Part II. Mitochondrial mutational status of high nitric oxide adapted cell line BT-20 (BT-20-HNO) as it relates to human primary breast tumors

Tumor Biology

Volumn 34, Issue 1, 2013, Pages 337-347

  De Vitto, H ^a,b,c   Mendonca B S ^a   Elseth, K M ^b,c   Vesper, B J ^b,c   Portari, E A ^d   Gallo, C V M ^e   Paradise, W A ^b   Rumjanek, F D ^a   Radosevich, J A ^b,c  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c JESSE BROWN VA MEDICAL CENTER   (United States)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

^e STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Breast cancer; mtDNA copy number; NADH dehydrogenase (complex I); Nitric oxide (NO); Somatic mtDNA mutations

Indexed keywords

MITOCHONDRIAL DNA; NITRIC OXIDE;

AMINO ACID SUBSTITUTION; ARTICLE; BREAST CARCINOGENESIS; BREAST TUMOR; CANCER PATIENT; CANCER TISSUE; CELL STRAIN BT 20 HNO; CLONAL VARIATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DNA SEQUENCE; DONOR; GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MITOCHONDRIAL GENOME; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; P53 GENE; POINT MUTATION; PRIMARY TUMOR; PRIORITY JOURNAL; PROMOTER REGION; SOMATIC MUTATION; TRANSCRIPTION INITIATION SITE; TUMOR BIOPSY; TUMOR CELL CULTURE;

EID: 84872761372     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-012-0555-4     Document Type: Article

References (47)

1. JT Hancock 2009 The role of redox mechanisms in cell signalling Mol Biotechnol 43 2 162 6 19507067 10.1007/s12033-009-9189-1 1:CAS:528: DC%2BD1MXhtFCitrvM
2. Wallace DC. Mitochondria as chi. Genetics. 2008;179(2):727-35.
3. LL Clay Montier JJ Deng Y Bai 2009 Number matters: control of mammalian mitochondrial DNA copy number J Genet Genomics 36 3 125 31 19302968 10.1016/S1673-8527(08)60099-5
4. NG Larsson 2010 Somatic mitochondrial DNA mutations in mammalian aging Annu Rev Biochem 79 683 706 20350166 10.1146/annurev-biochem-060408-093701 1:CAS:528:DC%2BC3cXpslSht7s%3D
5. DC Wallace 2005 A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Annu Rev Genet 39 359 407 16285865 10.1146/annurev.genet.39.110304.095751 1:CAS:528: DC%2BD28Xlt1Wrtw%3D%3D
6. A Chatterjee E Mambo D Sidransky 2006 Mitochondrial DNA mutations in human cancer Oncogene 25 34 4663 74 16892080 10.1038/sj.onc.1209604 1:CAS:528:DC%2BD28Xnsl2hsLs%3D
7. HC Lee YH Wei 2009 Mitochondrial DNA instability and metabolic shift in human cancers Int J Mol Sci 10 2 674 701 19333428 10.3390/ijms10020674 1:CAS:528:DC%2BD1MXislOqu74%3D
8. J Lu LK Sharma Y Bai 2009 Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis Cell Res 19 7 802 15 19532122 10.1038/cr.2009.69 1:CAS:528:DC%2BD1MXot12ltb0%3D
9. LL Thomsen, et al. 1995 Nitric oxide synthase activity in human breast cancer Br J Cancer 72 1 41 4 7541238 10.1038/bjc.1995.274 1:CAS:528: DyaK2MXnvFyisLk%3D
10. BG Bentz, et al. 1999 Nitric oxide synthase type 3 is increased in squamous hyperplasia, dysplasia, and squamous cell carcinoma of the head and neck Ann Otol Rhinol Laryngol 108 8 781 7 10453787 1:STN:280: DyaK1MzotFGqsg%3D%3D
11. S Ambs, et al. 1998 Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression Cancer Res 58 2 334 41 9443414 1:CAS:528:DyaK1cXnt1ajtA%3D%3D
12. BG Bentz, et al. 1998 Endothelial constitutive nitric oxide synthase (ecNOS) localization in normal and neoplastic salivary tissue Head Neck 20 4 304 9 9588702 10.1002/(SICI)1097-0347(199807)20:4<304::AID-HED4>3.0.CO;2-2 1:STN:280:DyaK1c3kvVWitA%3D%3D
13. DA Wink, et al. 1998 The multifaceted roles of nitric oxide in cancer Carcinogenesis 19 5 711 21 9635855 10.1093/carcin/19.5.711 1:CAS:528: DyaK1cXjsVGgtbw%3D
14. SA Glynn, et al. 2010 Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients J Clin Invest 120 11 3843 54 20978357 10.1172/JCI42059 1:CAS:528:DC%2BC3cXhsVWgtbrL
15. BG Bentz GK Haines 3rd JA Radosevich 2000 Increased protein nitrosylation in head and neck squamous cell carcinogenesis Head Neck 22 1 64 70 10585607 10.1002/(SICI)1097-0347(200001)22:1<64::AID-HED10>3.0.CO;2-J 1:STN:280:DC%2BD3c%2FlsVensg%3D%3D
16. DD Thomas, et al. 2008 The chemical biology of nitric oxide: implications in cellular signaling Free Radic Biol Med 45 1 18 31 18439435 10.1016/j.freeradbiomed.2008.03.020 1:CAS:528:DC%2BD1cXmvFaqt7w%3D
17. DC Jenkins, et al. 1995 Roles of nitric oxide in tumor growth Proc Natl Acad Sci U S A 92 10 4392 6 7538668 10.1073/pnas.92.10.4392 1:CAS:528: DyaK2MXls1aksrw%3D
18. JA Koufman AJ Burke 1997 The etiology and pathogenesis of laryngeal carcinoma Otolaryngol Clin North Am 30 1 1 19 8995133 1:STN:280: DyaK2s7lt1ehsw%3D%3D
19. P Moller, et al. 2008 Air pollution, oxidative damage to DNA, and carcinogenesis Cancer Lett 266 1 84 97 18367322 10.1016/j.canlet.2008.02.030 1:CAS:528:DC%2BD1cXmsFKksrs%3D
20. M Brandon P Baldi DC Wallace 2006 Mitochondrial mutations in cancer Oncogene 25 34 4647 62 16892079 10.1038/sj.onc.1209607 1:CAS:528: DC%2BD28Xnsl2hsLY%3D
21. DC Wallace 2007 Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine Annu Rev Biochem 76 781 821 17506638 10.1146/annurev.biochem.76.081205.150955 1:CAS:528:DC%2BD2sXhtVehtb3M
22. SJ Ralph, et al. 2010 The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation-why mitochondria are targets for cancer therapy Mol Aspects Med 31 2 145 70 20206201 10.1016/j.mam.2010.02.008 1:CAS:528:DC%2BC3cXksFGqurk%3D
23. D Chandra KK Singh 2011 Genetic insights into OXPHOS defect and its role in cancer Biochim Biophys Acta 1807 6 620 5 21074512 10.1016/j.bbabio.2010.10. 023 1:CAS:528:DC%2BC3MXlsFSisbY%3D
24. IN Todorov GI Todorov 2009 Multifactorial nature of high frequency of mitochondrial DNA mutations in somatic mammalian cells Biochemistry (Mosc) 74 9 962 70 10.1134/S000629790909003X 1:CAS:528:DC%2BD1MXht1ertLvM
25. G Attardi G Schatz 1988 Biogenesis of mitochondria Annu Rev Cell Biol 4 289 333 2461720 10.1146/annurev.cb.04.110188.001445 1:CAS:528: DyaL1MXltlSitg%3D%3D
26. P Liu B Demple 2010 DNA repair in mammalian mitochondria: much more than we thought? Environ Mol Mutagen 51 5 417 26 20544882 1:CAS:528: DC%2BC3cXnsVWgt7Y%3D
27. Vesper BJ, et al. Long-term adaptation of breast tumor cell lines to high concentrations of nitric oxide. Tumor Biol. 2010;31(4):267-75.
28. EY Lasfargues L Ozzello 1958 Cultivation of human breast carcinomas J Natl Cancer Inst 21 6 1131 47 13611537 1:CAS:528:DyaG1MXks1Crug%3D%3D
29. N Blin DW Stafford 1976 A general method for isolation of high molecular weight DNA from eukaryotes Nucleic Acids Res 3 9 2303 8 987581 10.1093/nar/3.9.2303 1:CAS:528:DyaE28Xltl2ntL0%3D
30. S Anderson, et al. 1981 Sequence and organization of the human mitochondrial genome Nature 290 5806 457 65 7219534 10.1038/290457a0 1:CAS:528:DyaL3MXlt1OlsL8%3D
31. E Mambo, et al. 2005 Tumor-specific changes in mtDNA content in human cancer Int J Cancer 116 6 920 4 15856456 10.1002/ijc.21110 1:CAS:528: DC%2BD2MXpsVegtL0%3D
32. J Fish N Raule G Attardi 2004 Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis Science 306 5704 2098 101 15604407 10.1126/science.1102077 1:CAS:528:DC%2BD2cXhtVOjsLrO
33. DJ Tan RK Bai LJ Wong 2002 Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer Cancer Res 62 4 972 6 11861366 1:CAS:528:DC%2BD38XitVSms7k%3D
34. G Gasparre, et al. 2007 Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors Proc Natl Acad Sci U S A 104 21 9001 6 17517629 10.1073/pnas.0703056104 1:CAS:528: DC%2BD2sXmt1Wlsbk%3D
35. WY Hung, et al. 2010 Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer Biochim Biophys Acta 1800 3 264 70 19527772 10.1016/j.bbagen.2009.06.006 1:CAS:528: DC%2BC3cXitlWitrs%3D
36. S Gochhait, et al. 2008 Concomitant presence of mutations in mitochondrial genome and p53 in cancer development-a study in north Indian sporadic breast and esophageal cancer patients Int J Cancer 123 11 2580 6 18792899 10.1002/ijc.23817 1:CAS:528:DC%2BD1cXhtlyru7jM
37. A Salas, et al. 2005 A critical reassessment of the role of mitochondria in tumorigenesis PLoS Med 2 11 e296 16187796 10.1371/journal.pmed.0020296
38. AM Czarnecka, et al. 2010 Molecular oncology focus-is carcinogenesis a 'mitochondriopathy'? J Biomed Sci 17 31 20416110 10.1186/1423-0127-17-31
39. MP Bayona-Bafaluy, et al. 2011 Maternally inherited susceptibility to cancer Biochim Biophys Acta 1807 6 643 9 20732295 10.1016/j.bbabio.2010.08.004 1:CAS:528:DC%2BC3MXlsFSitr8%3D
40. O Warburg 1956 On respiratory impairment in cancer cells Science 124 3215 269 70 13351639 1:STN:280:DyaG287gsVeksA%3D%3D
41. Vesper BJ, Onul A, Haines III GK, et al. Part I. Molecular and cellular characteristics of high nitric oxide-adapted human breast adenocarcinoma cell lines. Tumor Biol. 2012. doi: 10.1007/s13277-012-0530-0.
42. De Vitto H, Mendonça BS, Elseth KM, et al. Part III. Molecular changes induced by high nitric oxide adaptation in human breast cancer cell line BT-20 (BT-20-HNO): a switch from aerobic to anaerobic metabolism. Tumor Biol. 2012. doi: 10.1007/s13277-012-0564-3.
43. M Yu, et al. 2007 Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients IUBMB Life 59 7 450 7 17654121 10.1080/15216540701509955 1:CAS:528: DC%2BD2sXotV2rs7o%3D
44. KA Laderman, et al. 1996 Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells J Biol Chem 271 27 15891 7 8663253 10.1074/jbc.271.27.15891 1:CAS:528:DyaK28XktFait78%3D
45. K Heyne, et al. 2004 Identification of a putative p53 binding sequence within the human mitochondrial genome FEBS Lett 578 1-2 198 202 15581641 10.1016/j.febslet.2004.10.099 1:CAS:528:DC%2BD2cXhtVCltL7N
46. G Achanta, et al. 2005 Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma EMBO J 24 19 3482 92 16163384 10.1038/sj.emboj.7600819 1:CAS:528:DC%2BD2MXhtVKns7zF
47. Zhou S, et al. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A. 2007;104(18):7540-5.