In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity

International Journal of Pharmaceutics

Volumn 441, Issue 1-2, 2013, Pages 728-735

  Wang, Yancai ^a   Ma, Yingying ^a   Zheng, Ying ^b   Song, Ju ^b   Yang, Xiao ^b   Bi, Chao ^b   Zhang, Dianrui ^c   Zhang, Qiang ^d  

^a SHANDONG POLYTECHNIC UNIVERSITY   (China)

^b University of Macau   (Macao)

^c SHANDONG UNIVERSITY   (China)

^d PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Apoptosis; HT 29 cells; In vivo; Nanosuspensions; Puerarin

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PROPIDIUM IODIDE; PUERARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; BODY WEIGHT; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DISPERSION; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; HIGH PRESSURE HOMOGENIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NANOSUSPENSION; NANOTECHNOLOGY; NONHUMAN; PRESSURE GRADIENT; PRIORITY JOURNAL; STAINING; SUSPENSION; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL SURVIVAL; COLONIC NEOPLASMS; HT29 CELLS; HUMANS; ISOFLAVONES; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOPARTICLES; PARTICLE SIZE; SUSPENSIONS;

EID: 84872825927     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.10.021     Document Type: Article

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