Combined delivery of BMP-2 and bFGF from nanostructured colloidal gelatin gels and its effect on bone regeneration in vivo

Journal of Controlled Release

Volumn 166, Issue 2, 2013, Pages 172-181

  Wang, Huanan ^a,b   Zou, Qin ^b   Boerman, Otto C ^c   Nijhuis, Arnold W G ^a   Jansen, John A ^a   Li, Yubao ^b   Leeuwenburgh, Sander C G ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SICHUAN UNIVERSITY   (China)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

Colloidal gels; Dual growth factor; Gelatin; Nanospheres; Osteogenesis; Sequential release

Indexed keywords

COLLOIDAL GELS; GELATIN; GROWTH FACTOR; OSTEOGENESIS; SEQUENTIAL RELEASE;

BIOCOMPATIBILITY; BIODEGRADATION; BIOMIMETICS; BONE; CROSSLINKING; DYES; LOADING; NANOSPHERES; PROTEINS; TISSUE; TISSUE REGENERATION;

GELS;

BONE MORPHOGENETIC PROTEIN 2; FIBROBLAST GROWTH FACTOR 2; GELATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; BONE REGENERATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CROSS LINKING; FRACTURE HEALING; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; COLLOIDS; CROSS-LINKING REAGENTS; DRUG CARRIERS; DRUG STABILITY; FEMUR; FIBROBLAST GROWTH FACTOR 2; GELS; IODINE RADIOISOTOPES; ISOTOPE LABELING; LIGHT; MALE; NANOSPHERES; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; RHEOLOGY; SCATTERING, RADIATION; X-RAY MICROTOMOGRAPHY;

EID: 84872771424     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.12.015     Document Type: Article

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