Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells

Biochemical Pharmacology

Volumn 85, Issue 3, 2013, Pages 426-438

  Schaefer, Eva A M ^a   Stohr, Stefanie ^a   Meister, Michael ^b,d   Aigner, Achim ^c   Gudermann, Thomas ^a,d   Buech, Thomas R H ^a,c  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d German Center for Lung Research (DZL)   (Germany)

Author keywords

Calcium signaling; Chemosensory ion channels; Lung cancer; TRPA1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALLYL ISOTHIOCYANATE; AP 18; CALCIUM; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; FORMALDEHYDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLASMID DNA; TOXIC SUBSTANCE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; VOLATILE AGENT;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CANCER CELL; CARCINOGENESIS; CELL GROWTH; CELL STRAIN HEK293; CELL SURVIVAL; CHEMOSENSITIVITY; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; LUNG SMALL CELL CANCER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SRC HOMOLOGY DOMAIN;

CALCIUM; CALCIUM CHANNELS; CELL SURVIVAL; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, SRC; HUMANS; ISOTHIOCYANATES; NERVE TISSUE PROTEINS; RNA, MESSENGER; SMALL CELL LUNG CARCINOMA; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TUMOR CELLS, CULTURED; VOLATILE ORGANIC COMPOUNDS;

EID: 84872676834     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.11.019     Document Type: Article

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