-
1
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 26, 921-923. (Pubitemid 23275809)
-
(1993)
Science
, vol.261
, Issue.5123
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
2
-
-
0027327267
-
Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease
-
Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43, 1467-1472. (Pubitemid 23230526)
-
(1993)
Neurology
, vol.43
, Issue.8
, pp. 1467-1472
-
-
Saunders, A.M.1
Strittmatter, W.J.2
Schmechel, D.3
St. George-Hyslop, P.H.4
Pericak-Vance, M.A.5
Joo, S.H.6
Rosi, B.L.7
Gusella, J.F.8
Crapper-MacLachlan, D.R.9
Alberts, M.J.10
Hulette, C.11
Crain, B.12
Goldgaber, D.13
Roses, A.D.14
-
3
-
-
0030005627
-
Apolipoprotein E alleles as risk factors in Alzheimer's disease
-
DOI 10.1146/annurev.med.47.1.387
-
Roses AD (1996) Apolipoprotein E alleles as risk factors in Alzheimer's disease. Ann Rev Med 47, 387-400. (Pubitemid 26138899)
-
(1996)
Annual Review of Medicine
, vol.47
, pp. 387-400
-
-
Roses, A.D.1
-
4
-
-
0029982815
-
Oxidative damage in Alzheimer's
-
Smith MA, Perry G, Richey PL, Sayre LM, Anderson VE, Beal MF, Kowall N (1996) Oxidative damage in Alzheimer's. Nature 382, 120-121.
-
(1996)
Nature
, vol.382
, pp. 120-121
-
-
Smith, M.A.1
Perry, G.2
Richey, P.L.3
Sayre, L.M.4
Anderson, V.E.5
Beal, M.F.6
Kowall, N.7
-
5
-
-
0028180518
-
A model for betaamyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
-
Hensley K, Carney JM, Mattson MP, Aksenova M, Harris M, Wu JF, Floyd RA, Butterfield DA (1994) A model for betaamyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease. Proc Natl Acad Sci U S A 91, 3270-3274.
-
(1994)
Proc Natl Acad Sci U S A.
, vol.91
, pp. 3270-3274
-
-
Hensley, K.1
Carney, J.M.2
Mattson, M.P.3
Aksenova, M.4
Harris, M.5
Wu, J.F.6
Floyd, R.A.7
Butterfield, D.A.8
-
6
-
-
79955769953
-
Soluble A oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors
-
Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ (2011) Soluble A oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci 31, 6627-6638.
-
(2011)
J Neurosci
, vol.31
, pp. 6627-6638
-
-
Li, S.1
Jin, M.2
Koeglsperger, T.3
Shepardson, N.E.4
Shankar, G.M.5
Selkoe, D.J.6
-
7
-
-
79955044494
-
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration
-
Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ (2011) Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A 108, 5819-5824.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 5819-5824
-
-
Jin, M.1
Shepardson, N.2
Yang, T.3
Chen, G.4
Walsh, D.5
Selkoe, D.J.6
-
8
-
-
84455173610
-
Amyloid-toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease
-
Lloret A, Badia MC, Giraldo E, Ermak G, Alonso MD, Pallard ́o FV, Davies KJ,Vi?na J (2011) Amyloid-toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease. J Alzheimers Dis 27, 701-709.
-
(2011)
J Alzheimers Dis
, vol.27
, pp. 701-709
-
-
Lloret, A.1
Badia, M.C.2
Giraldo, E.3
Ermak, G.4
Alonso, M.D.5
Pallard ́o, F.V.6
Davies, K.J.7
Vina, J.8
-
9
-
-
0033625696
-
GSK3β-mediated phosphorylation of the microtubule-associated protein 2C (MAP2C) prevents microtubule bundling
-
Śanchez C, Ṕerez M, Avila J (2000) GSK3beta-mediated phosphorylation of the microtubule-associated protein 2C (MAP2C) prevents microtubule bundling. Eur J Cell Biol 79, 252-260. (Pubitemid 30232570)
-
(2000)
European Journal of Cell Biology
, vol.79
, Issue.4
, pp. 252-260
-
-
Sanchez, C.1
Perez, M.2
Avila, J.3
-
10
-
-
34447306022
-
RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: A potential pathogenic process in neurodegeneration
-
DOI 10.1093/hmg/ddm049
-
Porta S, Serra SA, Huch M, Valverde MA, Llorens F, Estivill X, Arbońes ML, Mart́i E (2007) RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: A potential pathogenic process in neurodegeneration. Hum Mol Genet 16, 1039-1050. (Pubitemid 47062725)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.9
, pp. 1039-1050
-
-
Porta, S.1
Serra, S.A.2
Huch, M.3
Valverde, M.A.4
Llorens, F.5
Estivill, X.6
Arbones, M.L.7
Marti, E.8
-
11
-
-
18244391440
-
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models
-
DOI 10.1523/JNEUROSCI.0365-05.2005
-
Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, PorterNM(2005) Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. J Neurosci 25, 4649-4658. (Pubitemid 40629156)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.18
, pp. 4649-4658
-
-
Norris, C.M.1
Kadish, I.2
Blalock, E.M.3
Chen, K.-C.4
Thibault, V.5
Porter, N.M.6
Landfield, P.W.7
Kraner, S.D.8
-
12
-
-
79952009348
-
Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: Effects of the amyloid- peptide of amyloid precursor protein
-
Robinson RA, Lange MB, Sultana R, Galvan V, Fombonne J, Gorostiza O, Zhang J, Warrier G, Cai J, Pierce WM, Bredesen DE, Butterfield DA (2011) Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: Effects of the amyloid- peptide of amyloid precursor protein. Neuroscience 177, 207-222.
-
(2011)
Neuroscience
, vol.177
, pp. 207-222
-
-
Robinson, R.A.1
Lange, M.B.2
Sultana, R.3
Galvan, V.4
Fombonne, J.5
Gorostiza, O.6
Zhang, J.7
Warrier, G.8
Cai, J.9
Pierce, W.M.10
Bredesen, D.E.11
Butterfield, D.A.12
-
13
-
-
70350454809
-
Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling
-
Abdul HM, Sama MA, Furman JL, Mathis DM, Beckett TL, Weidner AM, Patel ES, Baig I, Murphy MP, LeVine H 3rd, Kraner SD, Norris CM (2009) Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. J Neurosci 29, 12957-12969.
-
(2009)
J Neurosci
, vol.29
, pp. 12957-12969
-
-
Abdul, H.M.1
Sama, M.A.2
Furman, J.L.3
Mathis, D.M.4
Beckett, T.L.5
Weidner, A.M.6
Patel, E.S.7
Baig, I.8
Murphy, M.P.9
LeVine III, H.10
Kraner, S.D.11
Norris, C.M.12
-
14
-
-
0037147666
-
Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimer's disease
-
DOI 10.1097/00001756-200212200-00011
-
Chang RC, Wong AK, Ng HK, Hugon J (2002) Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. Neuroreport 13, 2429-2432. (Pubitemid 36143538)
-
(2002)
NeuroReport
, vol.13
, Issue.18
, pp. 2429-2432
-
-
Chang, R.C.C.1
Wong, A.K.Y.2
Ng, H.-K.3
Hugon, J.4
-
15
-
-
79251575329
-
Modulation of tau phosphorylation by the kinase PKR: Implications in Alzheimer's disease
-
Bose A, Mouton-Liger F, Paquet C, Mazot P, Vigny M, Gray F, Hugon J (2011) Modulation of tau phosphorylation by the kinase PKR: Implications in Alzheimer's disease. Brain Pathol 21, 189-200.
-
(2011)
Brain Pathol
, vol.21
, pp. 189-200
-
-
Bose, A.1
Mouton -Liger, F.2
Paquet, C.3
Mazot, P.4
Vigny, M.5
Gray, F.6
Hugon, J.7
-
16
-
-
0020210930
-
Ultrasensitive staining of nucleic acids with silver
-
Beidler JL, Hilliard PR, Rill RL (1982) Ultrasensitive staining of nucleic acids with silver. Anal Biochem 126, 374-380.
-
(1982)
Anal Biochem
, vol.126
, pp. 374-380
-
-
Beidler, J.L.1
Hilliard, P.R.2
Rill, R.L.3
-
17
-
-
39849110726
-
The GSK3 hypothesis of Alzheimer's disease
-
DOI 10.1111/j.1471-4159.2007.05194.x
-
Hooper C, Killick R, Lovestone S (2008) The GSK3 hypothesis of Alzheimer's disease. J Neurochem 104, 1433-1439. (Pubitemid 351316776)
-
(2008)
Journal of Neurochemistry
, vol.104
, Issue.6
, pp. 1433-1439
-
-
Hooper, C.1
Killick, R.2
Lovestone, S.3
-
18
-
-
27844553889
-
Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain
-
DOI 10.1074/jbc.M507475200
-
Liu F, Grundke-Iqbal I, Iqbal K, Oda Y, Tomizawa K, Gong CX (2005) Truncation and activation of calcineurin A by calpain in Alzheimer disease brain. J Biol Chem 280, 37755-37762. (Pubitemid 41642385)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.45
, pp. 37755-37762
-
-
Liu, F.1
Iqbal-Grundke, I.2
Iqbal, K.3
Oda, Y.4
Tomizawa, K.5
Gong, C.-X.6
-
19
-
-
24644499539
-
Expression of calcipressin1, an inhibitor of the phosphatase calcineurin, is altered with aging and Alzheimer's disease
-
Cook CN, Hejna MJ, Magnuson DJ, Lee JM (2005) Expression of calcipressin1, an inhibitor of the phosphatase calcineurin, is altered with aging and Alzheimer's disease. J Alzheimers Dis 8, 63-73. (Pubitemid 41267325)
-
(2005)
Journal of Alzheimer's Disease
, vol.8
, Issue.1
, pp. 63-73
-
-
Cook, C.N.1
Hejna, M.J.2
Magnuson, D.J.3
Lee, J.M.4
-
20
-
-
79961243892
-
Evidence of neuronal compensation during episodic memory in subjective memory impairment
-
Erk S, Spottke A, Meisen A, Wagner M, Walter H, Jessen F (2011) Evidence of neuronal compensation during episodic memory in subjective memory impairment. Arch Gen Psychiatry 68, 845-852.
-
(2011)
Arch Gen Psychiatry
, vol.68
, pp. 845-852
-
-
Erk, S.1
Spottke, A.2
Meisen, A.3
Wagner, M.4
Walter, H.5
Jessen, F.6
-
21
-
-
12044254746
-
Binding of human apolipoprotein E to synthetic amyloid β peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
-
Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD (1993) Binding of human apolipoprotein E to synthetic amyloid beta peptide: Isoformspecific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A 90, 8098-8102. (Pubitemid 23260862)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.17
, pp. 8098-8102
-
-
Strittmatter, W.J.1
Weisgraber, K.H.2
Huang, D.Y.3
Dong, L.-M.4
Salvesen, G.S.5
Pericak-Vance, M.6
Schmechel, D.7
Saunders, A.M.8
Goldgaber, D.9
Roses, A.D.10
-
22
-
-
67650921433
-
Vitamin E paradox in Alzheimer's disease: It does not prevent loss of cognition and may even be detrimental
-
Lloret A, Bad́ia MC,Mora NJ, Pallard́o FV, Alonso MD,Vi?na J (2009) Vitamin E paradox in Alzheimer's disease: It does not prevent loss of cognition and may even be detrimental. J Alzheimers Dis 17, 143-149.
-
(2009)
J Alzheimers Dis
, vol.17
, pp. 143-149
-
-
Lloret, A.1
Bad́ia, M.C.2
Mora, N.J.3
Pallard́o, F.V.4
Alonso, M.D.5
Vina, J.6
-
23
-
-
33947606911
-
Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease
-
Calabrese V, Sultana R, Scapagnini G, Guagliano E, Sapienza M, Bella R, Kanski J, Pennisi G, Mancuso C, Stella AM, Butterfield DA (2006) Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease. Antioxid Redox Signal 8, 1975-1986. (Pubitemid 46489625)
-
(2006)
Antioxidants and Redox Signaling
, vol.8
, Issue.11-12
, pp. 1975-1986
-
-
Calabrese, V.1
Sultana, R.2
Scapagnini, G.3
Guagliano, E.4
Sapienza, M.5
Bella, R.6
Kanski, J.7
Pennisi, G.8
Mancuso, C.9
Stella, A.M.G.10
Butterfield, D.A.11
-
24
-
-
0031593610
-
Lymphocytes as cell model to study apoptosis in Alzheimer's disease: Vulnerability to programmed cell death appears to be altered
-
Eckert A, Cotman CW, Zerfass R, Hennerici M, M?uller WE (1998) Lymphocytes as cell model to study apoptosis in Alzheimer's disease: Vulnerability to programmed cell death appears to be altered. J Neural Transm Suppl 54, 259-267. (Pubitemid 28539362)
-
(1998)
Journal of Neural Transmission, Supplement
, Issue.54
, pp. 259-267
-
-
Eckert, A.1
Cotman, C.W.2
Zerfass, R.3
Hennerici, M.4
Muller, W.E.5
-
25
-
-
0036728812
-
Abeta(25-35) peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: Involvement of H2O2, caspase-3, NF-kappaB, p53 and c-Jun
-
V́elez-Pardo C, Ospina GG, Jiḿenez del Ŕio M (2002) Abeta(25-35) peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: Involvement of H2O2, caspase-3, NF-kappaB, p53 and c-Jun. Neurotoxicology 23, 351-365.
-
(2002)
Neurotoxicology
, vol.23
, pp. 351-365
-
-
V́elez-Pardo, C.1
Ospina, G.G.2
Jiḿenez Del Ŕio, M.3
-
26
-
-
0034108326
-
Amyloid β-peptide effects on synaptosomes from apolipoprotein E- deficient mice
-
DOI 10.1046/j.1471-4159.2000.0741579.x
-
Keller JN, Lauderback CM, Butterfield DA, Kindy MS, Yu J, Markesbery WR (2000) Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice. J Neurochem 74, 1579-1586. (Pubitemid 30163979)
-
(2000)
Journal of Neurochemistry
, vol.74
, Issue.4
, pp. 1579-1586
-
-
Keller, J.N.1
Lauderback, C.M.2
Butterfield, D.A.3
Kindy, M.S.4
Yu, J.5
Markesbery, W.R.6
-
27
-
-
0029765553
-
Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides
-
DOI 10.1038/ng0996-55
-
Miyata M, Smith JD (1996) Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta amyloid peptides. Nat Genet 14, 55-61. (Pubitemid 26301547)
-
(1996)
Nature Genetics
, vol.14
, Issue.1
, pp. 55-61
-
-
Miyata, M.1
Smith, J.D.2
-
28
-
-
0033537768
-
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
-
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC (1999) Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 284, 339-343.
-
(1999)
Science
, vol.284
, pp. 339-343
-
-
Wang, H.G.1
Pathan, N.2
Ethell, I.M.3
Krajewski, S.4
Yamaguchi, Y.5
Shibasaki, F.6
McKeon, F.7
Bobo, T.8
Franke, T.F.9
Reed, J.C.10
-
29
-
-
0034307421
-
Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury
-
Springer JE, Azbill RD, Nottingham SA, Kennedy SE (2000) Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury. J Neurosci 20, 7246-7251.
-
(2000)
J Neurosci
, vol.20
, pp. 7246-7251
-
-
Springer, J.E.1
Azbill, R.D.2
Nottingham, S.A.3
Kennedy, S.E.4
-
30
-
-
40949104298
-
Overactivation of calcineurin induced by amyloid-beta and prion proteins
-
Agostinho P, Lopes JP, Velez Z, Oliveira CR (2008) Overactivation of calcineurin induced by amyloid-beta and prion proteins. Neurochem Int 52, 1226-1233.
-
(2008)
Neurochem Int
, vol.52
, pp. 1226-1233
-
-
Agostinho, P.1
Lopes, J.P.2
Velez, Z.3
Oliveira, C.R.4
-
31
-
-
70350417480
-
Protection of neurons from apoptosis by apolipoprotein Econtaining lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cγ1 and inhibition of calcineurin
-
Hayashi H, Campenot RB, Vance DE, Vance JE (2009) Protection of neurons from apoptosis by apolipoprotein Econtaining lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cγ1 and inhibition of calcineurin. J Biol Chem 284, 29605-29613.
-
(2009)
J Biol Chem
, vol.284
, pp. 29605-29613
-
-
Hayashi, H.1
Campenot, R.B.2
Vance, D.E.3
Vance, J.E.4
-
32
-
-
77957233071
-
Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice
-
Dineley KT, Kayed R, Neugebauer V, Fu Y, Zhang W, Reese LC, Taglialatela G (2010) Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice. J Neurosci Res 88, 2923-2932.
-
(2010)
J Neurosci Res
, vol.88
, pp. 2923-2932
-
-
Dineley, K.T.1
Kayed, R.2
Neugebauer, V.3
Fu, Y.4
Zhang, W.5
Reese, L.C.6
Taglialatela, G.7
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