Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way-a randomized-controlled human intervention trial

Molecular Nutrition and Food Research

Volumn 57, Issue 2, 2013, Pages 191-202

  Ostertag, Luisa M ^a,b   Kroon, Paul A ^b   Wood, Sharon ^a   Horgan, Graham W ^c   Cienfuegos Jovellanos, Elena ^d   Saha, Shikha ^b   Duthie, Garry G ^a   De Roos, Baukje ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^c BIOMATHEMATICS AND STATISTICS SCOTLAND   (United Kingdom)

^d RESEARCH GROUP ON QUALITY   (Spain)

Author keywords

Cardiovascular disease; Cocoa; Flavan 3 ols; Platelet function; Randomized controlled human intervention trial

Indexed keywords

ADENOSINE DIPHOSPHATE; FIBRINOGEN; FLAVAN 3 OL; FLAVAN-3-OL; FLAVONOID; PADGEM PROTEIN; SUGAR; THROMBIN RECEPTOR;

ADULT; AGED; ARTICLE; BIOAVAILABILITY; CACAO; CHEMISTRY; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; THROMBOCYTE; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ADULT; AGED; BIOLOGICAL AVAILABILITY; BLOOD PLATELETS; CACAO; CANDY; FEMALE; FIBRINOGEN; FLAVONOIDS; HUMANS; MALE; MIDDLE AGED; P-SELECTIN; PLATELET AGGREGATION; RECEPTORS, THROMBIN; SEX FACTORS; YOUNG ADULT;

THEOBROMA CACAO;

EID: 84872808958     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200283     Document Type: Article

References (43)

1. Goldschmidt, P. J., Lopes, N., Crawford, L. E., Becker, R. C., in: Michelson, A. D. (Ed.), in: Platelets, Academic Press, Elsevier Inc., London, UK 2007, pp. 629-655.
2. Allender, S., Scarborough, P., Peto, V., Rayner, M. et al., British Heart Foundation Health Promotion Research Group & Health Economics Research Centre, Department of Public Health, University of Oxford, Oxford 2008, pp. 1-112.
3. Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J. et al., Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation 2011, 123, e18-e209.
4. Kris-Etherton, P. M., Etherton, T. D., Carlson, J., Gardner, C., Recent discoveries in inclusive food-based approaches and dietary patterns for reduction in risk for cardiovascular disease. Curr. Opin. Lipidol. 2002, 13, 397-407.
5. Ruggeri, Z. M., Platelets in atherothrombosis. Nat. Med. 2002, 8, 1227-1234.
6. Linden, M. D., Jackson, D. E., Platelets: pleiotropic roles in atherogenesis and atherothrombosis. Int. J. Biochem. Cell Biol. 2010, 42, 1762-1766.
7. Ostertag, L. M., O'Kennedy, N., Kroon, P. A., Duthie, G. G. et al., Impact of dietary polyphenols on human platelet function-a critical review of controlled dietary intervention studies. Mol. Nutr. Food Res. 2010, 54, 60-81.
8. Guerrero, J. A., Navarro-Nuñez, L., Lozano, M. L., Martínez, C. et al., Flavonoids inhibit the platelet TxA2 signalling pathway and antagonize TxA2 receptors (TP) in platelets and smooth muscle cells. Br. J. Clin. Pharmacol. 2007, 64, 133-144.
9. Nardini, M., Natella, F., Scaccini, C., Role of dietary polyphenols in platelet aggregation. A review of the supplementation studies. Platelets 2007, 18, 224-243.
10. Natella, F., Nardini, M., Virgili, F., Scaccini, C., Role of dietary polyphenols in the platelet aggregation network-a review of the in vitro studies. Curr. Top. Nutraceut. Res. 2006, 4, 1-22.
11. Rechner, A. R., Kroner, C., Anthocyanins and colonic metabolites of dietary polyphenols inhibit platelet function. Thromb. Res. 2005, 116, 327-334.
12. Hamed, M. S., Gambert, S., Bliden, K. P., Bailon, O. et al., Dark chocolate effect on platelet activity, C-reactive protein and lipid profile: a pilot study. South Med. J. 2008, 101, 1203-1208.
13. Holt, R. R., Schramm, D. D., Keen, C. L., Lazarus, S. A. et al., Chocolate consumption and platelet function. JAMA 2002, 287, 2212-2213.
14. Pearson, D. A., Paglieroni, T. G., Rein, D., Wun, T. et al., The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function. Thromb. Res. 2002, 106, 191-197.
15. Crozier, A., Del Rio, D., Clifford, M. N., Bioavailability of dietary flavonoids and phenolic compounds. Mol. Aspects Med. 2010, 31, 446-467.
16. Crozier, A., Jaganath, I. B., Clifford, M. N., Dietary phenolics: chemistry, bioavailability and effects on health. Nat. Prod. Rep. 2009, 26, 1001-1043.
17. Manach, C., Williamson, G., Morand, C., Scalbert, A. et al., Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 2005, 81, 230S-242S.
18. U.S. Department of Agriculture and U.S. Department of Health and Human Services, Dietary Guidelines for Americans, 7th Edition. U.S. Government Printing Office, Washington, DC 2010, December 2010.
19. U.S. Department of Agriculture, Agricultural Research Service, USDA National Nutritient Database for Standard Reference, Release 24, 2011 Nutrient Data Laboratory Home Page, Available from: http://www.ars.usda.gov/ba/bhnrc/ndl.
20. Cooper, K. A., Campos-Gimenez, E., Jimenez Alvarez, D., Nagy, K. et al., Rapid reversed phase ultra-performance liquid chromatography analysis of the major cocoa polyphenols and inter-relationships of their concentrations in chocolate. J. Agric. Food Chem. 2007, 55, 2841-2847.
21. Prior, R. L., Lazarus, S. A., Cao, G., Muccitelli, H. et al., Identification of procyanidins and anthocyanins in blueberries and cranberries (Vaccinium spp.) Using high-performance liquid chromatography/mass spectrometry. J. Agric. Food Chem. 2001, 49, 1270-1276.
22. Gu, L., Kelm, M., Hammerstone, J. F., Beecher, G. et al., Fractionation of polymeric procyanidins from lowbush blueberry and quantification of procyanidins in selected foods with an optimized normal-phase HPLC-MS fluorescent detection method. J. Agric. Food Chem. 2002, 50, 4852-4860.
23. Ostertag, L. M., O'Kennedy, N., Horgan, G. W., Kroon, P. A. et al., In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations. Mol. Nutr. Food Res. 2011, 55, 1624-1636.
24. Born, G. V., Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962, 194, 927-929.
25. Saha, S., Hollands, W., Needs, P. W., Ostertag, L. M. et al., Human O-sulfated metabolites of (-)-epicatechin and methyl-(-)-epicatechin are poor substrates for commercial aryl-sulfatases: implications for studies concerned with quantifying epicatechin bioavailability. Pharmacol. Res. 2012, 65, 592-602.
26. Garde, A. H., Hansen, Å. M., Kristiansen, J., Knudsen, L. E., Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration. Ann. Occup. Hyg. 2004, 48, 171-179.
27. Zamora-Ros, R., Rabassa, M., Cherubini, A., Urpi-Sarda, M. et al., Comparison of 24-h volume and creatinine-corrected total urinary polyphenol as a biomarker of total dietary polyphenols in the Invecchiare InCHIANTI study. Anal. Chim. Acta 2011, 704, 110-115.
28. De Keyzer, W., Huybrechts, I., Dekkers, A. L., Geelen, A. et al., Predicting urinary creatinine excretion and its usefulness to identify incomplete 24 h urine collections. Br. J. Nutr. 2012, 108, 1118-1125.
29. Mullen, W., Borges, G., Donovan, J. L., Edwards, C. A. et al., Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. Am. J. Clin. Nutr. 2009, 89, 1784-1791.
30. Erdmann, K., Cheung, B. W., Schroder, H., The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. J. Nutr. Biochem. 2008, 19, 643-654.
31. Manso, M. A., Escudero, C., Alijo, M., Lopez-Fandino, R., Platelet aggregation inhibitory activity of bovine, ovine, and caprine kappa-casein macropeptides and their tryptic hydrolysates. J. Food Prot. 2002, 65, 1992-1996.
32. Qian, Z. Y., Jollès, P., Migliore-Samour, D., Fiat, A. M., Isolation and characterization of sheep lactoferrin, an inhibitor of platelet aggregation and comparison with human lactoferrin. Biochim. Biophys. Acta 1995, 1243, 25-32.
33. Jolles, P., Levy-Toledano, S., Fiat, A. M., Analogy between fibrinogen and casein. Effect of an undecapeptide isolated from κ-casein on platelet function. Eur. J. Biochem. 1986, 158, 379-382.
34. Bailey, A. L., Scantlebury, D. C., Smyth, S. S., Thrombosis and antithrombotic therapy in women. Arterioscler. Thromb. Vasc. Biol. 2009, 29, 284-288.
35. Ajayi, A. A. L., Mathur, R., Halushka, P. V., Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation 1995, 91, 2742-2747.
36. Haque, S. F., Matsubayashi, H., Izumi, S. I., Sugi, T. et al., Sex difference in platelet aggregation detected by new aggregometry using light scattering. Endocr. J. 2001, 48, 33-41.
37. Faraday, N., Goldschmidt-Clermont, P. J., Bray, P. F., Gender differences in platelet GPIIb-IIIa activation. Thromb. Haemost. 1997, 77, 748-754.
38. Polagruto, J. A., Gross, H. B., Kamangar, F., Kosuna, K. et al., Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract. J. Med. Food 2007, 10, 725-730.
39. Rein, D., Paglieroni, T. G., Wun, T., Pearson, D. A. et al., Cocoa inhibits platelet activation and function. Am. J. Clin. Nutr. 2000, 72, 30-35.
40. Roell, A., Schueller, P., Schultz, A., Losel, R. et al., Effect of oral contraceptives and ovarian cycle on platelet function. Platelets 2007, 18, 165-170.
41. Holt, R. R., Lazarus, S. A., Cameron Sullards, M., Zhu, Q. Y. et al., Procyanidin dimer B2 [epicatechin-(4β-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am. J. Clin. Nutr. 2002, 76, 798-804.
42. Del Rio, D., Borges, G., Crozier, A., Berry flavonoids and phenolics: bioavailability and evidence of protective effects. Br. J. Nutr. 2010, 104, S67-S90.
43. Mullen, W., Borges, G., Donovan, J. L., Edwards, C. A. et al., Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. Am. J. Clin. Nutr. 2009, 89, 1784-1791.