Pancreatic Cancer Development and Progression: Remodeling the Model

Gastroenterology

Volumn 135, Issue 3, 2008, Pages 724-728

  Real, Francisco X ^a,b   Cibrián Uhalte, Elena ^c   Martinelli, Paola ^c  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A;

ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER STAGING; DISEASE COURSE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ENGINEERING; GENETIC IDENTIFICATION; HETEROZYGOSITY; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; METHYLATION; MICRODISSECTION; MUTATIONAL ANALYSIS; NONHUMAN; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SENESCENCE; STEM CELL; TELOMERE; TUMOR SUPPRESSOR GENE;

EID: 51249094938     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.07.033     Document Type: Article

References (33)

1. Hruban R.H., Goggins M., Parsons J., et al. Progression model for pancreatic cancer. Clin Cancer Res 6 (2000) 2969-2972
2. Maitra A., and Hruban R.H. Pancreatic cancer. Annu Rev Pathol Mech Dis 3 (2008) 157-188
3. Cubilla A.L., and Fitzgerald P.J. Morphological lesions associated with human primary invasive nonendocrine pancreatic cancer. Cancer Res 36 (1976) 2690-2698
4. Zhang L., Sanderson S.O., Lloyd R.V., et al. Pancreatic intraepithelial neoplasia in heterotopic pancreas: evidence for the progression model of pancreatic ductal adenocarcinoma. Am J Surg Pathol 31 (2007) 1191-1195
5. Luttges J., Reinecke-Luthge A., Mollmann B., et al. Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution. Virchows Arch 435 (1999) 461-468
6. Rosty C., Geradts J., Sato N., et al. p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. Am J Surg Pathol 27 (2003) 1495-1501
7. Crous-Bou M., Porta M., López T., et al. Lifetime history of tobacco consumption and K-ras mutations in exocrine pancreatic cancer. Pancreas 35 (2007) 135-141
8. Schutte M., Hruban R.H., Geradts J., et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res 57 (1997) 3126-3130
9. Yamano M., Fujii H., Takagaki T., et al. Genetic progression and divergence in pancreatic carcinoma. Am J Pathol 156 (2000) 2123-2133
10. Lüttges J., Galehdari H., Bröcker V., et al. Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis. Am J Pathol 158 (2001) 1677-1683
11. Fukushima N., Sato N., Ueki T., et al. Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. Am J Pathol 160 (2002) 1573-1581
12. Moskaluk C.A., Hruban R.H., and Kern S.E. p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 57 (1997) 2140-2143
13. Wilentz R.E., Geradts J., Maynard R., et al. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res 58 (1998) 4740-4744
14. Rosty C., Geradts J., Sato N., et al. p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. Am J Surg Pathol 27 (2003) 1495-1501
15. Bucholz M., Braun M., Heidenblut A., et al. Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions. Oncogene 24 (2005) 6626-6636
16. Collado M., Blasco M.A., and Serrano M. Cellular senescence in cancer and aging. Cell 130 (2007) 223-233
17. Serrano M., Lin A.W., McCurrach M.E., et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88 (1997) 593-602
18. Braig M., Lee S., Loddenkemper C., et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436 (2005) 660-665
19. Chen Z., Trotman L.C., Shaffer D., et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436 (2005) 725-730
20. Michaloglou C., Vredeveld L.C., Soengas M.S., et al. BRAF E600-associated senescence-like cell cycle arrest of human naevi. Nature 436 (2005) 720-724
21. Collado M., Gil J., Efeyan A., et al. Tumour biology: senescence in premalignant tumours. Nature 436 (2005) 642
22. Collado M., and Serrano M. The power and the promise of oncogene-induced senescence markers. Nat Rev Cancer 6 (2006) 472-476
23. van Heek N.T., Meeker A.K., Kern S.E., et al. Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol 161 (2002) 1541-1547
24. Shay J.W., Pereira-Smith O.M., and Wright W.E. A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 196 (1991) 33-39
25. Cosme-Blanco W., Shen M.F., Lazar A.J., et al. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep 8 (2007) 497-503
26. WAF1/CIP1 is an early event in the development of pancreatic intraepithelial neoplasia. Cancer Res 61 (2001) 8830-8837
27. Bardeesy N., Aguirre A.J., Chu G.C., et al. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A 103 (2006) 5947-5952
28. Hingorani S.R., Petricoin E.F., Maitra A., et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4 (2003) 437-450
29. Hingorani S.R., Wang L., Multani A.S., et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7 (2005) 469-483
30. Guerra C., Schuhmacher A.J., Cañamero M., et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11 (2007) 291-302
31. Jen J., Powell S.M., Papadopoulos N., et al. Molecular determinants of dysplasia in colorectal lesions. Cancer Res 54 (1994) 5523-5526
32. Knowles M.A. Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?. Carcinogenesis 27 (2006) 361-373
33. Stoehr R., Zietz S., Burger M., et al. Deletions of chromosomes 9 and 8p in histologically normal urothelium of patients with bladder cancer. Eur Urol 47 (2005) 58-63