메뉴 건너뛰기




Volumn 32, Issue 11, 2012, Pages 5121-5126

Prognostic factors of unresectable pancreatic cancer treated with nafamostat mesilate combined with gemcitabine chemotherapy

Author keywords

Chemotherapy; Gemcitabine; Nafamostat mesilate; Prognosis; Unresectable pancreatic cancer

Indexed keywords

C REACTIVE PROTEIN; CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; GEMCITABINE; NAFAMSTAT MESILATE;

EID: 84872663500     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (8)

References (35)
  • 1
    • 0028799366 scopus 로고
    • The National Cancer Date Base report on pancreatic cancer
    • Niederhuber JE, Brennan MF and Menck HR: The National Cancer Date Base report on pancreatic cancer. Cancer 76: 1671-1677, 1995.
    • (1995) Cancer , vol.76 , pp. 1671-1677
    • Niederhuber, J.E.1    Brennan, M.F.2    Menck, H.R.3
  • 3
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG and Benson AB 3rd: Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 20: 3270-3275, 2002.
    • (2002) J Clin Oncol , vol.20 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson III, A.B.6
  • 4
    • 0034885358 scopus 로고    scopus 로고
    • New insights into the role of nuclear factor-κB in cell growth regulation
    • Chen F, Castranova V and Shi X: New insights into the role of nuclear factor-κB in cell growth regulation. Am J Pathol 159: 387-397, 2001.
    • (2001) Am J Pathol , vol.159 , pp. 387-397
    • Chen, F.1    Castranova, V.2    Shi, X.3
  • 5
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-κB in preventing TNF-alpha-induced cell death
    • Amer BA and David B: An essential role for NF-κB in preventing TNF-alpha-induced cell death. Science 274: 782-784, 1996.
    • (1996) Science , vol.274 , pp. 782-784
    • Amer, B.A.1    David, B.2
  • 7
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin M and Lin A: NF-κB at the crossroads of life and death. Nature Immunol 3: 221-227, 2002.
    • (2002) Nature Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 8
    • 0034306969 scopus 로고    scopus 로고
    • Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8
    • Huang S, Robinson JB, DeGuzman A, Bucana CD and fiddler IJ: Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res 60: 5334-5339, 2000.
    • (2000) Cancer Res , vol.60 , pp. 5334-5339
    • Huang, S.1    Robinson, J.B.2    DeGuzman, A.3    Bucana, C.D.4    Fiddler, I.J.5
  • 9
    • 12944273470 scopus 로고    scopus 로고
    • Targeting of nuclear factor eκB pathways by dehydroxymethyleoxyquinomicin, a novel inhibitor of breast carcinomas: Antitumor and antiangiogenic potential in vivo
    • Matsumoto G, Namekawa J, Muta M, Nakamura T, Bando H, Tohyama K, Toi M and Umezawa K: Targeting of nuclear factor eκB pathways by dehydroxymethyleoxyquinomicin, a novel inhibitor of breast carcinomas: antitumor and antiangiogenic potential in vivo. Clin Cancer Res 11: 1287-1293, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 1287-1293
    • Matsumoto, G.1    Namekawa, J.2    Muta, M.3    Nakamura, T.4    Bando, H.5    Tohyama, K.6    Toi, M.7    Umezawa, K.8
  • 11
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang S, Pettaway CA, Uehara H, Bucana CD and Fidler IJ: Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20: 4188-4197, 2001.
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.A.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 12
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR and Chiano PJ: The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 5: 119-127, 1999.
    • (1999) Clin Cancer Res , vol.5 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiano, P.J.6
  • 13
    • 0033549875 scopus 로고    scopus 로고
    • Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regurated by constitutively activated RelA
    • Wang W, Abbruzzese JL, Evans DB and Chiano PJ: Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regurated by constitutively activated RelA. Oncogene 18: 4554-4563, 1999.
    • (1999) Oncogene , vol.18 , pp. 4554-4563
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Chiano, P.J.4
  • 16
    • 0019817468 scopus 로고
    • New synthetic inhibitors of C1r, C1 esterase, thrombin, kallikrein and trypsin
    • Fujii S and Hitomi Y: New synthetic inhibitors of C1r, C1 esterase, thrombin, kallikrein and trypsin. Biochimi Biophys Acta 661: 342-345, 1981.
    • (1981) Biochimi Biophys Acta , vol.661 , pp. 342-345
    • Fujii, S.1    Hitomi, Y.2
  • 17
    • 0021265581 scopus 로고
    • Pharmacological studies of FUT-175, nafamostat mesilate. I. Inhibition of protease avtivity in in vitro and in vivo experiments
    • Aoyama T, Ino Y, Ozeki M, Oda M, Sato T, Koshiyama Y, Suzuki S and Fujita M: Pharmacological studies of FUT-175, nafamostat mesilate. I. Inhibition of protease avtivity in in vitro and in vivo experiments. Jpn J Pharmacol 35: 207-227, 1984.
    • (1984) Jpn J Pharmacol , vol.35 , pp. 207-227
    • Aoyama, T.1    Ino, Y.2    Ozeki, M.3    Oda, M.4    Sato, T.5    Koshiyama, Y.6    Suzuki, S.7    Fujita, M.8
  • 18
    • 0022445090 scopus 로고
    • Pharmacological studies of FUT-175, nafamostat mesilate. V. Effects on pancreatic enzymes and experimental acute pancreatitis in rats
    • Iwaki M, Ino Y, Motoyoshi A, Ozeki M, Sato T, Kurumi M and Aoyama T: Pharmacological studies of FUT-175, nafamostat mesilate. V. Effects on pancreatic enzymes and experimental acute pancreatitis in rats. Jpn J Phamacol 41: 155-162, 1986.
    • (1986) Jpn J Phamacol , vol.41 , pp. 155-162
    • Iwaki, M.1    Ino, Y.2    Motoyoshi, A.3    Ozeki, M.4    Sato, T.5    Kurumi, M.6    Aoyama, T.7
  • 19
    • 0001465748 scopus 로고
    • Nafamostat mesilate (FUT-175) in the treatment of patients with disseminated intravascular coagulations
    • Takahashi H, Takizawa S, Tatewaki W, Nagai K, Wada K, Hanano M and Shibata A: Nafamostat mesilate (FUT-175) in the treatment of patients with disseminated intravascular coagulations. Thomb Haemost 62: 372, 1989.
    • (1989) Thomb Haemost , vol.62 , pp. 372
    • Takahashi, H.1    Takizawa, S.2    Tatewaki, W.3    Nagai, K.4    Wada, K.5    Hanano, M.6    Shibata, A.7
  • 20
    • 0026284758 scopus 로고
    • Nafamostat mesilate as anticoagulant in continuous hemofiltration and continuous hemodiafiltration
    • Ohtake Y, Hirasawa H, Sugai T, Oda S, Shiga H, Matsuda K and Kitamura N: Nafamostat mesilate as anticoagulant in continuous hemofiltration and continuous hemodiafiltration. Contr Nephrol 93: 215-7, 1991.
    • (1991) Contr Nephrol , vol.93 , pp. 215-217
    • Ohtake, Y.1    Hirasawa, H.2    Sugai, T.3    Oda, S.4    Shiga, H.5    Matsuda, K.6    Kitamura, N.7
  • 22
    • 77957361331 scopus 로고    scopus 로고
    • Anti-tumor effect by inhibition of NF-κB activation using nafamostat mesilate for pancreatic cancer in a mouse model
    • Furukawa K, Iida T, Shiba H, Fujiwara Y, Uwagawa T, Shimada Y, Misawa T, Ohashi T and Yanaga K: Anti-tumor effect by inhibition of NF-κB activation using nafamostat mesilate for pancreatic cancer in a mouse model. Oncol Rep 24 : 843-50, 2010.
    • (2010) Oncol Rep , vol.24 , pp. 843-850
    • Furukawa, K.1    Iida, T.2    Shiba, H.3    Fujiwara, Y.4    Uwagawa, T.5    Shimada, Y.6    Misawa, T.7    Ohashi, T.8    Yanaga, K.9
  • 23
    • 68549110308 scopus 로고    scopus 로고
    • Combination chemotherapy of nafamostat mesilate with gemcitabine for pancreatic cancer targeting NF-κB activation
    • Uwagawa T, Chiano PJ, Gocyo T, Hirohara S, Misawa T and Yanaga K: Combination chemotherapy of nafamostat mesilate with gemcitabine for pancreatic cancer targeting NF-κB activation. Anticancer Res 29: 3173-3178, 2009.
    • (2009) Anticancer Res , vol.29 , pp. 3173-3178
    • Uwagawa, T.1    Chiano, P.J.2    Gocyo, T.3    Hirohara, S.4    Misawa, T.5    Yanaga, K.6
  • 25
    • 84872955275 scopus 로고    scopus 로고
    • Phase II study of gemcitabine in combination with regional arterial infusion of nafamostat mesilate for advanced pancreatic cancer
    • Uwagawa T, Misawa T, Tsutsui N, Ito R, Gocho T, Hirohara S, Sadaoka S, Yanaga K. Phase II study of gemcitabine in combination with regional arterial infusion of nafamostat mesilate for advanced pancreatic cancer. Am J Clin Oncol 2011.
    • (2011) Am J Clin Oncol
    • Uwagawa, T.1    Misawa, T.2    Tsutsui, N.3    Ito, R.4    Gocho, T.5    Hirohara, S.6    Sadaoka, S.7    Yanaga, K.8
  • 30
    • 80052524782 scopus 로고    scopus 로고
    • Nafamostat mesilate can prevent adhesion, invasion and peritoneal dissemination of pancreatic cancer thorough nuclear factor-kappa B inhibition
    • Fujiwara Y, Furukawa K, Haruki K, Shimada Y, Iida T, Shiba H, Uwagawa T, Ohashi T and Yanaga K: Nafamostat mesilate can prevent adhesion, invasion and peritoneal dissemination of pancreatic cancer thorough nuclear factor-kappa B inhibition. J Hepatobiliary Pancreat Sci 18: 731-739, 2011.
    • (2011) J Hepatobiliary Pancreat Sci , vol.18 , pp. 731-739
    • Fujiwara, Y.1    Furukawa, K.2    Haruki, K.3    Shimada, Y.4    Iida, T.5    Shiba, H.6    Uwagawa, T.7    Ohashi, T.8    Yanaga, K.9
  • 35
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl HL: Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18: 6853-6866, 1999.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.