메뉴 건너뛰기




Volumn 73, Issue 5, 1999, Pages 2084-2092

Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons

Author keywords

Apoptosis; Caspase 3; Midkine; Mitogen activated protein kinase; Neurons; Phosphatidylinositol 3 kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; MIDKINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLEIOTROPHIN; PROTEIN SERINE THREONINE KINASE; WORTMANNIN;

EID: 0032739019     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.02084.x     Document Type: Article
Times cited : (174)

References (62)
  • 1
    • 0032562682 scopus 로고    scopus 로고
    • The activation of p38 and apoptosis by the inhibition of ERK is antagonized by the phosphoinositide 3-kinase/Akt pathway
    • Berra E., Diaz-Meco M. T., and Moscat J. (1998) The activation of p38 and apoptosis by the inhibition of ERK is antagonized by the phosphoinositide 3-kinase/Akt pathway. J. Biol. Chem. 273, 10792-10797.
    • (1998) J. Biol. Chem. , vol.273 , pp. 10792-10797
    • Berra, E.1    Diaz-Meco, M.T.2    Moscat, J.3
  • 2
    • 0030931876 scopus 로고    scopus 로고
    • Caspases: The executioners of apoptosis
    • Cohen G. M. (1997) Caspases: the executioners of apoptosis. Biochem. J. 326, 1-16.
    • (1997) Biochem. J. , vol.326 , pp. 1-16
    • Cohen, G.M.1
  • 3
    • 0032522924 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
    • Crowder R. J. and Freeman R. S. (1998) Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J. Neurosci. 18, 2933-2943.
    • (1998) J. Neurosci. , vol.18 , pp. 2933-2943
    • Crowder, R.J.1    Freeman, R.S.2
  • 6
    • 0029978182 scopus 로고    scopus 로고
    • Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
    • Enari M., Talanian R. V., Wong W. W., and Nagata S. (1996) Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380, 723-726.
    • (1996) Nature , vol.380 , pp. 723-726
    • Enari, M.1    Talanian, R.V.2    Wong, W.W.3    Nagata, S.4
  • 7
    • 0029894283 scopus 로고    scopus 로고
    • Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-xL
    • Erhardt P. and Cooper G. M. (1996) Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-xL. J. Biol. Chem. 271, 17601-17604.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17601-17604
    • Erhardt, P.1    Cooper, G.M.2
  • 9
    • 0030971056 scopus 로고    scopus 로고
    • Selective involvement of ceramide in cytokine-induced apoptosis
    • Gamard C. J., Dbaibo G. S., Liu B., Obeid L. M., and Hannun Y. A. (1997) Selective involvement of ceramide in cytokine-induced apoptosis. J. Biol. Chem. 272, 16474-16481.
    • (1997) J. Biol. Chem. , vol.272 , pp. 16474-16481
    • Gamard, C.J.1    Dbaibo, G.S.2    Liu, B.3    Obeid, L.M.4    Hannun, Y.A.5
  • 10
    • 0028021573 scopus 로고
    • Midkine and pleiotrophin expression in normal and malignant breast tissue
    • Garver R. I. Jr., Radford D. M., Donis-Keller H., Wick M. R., and Milner P. G. (1994) Midkine and pleiotrophin expression in normal and malignant breast tissue. Cancer 74, 1584-1590.
    • (1994) Cancer , vol.74 , pp. 1584-1590
    • Garver R.I., Jr.1    Radford, D.M.2    Donis-Keller, H.3    Wick, M.R.4    Milner, P.G.5
  • 11
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • Hannun Y. A. (1996) Functions of ceramide in coordinating cellular responses to stress. Science 274, 1855-1859.
    • (1996) Science , vol.274 , pp. 1855-1859
    • Hannun, Y.A.1
  • 12
    • 0029670038 scopus 로고    scopus 로고
    • Suppression of interleukin-1 beta-converting enzyme-mediated cell death by insulin-like growth factor
    • Jung Y., Miura M., and Yuan J. (1996) Suppression of interleukin-1 beta-converting enzyme-mediated cell death by insulin-like growth factor. J. Biol. Chem. 271, 5112-5117.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5112-5117
    • Jung, Y.1    Miura, M.2    Yuan, J.3
  • 13
    • 0023934902 scopus 로고
    • cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in midgestation period of mouse embryogenesis
    • Kadomatsu K., Tomomura M., and Muramatsu T. (1988) cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in midgestation period of mouse embryogenesis. Biochem. Biophys. Res. Commun. 151, 1312-1318.
    • (1988) Biochem. Biophys. Res. Commun. , vol.151 , pp. 1312-1318
    • Kadomatsu, K.1    Tomomura, M.2    Muramatsu, T.3
  • 14
    • 0025304674 scopus 로고
    • A retinoic acid responsive gene MK found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embryogenesis
    • Kadomatsu K., Huang R. P., Suganuma T., Murata F., and Muramatsu T. (1990) A retinoic acid responsive gene MK found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embryogenesis. J. Cell Biol. 110, 607-616.
    • (1990) J. Cell Biol. , vol.110 , pp. 607-616
    • Kadomatsu, K.1    Huang, R.P.2    Suganuma, T.3    Murata, F.4    Muramatsu, T.5
  • 16
    • 0030907924 scopus 로고    scopus 로고
    • Signal transduction by the neurotrophin receptors
    • Kaplan D. R. and Miller F. D. (1997) Signal transduction by the neurotrophin receptors. Curr. Opin. Cell Biol. 9, 213-221.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 213-221
    • Kaplan, D.R.1    Miller, F.D.2
  • 17
    • 0027364131 scopus 로고
    • Midkine, a novel neurotrophic factor, promotes survival of mesencephalic neurons in culture
    • Kikuchi S., Muramatsu H., Muramatsu T., and Kim S. U. (1993) Midkine, a novel neurotrophic factor, promotes survival of mesencephalic neurons in culture. Neurosci. Lett. 160, 9-12.
    • (1993) Neurosci. Lett. , vol.160 , pp. 9-12
    • Kikuchi, S.1    Muramatsu, H.2    Muramatsu, T.3    Kim, S.U.4
  • 18
    • 0032562591 scopus 로고    scopus 로고
    • Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth
    • Kinnunen T., Kaksonen M., Saarinen J., Kalkkinen N., Peng H. B., and Rauvala H. (1998) Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. J. Biol. Chem. 273, 10702-10708.
    • (1998) J. Biol. Chem. , vol.273 , pp. 10702-10708
    • Kinnunen, T.1    Kaksonen, M.2    Saarinen, J.3    Kalkkinen, N.4    Peng, H.B.5    Rauvala, H.6
  • 19
    • 0028963618 scopus 로고
    • Midkine enhances fibrinolytic activity of bovine endothelial cells
    • Kojima S., Muramatsu H., Amanuma H., and Muramatsu T. (1995a) Midkine enhances fibrinolytic activity of bovine endothelial cells. J. Biol. Chem. 270, 9590-9596.
    • (1995) J. Biol. Chem. , vol.270 , pp. 9590-9596
    • Kojima, S.1    Muramatsu, H.2    Amanuma, H.3    Muramatsu, T.4
  • 20
    • 0028883951 scopus 로고
    • Midkine is a heat and acid stable polypeptide capable of enhancing plasminogen activator activity and neurite outgrowth extension
    • Kojima S., Inui T., Muramatsu H., Kimura T., Sakakibara S., and Muramatsu T. (1995b) Midkine is a heat and acid stable polypeptide capable of enhancing plasminogen activator activity and neurite outgrowth extension. Biochem. Biophys. Res. Commun. 216, 574-581.
    • (1995) Biochem. Biophys. Res. Commun. , vol.216 , pp. 574-581
    • Kojima, S.1    Inui, T.2    Muramatsu, H.3    Kimura, T.4    Sakakibara, S.5    Muramatsu, T.6
  • 21
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 22
    • 0025615372 scopus 로고
    • Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity
    • Li Y. S., Milner P. G., Chauhan A. K., Watson M. A., Hoffman R. M., Kodner C. M., Milbrandt J., and Deuel T. F. (1990) Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science 250, 1690-1694.
    • (1990) Science , vol.250 , pp. 1690-1694
    • Li, Y.S.1    Milner, P.G.2    Chauhan, A.K.3    Watson, M.A.4    Hoffman, R.M.5    Kodner, C.M.6    Milbrandt, J.7    Deuel, T.F.8
  • 23
    • 0032514145 scopus 로고    scopus 로고
    • Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/ heparin-binding growth-associated molecule (HB-GAM) in neuronal migration
    • Maeda N. and Noda M. (1998) Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/ heparin-binding growth-associated molecule (HB-GAM) in neuronal migration. J. Cell Biol. 142, 203-216.
    • (1998) J. Cell Biol. , vol.142 , pp. 203-216
    • Maeda, N.1    Noda, M.2
  • 24
    • 0029834975 scopus 로고    scopus 로고
    • 6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)
    • Maeda N., Nishiwaki T., Shintani T., Hamanaka H., and Noda M. (1996) 6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM). J. Biol. Chem. 271, 21446-21452.
    • (1996) J. Biol. Chem. , vol.271 , pp. 21446-21452
    • Maeda, N.1    Nishiwaki, T.2    Shintani, T.3    Hamanaka, H.4    Noda, M.5
  • 25
    • 0029822276 scopus 로고    scopus 로고
    • Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons
    • Marsh H. N. and Palfrey H. C. (1996) Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons. J. Neurochem. 67, 952-963.
    • (1996) J. Neurochem. , vol.67 , pp. 952-963
    • Marsh, H.N.1    Palfrey, H.C.2
  • 27
    • 0025162762 scopus 로고
    • Molecular cloning of the 18-kDa growth-associated protein of developing brain
    • Merenmies J. and Rauvala H. (1990) Molecular cloning of the 18-kDa growth-associated protein of developing brain. J. Biol. Chem. 265, 16721-16724.
    • (1990) J. Biol. Chem. , vol.265 , pp. 16721-16724
    • Merenmies, J.1    Rauvala, H.2
  • 28
    • 0027216805 scopus 로고
    • Retinoic acid responsive gene product, midkine, has neurotrophic functions for mouse spinal cord and dorsal root ganglion neurons in culture
    • Michikawa M., Kikuchi S., Muramatsu H., Muramatsu T., and Kim S. U. (1993a) Retinoic acid responsive gene product, midkine, has neurotrophic functions for mouse spinal cord and dorsal root ganglion neurons in culture. J. Neurosci. Res. 35, 530-539.
    • (1993) J. Neurosci. Res. , vol.35 , pp. 530-539
    • Michikawa, M.1    Kikuchi, S.2    Muramatsu, H.3    Muramatsu, T.4    Kim, S.U.5
  • 29
    • 0027323433 scopus 로고
    • Midkine is a mediator of retinoic acid induced neuronal differentiation of embryonal carcinoma cells
    • Michikawa M., Xu R. Y., Muramatsu H., Muramatsu T., and Kim S. U. (1993b) Midkine is a mediator of retinoic acid induced neuronal differentiation of embryonal carcinoma cells. Biochem. Biophys. Res. Commun. 192, 1312-1318.
    • (1993) Biochem. Biophys. Res. Commun. , vol.192 , pp. 1312-1318
    • Michikawa, M.1    Xu, R.Y.2    Muramatsu, H.3    Muramatsu, T.4    Kim, S.U.5
  • 30
    • 0028851033 scopus 로고
    • Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis
    • Mitsiadis T. A., Salmivirta M., Muramatsu T., Muramatsu H., Rauvala H., Lehtonen E., Jalkanen M., and Thesleff I. (1995) Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis. Development 121, 37-51.
    • (1995) Development , vol.121 , pp. 37-51
    • Mitsiadis, T.A.1    Salmivirta, M.2    Muramatsu, T.3    Muramatsu, H.4    Rauvala, H.5    Lehtonen, E.6    Jalkanen, M.7    Thesleff, I.8
  • 31
    • 0025228723 scopus 로고
    • Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2
    • Miyasaka T., Chao M. V., Sherline P., and Saltiel A. R. (1990) Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2. J. Biol. Chem. 265, 4730-4735.
    • (1990) J. Biol. Chem. , vol.265 , pp. 4730-4735
    • Miyasaka, T.1    Chao, M.V.2    Sherline, P.3    Saltiel, A.R.4
  • 32
    • 0025800487 scopus 로고
    • Purification of recombinant midkine and examination of its biological activities: Functional comparison of new heparin binding factors
    • Muramatsu H. and Muramatsu T. (1991) Purification of recombinant midkine and examination of its biological activities: functional comparison of new heparin binding factors. Biochem. Biophys. Res. Commun. 177, 652-658.
    • (1991) Biochem. Biophys. Res. Commun. , vol.177 , pp. 652-658
    • Muramatsu, H.1    Muramatsu, T.2
  • 33
    • 0027420495 scopus 로고
    • Midkine, a retinoic acid-inducible growth/differentiation factor: Immunochemical evidence for the function and distribution
    • Muramatsu H., Shirahama H., Yonezawa S., Maruta H., and Muramatsu T. (1993) Midkine, a retinoic acid-inducible growth/differentiation factor: immunochemical evidence for the function and distribution. Dev. Biol. 159, 392-402.
    • (1993) Dev. Biol. , vol.159 , pp. 392-402
    • Muramatsu, H.1    Shirahama, H.2    Yonezawa, S.3    Maruta, H.4    Muramatsu, T.5
  • 34
    • 0027168645 scopus 로고
    • Midkine (MK), the product of a retinoic acid responsive gene, and pleiotrophin constitute a new protein family regulating growth and differentiation
    • Muramatsu T. (1993) Midkine (MK), the product of a retinoic acid responsive gene, and pleiotrophin constitute a new protein family regulating growth and differentiation. Int. J. Dev. Biol. 37, 183-188.
    • (1993) Int. J. Dev. Biol. , vol.37 , pp. 183-188
    • Muramatsu, T.1
  • 35
    • 0028228479 scopus 로고
    • The midkine family of growth/differentiation factors
    • Muramatsu T. (1994) The midkine family of growth/differentiation factors. Dev. Growth Differ. 36, 1-8.
    • (1994) Dev. Growth Differ. , vol.36 , pp. 1-8
    • Muramatsu, T.1
  • 38
    • 0031014651 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways
    • Párrizas M., Saltiel A. R., and LeRoith D. (1997) Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 272, 154-161.
    • (1997) J. Biol. Chem. , vol.272 , pp. 154-161
    • Párrizas, M.1    Saltiel, A.R.2    LeRoith, D.3
  • 39
    • 0032055973 scopus 로고    scopus 로고
    • Neuronal cell death
    • Pettmann B. and Henderson C. E. (1998) Neuronal cell death. Neuron 20, 633-647.
    • (1998) Neuron , vol.20 , pp. 633-647
    • Pettmann, B.1    Henderson, C.E.2
  • 42
    • 0032488833 scopus 로고    scopus 로고
    • Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases
    • Ratovitski E. A., Kotzbauer P. T., Milbrandt J., Lowenstein C. J., and Burrow C. R. (1998) Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases. J. Biol. Chem. 273, 3654-3660.
    • (1998) J. Biol. Chem. , vol.273 , pp. 3654-3660
    • Ratovitski, E.A.1    Kotzbauer, P.T.2    Milbrandt, J.3    Lowenstein, C.J.4    Burrow, C.R.5
  • 43
    • 0028216755 scopus 로고
    • Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)
    • Raulo E., Chernousov M. A., Carey D. J., Nolo R., and Rauvala H. (1994) Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3). J. Biol. Chem. 269, 12999-13004.
    • (1994) J. Biol. Chem. , vol.269 , pp. 12999-13004
    • Raulo, E.1    Chernousov, M.A.2    Carey, D.J.3    Nolo, R.4    Rauvala, H.5
  • 44
    • 0030702084 scopus 로고    scopus 로고
    • Caspases: Intracellular signaling by proteolysis
    • Salvesen G. S. and Dixit V. M. (1997) Caspases: intracellular signaling by proteolysis. Cell 91, 443-446.
    • (1997) Cell , vol.91 , pp. 443-446
    • Salvesen, G.S.1    Dixit, V.M.2
  • 47
    • 0032493829 scopus 로고    scopus 로고
    • Cytokine-mediated induction of ceramide production is redox-sensitive
    • Singh I., Pahan K., Khan M., and Singh A. K. (1998) Cytokine-mediated induction of ceramide production is redox-sensitive. J. Biol. Chem. 273, 20354-20362.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20354-20362
    • Singh, I.1    Pahan, K.2    Khan, M.3    Singh, A.K.4
  • 48
    • 0031978372 scopus 로고    scopus 로고
    • Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death: Selective involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway
    • Skaper S. D., Floreani M., Negro A., Facci L., and Giusti P. (1998) Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death: selective involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway. J. Neurochem. 70, 1859-1868.
    • (1998) J. Neurochem. , vol.70 , pp. 1859-1868
    • Skaper, S.D.1    Floreani, M.2    Negro, A.3    Facci, L.4    Giusti, P.5
  • 49
    • 0030836664 scopus 로고    scopus 로고
    • Signal transduction pathways involved in the mitogenic activity of pleiotrophin. Implication of mitogen-activated protein kinase and phosphoinositide 3-kinase pathways
    • Souttou B., Ahmad S., Riegel A. T., and Wellstein A. (1997) Signal transduction pathways involved in the mitogenic activity of pleiotrophin. Implication of mitogen-activated protein kinase and phosphoinositide 3-kinase pathways. J. Biol. Chem. 272, 19588-19593.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19588-19593
    • Souttou, B.1    Ahmad, S.2    Riegel, A.T.3    Wellstein, A.4
  • 50
    • 0030824409 scopus 로고    scopus 로고
    • Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: Chemotactic activity to neutrophils and association with inflammatory synovitis
    • Takada T., Toriyama K., Muramatsu H., Song X. J., Torii S., and Muramatsu T. (1997a) Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis. J. Biochem. (Tokyo) 122, 453-458.
    • (1997) J. Biochem. (Tokyo) , vol.122 , pp. 453-458
    • Takada, T.1    Toriyama, K.2    Muramatsu, H.3    Song, X.J.4    Torii, S.5    Muramatsu, T.6
  • 51
    • 0031590783 scopus 로고    scopus 로고
    • Midkine, a retinoic acid-inducible heparin-binding cytokine, is a novel regulator of intracellular calcium in human neutrophils
    • Takada T., Kinkori T., Muramatsu H., Hayakawa A., Torii S., and Muramatsu T. (1997b) Midkine, a retinoic acid-inducible heparin-binding cytokine, is a novel regulator of intracellular calcium in human neutrophils. Biochem. Biophys. Res. Commun. 241, 756-761.
    • (1997) Biochem. Biophys. Res. Commun. , vol.241 , pp. 756-761
    • Takada, T.1    Kinkori, T.2    Muramatsu, H.3    Hayakawa, A.4    Torii, S.5    Muramatsu, T.6
  • 52
    • 0025316866 scopus 로고
    • A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product
    • Tomomura M., Kadomatsu K., Matsubara S., and Muramatsu T. (1990a) A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product. J. Biol. Chem. 265, 10765-10770.
    • (1990) J. Biol. Chem. , vol.265 , pp. 10765-10770
    • Tomomura, M.1    Kadomatsu, K.2    Matsubara, S.3    Muramatsu, T.4
  • 54
    • 0027407537 scopus 로고
    • A new family of heparin-binding growth/differentiation factors: Increased midkine expression in Wilms' tumor and other human carcinomas
    • Tsutsui J., Kadomatsu K., Matsubara S., Nakagawara A., Hamanoue M., Takao S., Shimazu H., Ohi Y., and Muramatsu T. (1993) A new family of heparin-binding growth/differentiation factors: increased midkine expression in Wilms' tumor and other human carcinomas. Cancer Res. 53, 1281-1285.
    • (1993) Cancer Res. , vol.53 , pp. 1281-1285
    • Tsutsui, J.1    Kadomatsu, K.2    Matsubara, S.3    Nakagawara, A.4    Hamanoue, M.5    Takao, S.6    Shimazu, H.7    Ohi, Y.8    Muramatsu, T.9
  • 57
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., Dickens M., Raingeaud J., Davis R. J., and Greenberg M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 58
    • 15844393942 scopus 로고    scopus 로고
    • Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme
    • Yamin T. T., Ayala J. M., and Miller D. K. (1996) Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme. J. Biol. Chem. 271, 13273-13282.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13273-13282
    • Yamin, T.T.1    Ayala, J.M.2    Miller, D.K.3
  • 59
    • 0028963084 scopus 로고
    • Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
    • Yao R. and Cooper G. M. (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267, 2003-2006.
    • (1995) Science , vol.267 , pp. 2003-2006
    • Yao, R.1    Cooper, G.M.2
  • 62
    • 0032128301 scopus 로고    scopus 로고
    • Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
    • Zundel W. and Giaccia A. (1998) Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Genes Dev. 12, 1941-1946.
    • (1998) Genes Dev. , vol.12 , pp. 1941-1946
    • Zundel, W.1    Giaccia, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.