Development of a chemically stable 10-hydroxycamptothecin nanosuspensions

International Journal of Pharmaceutics

Volumn 379, Issue 1-2, 2009, Pages 167-173

  Pu, Xiaohui ^a   Sun, Jin ^a   Wang, Yan ^a   Wang, Yongjun ^a   Liu, Xiaohong ^a   Zhang, Peng ^a   Tang, Xing ^a   Pan, Weisan ^a   Han, Jihong ^b   He, Zhonggui ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b KEELE UNIVERSITY   (United Kingdom)

Author keywords

10 Hydroxycamptothecin; Anticancer drugs; Chemical stability improvement; Microprecipitation high pressure homogenization; Nanosuspensions

Indexed keywords

10 HYDROXYCAMPTOTHECIN; CARBOXYLIC ACID; LACTONE; POLOXAMER; POLYOXYETHYLENE;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; PARTICLE SIZE; PH; PRECIPITATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SOLID STATE; SUSPENSION; TRANSMISSION ELECTRON MICROSCOPY; X RAY POWDER DIFFRACTION; ZETA POTENTIAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CALORIMETRY, DIFFERENTIAL SCANNING; CAMPTOTHECIN; DRUG STABILITY; FREEZE DRYING; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; PRECIPITATION; SOLUBILITY; SUSPENSIONS; X-RAY DIFFRACTION;

EID: 68649105183     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.05.062     Document Type: Article

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