A comparative study on the activity of lansoprazole, omeprazole and pd-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat

Clinical and Experimental Pharmacology and Physiology

Volumn 29, Issue 3, 2002, Pages 173-180

  Chandranath, S I ^a   Bastaki, S M A ^a   Singh, J ^b  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

Acidified ethanol; Gastric haemorrhagic lesion; Gastric ulcer; Indomethacin; Lansoprazole; NG nitro L arginine methyl ester; Omeprazole; PD 136450; Rats

Indexed keywords

ALCOHOL; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; INDOMETACIN; LANSOPRAZOLE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; OMEPRAZOLE; PD 136450; PROSTAGLANDIN; PROSTANOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CRYOPROTECTION; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; FEMALE; IC 50; MALE; NONHUMAN; RAT; RATING SCALE; STOMACH ACID SECRETION; STOMACH LESION; STOMACH PROTECTION; STOMACH ULCER; ULCEROGENESIS;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ENZYME INHIBITORS; ETHANOL; FEMALE; INDOLES; INDOMETHACIN; MALE; OMEPRAZOLE; PHENETHYLAMINES; RATS; RATS, WISTAR; STOMACH ULCER;

EID: 0036128096     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2002.03626.x     Document Type: Article

References (48)

1. Appropriate acid suppression for the management of gastro-oesophageal reflux disease
2. Is there an optimal degree of acid suppression for healing of duodenal ulcer? A model of the relationship between ulcer healing and acid suppression
3. Twenty-four hour intragastric acidity and plasma gastrin concentration before and during treatment with either ranitidine and omeprazole
4. Inhibition of gastric secretion by omeprazole in the dog and rat
5. Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats
6. +-ATPase activity in canine gastric microsomes and acid formation in isolated canine parietal cells
7. Biochemistry of gastric acid secretion
8. Omeprazole provides quicker symptom relief and duodenal ulcer healing than ranitidine
9. Rationally designed 'dipeptoid' analogues of CCK. α-methyl-tryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic properties
10. Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat
11. Effect of gastrin receptor blockade on endocrine cells in rats during achlorhydria
12. The effect of CCKB/gastrin antagonist on stimulated gastric acid secretion in the anaesthetized rat
13. Cholecystokinin and gastrin antagonists
14. + secretion and growth of H. Pylori
15. +-ATPase
16. PD-136,450. A CCK-B (gastrin) receptor antagonist with a novel spectrum of antiulcer activity
17. +-ATPase inhibition and CCK receptors
18. Protection induced by cholecystokinin 8 in ethanol-induced gastric lesions is mediated by vagal capsaicin sensitive fibers and CCK-A receptors
19. Influence of peripherally administered peptides on ethanol-induced gastric ulcers in the rat
20. Cholecystokinin is a potent protective agent against alcohol-induced gastric injury in the rat
21. YM022 {(R)-1-[2,3-dihydro-1-(2′-methylphenacyl)-2-oxo-5-phenyl-1H-1, 4-benzodiazepin-3-yl]-3-(methylphenyl) urea}, a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats
22. Role of food in gastrointestinal ulceration produced by indomethacin in the rat
23. Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin
24. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat
25. Lansoprazole. A new proton pump inhibitor for the treatment of peptic ulceration and reflux oesophagitis
26. 2-receptor antagonist in the rat
27. Effects of cimetidine and atropine sulfate on gastric secretion and healing of gastric and duodenal ulcers in rats
28. 2-receptor antagonists and hormones
29. Pathogenic factors in peptic ulcer disease
30. Effects of lansoprazole (AG-1749) on duodenal bicarbonate secretion in anaesthetized rats
31. Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats
32. Effects of various drugs and vagotomy on indomethacin-induced gastric ulcers in the rat
33. Mechanism of nonsteroidal anti-inflammatory drug-induced gastric damage
34. Mechanism of gastric mucosal cytoprotection by prostaglandins
35. Prostaglandin cytoprotection of gastric mucosa
36. Potentiation of taurocholate-induced rat gastric erosions following parenteral administration of cyclooxygenase inhibitors
37. Endogenous nitric oxide in gastric alkaline response in the rat stomach after damage
38. Sensory neurons signal for an increase in rat gastric mucosal blood flow in the face of pending acid injury
39. A new model of duodenal ulcers induced in rats by indomethacin plus histamine
40. 2 aggravates gastric mucosal injury induced by histamine in rats. Possible role of the increased mucosal vascular permeability
41. Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats
42. 2 receptor antagonist: A controlled clinical trial
43. Regulation of gastric mucosal integrity by endogenous nitric oxide: Interactions with prostanoids and sensory neuropeptides in the rat
44. Mechanism of gastric alkaline response in the stomach after damage. Roles of nitric oxide and prostaglandins
45. Mechanism of acid secretory changes in rat stomach after damage by taurocholate: Role of nitric oxide, histamine and sensory neurons
46. Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells
47. The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation
48. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury