Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis

Science

Volumn 306, Issue 5704, 2004, Pages 2098-2101

  Fish, Jennifer ^a   Raule, Nicola ^a   Attardi, Giuseppe ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; PHYSIOLOGY;

CELL LINES; CONTROL POINT; REPLICATIONS; STEADY-STATE CONDITIONS;

DNA;

MITOCHONDRIAL DNA;

DNA;

ARTICLE; DNA REPLICATION ORIGIN; DNA STRAND; DNA SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CELL LINE; CELL LINE, TUMOR; DNA PRIMERS; DNA PROBES; DNA REPLICATION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ETHIDIUM; HELA CELLS; HUMANS; LYMPHOCYTES; NUCLEIC ACID CONFORMATION; POLYMERASE CHAIN REACTION; REPLICATION ORIGIN;

MAMMALIA;

EID: 10844295852     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1102077     Document Type: Article

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25. Supported by NIH grant GM11726 (G.A.). We thank J. Zhang for providing additional data, A. Chomyn for valuable discussions and comments on the manuscript, and M. Roldan-Ortiz and R. Zedan for expert technical assistance.