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1
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47749124575
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Stem cells and cell therapies in lung biology and lung diseases
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This article by Weiss et al. is a comprehensive summary of a conference entitled 'Stem Cells and Cell Therapies in Lung Biology and Lung Diseases' with extensive review of recent literature related to cell therapy for lung diseases. This includes the current status of structure engraftment by exogenous stem cells, new development related to lung tissue engineering, and the immunomodulation role of mesenchymal stem cells in lung injury. We would recommend this article as an overview review of current status of cell therapy for lung diseases field.
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Weiss D.J., Kolls J.K., Ortiz L.A., Panoskaltsis-Mortari A., and Prockop D.J. Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc 5 (2008) 637-667. This article by Weiss et al. is a comprehensive summary of a conference entitled 'Stem Cells and Cell Therapies in Lung Biology and Lung Diseases' with extensive review of recent literature related to cell therapy for lung diseases. This includes the current status of structure engraftment by exogenous stem cells, new development related to lung tissue engineering, and the immunomodulation role of mesenchymal stem cells in lung injury. We would recommend this article as an overview review of current status of cell therapy for lung diseases field.
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(2008)
Proc Am Thorac Soc
, vol.5
, pp. 637-667
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Weiss, D.J.1
Kolls, J.K.2
Ortiz, L.A.3
Panoskaltsis-Mortari, A.4
Prockop, D.J.5
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2
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41749083316
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Derivation of lung epithelium from human cord blood-derived mesenchymal stem cells
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This article by Sueblinvong et al. reported the use of cord blood as a source of mesenchymal stem cells. The authors reported approximately 39% of human cord blood sample yield mesenchymal stem cells (MSC). After characterization, they subsequently injected stem cells into NOD/SCID mice following low dose irradiation. They reported small number of human-derived airway epithelial cells up to three months following the injection. This study demonstrated that MSCs obtained from human umbilical cord blood can engraft NOD/SCID mice airway following low dose irradiation. However, the yield of engraftment is not significantly better than that achieved with bone marrow-derived MSCs. Although this study did not show benefit of MSCs derived from cord blood over bone marrow cells, this is a well-designed study.
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Sueblinvong V., Loi R., Eisenhauer P.L., Bernstein I.M., Suratt B.T., Spees J.L., and Weiss D.J. Derivation of lung epithelium from human cord blood-derived mesenchymal stem cells. Am J Respir Crit Care Med 177 (2008) 701-711. This article by Sueblinvong et al. reported the use of cord blood as a source of mesenchymal stem cells. The authors reported approximately 39% of human cord blood sample yield mesenchymal stem cells (MSC). After characterization, they subsequently injected stem cells into NOD/SCID mice following low dose irradiation. They reported small number of human-derived airway epithelial cells up to three months following the injection. This study demonstrated that MSCs obtained from human umbilical cord blood can engraft NOD/SCID mice airway following low dose irradiation. However, the yield of engraftment is not significantly better than that achieved with bone marrow-derived MSCs. Although this study did not show benefit of MSCs derived from cord blood over bone marrow cells, this is a well-designed study.
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(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 701-711
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Sueblinvong, V.1
Loi, R.2
Eisenhauer, P.L.3
Bernstein, I.M.4
Suratt, B.T.5
Spees, J.L.6
Weiss, D.J.7
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3
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31944451977
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Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells
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Loi R., Beckett T., Goncz K.K., Suratt B.T., and Weiss D.J. Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells. Am J Respir Crit Care Med 173 (2006) 171-179
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(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 171-179
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Loi, R.1
Beckett, T.2
Goncz, K.K.3
Suratt, B.T.4
Weiss, D.J.5
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4
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47149090755
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Endothelial progenitor cells: new perspectives and applications in cardiovascular therapies
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This article by Marsboom et al. reviewed literature over the past 10 years on endothelial progenitor cells (EPC) and their role in cardiovascular diseases. The field of EPCs has advanced rapidly and now, although limited, there are clinical trials underway including pilot trial in patients with pulmonary hypertension. This is an excellent review on EPCs and related translational research.
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Marsboom G., and Janssens S. Endothelial progenitor cells: new perspectives and applications in cardiovascular therapies. Expert Rev Cardiovasc Ther 6 (2008) 687-701. This article by Marsboom et al. reviewed literature over the past 10 years on endothelial progenitor cells (EPC) and their role in cardiovascular diseases. The field of EPCs has advanced rapidly and now, although limited, there are clinical trials underway including pilot trial in patients with pulmonary hypertension. This is an excellent review on EPCs and related translational research.
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(2008)
Expert Rev Cardiovasc Ther
, vol.6
, pp. 687-701
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Marsboom, G.1
Janssens, S.2
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5
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34848869955
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Depletion of endothelial progenitor cells may link pulmonary fibrosis and pulmonary hypertension
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author reply 725
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Fadini G.P., Schiavon M., Rea F., Avogaro A., and Agostini C. Depletion of endothelial progenitor cells may link pulmonary fibrosis and pulmonary hypertension. Am J Respir Crit Care Med 176 (2007) 724-725 author reply 725
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(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 724-725
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Fadini, G.P.1
Schiavon, M.2
Rea, F.3
Avogaro, A.4
Agostini, C.5
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6
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34047108549
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Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial
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Wang X.X., Zhang F.R., Shang Y.P., Zhu J.H., Xie X.D., Tao Q.M., and Chen J.Z. Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial. J Am Coll Cardiol 49 (2007) 1566-1571
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(2007)
J Am Coll Cardiol
, vol.49
, pp. 1566-1571
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Wang, X.X.1
Zhang, F.R.2
Shang, Y.P.3
Zhu, J.H.4
Xie, X.D.5
Tao, Q.M.6
Chen, J.Z.7
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7
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49349116828
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Safety and efficacy of autologous endothelial progenitor cells transplantation in children with idiopathic pulmonary arterial hypertension: Open-label pilot study
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This article by Zhu et al. is done to look at the safety and efficacy of autologous endothelial progenitor cells (EPC) transplantation in children with idiopathic pulmonary arterial hypertension (IPAH). This group from China previously reported potential benefit of autologous EPC transplantation in adult with IPAH (see reference [6]). This study was performed with 13 children with IPAH receiving intravenous infusion of autologous EPC and found an improvement in functional class based on NYHA classification, 6-min walk distance, mean pulmonary artery pressure, and cardiac output at 12 weeks. This is an interesting study; however, longer follow up time to assess for potential side effects would be required. Further, a larger multi-center trial to establish the efficacy would be important.
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Zhu J.H., Wang X.X., Zhang F.R., Shang Y.P., Tao Q.M., and Chen J.Z. Safety and efficacy of autologous endothelial progenitor cells transplantation in children with idiopathic pulmonary arterial hypertension: Open-label pilot study. Pediatr Transplant 12 (2008) 650-655. This article by Zhu et al. is done to look at the safety and efficacy of autologous endothelial progenitor cells (EPC) transplantation in children with idiopathic pulmonary arterial hypertension (IPAH). This group from China previously reported potential benefit of autologous EPC transplantation in adult with IPAH (see reference [6]). This study was performed with 13 children with IPAH receiving intravenous infusion of autologous EPC and found an improvement in functional class based on NYHA classification, 6-min walk distance, mean pulmonary artery pressure, and cardiac output at 12 weeks. This is an interesting study; however, longer follow up time to assess for potential side effects would be required. Further, a larger multi-center trial to establish the efficacy would be important.
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(2008)
Pediatr Transplant
, vol.12
, pp. 650-655
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Zhu, J.H.1
Wang, X.X.2
Zhang, F.R.3
Shang, Y.P.4
Tao, Q.M.5
Chen, J.Z.6
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8
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49449093753
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Engineering of a complex organ: progress toward development of a tissue-engineered lung
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This is an excellent review article by Nichols and Cortiella on the rapid advancing field of lung tissue engineering. This article reviewed the overall tissue engineering with in-depth discussion on issues pertaining to complexity of the lung. It is a well structured and concise review of current status of this field.
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Nichols J.E., and Cortiella J. Engineering of a complex organ: progress toward development of a tissue-engineered lung. Proc Am Thorac Soc 5 (2008) 723-730. This is an excellent review article by Nichols and Cortiella on the rapid advancing field of lung tissue engineering. This article reviewed the overall tissue engineering with in-depth discussion on issues pertaining to complexity of the lung. It is a well structured and concise review of current status of this field.
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(2008)
Proc Am Thorac Soc
, vol.5
, pp. 723-730
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Nichols, J.E.1
Cortiella, J.2
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9
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64749095000
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3d collagen cultures under well-defined dynamic strain: a novel strain device with a porous elastomeric support
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Tomei et al. presented a unique composite matrix and strain device for culturing cells in physiological, mechanically dynamic three-dimensional environment using engineered polyurethane sponge computerized strain device. Over the past few decades, it is well accepted that dynamic stresses and strains have an impact on cells and tissues organization. This study reported a potential device to be used in combination of stem cells for potential tissue engineering of the lung.
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Tomei A.A., Boschetti F., Gervaso F., and Swartz M.A. 3d collagen cultures under well-defined dynamic strain: a novel strain device with a porous elastomeric support. Biotechnol Bioeng 103 (2009) 217-225. Tomei et al. presented a unique composite matrix and strain device for culturing cells in physiological, mechanically dynamic three-dimensional environment using engineered polyurethane sponge computerized strain device. Over the past few decades, it is well accepted that dynamic stresses and strains have an impact on cells and tissues organization. This study reported a potential device to be used in combination of stem cells for potential tissue engineering of the lung.
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(2009)
Biotechnol Bioeng
, vol.103
, pp. 217-225
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Tomei, A.A.1
Boschetti, F.2
Gervaso, F.3
Swartz, M.A.4
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10
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50249158511
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Mesenchymal stem cells in health and disease
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Uccelli A., Moretta L., and Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 8 (2008) 726-736
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(2008)
Nat Rev Immunol
, vol.8
, pp. 726-736
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Uccelli, A.1
Moretta, L.2
Pistoia, V.3
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11
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43649097601
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Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies
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Iyer S.S., and Rojas M. Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies. Expert Opin Biol Ther 8 (2008) 569-581
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(2008)
Expert Opin Biol Ther
, vol.8
, pp. 569-581
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Iyer, S.S.1
Rojas, M.2
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12
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23244448042
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Stem cells and pulmonary metamorphosis: new concepts in repair and regeneration
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Aliotta J.M., Passero M., Meharg J., Klinger J., Dooner M.S., Pimentel J., and Quesenberry P.J. Stem cells and pulmonary metamorphosis: new concepts in repair and regeneration. J Cell Physiol 204 (2005) 725-741
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(2005)
J Cell Physiol
, vol.204
, pp. 725-741
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Aliotta, J.M.1
Passero, M.2
Meharg, J.3
Klinger, J.4
Dooner, M.S.5
Pimentel, J.6
Quesenberry, P.J.7
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14
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21044459524
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Bone marrow-derived SP cells can contribute to the respiratory tract of mice in vivo
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It has been shown that bone marrow-derived cells could contribute to cells of other organs including lung. This study by Macpherson et al. further defined the specific bone marrow cell populations called side population (SP). They demonstrated increased survival among lethally irradiated mice receiving systemic injection of these cells. They found that only 0.8% of tracheal epithelial cells are donor in origin. Although, they did not find an increase in donor-derived cells engrafted in recipient airways as compared to other studies using bone marrow-derived mesenchymal stem cells (MSC) or stromal cells, this study showed that SP might also have the same immunomodulatory effect as MSC as demonstrated by improvement in mortality in lethally irradiated mice received cells.
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Macpherson H., Keir P., Webb S., Samuel K., Boyle S., Bickmore W., Forrester L., and Dorin J. Bone marrow-derived SP cells can contribute to the respiratory tract of mice in vivo. J Cell Sci 118 (2005) 2441-2450. It has been shown that bone marrow-derived cells could contribute to cells of other organs including lung. This study by Macpherson et al. further defined the specific bone marrow cell populations called side population (SP). They demonstrated increased survival among lethally irradiated mice receiving systemic injection of these cells. They found that only 0.8% of tracheal epithelial cells are donor in origin. Although, they did not find an increase in donor-derived cells engrafted in recipient airways as compared to other studies using bone marrow-derived mesenchymal stem cells (MSC) or stromal cells, this study showed that SP might also have the same immunomodulatory effect as MSC as demonstrated by improvement in mortality in lethally irradiated mice received cells.
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(2005)
J Cell Sci
, vol.118
, pp. 2441-2450
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Macpherson, H.1
Keir, P.2
Webb, S.3
Samuel, K.4
Boyle, S.5
Bickmore, W.6
Forrester, L.7
Dorin, J.8
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15
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24344448730
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Bone marrow-derived mesenchymal stem cells in repair of the injured lung
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Rojas M., Xu J., Woods C.R., Mora A.L., Spears W., Roman J., and Brigham K.L. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 33 (2005) 145-152
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(2005)
Am J Respir Cell Mol Biol
, vol.33
, pp. 145-152
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Rojas, M.1
Xu, J.2
Woods, C.R.3
Mora, A.L.4
Spears, W.5
Roman, J.6
Brigham, K.L.7
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16
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34547948216
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Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis
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Spees J.L., Pociask D.A., Sullivan D.E., Whitney M.J., Lasky J.A., Prockop D.J., and Brody A.R. Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis. Am J Respir Crit Care Med 176 (2007) 385-394
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(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 385-394
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Spees, J.L.1
Pociask, D.A.2
Sullivan, D.E.3
Whitney, M.J.4
Lasky, J.A.5
Prockop, D.J.6
Brody, A.R.7
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17
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42049123439
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Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension
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Spees J.L., Whitney M.J., Sullivan D.E., Lasky J.A., Laboy M., Ylostalo J., and Prockop D.J. Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension. FASEB J 22 (2008) 1226-1236
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(2008)
FASEB J
, vol.22
, pp. 1226-1236
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Spees, J.L.1
Whitney, M.J.2
Sullivan, D.E.3
Lasky, J.A.4
Laboy, M.5
Ylostalo, J.6
Prockop, D.J.7
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18
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34848831817
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Gene delivery by the hsp-b promoter to lung alveolar type ii epithelial cells in lal-knockout mice through bone marrow mesenchymal stem cells
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Yan C., Lian X., Dai Y., Wang X., Qu P., White A., Qin Y., and Du H. Gene delivery by the hsp-b promoter to lung alveolar type ii epithelial cells in lal-knockout mice through bone marrow mesenchymal stem cells. Gene Ther 14 (2007) 1461-1470
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(2007)
Gene Ther
, vol.14
, pp. 1461-1470
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Yan, C.1
Lian, X.2
Dai, Y.3
Wang, X.4
Qu, P.5
White, A.6
Qin, Y.7
Du, H.8
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19
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34548610480
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Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice
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Gupta N., Su X., Popov B., Lee J.W., Serikov V., and Matthay M.A. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 179 (2007) 1855-1863
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(2007)
J Immunol
, vol.179
, pp. 1855-1863
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Gupta, N.1
Su, X.2
Popov, B.3
Lee, J.W.4
Serikov, V.5
Matthay, M.A.6
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20
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55049093300
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Characterization of side population cells from human airway epithelium
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Hackett T.L., Shaheen F., Johnson A., Wadsworth S., Pechkovsky D.V., Jacoby D.B., Kicic A., Stick S.M., and Knight D.A. Characterization of side population cells from human airway epithelium. Stem Cells 26 (2008) 2576-2585
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(2008)
Stem Cells
, vol.26
, pp. 2576-2585
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Hackett, T.L.1
Shaheen, F.2
Johnson, A.3
Wadsworth, S.4
Pechkovsky, D.V.5
Jacoby, D.B.6
Kicic, A.7
Stick, S.M.8
Knight, D.A.9
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21
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33751223869
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Engraftment of marrow-derived epithelial cells: the role of fusion
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This is one of the studies that identify fusion as a potential mechanism in which stem cells engrafted and differentiate into airway epithelial cells.
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Herzog E.L., and Krause D.S. Engraftment of marrow-derived epithelial cells: the role of fusion. Proc Am Thorac Soc 3 (2006) 691-695. This is one of the studies that identify fusion as a potential mechanism in which stem cells engrafted and differentiate into airway epithelial cells.
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(2006)
Proc Am Thorac Soc
, vol.3
, pp. 691-695
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Herzog, E.L.1
Krause, D.S.2
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22
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0037418179
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Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma
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Spees J.L., Olson S.D., Ylostalo J., Lynch P.J., Smith J., Perry A., Peister A., Wang M.Y., and Prockop D.J. Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc Natl Acad Sci U S A 100 (2003) 2397-2402
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(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 2397-2402
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Spees, J.L.1
Olson, S.D.2
Ylostalo, J.3
Lynch, P.J.4
Smith, J.5
Perry, A.6
Peister, A.7
Wang, M.Y.8
Prockop, D.J.9
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23
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46249127489
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A gata6-wnt pathway required for epithelial stem cell development and airway regeneration
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Zhang Y., Goss A.M., Cohen E.D., Kadzik R., Lepore J.J., Muthukumaraswamy K., Yang J., DeMayo F.J., Whitsett J.A., Parmacek M.S., et al. A gata6-wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet 40 (2008) 862-870
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(2008)
Nat Genet
, vol.40
, pp. 862-870
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Zhang, Y.1
Goss, A.M.2
Cohen, E.D.3
Kadzik, R.4
Lepore, J.J.5
Muthukumaraswamy, K.6
Yang, J.7
DeMayo, F.J.8
Whitsett, J.A.9
Parmacek, M.S.10
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24
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34748870750
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Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: a novel mechanism for phenotype modulation
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•,22]), this study reported a novel concept of microvesicles for RNA transfer between mature cells and stem cells.
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•,22]), this study reported a novel concept of microvesicles for RNA transfer between mature cells and stem cells.
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(2007)
Stem Cells
, vol.25
, pp. 2245-2256
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Aliotta, J.M.1
Sanchez-Guijo, F.M.2
Dooner, G.J.3
Johnson, K.W.4
Dooner, M.S.5
Greer, K.A.6
Greer, D.7
Pimentel, J.8
Kolankiewicz, L.M.9
Puente, N.10
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25
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58149185597
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The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles
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Quesenberry P.J., and Aliotta J.M. The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles. Stem Cell Rev 4 (2008) 137-147
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(2008)
Stem Cell Rev
, vol.4
, pp. 137-147
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Quesenberry, P.J.1
Aliotta, J.M.2
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26
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35548992707
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Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury
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Kahler C.M., Wechselberger J., Hilbe W., Gschwendtner A., Colleselli D., Niederegger H., Boneberg E.M., Spizzo G., Wendel A., Gunsilius E., et al. Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury. Respir Res 8 (2007) 50
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(2007)
Respir Res
, vol.8
, pp. 50
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Kahler, C.M.1
Wechselberger, J.2
Hilbe, W.3
Gschwendtner, A.4
Colleselli, D.5
Niederegger, H.6
Boneberg, E.M.7
Spizzo, G.8
Wendel, A.9
Gunsilius, E.10
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27
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47149101095
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Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia
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Suzuki H., Hogg J.C., and van Eeden S.F. Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia. Respir Res 9 (2008) 25
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(2008)
Respir Res
, vol.9
, pp. 25
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Suzuki, H.1
Hogg, J.C.2
van Eeden, S.F.3
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28
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34548164083
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Injured microenvironment directly guides the differentiation of engrafted flk-1(+) mesenchymal stem cell in lung
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Yan X., Liu Y., Han Q., Jia M., Liao L., Qi M., and Zhao R.C. Injured microenvironment directly guides the differentiation of engrafted flk-1(+) mesenchymal stem cell in lung. Exp Hematol 35 (2007) 1466-1475
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(2007)
Exp Hematol
, vol.35
, pp. 1466-1475
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Yan, X.1
Liu, Y.2
Han, Q.3
Jia, M.4
Liao, L.5
Qi, M.6
Zhao, R.C.7
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29
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33750602761
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Reduced irradiation pulmonary fibrosis and stromal cell migration in smad3-/- marrow chimeric mice
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Epperly M.W., Franicola D., Zhang X., Nie S., Wang H., Bahnson A.B., Shields D.S., Goff J.P., Shen H., and Greenberger J.S. Reduced irradiation pulmonary fibrosis and stromal cell migration in smad3-/- marrow chimeric mice. In Vivo 20 (2006) 573-582
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(2006)
In Vivo
, vol.20
, pp. 573-582
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Epperly, M.W.1
Franicola, D.2
Zhang, X.3
Nie, S.4
Wang, H.5
Bahnson, A.B.6
Shields, D.S.7
Goff, J.P.8
Shen, H.9
Greenberger, J.S.10
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30
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65749119942
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Mesenchymal stem cells induce a weak immune response in the rat striatum after allo or xenotransplantation
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[Epub ahead of print]
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Rossignol J., Boyer C., Thinard R., Remy S., Dugast A.S., Dubayle D., Dey N.D., Boeffard F., Delecrin J., Heymann D., et al. Mesenchymal stem cells induce a weak immune response in the rat striatum after allo or xenotransplantation. J Cell Mol Med (2009) [Epub ahead of print]
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(2009)
J Cell Mol Med
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Rossignol, J.1
Boyer, C.2
Thinard, R.3
Remy, S.4
Dugast, A.S.5
Dubayle, D.6
Dey, N.D.7
Boeffard, F.8
Delecrin, J.9
Heymann, D.10
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31
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34247645937
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Functional expression of n-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells
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Viswanathan A., Painter R.G., Lanson Jr. N.A., and Wang G. Functional expression of n-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells. Stem Cells 25 (2007) 1263-1269
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(2007)
Stem Cells
, vol.25
, pp. 1263-1269
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Viswanathan, A.1
Painter, R.G.2
Lanson Jr., N.A.3
Wang, G.4
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32
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54249094572
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Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea
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Omori K., Tada Y., Suzuki T., Nomoto Y., Matsuzuka T., Kobayashi K., Nakamura T., Kanemaru S., Yamashita M., and Asato R. Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea. Ann Otol Rhinol Laryngol 117 (2008) 673-678
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(2008)
Ann Otol Rhinol Laryngol
, vol.117
, pp. 673-678
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Omori, K.1
Tada, Y.2
Suzuki, T.3
Nomoto, Y.4
Matsuzuka, T.5
Kobayashi, K.6
Nakamura, T.7
Kanemaru, S.8
Yamashita, M.9
Asato, R.10
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33
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50849117801
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Evaluation of diaphragmatic hernia repair using plga mesh-collagen sponge hybrid scaffold: an experimental study in a rat model
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Urita Y., Komuro H., Chen G., Shinya M., Saihara R., and Kaneko M. Evaluation of diaphragmatic hernia repair using plga mesh-collagen sponge hybrid scaffold: an experimental study in a rat model. Pediatr Surg Int 24 (2008) 1041-1045
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