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Volumn 9, Issue 3, 2009, Pages 268-273

Cell therapy approaches for lung diseases: current status

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; STEROID;

EID: 65749107312     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2009.03.002     Document Type: Review
Times cited : (70)

References (52)
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    • This article by Sueblinvong et al. reported the use of cord blood as a source of mesenchymal stem cells. The authors reported approximately 39% of human cord blood sample yield mesenchymal stem cells (MSC). After characterization, they subsequently injected stem cells into NOD/SCID mice following low dose irradiation. They reported small number of human-derived airway epithelial cells up to three months following the injection. This study demonstrated that MSCs obtained from human umbilical cord blood can engraft NOD/SCID mice airway following low dose irradiation. However, the yield of engraftment is not significantly better than that achieved with bone marrow-derived MSCs. Although this study did not show benefit of MSCs derived from cord blood over bone marrow cells, this is a well-designed study.
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    • This article by Marsboom et al. reviewed literature over the past 10 years on endothelial progenitor cells (EPC) and their role in cardiovascular diseases. The field of EPCs has advanced rapidly and now, although limited, there are clinical trials underway including pilot trial in patients with pulmonary hypertension. This is an excellent review on EPCs and related translational research.
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    • This article by Zhu et al. is done to look at the safety and efficacy of autologous endothelial progenitor cells (EPC) transplantation in children with idiopathic pulmonary arterial hypertension (IPAH). This group from China previously reported potential benefit of autologous EPC transplantation in adult with IPAH (see reference [6]). This study was performed with 13 children with IPAH receiving intravenous infusion of autologous EPC and found an improvement in functional class based on NYHA classification, 6-min walk distance, mean pulmonary artery pressure, and cardiac output at 12 weeks. This is an interesting study; however, longer follow up time to assess for potential side effects would be required. Further, a larger multi-center trial to establish the efficacy would be important.
    • Zhu J.H., Wang X.X., Zhang F.R., Shang Y.P., Tao Q.M., and Chen J.Z. Safety and efficacy of autologous endothelial progenitor cells transplantation in children with idiopathic pulmonary arterial hypertension: Open-label pilot study. Pediatr Transplant 12 (2008) 650-655. This article by Zhu et al. is done to look at the safety and efficacy of autologous endothelial progenitor cells (EPC) transplantation in children with idiopathic pulmonary arterial hypertension (IPAH). This group from China previously reported potential benefit of autologous EPC transplantation in adult with IPAH (see reference [6]). This study was performed with 13 children with IPAH receiving intravenous infusion of autologous EPC and found an improvement in functional class based on NYHA classification, 6-min walk distance, mean pulmonary artery pressure, and cardiac output at 12 weeks. This is an interesting study; however, longer follow up time to assess for potential side effects would be required. Further, a larger multi-center trial to establish the efficacy would be important.
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    • This is an excellent review article by Nichols and Cortiella on the rapid advancing field of lung tissue engineering. This article reviewed the overall tissue engineering with in-depth discussion on issues pertaining to complexity of the lung. It is a well structured and concise review of current status of this field.
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    • It has been shown that bone marrow-derived cells could contribute to cells of other organs including lung. This study by Macpherson et al. further defined the specific bone marrow cell populations called side population (SP). They demonstrated increased survival among lethally irradiated mice receiving systemic injection of these cells. They found that only 0.8% of tracheal epithelial cells are donor in origin. Although, they did not find an increase in donor-derived cells engrafted in recipient airways as compared to other studies using bone marrow-derived mesenchymal stem cells (MSC) or stromal cells, this study showed that SP might also have the same immunomodulatory effect as MSC as demonstrated by improvement in mortality in lethally irradiated mice received cells.
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    • Ortiz et al. reported a potential mechanism in which mesenchymal stem cells (MSC) attenuate inflammation and fibrosis in bleomycin-induced lung injury. It is one of the first studies to identify a potential molecule produced by MSC. It is a well-designed study. Although, more than one mechanism might be responsible for anti-inflammatory effect by MSC, this article is one of the important article to review in this field.
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    • U.S. National institutes of health 2008. http://clinicaltrials.gov, An excellent resource of ongoing clinical trials related to stem cells in variety of diseases including COPD, pulmonary hypertension, etc.
    • U.S. National institutes of health 2008. http://clinicaltrials.gov, An excellent resource of ongoing clinical trials related to stem cells in variety of diseases including COPD, pulmonary hypertension, etc.
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