Essential oils from medicinal and aromatic plants: A review of the gastroprotective and ulcer-healing activities

Fundamental and Clinical Pharmacology

Volumn 27, Issue 1, 2013, Pages 51-63

  Rozza, Ariane Leite ^a   Pellizzon, Cláudia Helena ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Essential oil; Gastric ulcer; Gastroprotection; Medicinal plants; Natural products

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIULCER AGENT; ESSENTIAL OIL; GASTROINTESTINAL AGENT; HERBACEOUS AGENT; INDOMETACIN;

ANTIINFLAMMATORY ACTIVITY; ASTERACEAE; BACCHARIS DRACUNCULIFOLIA; BARK; CARLINA ACANTHIFOLIA; CASEARIA; CASEARIA SYLVESTRIS; CITRUS; CITRUS LEMON; CLOVE; CROTON; CROTON CAJUCARA; DRUG DETERMINATION; FABACEAE; FLOWER; FRUIT; HUMAN; HYPTIS; HYPTIS MARTIUSII; HYPTIS SPICIGERA; LAVANDULA HYBRIDA; LAVENDER; LIPPIA; LIPPIA SIDOIDES; MEDICINAL PLANT; NONHUMAN; OCIMUM; OCIMUM MINIMUM; PAW EDEMA; PLANT LEAF; PLANT ROOT; PLANT SEED; PLANT STEM; PRIORITY JOURNAL; PTERODON EMARGINATUS; REVIEW; SOUR ORANGE; STOMACH PROTECTION; STOMACH ULCER; SYZYGIUM; ULCER HEALING; VANILLOSMOPSIS ARBOREA;

ANIMALS; ANTI-ULCER AGENTS; BRAZIL; DIETARY SUPPLEMENTS; ETHNOPHARMACOLOGY; GASTROINTESTINAL AGENTS; HUMANS; MEXICO; NIGERIA; OILS, VOLATILE; PLANTS, MEDICINAL; PROTECTIVE AGENTS; SERBIA; STOMACH ULCER; VOLATILIZATION;

EID: 84872418750     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2012.01067.x     Document Type: Review

References (70)

1. Laine L., Takeuchi K., Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology (2008) 135 41-60.
2. a ed, Guanabara Koogan, Rio de Janeiro, Brazil, 2006, pp. 820.
3. Toma W., Hiruma-Lima C.A., Guerrero R.O., Souza Brito A.R. Preliminary studies of Mammea americana L. (Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer models in mice. Phytomedicine (2005) 12 345-350.
4. Jainu M., Devi C.S.S. Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation. J. Ethnopharmacol. (2006) 104 156-163.
5. Al-Howiriny T., Alsheikh A., Alqasoumi S., Al-Yahya M., ElTahir K., Rafatullah S. Protective effect of Origanum majorana L. 'Marjoram' on various models of gastric mucosal injury in rats. Am. J. Chin. Med. (2009) 37 531-545.
6. Zanatta F., Gandolfi R.B., Lemos M. et al. Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae). Chem. Biol. Interact. (2009) 180 312-317.
7. Banerjee D., Maity B., Nag S.K., Bandyopadhyay S.K., Chattopadhyay S. Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration. BMC Complement Altern. Med. (2008) 8 3-16.
8. Ozbakis Dengiz G., Odabasoglu F., Halici Z., Cadirci E., Suleyman H. Gastroprotective and antioxidant effects of Montelukast on indomethacin-induced gastric ulcer in rats. J. Pharmacol. Sci. (2007) 105 94-102.
9. Onasanwo S.A., Singh N., Olaleye S.B., Mishra V., Palit G. Anti-ulcer & antioxidant activities of Hedranthera barteri {(Hook F.) Pichon} with possible involvement of H+, K+ ATPase inhibitory activity. Indian J. Med. Res. (2010) 132 442-449.
10. Chandranath S.I., Bastaki S.M., Singh J. A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol and indomethacin-induced gastric lesions in the rat. Clin. Exp. Pharmacol. Physiol. (2002) 29 173-180.
11. Brzozowski T., Konturek P.C., Konturek S.J., Brzozowska I., Pawlik T. Role of prostaglandins in gastroprotection and gastric adaptation. J. Physiol. Pharmacol. (2005) 56 33-55.
12. Hatazawa R., Tanigami M., Izumi N., Kamei K., Tanaka A., Takeuchi K. Prostaglandin E2 stimulates VEGF expression in primary rat gastric fibroblasts through EP4 receptors. Inflammopharmacology (2007) 15 214-217.
13. Peskar B.M., Ehrlich K., Peskar B.A. Role of ATP-sensitive potassium channels in prostaglandin-mediated gastroprotection in the rat. J. Pharmacol. Exp. Ther. (2002) 301 969-974.
14. Whittle B.J., Lopez-Belmonte J., Moncada S. Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. Br. J. Pharmacol. (1990) 99 607-611.
15. Gyires K. Neuropeptides and gastric mucosal homeostasis. Curr. Top. Med. Chem. (2004) 4 63-73.
16. Tache Y. Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents. Curr. Med. Chem. (2012) 19 35-42.
17. Gyires K., Müllner K., Fürst S., Rónai A.Z. Alpha-2 adrenergic and opioid receptor-mediated gastroprotection. J. Physiol. Paris (2000) 94 117-121.
18. Del Soldato P. Gastric lesion-preventing or potentiating action of clonidine in rats. Jpn. J. Pharmacol. (1986) 41 257-279.
19. Whelan A.M., Jurgens T.M., Lord L. Evaluating the quality of randomized controlled trials that examine the efficacy of natural health products: a systematic review of critical appraisal instruments. Evid. Based Complement Alternat. Med. (2009) 6 441-448.
20. Robert A., Nezamis J.E., Lancaster C., Hanchar A.J. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology (1979) 77 433-443.
21. Abdel-Salam O.M., Czimmer J., Debreceni A., Szolcsányi J., Mózsik G. Gastric mucosal integrity: gastric mucosal blood flow and microcirculation. An overview. J. Physiol. Paris (2001) 95 105-127.
22. Siegmund S., Haas S., Schneider A., Singer M.V. Animal models in gastrointestinal alcohol research - a short appraisal of the different models and their results. Best Pract. Res. Clin. Gastroenterol. (2003) 17 519-542.
23. Alqasoumi S., Al-Sohaibani M., Al-Howiriny T., Al-Yahya M., Rafatullah S. Rocket Eruca sativa: a salad herb with potential gastric anti-ulcer activity. World J. Gastroenterol. (2009) 15 1958-1965.
24. Alam S., Asad M., Asdaq S.M., Prasad V.S. Antiulcer activity of methanolic extract of Momordica charantia L. in rats. J. Ethnopharmacol. (2009) 123 464-469.
25. Wallace J.L., McKnight W., Reuter B.K., Vergnolle N. NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology (2000) 119 706-714.
26. Lu H., Graham D.Y. New development in the mechanistic understanding of peptic ulcer diseases. Drug Discov. Today (2006) 3 431-437.
27. Valle D.L. Peptic ulcer diseases and related disorders, in: Braunwald E., Fauci A.S., Kasper D.L., Hauser S.L., Longo D.L., Jameson J.L. (Eds), Harrison's principles of internal medicine, McGraw-Hill, New York, 2005, pp. 1746-1762.
28. Bakkali F., Averbeck S., Averbeck D., Idaomar M. Biological effects of essential oils - a review. Food Chem. Toxicol. (2008) 46 446-475.
29. 2 extraction. Flavour Fragr. J. (1997) 12 173-176.
30. Massignani J.J., Lemos M., Maistro E.L. et al. Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats. Phytother. Res. (2009) 23 1355-1360.
31. Menezes H. Avaliação da atividade anti-inflamatória do extrato aquoso de Baccharis dracunculifolia (Asteraceae). Arq. Inst. Biol. de São Paulo (2005) 72 1-64.
32. Dordević S., Petrović S., Dobrić S. et al. Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil. J. Ethnopharmacol. (2007) 109 458-463.
33. Acar J.F., Goldstein F.W. Disc susceptibility test, in: Lorian V. (Ed.), Antibiotics in laboratory medicine, 4th edn, Williams & Wilkins, Baltimore, MD, 1996, pp. 1-51.
34. Candan F., Unlu M., Tepe B. et al. Antioxidant and antimicrobial activity of essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan. (Asteraceae). J. Ethnopharmacol. (2003) 87 215-220.
35. Oyanagi Y., Sato S. Inhibition by nilvadipine of ischemic and carrageenan paw edema as well as of superoxide radical production from neutrophils and xanthine oxidase. Arzneimittelforschung (1991) 41 469-474.
36. Esteves I., Souza I.R., Rodrigues M. et al. Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw. J. Ethnopharmacol. (2005) 101 191-196.
37. Lorenzi H., Abreu Matos F.J. Plantas Medicinais no Brasil. Instituto Plantarum, Nova Odessa, Brazil, 2002.
38. Moraes T.M., Kushima H., Moleiro F.C. et al. Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus secretion. Chem. Biol. Interact. (2009) 180 499-505.
39. Sanguinetti E.E. Plantas que curam. Editora Rigel, Porto Alegre, Brazil, 1989.
40. Rozza A.L., Moraes T.M., Kushima H. et al. Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: Involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E2. Chem. Biol. Interact. (2011) 189 82-89.
41. Ceccarelli I., Lariviere W.R., Fiorenzani P., Sacerdote P., Aloisi A.M. Effects of long-term exposure of lemon essential oil odor on behavioral, hormonal and neuronal parameters in male and female rats. Brain Res. (2004) 1001 78-86.
42. Hiruma-Lima C.A., Gracioso J.S., Nunes D.S., Souza-Brito A.R.M. Effects of an essential oil from the bark of Croton cajucara Benth. on experimental gastric ulcer models in rats and mice. J. Pharm. Pharmacol. (1999) 51 341-346.
43. Hiruma-Lima C.A., Gracioso J.S., Bighetti E.J.B., Grassi-Kassisse D.M., Nunes D.S., Souza-Brito A.R.M. Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa. Phytomedicine (2002) 9 523-529.
44. Rozza A.L., Moraes T.M., Kushima H., Nunes D.S., Hiruma-Lima C.A., Pellizzon C.H. Involvement of glutathione, sulfhydryl compounds, nitric oxide, vasoactive intestinal peptide, and heat-shock protein-70 in the gastroprotective mechanism of Croton cajucara Benth. (Euphorbiaceae) essential oil. J. Med. Food (2011) 14 1011-1017.
45. Di Stasi L.C., Santos E.M.G., Santos C.M., Hiruma C.A. Plantas Medicinais da Amazônia. Editora UNESP, São Paulo, Brazil, 1989.
46. Caldas G.F., do Amaral Costa I.M., da Silva J.B. et al. Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae). J. Ethnopharmacol. (2011) 137 886-892.
47. Almeida C.F.C.B.R., Albuquerque U.P. Check-list of the family Lamiaceae in Pernambuco, Brazil. Braz. Arch. Biol. Technol. (2002) 45 343-353.
48. Agra M.F., Silva K.N., Basílio I.J.L.D., França P.F., Barbosa-Filho J.M. Survey of medicinal plants used in the region northeast of Brazil. Rev. Bras. Farmacogn. (2008) 18 472-508.
49. Takayama C., de-Faria F.M., de Almeida A.C. et al. Gastroprotective and ulcer healing effects of essential oil from Hyptis spicigera Lam. (Lamiaceae). J. Ethnopharmacol. (2011) 135 147-155.
50. Onayade O.A., Looman A., Scheffer J.J.C., Svendsen A.B. Composition of the herb essential oil of Hyptis spicigera Lam. Flavour Fragr. J. (1990) 5 101-105.
51. Kini F., Kam B., Aycard J.P., Gaydou E.M., Bombarda I. Chemical composition of the essential oil of Hyptis spicigera Lam. from Burkina Faso. J. Essent. Oil Res. (1993) 5 219-221.
52. Barocelli E., Calcina F., Chiavarini M. et al. Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil. Life Sci. (2004) 76 213-223.
53. Graham P.H., Browne L., Cox H., Graham J. Inhalation aromatherapy during radiotherapy: results of a placebo controlled double-blind randomized trial. J. Clin. Oncol. (2003) 21 2372-2376.
54. Dunn C., Sleep J., Collett D. Sensing an improvement: an experimental study to evaluate the use of aromatherapy, massage and periods of rest in an intensive care unit. J. Adv. Nurs. (1995) 21 34-40.
55. Yamada K., Mimaki Y., Sashida Y. Anticonvulsive effects of inhaling lavender oil vapour. Biol. Pharm. Bull. (1994) 17 359-360.
56. Ghelardini C., Galeotti N., Salvatore G., Mazzanti G. Local anaesthetic activity of the essential oil of Lavandula angustifolia. Planta Med. (1999) 65 700-703.
57. Lis-Balchin M., Hart S. A preliminary study of the effect of essential oils on skeletal and smooth muscle in vitro. J. Ethnopharmacol. (1997) 58 183-187.
58. Monteiro M.V., de Melo Leite A.K., Bertini L.M., de Morais S.M., Nunes-Pinheiro D.C. Topical anti-inflammatory, gastroprotective and antioxidant effects of the essential oil of Lippia sidoides Cham. leaves. J. Ethnopharmacol. (2007) 111 378-382.
59. Aguiar M.L.B.A., Matos F.J.A., Moura V.R. A atividade antibiótica de plantas da flora nordestina. Cien Cult (1984) 36 547.
60. Fernandes-Filho E.S., Morais S.M., Fonseca S.G.C., Mota O.M.L. Preparação e avaliação clínica do óleo essencial da planta medicinal Lippia sidoides Cham (Alecrim-pimenta). ABO Nac (1998) 6 323-325.
61. Girão V.C.C., Nunes-Pinheiro D.C.S., Morais S.M., Sequeira J.L., Gioso M.A. A clinical trial of a mouth-rinse prepared with Lippia sidoides Cham. essential oil in dogs with mild gingival disease. Prev. Vet. Med. (2003) 59 95-102.
62. Matos F.J.A. Farmácias Vivas: Sistema de utilização de plantas medicinais projetado para pequenas comunidades. UFC, Fortaleza, Brazil, 1994.
63. Maia M.B.S., Melo O.F., Castro C.M.M.B., Ximenes E.A., Silva N.H., Silva M.P.C. Evaluation of the gastric antiulcer, antimicrobial and antioxidant activities of the essential oil from Ocimum minimum Linn. Acta Farm. Bonaer. (2005) 24 331-336.
64. Dutra R.C., Fava M.B., Alves C.C., Ferreira A.P., Barbosa N.R. Antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds. J. Pharm. Pharmacol. (2009) 61 243-250.
65. Leite de Almeida M.E., Gottlieb O.R. The chemistry of Brazilian Leguminosae, further isoflavones from Pterodon apparicia. Phytochemistry (1975) 14 2716-2720.
66. Arriaga A.M.C., de Castro M.A.B., Silveira E.R., Braz-Filho R. Further diterpenoids isolated from Pterodon polygalaeflorus. J. Braz. Chem. Soc. (2000) 11 187-190.
67. Santin J.R., Lemos M., Klein-Júnior L.C. et al. Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn Schmiedebergs Arch. Pharmacol. (2011) 383 149-158.
68. Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol. Aspects Med. (2006) 27 1-93.
69. Domaracky M., Rehak P., Juhas S., Koppel J. Effects of selected plant essential oils on the growth and development of mouse preimplantation embryos in vivo. Physiol. Res. (2007) 56 97-104.
70. Leite G.O., da Penha A.R., Fernandes C.N., Souza H.H., da Costa J.G., Campos A.R. Gastroprotective mechanism of Vanillosmopsis arborea bark essential oil. Fitoterapia (2009) 80 77-80.