B1, a novel naphthalimide-based DNA intercalator, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation

Investigational New Drugs

Volumn 29, Issue 4, 2011, Pages 646-658

  Liang, Xin ^a   Wu, Aibin ^a   Xu, Yufang ^a   Xu, Ke ^a   Liu, Jianwen ^a   Qian, Xuhong ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; B1; Cell cycle arrest; Cervix carcinoma; p53

Indexed keywords

B 1; CYTOCHROME C; INTERCALATING AGENT; MITOCHONDRIAL ENZYME; N [2 (DIMETHYLAMINO)ETHYL] 2 AMINOTHIAZONAPHTHALIMIDE; NAPHTHALIMIDE DERIVATIVE; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; ENZYME RELEASE; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA;

APOPTOSIS; BENZOTHIAZOLES; CASPASES; CELL CYCLE; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CYTOCHROMES C; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; FLUORESCENCE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; INTERCALATING AGENTS; MITOCHONDRIA; NAPHTHALIMIDES; NECROSIS; RNA, MESSENGER; RNA, SMALL INTERFERING; STAINING AND LABELING; TIME FACTORS; TUMOR STEM CELL ASSAY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79959719799     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9403-9     Document Type: Article

References (30)

1. Viglasky V, Danko P (2007) Intercalators: contra cruciform extrusion in DNA. Anal Biochem 360:7-13 (Pubitemid 44894356)
2. Berman HM, Young PR (1981) The interaction of intercalating drugs with nucleic acids. Annu Rev Biophys Bioeng 10:87-114
3. WilsonWD, Jones RL (1981) Intercalating drugs: DNA binding and molecular pharmacology. Adv Pharmacol Chemother 18:177-222
4. Martinez R, Chacon-Garcia L (2005) The search of DNA intercalators as antitumoral drugs: what it worked and what did not work. Curr Med Chem 12:127-151 (Pubitemid 40089830)
5. Qian XH, Li ZG, Yang Q (2007) Highly efficient antitumor agents of heterocycles containing sulfur atom: Linear and angular thiazonaphthalimides against human lung cancer cell in vitro. Bioorgan Med Chem 15:6846-6851
6. Benchimol S (2001) P53-dependent pathways of apoptosis. Cell Death Differ 8:1049-1051
7. WAF1/CIP1 pathway. Cancer Sci 97:430-436
8. Colman MS, Afshari CA, Barrett JC (2000) Regulation of p53 stability and activity in response to genotoxic stress. Mutat Res 462:179-188 (Pubitemid 30190225)
9. Liu LJ, Yang F, Zhang Y, Li JL (2007) Studies on the cell immunosuppressive mechanism of Oridonin from Isodon serra. Int Immunopharm 7:945-954 (Pubitemid 46702844)
10. 2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Cancer Lett 241:102-109
11. Verma M, Singh SK, Bhushan S et al (2008) In vitro cytotoxic potential of Polyalthia longifolia on human cancer cell lines and induction of apoptosis through mitochondrial-dependent pathway in HL-60 cells. Chem-Biol Interact 171:45-56
12. Levites Y, Youdim MBH, Maor G, Mandel S (2002) Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclearfactor-kappa B (NF-kappa B) activation and cell death by tea extracts in neuronal cultures. Biochem Pharmacol 63:21-29 (Pubitemid 34075289)
13. Zhang J, Shen YL, Liu JW, Wei DZ (2005) Antimetastatic effect of prodigiosin through inhibition of tumor invasion. Biochem Pharmacol 69:407-414 (Pubitemid 40094501)
14. Liu Y, Zhang SP, Cai YQ (2007) Cytoprotective effects of selenium on cadmium-induced LLC-PK1 cells apoptosis by activating JNK pathway. Toxicol In Vitro 21:677-684 (Pubitemid 46550757)
15. 2/M checkpoints of the cell cycle in EBV-lymphocytes. Apoptosis 8:399-406
16. Li CL, Wu HZ, Xu W et al (2008) 6-O-Angeloylenolin induces apoptosis through a mitochondrial/caspase and NF-κB pathway in human leukemia HL60 cell. Biomed Pharmacother 62:401-409
17. Rello S, Stockert JC, Moreno V et al (2005) Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments. Apoptosis 10:201-208 (Pubitemid 40558128)
18. Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000) The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 14:289-300 (Pubitemid 30106484)
19. 1 arrest in resulting tetraploid cells. Cancer Res 61:7660-7668
20. Haupt S, Berger M, Goldberg Z, Haupt Y (2003) Apoptosis - the p53 network. J Cell Sci 116:4077-4085 (Pubitemid 37337082)
21. 2 checkpoint through Cyclin B1. Proc Natl Acad Sci USA 96:2147-2152
22. Sherr CJ (2000) The Pezcoller lecture: cancer cell cycles revisited. Cancer Res 60:3689-3695
23. Mousli M, Hopfner R, Abbady AQ et al (2003) ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. Brit J Cancer 89:120-127 (Pubitemid 36897947)
24. Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition. Genes Cells 9:131-142
25. Hu W, Kavanagh JJ (2003) Anticancer therapy targeting the apoptotic pathway. Lancet Oncol 4:721-729 (Pubitemid 37527207)
26. Andrew M (1995) Cyclin ubiquitination: the destructive end of mitosis. Cell 81:149-152
27. Antonsson B, Martinou JC (2000) The Bcl-2 protein family. Exp Cell Res 256:50-57 (Pubitemid 30211166)
28. Reed JC (1997) Double identity for proteins of the Bcl-2 family. Nature 387:773-776
29. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326:1-16
30. Ashkenazi A, Dixit VM (1998) Death receptor: signaling and modulation. Science 281:1305-1308