Protective effect of beraprost sodium, a stable prostacyclin analog, in the development of cigarette smoke extract-induced emphysema

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 296, Issue 4, 2009, Pages

  Chen, Yan ^a,b   Hanaoka, Masayuki ^a   Chen, Ping ^b   Droma, Yunden ^a   Voelkel, Norbert F ^c   Kubo, Keishi ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Apoptosis; Inflammation; Matrix metalloproteinase; Oxidative stress; Rat

Indexed keywords

ANTIOXIDANT; BERAPROST; CASPASE 3; CIGARETTE SMOKE; CYCLIC AMP; CYTOKINE; DNA; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; PROSTACYCLIN DERIVATIVE; PROSTACYCLIN RECEPTOR; PROTEINASE; TUMOR NECROSIS FACTOR ALPHA; 6 OXOPROSTAGLANDIN F1 ALPHA; DRUG DERIVATIVE; PROSTACYCLIN; PROTECTIVE AGENT;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DNA DAMAGE; EMPHYSEMA; ENZYME ACTIVITY; LUNG ALVEOLUS CELL; LUNG PARENCHYMA; MALE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; SERUM; SPRAGUE DAWLEY RAT; ANIMAL; BLOOD; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; EPITHELIUM CELL; LUNG; LUNG EMPHYSEMA; METABOLISM; NICK END LABELING; PATHOLOGY; PNEUMONIA; SMOKING;

6-KETOPROSTAGLANDIN F1 ALPHA; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CYCLIC AMP; CYTOKINES; ENZYME ACTIVATION; EPITHELIAL CELLS; EPOPROSTENOL; IN SITU NICK-END LABELING; LUNG; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PNEUMONIA; PROTECTIVE AGENTS; PULMONARY EMPHYSEMA; RATS; RATS, SPRAGUE-DAWLEY; SMOKING;

EID: 65549123086     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90270.2008     Document Type: Article

References (38)

1. Adderley SR, Fitzgerald DJ. Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2. J Biol Chem 274: 5038-5046, 1999.
2. Agusti A, MacNee W, Donaldson K, Cosio M. Hypothesis: does COPD have an autoimmune component? Thorax 58: 832-834, 2003. (Pubitemid 37239227)
3. Aoshiba K, Yokohori N, Nagai A. Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am J Respir Cell Mol Biol 28: 555-562, 2003. (Pubitemid 36543402)
4. Atkinson JJ, Senior RM. Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol 28: 12-24, 2003.
5. Betsuyaku T, Nishimura M, Takeyabu K, Tanino M, Venge P, Xu S, Kawakami Y. Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema. Am J Respir Crit Care Med 159: 1985-1991, 1999.
6. Cataldo DD, Gueders MM, Rocks N, Sounni NE, Evrard B, Bartsch P, Louis R, Noel A, Foidart JM. Pathogenic role of matrix metalloproteases and their inhibitors in asthma and chronic obstructive pulmonary disease and therapeutic relevance of matrix metalloproteases inhibitors. Cell Mol Biol 49: 875-884, 2003.
7. Cataldo D, Munaut C, Noel A, Frankenne F, Bartsch P, Foidart JM, Louis R. MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease. Int Arch Allergy Immunol 123: 259-267, 2000.
8. Chen CH, Lin H, Hsu YH, Sue YM, Cheng TH, Chan P, Chen TH. The protective effect of prostacyclin on adriamycin-induced apoptosis in rat renal tubular cells. Eur J Pharmacol 529: 8-15, 2006. (Pubitemid 43005279)
9. Choe KH, Taraseviciene-Stewart L, Scerbavicius R, Gera L, Tuder RM, Voelkel NF. Methylprednisolone causes matrix metalloproteinase-dependent emphysema in adult rats. Am J Respir Crit Care Med 167: 1516-1521, 2003. (Pubitemid 37363361)
10. Chung KF. Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl 34: 50s-59s, 2001.
11. Cutler NS, Graves-Deal R, LaFleur BJ, Gao Z, Boman BM, Whitehead RH, Terry E, Morrow JD, Coffey RJ. Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells. Cancer Res 63: 1748-1751, 2003. (Pubitemid 36460831)
12. Drvota V, Vesterqvist O, Green K. Effects of non-steroidal anti-inflammatory drugs on the in vivo synthesis of thromboxane and prostacyclin in humans. Adv Prostaglandin Thromboxane Leukot Res 21A: 153-156, 1991.
13. Hodge S, Hodge G, Scicchitano R, Reynolds PN, Holmes M. Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells. Immunol Cell Biol 81: 289-296, 2003. (Pubitemid 36904336)
14. Itoh T, Nagaya N, Fujii T, Iwase T, Nakanishi N, Hamada K, Kangawa K, Kimura H. A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med 169: 34-38, 2004. (Pubitemid 38233886)
15. Kainoh M, Maruyama I, Nishio S, Nakadate T. Enhancement by beraprost sodium, a stable analogue of prostacyclin, in thrombomodulin expression on membrane surface of cultured vascular endothelial cells via increase in cyclic AMP level. Biochem Pharmacol 41: 1135-1140, 1991.
16. Kamio K, Liu X, Sugiura H, Togo S, Kobayashi T, Kawasaki S, Wang X, Mao L, Ahn Y, Hogaboam C, Toews ML, Rennard SI. Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathway. Am J Respir Cell Mol Biol 37: 113-120, 2007. (Pubitemid 46999543)
17. Kirschvink N, Vincke G, Fievez L, Onclinx C, Wirth D, Belleflamme M, Louis R, Cataldo D, Peck MJ, Gustin P. Repeated cadmium nebulizations induce pulmonary MMP-2 and MMP-9 production and emphysema in rats. Toxicology 211: 36-48, 2005. (Pubitemid 40603625)
18. Kitahara M, Ichikawa M, Kinoshita T, Shiozawa S, Shigematsu H, Komiyama A. Prostacyclin inhibits the production of MMP-9 induced by phorbol ester through protein kinase A activation, but does not affect the production of MMP-2 in human cultured mesangial cells. Kidney Blood Press Res 24: 18-26, 2001. (Pubitemid 32098501)
19. Lopez AD, Mathers CD. Measuring the global burden of disease and epidemiological transitions: 2002-2030. Ann Trop Med Parasitol 100: 481-499, 2006.
20. Majo J, Ghezzo H, Cosio MG. Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema. Eur Respir J 17: 946-953, 2001. (Pubitemid 32600344)
21. Mao JT, Tashkin DP, Belloni PN, Baileyhealy I, Baratelli F, Roth MD. All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysema. Chest 124: 1724-1732, 2003. (Pubitemid 37433565)
22. Miyahara Y, Ohnishi S, Obata H, Ishino K, Sano S, Mori H, Kangawa K, Kitamura S, Nagaya N. Beraprost sodium enhances neovascularization in ischemic myocardium by mobilizing bone marrow cells in rats. Biochem Biophys Res Commun 349: 1242-1249, 2006. (Pubitemid 44419611)
23. Miyata M, Ueno Y, Sekine H, Ito O, Sakuma F, Koike H, Nishio S, Nishimaki T, Kasukawa R. Protective effect of beraprost sodium, a stable prostacyclin analogue, in development of monocrotaline-induced pulmonary hypertension. J Cardiovasc Pharmacol 27: 20-26, 1996. (Pubitemid 26010634)
24. Nana-Sinkam SP, Lee JD, Sotto-Santiago S, Stearman RS, Keith RL, Choudhury Q, Cool C, Parr J, Moore MD, Bull TM, Voelkel NF, Geraci MW. Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke. Am J Respir Crit Care Med 175: 676-685, 2007. (Pubitemid 46536482)
25. Ohmori M, Kitoh Y, Kawaguchi A, Harada K, Sugimoto K, Fujimura A. Enhanced neutrophil superoxide anion production and its modification by beraprost sodium in spontaneously hypertensive rats. Am J Hypertens 14: 722-728, 2001. (Pubitemid 32612540)
26. Ohnishi K, Takagi M, Kurokawa Y, Satomi S, Konttinen YT. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema. Lab Invest 78: 1077-1087, 1998. (Pubitemid 28440824)
27. Pauwels RA, Rabe KF. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364: 613-620, 2004.
28. Petrache I, Fijalkowska I, Zhen L, Medler TR, Brown E, Cruz P, Choe KH, Taraseviciene-Stewart L, Scerbavicius R, Shapiro L, Zhang B, Song S, Hicklin D, Voelkel NF, Flotte T, Tuder RM. A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema. Am J Respir Crit Care Med 173: 1222-1228, 2006. (Pubitemid 43848392)
29. Saetta M, Shiner RJ, Angus GE, Kim WD, Wang NS, King M, Ghezzo H, Cosio MG. Destructive index: a measurement of lung parenchymal destruction in smokers. Am Rev Respir Dis 131: 764-769, 1985. (Pubitemid 15066865)
30. + channels via the EP3 receptor. Am J Physiol Heart Circ Physiol 288: H2093-H2101, 2005.
31. 2) synthase is a constitutively expressed enzyme in human endothelial cells. Exp Cell Res 219: 507-513, 1995.
32. 2 analogues elicit vascular relaxation: cyclic AMP-independent, Gs-protein mediated-activation of maxik channel. Curr Med Chem Cardiovasc Hematol Agents 2: 257-265, 2004.
33. Taraseviciene-Stewart L, Burns N, Kraskauskas D, Nicolls MR, Tuder RM, Voelkel NF. Mechanisms of autoimmune emphysema. Proc Am Thorac Soc 3: 486-487, 2006. (Pubitemid 44285528)
34. Taraseviciene-Stewart L, Kraskauskas D, Lee JH, Hanaoka M, Burns N, Parr J, Kraskauskiene V, Voelkel NF. Cigarette smoke extract (CSE)-induced emphysema in mice (abstract). Am J Respir Crit Care Med 175: A529, 2007.
35. Taraseviciene-Stewart L, Nicolls MR, Burns N, Kraskauskas D, Voelkel NF. Intraperitoneal injection of cigarette smoke extract causes lung cell death and emphysema in rats (abstract). Am J Respir Crit Care Med 173: A626, 2006.
36. Tuder RM, Zhen L, Cho CY, Taraseviciene-Stewart L, Kasahara Y, Salvemini D, Voelkel NF, Flores SC. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol 29: 88-97, 2003. (Pubitemid 36783320)
37. Ueno M, Miyauchi T, Sakai S, Yamauchi-Kohno R, Goto K, Yamaguchi I. A combination of oral endothelin-A receptor antagonist and oral prostacyclin analogue is superior to each drug alone in ameliorating pulmonary hypertension in rats. J Am Coll Cardiol 40: 175-181, 2002. (Pubitemid 34701394)
38. Yokohori N, Aoshiba K, Nagai A. Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. Chest 125: 626-632, 2004. (Pubitemid 38223645)