메뉴 건너뛰기




Volumn 16, Issue 5, 2010, Pages 1402-1415

Critical role of Gα12 and Gα13 for human small cell lung cancer cell proliferation in vitro and tumor growth in vivo

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BRADYKININ; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN SUBUNIT; SHORT HAIRPIN RNA;

EID: 77649097719     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-09-1873     Document Type: Article
Times cited : (32)

References (51)
  • 1
    • 1542290456 scopus 로고    scopus 로고
    • G proteins in cancer: The prostate cancer paradigm
    • Daaka Y. G proteins in cancer: the prostate cancer paradigm. Sci STKE 2004;2004:re2.
    • (2004) Sci STKE 2004
    • Daaka, Y.1
  • 2
    • 0031051444 scopus 로고    scopus 로고
    • Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins
    • Fields TA, Casey PJ. Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. Biochem J 1997;321:561-71.
    • (1997) Biochem J , vol.321 , pp. 561-571
    • Fields, T.A.1    Casey, P.J.2
  • 4
    • 33846474121 scopus 로고    scopus 로고
    • G-protein-coupled receptors and cancer
    • Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007;7:79-94.
    • (2007) Nat Rev Cancer , vol.7 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 5
    • 0035952689 scopus 로고    scopus 로고
    • Transforming G proteins
    • Radhika V, Dhanasekaran N. Transforming G proteins. Oncogene 2001;20:1607-14.
    • (2001) Oncogene , vol.20 , pp. 1607-1614
    • Radhika, V.1    Dhanasekaran, N.2
  • 7
    • 0027217195 scopus 로고
    • A mutant α subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells
    • Xu N, Bradley L, Ambdukar I, Gutkind JS. A mutant α subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells. Proc Natl Acad Sci U S A 1993;90:6741-5.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6741-6745
    • Xu, N.1    Bradley, L.2    Ambdukar, I.3    Gutkind, J.S.4
  • 8
    • 69249209731 scopus 로고    scopus 로고
    • Role of G12 proteins in oncogenesis and metastasis
    • Juneja J, Casey PJ. Role of G12 proteins in oncogenesis and metastasis. Br J Pharmacol 2009;158:32-40.
    • (2009) Br J Pharmacol , vol.158 , pp. 32-40
    • Juneja, J.1    Casey, P.J.2
  • 9
    • 33744459471 scopus 로고    scopus 로고
    • The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis
    • Kelly P, Moeller BJ, Juneja J, et al. The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A 2006;103:8173-8.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 8173-8178
    • Kelly, P.1    Moeller, B.J.2    Juneja, J.3
  • 10
    • 33748744077 scopus 로고    scopus 로고
    • A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion
    • Kelly P, Stemmle LN, Madden JF, Fields TA, Daaka Y, Casey PJ. A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem 2006;281:26483-90.
    • (2006) J Biol Chem , vol.281 , pp. 26483-26490
    • Kelly, P.1    Stemmle, L.N.2    Madden, J.F.3    Fields, T.A.4    Daaka, Y.5    Casey, P.J.6
  • 11
    • 34250177985 scopus 로고    scopus 로고
    • Biologic functions of the G12 subfamily of heterotrimeric g proteins: Growth, migration, and metastasis
    • Kelly P, Casey PJ, Meigs TE. Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. Biochemistry 2007;46:6677-87.
    • (2007) Biochemistry , vol.46 , pp. 6677-6687
    • Kelly, P.1    Casey, P.J.2    Meigs, T.E.3
  • 12
    • 33750603100 scopus 로고    scopus 로고
    • Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database
    • Govindan R, Page N, Morgensztern D, et al. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 2006;24:4539-44.
    • (2006) J Clin Oncol , vol.24 , pp. 4539-4544
    • Govindan, R.1    Page, N.2    Morgensztern, D.3
  • 13
    • 0032995692 scopus 로고    scopus 로고
    • Autocrine loops, signal transduction, and cell cycle abnormalities in the molecular biology of lung cancer
    • Rozengurt E. Autocrine loops, signal transduction, and cell cycle abnormalities in the molecular biology of lung cancer. Curr Opin Oncol 1999;11:116-22.
    • (1999) Curr Opin Oncol , vol.11 , pp. 116-122
    • Rozengurt, E.1
  • 15
    • 34248597724 scopus 로고    scopus 로고
    • M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion
    • Song P, Sekhon HS, Lu A, et al. M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res 2007;67:3936-44.
    • (2007) Cancer Res , vol.67 , pp. 3936-3944
    • Song, P.1    Sekhon, H.S.2    Lu, A.3
  • 16
    • 0030614842 scopus 로고    scopus 로고
    • D-Arg1,D-Trp5,7,9, Leu11]substance P: A novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells
    • Seckl MJ, Higgins T, Widmer F, Rozengurt E. [D-Arg1,D-Trp5,7,9, Leu11]substance P: a novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells. Cancer Res 1997;57:51-4.
    • (1997) Cancer Res , vol.57 , pp. 51-54
    • Seckl, M.J.1    Higgins, T.2    Widmer, F.3    Rozengurt, E.4
  • 17
    • 0026801445 scopus 로고
    • Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo
    • Langdon S, Sethi T, Ritchie A, Muir M, Smyth J, Rozengurt E. Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo. Cancer Res 1992;52:4554-7.
    • (1992) Cancer Res , vol.52 , pp. 4554-4557
    • Langdon, S.1    Sethi, T.2    Ritchie, A.3    Muir, M.4    Smyth, J.5    Rozengurt, E.6
  • 18
    • 0026598085 scopus 로고
    • In vitro effects of substance P analogue [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P on human tumour and normal cell growth
    • Everard MJ, Macaulay VM, Miller JL, Smith IE. In vitro effects of substance P analogue [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P on human tumour and normal cell growth. Br J Cancer 1992;65: 388-92.
    • (1992) Br J Cancer , vol.65 , pp. 388-392
    • Everard, M.J.1    Macaulay, V.M.2    Miller, J.L.3    Smith, I.E.4
  • 19
    • 0025323953 scopus 로고
    • A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro
    • Woll PJ, Rozengurt E. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res 1990;50: 3968-73.
    • (1990) Cancer Res , vol.50 , pp. 3968-3973
    • Woll, P.J.1    Rozengurt, E.2
  • 20
    • 0034738958 scopus 로고    scopus 로고
    • The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins
    • Wittau N, Grosse R, Kalkbrenner F, Gohla A, Schultz G, Gudermann T. The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins. Oncogene 2000;19:4199-209.
    • (2000) Oncogene , vol.19 , pp. 4199-4209
    • Wittau, N.1    Grosse, R.2    Kalkbrenner, F.3    Gohla, A.4    Schultz, G.5    Gudermann, T.6
  • 21
    • 33846846701 scopus 로고    scopus 로고
    • Calcium-dependent growth regulation of small cell lung cancer cells by neuropeptides
    • Gudermann T, Roelle S. Calcium-dependent growth regulation of small cell lung cancer cells by neuropeptides. Endocr Related Cancer 2006;13:1069-84.
    • (2006) Endocr Related Cancer , vol.13 , pp. 1069-1084
    • Gudermann, T.1    Roelle, S.2
  • 22
    • 0030904698 scopus 로고    scopus 로고
    • Regulation of cadherin-mediated adhesion by the small GTP-binding protein Rho in small cell lung carcinoma cells
    • Tokman MG, Porter RA, Williams CL. Regulation of cadherin-mediated adhesion by the small GTP-binding protein Rho in small cell lung carcinoma cells. Cancer Res 1997;57:1785-93.
    • (1997) Cancer Res , vol.57 , pp. 1785-1793
    • Tokman, M.G.1    Porter, R.A.2    Williams, C.L.3
  • 23
    • 0642348940 scopus 로고    scopus 로고
    • Varker KA, Phelps SH, King MM, Williams CL. The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies. IntJ Oncol 2003;22:671-81.
    • Varker KA, Phelps SH, King MM, Williams CL. The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies. IntJ Oncol 2003;22:671-81.
  • 24
    • 18344388451 scopus 로고    scopus 로고
    • Bradykinin antagonist dimer, CU201, inhibits the growth of human lung cancer cell lines by a "biased agonist" mechanism
    • Chan D, Gera L, Stewart J, et al. Bradykinin antagonist dimer, CU201, inhibits the growth of human lung cancer cell lines by a "biased agonist" mechanism. Proc Natl Acad Sci U S A 2002;99: 4608-13.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 4608-4613
    • Chan, D.1    Gera, L.2    Stewart, J.3
  • 27
    • 0036351317 scopus 로고    scopus 로고
    • Analysis of gene function in somatic mammalian cells using small interfering RNAs
    • Elbashir SM, Harborth J, Weber K, Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 2002;26:199-213.
    • (2002) Methods , vol.26 , pp. 199-213
    • Elbashir, S.M.1    Harborth, J.2    Weber, K.3    Tuschl, T.4
  • 28
    • 0037084077 scopus 로고    scopus 로고
    • Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression
    • Hahn A, Barth H, Kress M, Mertens PR, Goppelt-Struebe M. Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression. Biochem J 2002;362:33-40.
    • (2002) Biochem J , vol.362 , pp. 33-40
    • Hahn, A.1    Barth, H.2    Kress, M.3    Mertens, P.R.4    Goppelt-Struebe, M.5
  • 29
    • 0025384728 scopus 로고
    • Autocrine growth stimulation by secreted Kaposi's fibroblast growth factor but not by endogenous basic fibroblast growth factor
    • Wellstein A, Lupu R, Zugmaier G, et al. Autocrine growth stimulation by secreted Kaposi's fibroblast growth factor but not by endogenous basic fibroblast growth factor. Cell Growth Differ 1990;1:63-71.
    • (1990) Cell Growth Differ , vol.1 , pp. 63-71
    • Wellstein, A.1    Lupu, R.2    Zugmaier, G.3
  • 30
    • 0036244546 scopus 로고    scopus 로고
    • Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development
    • Aigner A, Ray PE, Czubayko F, Wellstein A. Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development. Histochem Cell Biol 2002;117:1-11.
    • (2002) Histochem Cell Biol , vol.117 , pp. 1-11
    • Aigner, A.1    Ray, P.E.2    Czubayko, F.3    Wellstein, A.4
  • 31
    • 33646152761 scopus 로고    scopus 로고
    • Werth S, Urban-Klein B, Dai L, et al. A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes. J Control Release 2006;112:257-70
    • Werth S, Urban-Klein B, Dai L, et al. A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes. J Control Release 2006;112:257-70.
  • 33
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • Urban-Klein B, Werth S, Abuharbeid S, Czubayko F, Aigner A. RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther 2005;12:461-6.
    • (2005) Gene Ther , vol.12 , pp. 461-466
    • Urban-Klein, B.1    Werth, S.2    Abuharbeid, S.3    Czubayko, F.4    Aigner, A.5
  • 35
    • 40749147725 scopus 로고    scopus 로고
    • Essential role of Pyk2 and Src kinase activation in neuropeptide-induced proliferation of small cell lung cancer cells
    • Roelle S, Grosse R, Buech T, Chubanov V, Gudermann T. Essential role of Pyk2 and Src kinase activation in neuropeptide-induced proliferation of small cell lung cancer cells. Oncogene 2008;27:1737-48.
    • (2008) Oncogene , vol.27 , pp. 1737-1748
    • Roelle, S.1    Grosse, R.2    Buech, T.3    Chubanov, V.4    Gudermann, T.5
  • 36
    • 0032032681 scopus 로고    scopus 로고
    • Expression of catalytically inactive phospholipase Cβ disrupts phospholipase Cβ and mitogen-activated protein kinase signaling and inhibits small cell lung cancer growth
    • Beekman A, Helfrich B, Bunn PA, Jr., Heasley LE. Expression of catalytically inactive phospholipase Cβ disrupts phospholipase Cβ and mitogen-activated protein kinase signaling and inhibits small cell lung cancer growth. Cancer Res 1998;58:910-3.
    • (1998) Cancer Res , vol.58 , pp. 910-913
    • Beekman, A.1    Helfrich, B.2    Bunn Jr., P.A.3    Heasley, L.E.4
  • 37
    • 33947718172 scopus 로고    scopus 로고
    • Touge H, Chikumi H, Igishi T, et al. Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors. IntJ Oncol 2007;30:709-15.
    • Touge H, Chikumi H, Igishi T, et al. Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors. IntJ Oncol 2007;30:709-15.
  • 38
    • 33745861998 scopus 로고    scopus 로고
    • Involvement of Rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells
    • Li B, Zhao WD, Tan ZM, Fang WG, Zhu L, Chen YH. Involvement of Rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells. FEBS Lett 2006;580: 4252-60.
    • (2006) FEBS Lett , vol.580 , pp. 4252-4260
    • Li, B.1    Zhao, W.D.2    Tan, Z.M.3    Fang, W.G.4    Zhu, L.5    Chen, Y.H.6
  • 39
    • 0034636863 scopus 로고    scopus 로고
    • G13α-mediated PYK2 activation. PYK2 is a mediator of G13α -induced serum response element-dependent transcription
    • Shi CS, Sinnarajah S, Cho H, Kozasa T, Kehrl JH. G13α-mediated PYK2 activation. PYK2 is a mediator of G13α -induced serum response element-dependent transcription. J Biol Chem 2000;275: 24470-6.
    • (2000) J Biol Chem , vol.275 , pp. 24470-24476
    • Shi, C.S.1    Sinnarajah, S.2    Cho, H.3    Kozasa, T.4    Kehrl, J.H.5
  • 40
    • 28244459617 scopus 로고    scopus 로고
    • Radixin stimulates Rac1 and Ca2+/calmodulin-dependent kinase, CaMKII: Cross-talk with Gα13 signaling
    • Liu G, Voyno-Yasenetskaya TA. Radixin stimulates Rac1 and Ca2+/calmodulin-dependent kinase, CaMKII: cross-talk with Gα13 signaling. J Biol Chem 2005;280:39042-9.
    • (2005) J Biol Chem , vol.280 , pp. 39042-39049
    • Liu, G.1    Voyno-Yasenetskaya, T.A.2
  • 42
    • 0034647517 scopus 로고    scopus 로고
    • Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Gα q and Gá 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway
    • Fukuhara S, Marinissen MJ, Chiariello M, Gutkind JS. Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Gα q and Gá 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway. J Biol Chem 2000;275:21730-6.
    • (2000) J Biol Chem , vol.275 , pp. 21730-21736
    • Fukuhara, S.1    Marinissen, M.J.2    Chiariello, M.3    Gutkind, J.S.4
  • 44
    • 0035895142 scopus 로고    scopus 로고
    • Interaction of Gα 12 and Gα 13 with the cytoplasmic domain of cadherin provides a mechanism for β -catenin release
    • Meigs TE, Fields TA, McKee DD, Casey PJ. Interaction of Gα 12 and Gα 13 with the cytoplasmic domain of cadherin provides a mechanism for β -catenin release. Proc Natl Acad Sci U S A 2001;98:519-24.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 519-524
    • Meigs, T.E.1    Fields, T.A.2    McKee, D.D.3    Casey, P.J.4
  • 45
    • 0030611189 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation
    • Butterfield L, Storey B, Maas L, Heasley LE. c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation. J Biol Chem 1997;272:10110-6.
    • (1997) J Biol Chem , vol.272 , pp. 10110-10116
    • Butterfield, L.1    Storey, B.2    Maas, L.3    Heasley, L.E.4
  • 47
    • 34147141436 scopus 로고    scopus 로고
    • Expression of heat shock protein 70 and 27 in non-small cell lung cancer and its clinical significance
    • Huang Q, Zu Y, Fu X, Wu T. Expression of heat shock protein 70 and 27 in non-small cell lung cancer and its clinical significance. J Huazhong Univ Sci Technolog Med Sci 2005;25:693-5.
    • (2005) J Huazhong Univ Sci Technolog Med Sci , vol.25 , pp. 693-695
    • Huang, Q.1    Zu, Y.2    Fu, X.3    Wu, T.4
  • 48
    • 0023779995 scopus 로고
    • v-Ha-ras oncogene insertion: A model for tumor progression of human small cell lung cancer
    • Mabry M, Nakagawa T, Nelkin BD, et al. v-Ha-ras oncogene insertion: a model for tumor progression of human small cell lung cancer. Proc Natl Acad Sci U S A 1988;85:6523-7.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 6523-6527
    • Mabry, M.1    Nakagawa, T.2    Nelkin, B.D.3
  • 49
    • 0024334849 scopus 로고
    • Insertion of the v-Ha-ras oncogene induces differentiation of calcitonin-producing human small cell lung cancer
    • Mabry M, Nakagawa T, Baylin S, Pettengill O, Sorenson G, Nelkin B. Insertion of the v-Ha-ras oncogene induces differentiation of calcitonin-producing human small cell lung cancer. J Clin Invest 1989;84: 194-9.
    • (1989) J Clin Invest , vol.84 , pp. 194-199
    • Mabry, M.1    Nakagawa, T.2    Baylin, S.3    Pettengill, O.4    Sorenson, G.5    Nelkin, B.6
  • 50
    • 0031985094 scopus 로고    scopus 로고
    • Activated Raf-1 causes growth arrest in human small cell lung cancer cells
    • Ravi RK, Weber E, McMahon M, et al. Activated Raf-1 causes growth arrest in human small cell lung cancer cells. J Clin Invest 1998;101: 153-9.
    • (1998) J Clin Invest , vol.101 , pp. 153-159
    • Ravi, R.K.1    Weber, E.2    McMahon, M.3
  • 51
    • 0037805630 scopus 로고    scopus 로고
    • Roles of Src and epidermal growth factor receptor transactivation in transient and sustained ERK1/2 responses to gonadotropin-releasing hormone receptor activation
    • Shah BH, Farshori MP, Jambusaria A, Catt KJ. Roles of Src and epidermal growth factor receptor transactivation in transient and sustained ERK1/2 responses to gonadotropin-releasing hormone receptor activation. J Biol Chem 2003;278:19118-26.
    • (2003) J Biol Chem , vol.278 , pp. 19118-19126
    • Shah, B.H.1    Farshori, M.P.2    Jambusaria, A.3    Catt, K.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.