Oxo-heterocyclic fused naphthalimides as antitumor agents: Synthesis and biological evaluation

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 130-138

  Tan, Shaoying ^a,c   Yin, Hong ^b,c   Chen, Zhuo ^c   Qian, Xuhong ^a,b,c   Xu, Yufang ^a,b,c  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antitumor agents; DNA intercalation; Naphthalimides; Oxo heterocyclic; Topo I; Topo II

Indexed keywords

AMONAFIDE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; GYRASE INHIBITOR; N (2' PIPERAZIDINE ETHYL) BENZO[B]FURANO[2,1 C]NAPHTHALIMIDE; N (2' PIPERAZIDINE ETHYL) BENZO[K,L]XANTHENE 3,4 NAPHTHALIMIDE; N (BUTYL) BENZO[B]FURANO[2,1 C]NAPHTHALIMIDE; N (BUTYL) BENZO[K,L]XANTHENE 3,4 NAPHTHALIMIDE; N (N',N' DIMETHYLAMINE ETHYL) 9 (2' METHOXY PHENYL) OXAZOLE[4,5 C] NAPHTHALIMIDE; N (N',N' DIMETHYLAMINE ETHYL) 9 (4' CHLORO PHENYL) OXAZOLE[4,5 C] NAPHTHALIMIDE; N (N',N' DIMETHYLAMINE ETHYL) 9 (4' METHOXY PHENYL) OXAZOLE[4,5 C] NAPHTHALIMIDE; N (N',N' DIMETHYLAMINE ETHYL) 9 (4' METHYL PHENYL) OXAZOLE[4,5 C] NAPHTHALIMIDE; N (N',N' DIMETHYLAMINE ETHYL) 9 (4' NITRO PHENYL) OXAZOLE[4,5 C] NAPHTHALIMIDE; N (N',N' DIMETHYLAMINE ETHYL) 9 PHENYL OXAZOLE[4,5 C] NAPHTHALIMIDE; N (N',N' DIMETHYLAMINE ETHYL) BENZO[B]FURANO[2,1 C]NAPHTHALIMIDE; N (N',N' DIMETHYLAMINE ETHYL) BENZO[K,L]XANTHENE 3,4 NAPHTHALIMIDE; N (N',N' DIMETHYLAMINE PROPYL) BENZO[B]FURANO[2,1 C]NAPHTHALIMIDE; N (N',N' DIMETHYLAMINE PROPYL) BENZO[K,L]XANTHENE 3,4 NAPHTHALIMIDE; NAPHTHALIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CIRCULAR DICHROISM; DNA SEQUENCE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LUNG CANCER; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HETEROCYCLIC COMPOUNDS; HUMANS; MICE; MOLECULAR STRUCTURE; NAPHTHALIMIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872685443     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.039     Document Type: Article

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