Molecular alterations in pancreatic carcinoma: Expression profiling shows that dysregulated expression of S100 genes is highly prevalent

Journal of Pathology

Volumn 201, Issue 1, 2003, Pages 63-74

  Crnogorac Jurcevic, Tatjana ^a   Missiaglia, Edoardo ^a,b   Blaveri, Ekaterina ^a   Gangeswaran, Rathi ^a   Jones, Melanie ^a   Terris, Benoit ^a   Costello, Eithne ^c   Neoptolemos, John P ^c   Lemoine, Nicholas R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF VERONA   (Italy)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Adenocarcinoma; cDNA microarray; Pancreas; S100 genes; Tissue microarray

Indexed keywords

BIOLOGICAL MARKER; CALCIUM BINDING PROTEIN; CALCYCLIN; COMPLEMENTARY DNA; FLUORESCENT DYE; PROTEIN S 100; PROTEIN S100P; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DIFFERENTIAL DIAGNOSIS; DNA MICROARRAY; FLUORESCENCE ANALYSIS; GENE EXPRESSION PROFILING; GENE INDUCTION; GENE REPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NUCLEOTIDE SEQUENCE; PANCREAS; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN FAMILY; SENSITIVITY AND SPECIFICITY; TUMOR CLASSIFICATION; UNINDEXED SEQUENCE;

ADENOCARCINOMA; CALCIUM-BINDING PROTEINS; CELL CYCLE PROTEINS; DNA, NEOPLASM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; S100 PROTEINS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0141626696     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1418     Document Type: Article

References (34)

1. Shoemaker DD, Schadt EE, Armour CD, et al. Experimental annotation of the human genome using microarray technology. Nature 2001; 409: 922-927.
2. Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999; 286: 531-537.
3. Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000; 406: 747-752.
4. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503-511.
5. Ross DT, Scherf U, Eisen MB, et al. Systematic variation in gene expression patterns in human cancer cell lines. Nature Genet 2000; 24: 227-235.
6. Lemoine NR. Molecular advances in pancreatic cancer. Digestion 1997; 58: 550-556.
7. Crnogorac-Jurcevic T, Efthimiou E, Capelli P, et al. Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene 2001; 20: 7437-7446.
8. Crnogorac-Jurcevic T, Efthimiou E, Neilsen T, et al. Expression profiling in microdissected adenocarcinomas of the pancreas. Oncogene 2002; 21: 4587-4594.
9. Furukawa T, Duguid WP, Rosenberg L, et al. Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6/E7 gene of human papilloma virus 16. Am J Pathol 1996; 148: 1763-1770.
10. Yang Y, Dudoit S, Luu P, et al. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 2002; 15: e15.
11. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. PNAS 1998; 95: 14863-14868.
12. Audic S, Claverie JM. The significance of digital gene expression profiles. Genome Res 1997; 7: 986-995.
13. Maass N, Hojo T, Ueding M, et al. Expression of the tumor suppressor gene Maspin in human pancreatic cancers. Clin Cancer Res 2001; 7: 812-817.
14. Ebert M, Yokoyama M, Kobrin MS, et al. Induction and expression of amphiregulin in human pancreatic cancer. Cancer Res 1994; 54: 3959-3962.
15. Ryu B, Jones J, Hollingsworth MA, Hruban RH, Kern SE. Invasion-specific genes in malignancy: serial analysis of gene expression comparisons of primary and passaged cancers. Cancer Res 2001; 61: 1833-1838.
16. Gress TM, Muller-Pillasch F, Geng M, et al. A pancreatic cancer-specific expression profile. Oncogene 1996; 13: 1819-1830.
17. Iacobuzio-Donahue CA, Maitra A, Shen-Ong GL, et al. Discovery of novel tumor markers of pancreatic cancer using global gene expression technology. Am J Pathol 2002; 160: 1239-1249.
18. Ryu B, Jones J, Blades NJ, et al. Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression. Cancer Res 2002; 62: 819-826.
19. Argani P, Rosty C, Reiter RE, et al. Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma. Cancer Res 2001; 61: 4320-4324.
20. Schafer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW. Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Genomics 1995; 25: 638-643.
21. Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 2001; 33: 637-668.
22. Ilg EC, Schafer BW, Heizmann CW. Expression pattern of S100 calcium-binding proteins in human tumors. Int J Cancer 1996; 68: 325-332.
23. Ljubimova JY, Khazenzon NM, Chen Z, et al. Gene expression abnormalities in human glial tumors identified by gene array. Int J Oncol 2001; 18: 287-295.
24. Hough CD, Cho KR, Zonderman AB, Schwartz DR, Morin PJ. Coordinately up-regulated genes in ovarian cancer. Cancer Res 2001; 61: 3869-3876.
25. Cochran AJ, Lu HF, Li PX, Saxton R, Wen DR. S-100 protein remains a practical marker for melanocytic and other tumours. Melanoma Res 1993; 3: 325-330.
26. Rosty C, Ueki T, Argani P, et al. Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol 2002; 160: 45-50.
27. Emoto Y, Kobayashi R, Akatsuka H, Hidaka H. Purification and characterization of a new member of the S-100 protein family from human placenta. Biochem Biophys Res Commun 1992; 182: 1246-1253.
28. Becker T, Gerke V, Kube E, Weber K. S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca(2+) binding properties. Eur J Biochem 1992; 207: 541-547.
29. Da Silva IDCG, Fu Hu Y, Russo IH, et al. S100P calcium-binding protein overexpression is associated with immortalization of human breast epithelial cells in vitro and early stages of breast cancer development in vivo. Int J Oncol 2000; 16: 231-240.
30. Amler LC, Agus DB, LeDuc C, et al. Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model CWR22-R1. Cancer Res 2000; 60: 6134-6141.
31. Mousses S, Bubendorf L, Wagner U, et al. Clinical validation of candidate genes associated with prostate cancer progression in the CWR22 model system using tissue microarrays. Cancer Res 2002; 62: 1256-1260.
32. Terris B, Blaveri E, Crnogorac-Jurcevic T, et al. Characterization of gene expression profiles in intraductal papillarymucinous tumors of the pancreas. Am J Pathol 2002; 160: 1745-1754.
33. Cullen PJ, Lockyer PJ. Integration of calcium and Ras signalling. Nature Rev Mol Cell Biol 2002; 3: 339-348.
34. Chambers AF, Tuck AB. Ras-responsive genes and tumor metastasis. Crit Rev Oncog 1993; 4: 95-114.