 로고
    • Analgesic-induced papillary necrosis
    • Sabatini S. Analgesic-induced papillary necrosis. Semin Nephrol 1988; 8(1): 41-54.
    • (1988) Semin Nephrol , vol.8 , Issue.1 , pp. 41-54
    • Sabatini, S.1
  • 48
    • 0018127792 scopus 로고
    • Pharmacological mechanisms of analgesic nephropathy
    • Shelley JH. Pharmacological mechanisms of analgesic nephropathy. Kidney Int 1978; 13: 15-26.
    • (1978) Kidney Int , vol.13 , pp. 15-26
    • Shelley, J.H.1
  • 49
    • 0029565805 scopus 로고
    • Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis)
    • Holmes E, Bonner FW, Nicholson JK. Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis). Arch Toxicol 1995; 70: 89-95.
    • (1995) Arch Toxicol , vol.70 , pp. 89-95
    • Holmes, E.1    Bonner, F.W.2    Nicholson, J.K.3
  • 50
    • 0025954351 scopus 로고
    • Altered renal fibronectin excretion in early adriamycin nephrosis of rats
    • Soose M, Gwinner W, Grotkamp J, Hansemann W, Stolte H. Altered renal fibronectin excretion in early adriamycin nephrosis of rats. J Pharm Exp Ther 1991; 257(1): 493-499.
    • (1991) J Pharm Exp Ther , vol.257 , Issue.1 , pp. 493-499
    • Soose, M.1    Gwinner, W.2    Grotkamp, J.3    Hansemann, W.4    Stolte, H.5
  • 51
    • 0022252916 scopus 로고
    • Adriamycin-induced chronic proteinuria: A structural and functional study
    • O’Donnell MP, Michels L, Kasiske B, Raij L, Keane WF. Adriamycin-induced chronic proteinuria: a structural and functional study. J Lab Clin Med 1985; 106(1): 62-67.
    • (1985) J Lab Clin Med , vol.106 , Issue.1 , pp. 62-67
    • O’Donnell, M.P.1    Michels, L.2    Kasiske, B.3    Raij, L.4    Keane, W.F.5
  • 52
    • 0021996130 scopus 로고
    • Mesangial function and glomerular sclerosis in rats with aminonucleoside nephrosis
    • Grond J, Koudstaal J, Elema JD. Mesangial function and glomerular sclerosis in rats with aminonucleoside nephrosis. Kidney Int 1985; 27(2): 405-410.
    • (1985) Kidney Int , vol.27 , Issue.2 , pp. 405-410
    • Grond, J.1    Koudstaal, J.2    Elema, J.D.3
  • 53
    • 0022519363 scopus 로고
    • Drug associated glomerulopathies
    • Hill GS. Drug associated glomerulopathies. Toxicol Pathol 1986; 14: 37-44.
    • (1986) Toxicol Pathol , vol.14 , pp. 37-44
    • Hill, G.S.1
  • 55
    • 0015576741 scopus 로고
    • Strain differences in metabolism and susceptibility to the nephrotoxic effects of methoxyfluorane in rats
    • Mazze RI, Cousins MJ, Kosek JC. Strain differences in metabolism and susceptibility to the nephrotoxic effects of methoxyfluorane in rats. J Pharmacol Exp Ther 1973; 184: 481-488.
    • (1973) J Pharmacol Exp Ther , vol.184 , pp. 481-488
    • Mazze, R.I.1    Cousins, M.J.2    Kosek, J.C.3
  • 56
    • 0020695965 scopus 로고
    • A new reproducible experimental model of analgesic nephropathy
    • Henry MA, Sweet RS, Tange JD. A new reproducible experimental model of analgesic nephropathy. J Pathol 1983; 139: 23-32.
    • (1983) J Pathol , vol.139 , pp. 23-32
    • Henry, M.A.1    Sweet, R.S.2    Tange, J.D.3
  • 57
    • 3042619232 scopus 로고    scopus 로고
    • Comparative biochemical effects of low doses of mercury II chloride in the F344 rat and the multimammate mouse (Mastomys natalensis)
    • Holmes E, Bonner FW, Nicholson JK. Comparative biochemical effects of low doses of mercury II chloride in the F344 rat and the multimammate mouse (Mastomys natalensis). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1996; 114(1): 7-15.
    • (1996) Comp Biochem Physiol C Pharmacol Toxicol Endocrinol , vol.114 , Issue.1 , pp. 7-15
    • Holmes, E.1    Bonner, F.W.2    Nicholson, J.K.3
  • 58
    • 0030612030 scopus 로고    scopus 로고
    • 1H NMR spectroscopic and histopathological studies on propyleneimine-induced renal papillary necrosis in the rat the multimammate desert mouse (Mastomys natalensis)
    • 1H NMR spectroscopic and histopathological studies on propyleneimine-induced renal papillary necrosis in the rat the multimammate desert mouse (Mastomys natalensis). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1997; 116(2): 125-134.
    • (1997) Comp Biochem Physiol C Pharmacol Toxicol Endocrinol , vol.116 , Issue.2 , pp. 125-134
    • Holmes, E.1    Bonner, F.W.2    Nicholson, J.K.3
  • 59
    • 0025287178 scopus 로고
    • Acute cadmium chloride-induced renal toxicity in the Syrian hamster
    • Rehm S, Waalkes MP. Acute cadmium chloride-induced renal toxicity in the Syrian hamster. Toxicol Appl Pharmacol 1990; 104(1): 94-105.
    • (1990) Toxicol Appl Pharmacol , vol.104 , Issue.1 , pp. 94-105
    • Rehm, S.1    Waalkes, M.P.2
  • 60
    • 0025285388 scopus 로고
    • Diphenylamine-induced renal papillary necrosis and necrosis of the pars recta in laboratory rodents
    • Lenz SD, Carlton WW. Diphenylamine-induced renal papillary necrosis and necrosis of the pars recta in laboratory rodents. Vet Pathol 1990; 27(3): 171-178.
    • (1990) Vet Pathol , vol.27 , Issue.3 , pp. 171-178
    • Lenz, S.D.1    Carlton, W.W.2
  • 61
    • 0036917875 scopus 로고    scopus 로고
    • Chemometric contributions to the evolution of metabonomics: Mathematical solutions to characterising and interpreting complex biological NMR spectra
    • Holmes E, Antti H. Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterising and interpreting complex biological NMR spectra. Analyst 2002; 127: 549-1557.
    • (2002) Analyst , vol.127 , pp. 549-1557
    • Holmes, E.1    Antti, H.2
  • 62
    • 0027052705 scopus 로고
    • Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury (II) chloride and 2-bromoethanamine
    • Holmes E, Bonner FW, Sweatman BC, Lindon JC, Beddell CR, Rahr E, Nicholson JK. Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury (II) chloride and 2-bromoethanamine. Mol Pharmacol 1992; 42: 922-930.
    • (1992) Mol Pharmacol , vol.42 , pp. 922-930
    • Holmes, E.1    Bonner, F.W.2    Sweatman, B.C.3    Lindon, J.C.4    Beddell, C.R.5    Rahr, E.6    Nicholson, J.K.7
  • 63
    • 0026611216 scopus 로고
    • 1H NMR spectroscopy as a means of monitoring nephrotoxicity as exemplified by studies with cephaloridine
    • Murgatroyd LB, Pickford RJ, Smith IK, Wilson ID, Middleton BJ. 1H NMR spectroscopy as a means of monitoring nephrotoxicity as exemplified by studies with cephaloridine. Hum Exp Toxicol 1992; 11(1): 35-41.
    • (1992) Hum Exp Toxicol , vol.11 , Issue.1 , pp. 35-41
    • Murgatroyd, L.B.1    Pickford, R.J.2    Smith, I.K.3    Wilson, I.D.4    Middleton, B.J.5
  • 64
    • 0025609215 scopus 로고
    • Proton NMR studies on the effects of uranyl nitrate on the biochemical composition of rat urine and plasma
    • Gartland KP, Anthony ML, Beddell CR, Lindon JC, Nicholson JK. Proton NMR studies on the effects of uranyl nitrate on the biochemical composition of rat urine and plasma. J Pharm Biomed Anal 1990; 8(8-12): 951-954.
    • (1990) J Pharm Biomed Anal , vol.8 , Issue.8-12 , pp. 951-954
    • Gartland, K.P.1    Anthony, M.L.2    Beddell, C.R.3    Lindon, J.C.4    Nicholson, J.K.5
  • 65
    • 0029814551 scopus 로고    scopus 로고
    • Characterization of coronary arterial lesions in the dog following administration of SKandF 95654, a phosphodiesterase III inhibitor
    • Joseph EC, Jones HB, Kerns WD. Characterization of coronary arterial lesions in the dog following administration of SKandF 95654, a phosphodiesterase III inhibitor. Toxicol Pathol 1996; 24: 429-435.
    • (1996) Toxicol Pathol , vol.24 , pp. 429-435
    • Joseph, E.C.1    Jones, H.B.2    Kerns, W.D.3
  • 66
    • 0030053450 scopus 로고    scopus 로고
    • The toxicity of repeated exposures to rolipram, a type IV phosphodiesterase inhibitor, in rats
    • Larson JL, Pino MV, Geiger LE, Simeone CR. The toxicity of repeated exposures to rolipram, a type IV phosphodiesterase inhibitor, in rats. Pharmacol Toxicol 1996; 78: 44-49.
    • (1996) Pharmacol Toxicol , vol.78 , pp. 44-49
    • Larson, J.L.1    Pino, M.V.2    Geiger, L.E.3    Simeone, C.R.4
  • 69
    • 0025916292 scopus 로고
    • Acute cardiovascular toxicity induced by an adenosine agonist-antihypertensive in beagles
    • Metz AL, Dominick MA, Suchanek G, Gough AW. Acute cardiovascular toxicity induced by an adenosine agonist-antihypertensive in beagles. Toxicol Pathol 1991; 19: 98-107.
    • (1991) Toxicol Pathol , vol.19 , pp. 98-107
    • Metz, A.L.1    Dominick, M.A.2    Suchanek, G.3    Gough, A.W.4
  • 73
    • 4243746458 scopus 로고    scopus 로고
    • Preclinical toxicity studies of the phosphodiesterase IV inhibitor CI-1018 in rats
    • Dethloff LA, Pegg DG, Metz AL. Preclinical toxicity studies of the phosphodiesterase IV inhibitor CI-1018 in rats. Toxicol Sci 1999; 48(1S): 1502a.
    • (1999) Toxicol Sci , vol.48 , Issue.1 , pp. 1502
    • Dethloff, L.A.1    Pegg, D.G.2    Metz, A.L.3
  • 74
    • 0036406930 scopus 로고    scopus 로고
    • Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced mesenteric vascular lesions in rats
    • Slim RM, Robertson DG, Albassam M, Reily MD, Robosky L, Dethloff LA. Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced mesenteric vascular lesions in rats. Toxicol Appl Pharmacol 2002; 183: 108-116.
    • (2002) Toxicol Appl Pharmacol , vol.183 , pp. 108-116
    • Slim, R.M.1    Robertson, D.G.2    Albassam, M.3    Reily, M.D.4    Robosky, L.5    Dethloff, L.A.6
  • 75
    • 0034738997 scopus 로고    scopus 로고
    • Pathogenic principles in giant cell arteritis
    • Weyand CM, Goronzy JJ. Pathogenic principles in giant cell arteritis. Int J Cardiol 2000; 75: S9-S19.
    • (2000) Int J Cardiol , vol.75 , pp. S9-S19
    • Weyand, C.M.1    Goronzy, J.J.2
  • 76
    • 0035667990 scopus 로고    scopus 로고
    • Elevated serum levels of macrophage colonystimulating factor in patients with Kawasaki disease complicated by cardiac lesions
    • Igarashi H, Hatake K, Shiraishi H, Samada K, Tomizuka H, Momoi MY. Elevated serum levels of macrophage colonystimulating factor in patients with Kawasaki disease complicated by cardiac lesions. Clin Exp Rheumatol 2001; 19: 751-756.
    • (2001) Clin Exp Rheumatol , vol.19 , pp. 751-756
    • Igarashi, H.1    Hatake, K.2    Shiraishi, H.3    Samada, K.4    Tomizuka, H.5    Momoi, M.Y.6
  • 77
    • 0035166821 scopus 로고    scopus 로고
    • Drug-induced vasculitis
    • Merkel, PA. Drug-induced vasculitis. Rheum Dis Clin North Am 2001; 27: 849-862.
    • (2001) Rheum Dis Clin North Am , vol.27 , pp. 849-862
    • Merkel, P.A.1


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