TRP channels in human prostate

TheScientificWorldJournal

Volumn 10, Issue , 2010, Pages 1597-1611

  Van Haute, Carl ^a   De Ridder, Dirk ^a   Nilius, Bernd ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Prostate; Prostate cancer; Prostate diseases; Transient receptor potential channels; TRP

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ANANDAMIDE; ANDROGEN; ANDROGEN RECEPTOR; ANKYRIN; CALCIUM ION; CANNABINOID DERIVATIVE; CAPSAICIN; ENDONUCLEASE; ISOENZYME; MELASTATIN; MUCOLIPIN; PHOSPHOLIPASE; PIPERIDINE; POLYCYSTIN; PROSTATE SPECIFIC ANTIGEN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEINASE; REACTIVE OXYGEN METABOLITE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; TRANSIENT RECEPTOR POTENTIAL CHANNEL 8; UBIQUINONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR; CALCIUM CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM8 PROTEIN, HUMAN; TRPV6 PROTEIN, HUMAN;

CALCIUM TRANSPORT; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER SCREENING; CARCINOGENESIS; CELL STRAIN LNCAP; GENE EXPRESSION REGULATION; GENE SILENCING; HORMONAL REGULATION; HUMAN; IMMUNOHISTOCHEMISTRY; INNERVATION; MEMBRANE TRANSPORT; MOLECULAR CLONING; MORPHOLOGY; NONHUMAN; PROSTATE; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REVIEW; TISSUE DISTRIBUTION; TUMOR GROWTH; GENETICS; HISTOLOGY; MALE; METABOLISM; PATHOLOGY; PROSTATE TUMOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CALCIUM CHANNELS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PROSTATE; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPM CATION CHANNELS; TRPV CATION CHANNELS;

EID: 78349291558     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2010.149     Document Type: Review

References (88)

1. Huggins, C. (1945) The physiology of the prostate gland. Physiol. Rev. 25, 281-295.
2. Pennefather, J.N., Lau, W.A., Mitchelson, F., and Ventura, S. (2000) The autonomic and sensory innervation of the smooth muscle of the prostate gland: a review of pharmacological and histological studies. J. Auton. Pharmacol. 20, 193-206. (Pubitemid 34211031)
3. Wein, A.J., Kavoussi, L.R., Novick, A.C., Partin, A.W., and Peters, C.A. (2007) Prostate. In Campbell-Walsh UROLOGY. Saunders Elsevier. pp. 6511-7655.
4. McNeal, J.E. (1972) The prostate and prostatic urethra: a morphologic synthesis. J. Urol. 107, 1008-1016.
5. McNeal, J.E. (1988) Normal histology of the prostate. Am. J. Surg. Pathol. 12, 619-633.
6. Isaacs, J.T. and Coffey, D.S. (1989) Etiology and disease process of benign prostatic hyperplasia. Prostate Suppl. 2, 33-50. (Pubitemid 20075619)
7. De Marzo, A.M., Meeker, A.K., Epstein, J.I., and Coffey, D.S. (1998) Prostate stem cell compartments: expression of the cell cycle inhibitor p27Kip1 in normal, hyperplastic, and neoplastic cells. Am. J. Pathol. 153, 911-919.
8. Higgins, J.R. and Gosling, J.A. (1989) Studies on the structure and intrinsic innervation of the normal human prostate. Prostate Suppl. 2, 5-16.
9. Gosling, J.A. (1983) Autonomic innervation of the prostate. In Benign Prostatic Hypertrophy. Hinman, F., Jr., Ed. Springer. pp. 349-360.
10. Crowe, R., Chapple, C.R., and Burnstock, G. (1991) The human prostate gland: a histochemical and immunohistochemical study of neuropeptides, serotonin, dopamine beta-hydroxylase and acetylcholinesterase in autonomic nerves and ganglia. Br. J. Urol. 68, 53-61.
11. Michel, M.C. and Vrydag, W. (2006) Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate. Br. J. Pharmacol. 147(Suppl. 2), S88-119.
12. Witte, L.P., Chapple, C.R., de la Rosette, J.J., and Michel, M.C. (2008) Cholinergic innervation and muscarinic receptors in the human prostate. Eur. Urol. 54, 326-334.
13. McVary, K.T., McKenna, K.E., and Lee, C. (1998) Prostate innervation. Prostate Suppl. 8, 2-13.
14. Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., and Thun, M.J. (2009) Cancer statistics, 2009. CA Cancer J. Clin. 59, 225-249.
15. Ferlay, J., Parkin, D.M., and Steliarova-Foucher, E. (2010) Estimates of cancer incidence and mortality in Europe in 2008. Eur. J. Cancer 46, 765-781.
16. Gleason, D.F. and Mellinger, G.T. (1974) Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J. Urol. 111, 58-64.
17. Huggins, C. and Hodges, C.V. (1941) Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res. 1, 293-297.
18. Kyprianou, N. and Isaacs, J.T. (1988) Activation of programmed cell death in the rat ventral prostate after castration. Endocrinology 122, 552-562. (Pubitemid 18060946)
19. So, A.I., Hurtado-Coll, A., and Gleave, M.E. (2003) Androgens and prostate cancer. World J. Urol. 21, 325-337.
20. Nilius, B., Owsianik, G., Voets, T., and Peters, J.A. (2007) Transient receptor potential cation channels in disease. Physiol. Rev. 87, 165-217. (Pubitemid 46207713)
21. Owsianik, G., D'Hoedt, D., Voets, T., and Nilius, B. (2006) Structure-function relationship of the TRP channel superfamily. Rev. Physiol. Biochem. Pharmacol. 156, 61-90.
22. Cheng, X., Shen, D., Samie, M., and Xu, H. (2010) Mucolipins: intracellular TRPML1-3 channels. FEBS Lett. 584, 2013-2021.
23. Voets, T., Talavera, K., Owsianik, G., and Nilius, B. (2005) Sensing with TRP channels. Nat. Chem. Biol. 1, 85-92.
24. Everaerts, W., Nilius, B., and Owsianik, G. (2009) The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog. Biophys. Mol. Biol. [Epub ahead of print]
25. Everaerts, W., Gevaert, T., Nilius, B., and De Ridder, D. (2008) On the origin of bladder sensing: Tr(i)ps in urology. Neurourol. Urodyn. 27, 264-273. (Pubitemid 351656394)
26. Hsu, Y.J., Hoenderop, J.G., and Bindels, R.J. (2007) TRP channels in kidney disease. Biochim. Biophys. Acta 1772, 928-936.
27. Tsavaler, L., Shapero, M.H., Morkowski, S., and Laus, R. (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res. 61, 3760-3769. (Pubitemid 32694990)
28. McKemy, D.D., Neuhausser, W.M., and Julius, D. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52-58.
29. Peier, A.M., Moqrich, A., Hergarden, A.C., Reeve, A.J., Andersson, D.A., Story, G.M., Earley, T.J., Dragoni, I., McIntyre, P., Bevan, S., and Patapoutian, A. (2002) A TRP channel that senses cold stimuli and menthol. Cell 108, 705-715. (Pubitemid 34241429)
30. Voets, T., Owsianik, G., and Nilius, B. (2007) Trpm8. Handb. Exp. Pharmacol. (179), 329-344.
31. Bidaux, G., Roudbaraki, M., Merle, C., Crepin, A., Delcourt, P., Slomianny, C., Thebault, S., Bonnal, J.L., Benahmed, M., Cabon, F., Mauroy, B., and Prevarskaya, N. (2005) Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement. Endocr. Relat. Cancer 12, 367-382.
32. Bidaux, G., Flourakis, M., Thebault, S., Zholos, A., Beck, B., Gkika, D., Roudbaraki, M., Bonnal, J.L., Mauroy, B., Shuba, Y., Skryma, R., and Prevarskaya, N. (2007) Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function. J. Clin. Invest. 117, 1647-1657.
33. Horoszewicz, J.S., Leong, S.S., Kawinski, E., Karr, J.P., Rosenthal, H., Chu, T.M., Mirand, E.A., and Murphy, G.P. (1983) LNCaP model of human prostatic carcinoma. Cancer Res. 43, 1809-1818.
34. Zhang, L. and Barritt, G.J. (2004) Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells. Cancer Res. 64, 8365-8373.
35. Reid, G. and Flonta, M.L. (2001) Physiology. Cold current in thermoreceptive neurons. Nature 413, 480.
36. Mahieu, F., Owsianik, G., Verbert, L., Janssens, A., De Smedt, H., Nilius, B., and Voets, T. (2007) TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi. J. Biol. Chem. 282, 3325-3336.
37. Bodding, M., Wissenbach, U., and Flockerzi, V. (2007) Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 42, 618-628.
38. Kim, S.H., Nam, J.H., Park, E.J., Kim, B.J., Kim, S.J., So, I., and Jeon, J.H. (2009) Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells. Biochim. Biophys. Acta 1792, 33-38.
39. Thebault, S., Lemonnier, L., Bidaux, G., Flourakis, M., Bavencoffe, A., Gordienko, D., Roudbaraki, M., Delcourt, P., Panchin, Y., Shuba, Y., Skryma, R., and Prevarskaya, N. (2005) Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells. J. Biol. Chem. 280, 39423-39435.
40. Henshall, S.M., Afar, D.E., Hiller, J., Horvath, L.G., Quinn, D.I., Rasiah, K.K., Gish, K., Willhite, D., Kench, J.G., Gardiner-Garden, M., Stricker, P.D., Scher, H.I., Grygiel, J.J., Agus, D.B., Mack, D.H., and Sutherland, R.L. (2003) Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse. Cancer Res. 63, 4196-4203.
41. Schroder, F.H., Hugosson, J., Roobol, M.J., Tammela, T.L., Ciatto, S., Nelen, V., Kwiatkowski, M., Lujan, M., Lilja, H., Zappa, M., Denis, L.J., Recker, F., Berenguer, A., Maattanen, L., Bangma, C.H., Aus, G., Villers, A., Rebillard, X., van der Kwast, T., Blijenberg, B.G., Moss, S.M., de Koning, H.J., and Auvinen, A. (2009) Screening and prostate-cancer mortality in a randomized European study. N Engl J Med 360, 1320-1328.
42. Fuessel, S., Sickert, D., Meye, A., Klenk, U., Schmidt, U., Schmitz, M., Rost, A.K., Weigle, B., Kiessling, A., and Wirth, M.P. (2003) Multiple tumor marker analyses (PSA, hK2, PSCA, trp-p8) in primary prostate cancers using quantitative RT-PCR. Int. J. Oncol. 23, 221-228.
43. Kiessling, A., Fussel, S., Schmitz, M., Stevanovic, S., Meye, A., Weigle, B., Klenk, U., Wirth, M.P., and Rieber, E.P. (2003) Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8. Prostate 56, 270-279. (Pubitemid 36988747)
44. Paubert-Braquet, M., Cousse, H., Raynaud, J.P., Mencia-Huerta, J.M., and Braquet, P. (1998) Effect of the lipidosterolic extract of Serenoa repens (Permixon) and its major components on basic fibroblast growth factor-induced proliferation of cultures of human prostate biopsies. Eur. Urol. 33, 340-347. (Pubitemid 28140436)
45. Wissenbach, U. and Niemeyer, B.A. (2007) Trpv6. Handb. Exp. Pharmacol. (179), 221-234.
46. Peng, J.B., Chen, X.Z., Berger, U.V., Weremowicz, S., Morton, C.C., Vassilev, P.M., Brown, E.M., and Hediger, M.A. (2000) Human calcium transport protein CaT1. Biochem. Biophys. Res. Commun. 278, 326-332.
47. Wissenbach, U., Niemeyer, B.A., Fixemer, T., Schneidewind, A., Trost, C., Cavalie, A., Reus, K., Meese, E., Bonkhoff, H., and Flockerzi, V. (2001) Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer. J. Biol. Chem. 276, 19461-19468. (Pubitemid 37411283)
48. Kessler, T., Wissenbach, U., Grobholz, R., and Flockerzi, V. (2009) TRPV6 alleles do not influence prostate cancer progression. BMC Cancer 9, 380.
49. Zhuang, L., Peng, J.B., Tou, L., Takanaga, H., Adam, R.M., Hediger, M.A., and Freeman, M.R. (2002) Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab. Invest. 82, 1755-1764. (Pubitemid 35462988)
50. Fixemer, T., Wissenbach, U., Flockerzi, V., and Bonkhoff, H. (2003) Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene 22, 7858-7861. (Pubitemid 37485545)
51. Peng, J.B., Zhuang, L., Berger, U.V., Adam, R.M., Williams, B.J., Brown, E.M., Hediger, M.A., and Freeman, M.R. (2001) CaT1 expression correlates with tumor grade in prostate cancer. Biochem. Biophys. Res. Commun. 282, 729-734. (Pubitemid 32924618)
52. Lehen'kyi, V., Flourakis, M., Skryma, R., and Prevarskaya, N. (2007) TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways. Oncogene 26, 7380-7385.
53. Alexander, S.P., Mathie, A., and Peters, J.A. (2007) Guide to Receptors and Channels (GRAC), 2nd edition (2007 Revision). Br. J. Pharmacol. 150(Suppl. 1), S1-168. (Pubitemid 46215412)
54. Lallet-Daher, H., Roudbaraki, M., Bavencoffe, A., Mariot, P., Gackiere, F., Bidaux, G., Urbain, R., Gosset, P., Delcourt, P., Fleurisse, L., Slomianny, C., Dewailly, E., Mauroy, B., Bonnal, J.L., Skryma, R., and Prevarskaya, N. (2009) Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry. Oncogene 28, 1792-1806.
55. Schwarz, E.C., Wissenbach, U., Niemeyer, B.A., Strauss, B., Philipp, S.E., Flockerzi, V., and Hoth, M. (2006) TRPV6 potentiates calcium-dependent cell proliferation. Cell Calcium 39, 163-173. (Pubitemid 43013848)
56. Zhu, X., Jiang, M., Peyton, M., Boulay, G., Hurst, R., Stefani, E., and Birnbaumer, L. (1996) trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell 85, 661-671. (Pubitemid 126334349)
57. Riccio, A., Medhurst, A.D., Mattei, C., Kelsell, R.E., Calver, A.R., Randall, A.D., Benham, C.D., and Pangalos, M.N. (2002) mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res. Mol. Brain Res. 109, 95-104. (Pubitemid 36082877)
58. Yue, D., Wang, Y., Xiao, J.Y., Wang, P., and Ren, C.S. (2009) Expression of TRPC6 in benign and malignant human prostate tissues. Asian J. Androl. 11, 541-547.
59. Thebault, S., Flourakis, M., Vanoverberghe, K., Vandermoere, F., Roudbaraki, M., Lehen'kyi, V., Slomianny, C., Beck, B., Mariot, P., Bonnal, J.L., Mauroy, B., Shuba, Y., Capiod, T., Skryma, R., and Prevarskaya, N. (2006) Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. Cancer Res. 66, 2038-2047.
60. Pigozzi, D., Ducret, T., Tajeddine, N., Gala, J.L., Tombal, B., and Gailly, P. (2006) Calcium store contents control the expression of TRPC1, TRPC3 and TRPV6 proteins in LNCaP prostate cancer cell line. Cell Calcium 39, 401-415.
61. Zeng, X., Sikka, S.C., Huang, L., Sun, C., Xu, C., Jia, D., Abdel-Mageed, A.B., Pottle, J.E., Taylor, J.T., and Li, M. (2009) Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation. Prostate Cancer Prostatic Dis. 13, 195-201.
62. Starkus, J., Fleig, A., and Penner, R. (2010) TRPM2 is modulated by cellular acidification. J. Physiol. 588, 1227-1240.
63. Xu, X.Z., Moebius, F., Gill, D.L., and Montell, C. (2001) Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc. Natl. Acad. Sci. U. S. A. 98, 10692-10697.
64. Launay, P., Fleig, A., Perraud, A.L., Scharenberg, A.M., Penner, R., and Kinet, J.P. (2002) TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell 109, 397-407.
65. Nilius, B., Prenen, J., Droogmans, G., Voets, T., Vennekens, R., Freichel, M., Wissenbach, U., and Flockerzi, V. (2003) Voltage dependence of the Ca2+-activated cation channel TRPM4. J. Biol. Chem. 278, 30813-30820.
66. Vriens, J., Appendino, G., and Nilius, B. (2009) Pharmacology of vanilloid transient receptor potential cation channels. Mol. Pharmacol. 75, 1262-1279.
67. Nilius, B. and Voets, T. (2005) TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch. 451, 1-10.
68. Stein, R.J., Santos, S., Nagatomi, J., Hayashi, Y., Minnery, B.S., Xavier, M., Patel, A.S., Nelson, J.B., Futrell, W.J., Yoshimura, N., Chancellor, M.B., and De Miguel, F. (2004) Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract. J. Urol. 172, 1175-1178.
69. Sanchez, M.G., Sanchez, A.M., Collado, B., Malagarie-Cazenave, S., Olea, N., Carmena, M.J., Prieto, J.C., and Diaz-Laviada, I.I. (2005) Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-3 prostate cancer cells and in human prostate tissue. Eur. J. Pharmacol. 515, 20-27.
70. Czifra, G., Varga, A., Nyeste, K., Marincsak, R., Toth, B.I., Kovacs, I., Kovacs, L., and Biro, T. (2009) Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma. J. Cancer Res. Clin. Oncol. 135, 507-514.
71. Dinis, P., Charrua, A., Avelino, A., Nagy, I., Quintas, J., Ribau, U., and Cruz, F. (2005) The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate. Eur. Urol. 48, 162-167.
72. Sanchez, A.M., Sanchez, M.G., Malagarie-Cazenave, S., Olea, N., and Diaz-Laviada, I. (2006) Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin. Apoptosis 11, 89-99.
73. Ziglioli, F., Frattini, A., Maestroni, U., Dinale, F., Ciufifeda, M., and Cortellini, P. (2009) Vanilloid-mediated apoptosis in prostate cancer cells through a TRPV-1 dependent and a TRPV-1-independent mechanism. Acta Biomed. 80, 13-20.
74. Kowase, T., Nakazato, Y., Yoko, O.H., Morikawa, A., and Kojima, I. (2002) Immunohistochemical localization of growth factor-regulated channel (GRC) in human tissues. Endocr. J. 49, 349-355.
75. Bang, S., Kim, K.Y., Yoo, S., Lee, S.H., and Hwang, S.W. (2007) Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci. Lett. 425, 120-125.
76. Neeper, M.P., Liu, Y., Hutchinson, T.L., Wang, Y., Flores, C.M., and Qin, N. (2007) Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence. J. Biol. Chem. 282, 15894-15902. (Pubitemid 47093309)
77. Monet, M., Lehen'kyi, V., Gackiere, F., Firlej, V., Vandenberghe, M., Roudbaraki, M., Gkika, D., Pourtier, A., Bidaux, G., Slomianny, C., Delcourt, P., Rassendren, F., Bergerat, J.P., Ceraline, J., Cabon, F., Humez, S., and Prevarskaya, N. (2010) Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res. 70, 1225-1235.
78. Karashima, Y., Talavera, K., Everaerts, W., Janssens, A., Kwan, K.Y., Vennekens, R., Nilius, B., and Voets, T. (2009) TRPA1 acts as a cold sensor in vitro and in vivo. Proc. Natl. Acad. Sci. U. S. A. 106, 1273-1278.
79. Bandell, M., Story, G.M., Hwang, S.W., Viswanath, V., Eid, S.R., Petrus, M.J., Earley, T.J., and Patapoutian, A. (2004) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41, 849-857. (Pubitemid 38429729)
80. Bautista, D.M., Jordt, S.E., Nikai, T., Tsuruda, P.R., Read, A.J., Poblete, J., Yamoah, E.N., Basbaum, A.I., and Julius, D. (2006) TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124, 1269-1282.
81. Du, S., Araki, I., Kobayashi, H., Zakoji, H., Sawada, N., and Takeda, M. (2008) Differential expression profile of cold (TRPA1) and cool (TRPM8) receptors in human urogenital organs. Urology 72, 450-455.
82. Gratzke, C., Weinhold, P., Reich, O., Seitz, M., Schlenker, B., Stief, C.G., Andersson, K.E., and Hedlund, P. (2009) Transient receptor potential A1 and cannabinoid receptor activity in human normal and hyperplastic prostate: relation to nerves and interstitial cells. Eur. Urol. [Epub ahead of print]
83. Prawitt, D., Enklaar, T., Klemm, G., Gartner, B., Spangenberg, C., Winterpacht, A., Higgins, M., Pelletier, J., and Zabel, B. (2000) Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allelespecific expression. Hum. Mol. Genet. 9, 203-216. (Pubitemid 30052744)
84. Fonfria, E., Murdock, P.R., Cusdin, F.S., Benham, C.D., Kelsell, R.E., and McNulty, S. (2006) Tissue distribution profiles of the human TRPM cation channel family. J. Recept. Signal Transduct. Res. 26, 159-178.
85. Delany, N.S., Hurle, M., Facer, P., Alnadaf, T., Plumpton, C., Kinghorn, I., See, C.G., Costigan, M., Anand, P., Woolf, C.J., Crowther, D., Sanseau, P., and Tate, S.N. (2001) Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol. Genomics 4, 165-174.
86. Muller, D., Hoenderop, J.G., Meij, I.C., van den Heuvel, L.P., Knoers, N.V., den Hollander, A.I., Eggert, P., Garcia-Nieto, V., Claverie-Martin, F., and Bindels, R.J. (2000) Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1). Genomics 67, 48-53. (Pubitemid 30471120)
87. van Bokhoven, A., Varella-Garcia, M., Korch, C., Johannes, W.U., Smith, E.E., Miller, H.L., Nordeen, S.K., Miller, G.J., and Lucia, M.S. (2003) Molecular characterization of human prostate carcinoma cell lines. Prostate 57, 205-225. (Pubitemid 37267805)
88. Everaerts, W., Sepúlveda, M.R., Gevaert, T., Roskams, T., Nilius, B., and De Ridder, D. (2009) Where is TRPV1 expressed in the bladder, do we see the real channel? Naunyn Schmiedebergs Arch. Pharmacol. 379, 421-425.