Protective effect of Origanum majorana L. 'Marjoram' on various models of gastric mucosal injury in rats

American Journal of Chinese Medicine

Volumn 37, Issue 3, 2009, Pages 531-545

  Al Howiriny, Tawfeq ^a   Alsheikh, Abdulmalik ^b   Alqasoumi, Saleh ^a   Al Yahya, Mohammed ^a   ElTahir, Kamal ^a   Rafatullah, Syed ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

Author keywords

Antioxidant; Antisecretory; Antiulcer; Marjoram; Origanum majorana

Indexed keywords

ALCOHOL; ESSENTIAL OIL; FLAVONOID; INDOMETACIN; MALONALDEHYDE; ORIGANUM MAJORANA EXTRACT; SODIUM CHLORIDE; SODIUM HYDROXIDE; STEROL; TANNIN; THIOL GROUP; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG MEGADOSE; FEMALE; HISTOPATHOLOGY; HYPOTHERMIC RESTRAINT STRESS INDUCED ULCER; INDUCED HYPOTHERMIA; LD 50; LIPID PEROXIDATION; LOW DRUG DOSE; MALE; NONHUMAN; PHYTOCHEMISTRY; PYLORUS; RAT; RAT STRAIN; SOLVENT EXTRACTION; STOMACH ACID SECRETION; STOMACH MUCOSA INJURY; STOMACH PH; STOMACH ULCER; STOMACH WALL; SWISS ALBINO RAT; TOXICITY TESTING; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; FEMALE; GASTRIC ACID; GASTRIC MUCOSA; INDOMETHACIN; MALE; MALONDIALDEHYDE; MICE; OILS, VOLATILE; ORIGANUM; PHYTOSTEROLS; RATS; STOMACH ULCER; SULFHYDRYL COMPOUNDS; TANNINS; TRITERPENES;

EID: 68149098578     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X0900703X     Document Type: Article

References (67)

1. Al-Howiriny, T., M. Al-Sohaibani, K. ElTahir and S. Rafatullah. Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum. Am. J. Chin. Med. 31: 699-711, 2003.
2. Al-Howiriny, T. Evaluation of hepatoprotective activity of broccoli " Brassica Oleracea" in rats. Hungarian Med. J. 1(2): 147-158, 2008a.
3. Al-Howiriny, T. Protective effect of 'Purslane' on rat liver injury induced by carbon tetrachloride. Saudi Pharm. J. 16(3-4): 239-244, 2008b.
4. Allen, A., W.J. Cunliffe, J.P. Pearson, L.A. Sellers and R. Ward. Studies on gastrointestinal mucus. Scand. J. Gastroenterol. 93: S101-S113, 1984.
5. Allen, A. and G. Flemstrom. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am. J. Physiol. Cell 288: C1-C19, 2005.
6. Al-Mofleh, I.A., A.A. Alhaider, J.S. Mossa, M.O. Al-Sohaibani, S. Qureshi and S. Rafatullah. Pharmacological studies on 'Clove' Eugenia caryophyllata. Phcog. Mag. 1: 105-109, 2005.
7. Al-Mofleh, I.A., A. A. Alhaider, J.S. Mossa, M.O. Al-Sohaibani and S. Rafatullah. Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers. World J. Gastroenterol. 13(7): 1112-1118, 2007.
8. Alqasoumi, S., T. Howiriny, M.A. Al-Yahya and S. Rafatullah. Gastroprotective effects of radish "Raphanus sativus" L. on experimental gastric ulcer models in rats. Farmacia LVI: 204-214, 2008.
9. Al-Rehaily, A.J., T.A. Al-Howiriny, M.O. Al-Sohaibani and S. Rafatulah. Gastroprotective effects of "Amla" Emblica officinalis on in vivo test models in rats. Phytomedicine 9: 515-522, 2002.
10. Al-Yahya, M.A., S. Rafatullah, J.S. Mossa, A.M. Ageel, N.S. Parmar and M. Tariq. Gastroprotective activity of ginger Zingiber officinale rocs., in albino rats. Am. J. Chin. Med. 17: 51-56, 1989.
11. Andreo, M.A., K.V.R. Ballesteros, C.A. da Hiruma-Lima, L.R.M. Rocha, A.R.M.S. Brito and W. Vilegas. Effect of Mouriri pusa extract experimentally induced gastric lesions in rodents: Role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection. J. Ethanopharmacol. 107: 431-441, 2006.
12. Assaf, M.H., A.A. Ali, M.A. Makboul, I.P. Beck and R. Anton. Preliminary study of phenolic glycosides form Origanum majorana: Quantitative estimation of arbsutin, cytotoxic activity of hydroquinone. Planta Med. 53: 343-345, 1987.
13. Avila, J.R., C. Alarcón de la Lastra, M.J. Martin, V. Motilva, I. Luque, D. Delgado, J. Esteban and J.R. Herrerias. Role of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats. Inflamm. Res. 45: 83-88, 1996.
14. Baggio, C.H., C.S. Freitas, L. Rieck and M.C. Marques. Gastroprotective effects of a crude extract of Baccharis illinita DC in rats. Pharmacol. Res. 47: 93-98, 2003.
15. Belaiche, J., A. Burette, M. De Vos, E. Louis, M. Huybrechts and M. Deltenre. Study group of NSAID-G1 complications. Observational survey of NSAID-related upper gastro-intestinal adverse events in Belgium. Acta Gastroenterol. Belg. 65: 65-73, 2002.
16. Bhargawa, K.P., M.B. Gupta and K.K. Tangri. Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone. Eur. J. Pharmacol. 22: 191-195, 1973.
17. Bhargawa, K., M. Dass and M. Gupta. Study of central neurotransmitters in stress-induced gastric ulceration in albino rats. Br. J. Pharmacol. 68: 765-772, 1980.
18. Chiu, P.J.S., C. Gerhart, A.D. Brown and A. Barnett. Effects of a gastric antisecretory cytoprotectant 2-methyl-8-(phenylmethoxy)imidazo (1,2-a)-pyridine-3-acetonitrile (Sch 28080) on cysteamine, reserpine and stress ulcers in rats. Arzneim. Forsch. 34: 783, 1984.
19. Crone, S.J., S.M. Morrissey and R.J. Woods. A method for the quantitative estimation of gastric barrier mucus. J. Physiol. 242: 116-117, 1974.
20. Culling, C.F.A. Handbook of Histopathogical and Histochemical Techniques, 3rd Ed. Butterworth and Co., London, 1974, pp. 73, 126, 159.
21. Dogan, Y., S. Baslar, G. Ay and H.H. Mert. The use of wild edible plants in Western and Central Anatolia (Turkey). Econ. Bot. 58(4): 684-690, 2004.
22. Dorman, H.J. and S.G. Deans. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J. Appl. Microbiol. 88: 308-316, 2000.
23. Droy-Lefaix, M.T. Prostaglandins. In: P.B. Curtis-Prior (ed.) Biology and Chemistry of Prostaglandins and Related Eicosanoids. Churchill Livingstone, New York, 1988, pp. 345-360.
24. Farnsworth, N.R. Biological and phytochemical screening of plants. J. Pharm. Sci. 55(3): 225, 1966.
25. File, S. and J. Pearce. Benzodiazepines reduce gastric ulcers induced in rats by stress. Br. J. Pharmacol. 74: 593-599, 1981.
26. Garner, A. Adaptation in the pharmaceutical industry, with particular reference to gastrointestinal drugs and diseases. Review. Scand. J. Gastroenterol. 193: S83-S89, 1992.
27. Ghosh, M.N. Fundamentals of Experimental Pharmacology. Scientific Book Agency, Calcutta, 1984, pp. 153-158 and 187-189.
28. Goa, K.L. and J.P. Monk. Emprostil: A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of peptic ulcer disease. Drugs 3: 539-559, 1987.
29. Gong, D.H., B. Turner, K.R. Bhaskar and J.T. Lamont. Lipid binding to gastricmucin: Protective effect against oxygen radicals. Am. J. Physiol. 259: G681-G686, 1990.
30. Gonzalez, F.G. and L.C. Di Stasi. Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice. Phytomedicine 9: 125-134, 2002.
31. Gracioso, J.S., W. Vilegas, C.A. Hiruma-Lima and A.R. Souza Brito. Effects of tea from Turnera ulmifolia L. on mouse gastric mucosa support the Turneraceae as a newsource of antiulcerogenic drugs. Biol. Pharm. Bull. 25: 487-491, 2002.
32. Guth, P.H. Gastric blood flow in restraint stress. Dig. Dis. 17: 807-813, 1972.
33. Guth, P.H., G. Paulsen and H. Nagata. Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rats: Effects of prostaglandin cytoprotection. Gastroenterology 87: 1083-1090, 1984.
34. Halter, F., A. Schmassmann and B.M. Peskar. Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: Controversial issues and perspectives. Gut 49: 443-453, 2001.
35. Hiraishi, H., A. Terano, S. Ota, S. Mutoh, T. Sugimoto, T. Hirada, M. Razandi and K.J. Ivey. Role for mucus glycoprotein in protecting cultured gastric mucosal cells against toxic oxygen metabolites. J. Lab. Clin. Med. 121: 570-578, 1993.
36. Jellin, J.M., P. Gregory, F. Batz and K. Hitchens. Pharmacist's Letter/Prescriber's Letter Natural Medicines Comprehensive Database, 3rd ed. TherapeuticResearch Faculty Stockton, CA, 2000, p. 709.
37. Kamal, H. Encyclopaedia of Islamic Medicine. General Egyptian Book Organization, Egypt, 1975.
38. Kitagawa, H., M. Fujiwara and Y. Osumi. Effects of water immersion stress on gastric secretion and mucosal blood flow in rats. Gastroenterology 77: 298-302, 1979.
39. Kitazawa, E., A. Sato, H. Takahashi, H. Kuwano and A. Ogiso. Novel diterpenelactones with anti-peptic ulcer activity from Croton sublyratus. Chem. Pharm. Bull. 28: 227-234, 1980.
40. Konturek, S.J. Gastric cytoprotection. Scand. J. Gastroenterol. 20: 543-553, 1985.
41. Koo, M.W.L., C.W. Ogle and C.H. Cho. Effect of verapamil, carbenoxolone and N-acetylcysteine on gastric wall mucus and ulceration in stressed rats. Pharmacology 32: 326-234, 1986.
42. Levine, R.J. A method for rapid production of stress ulcers in rats. In: C.J. Pfeiffer (ed.) Peptic Ulcer. Munksgaard, Copenhagen, 1971, pp. 92-97.
43. Lust, J.B. The Herb Book. Bantam Books, New York, 1980.
44. Mizui, T. and M. Doteuchi. Effect of polyamines on acidified ethanol-induced gastric lesion in rats. Japan J. Pharmacol. 33: 939-945, 1983.
45. Murakami, M., S.K. Lam, M. Inada and T. Miyake. Pathophysiology and pathogenesis on acute gastric mucosal lesions after hypothermic restraint stress in rats. Gastroenterology 88: 660-665, 1985.
46. Parnaham, M.J. and K. Brune. Therapeutic control of inflammatory diseases. Agents Actions 21: 232-234, 1987.
47. Perry, L.M. Medicinal Plants of East and South East Asia: Attributed Properties and Uses. The MIT Press, London, England, 1980, p. 190.
48. Rafatullah, S., M. Tariq, M.A. Al-Yahya, J.S. Mossa and A.M. Ageel. Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. J. Ethnopharmacol. 29: 25-34, 1990.
49. Rafatullah, S., A.M. Galal, M.A. Al-Yahya and M.S. Al-Said. Gastric and duodenal antiulcer and cytoprotective effects of Afromomum melegueta in rats. Int. J. Pharmacogn. 33: 311-316, 1995.
50. Rainsford, K.D. Gastric ulcerogenicity of non-steroidal anti-inflammatory drugs in mice with mucosa sensitized by cholinomimetic treatment. J. Pharm. Pharmacol. 39: 669-672, 1978.
51. Robert, A., J.E. Nezamis, C. Lancaster, J.P. Davis, S.O. Field and A.J. Hanchar. Mild irritants prevent gastric necrosis through adaptive cytoprotection mediated by prostaglandins. Am. J. Physiol. 245: G113, 1983.
52. Robert, A., J.E. Nezamis, C. Lancaster and A.J. Hanchar. Cytoprotection by Pgs in rats. Prevention of gastric necroses produced by alcohol, HCl, NaOH, hypotonic and thermal injury. Gastroenterology 77: 433-433, 1979.
53. Salim, A.S. Sulfhydryl-containing agents: New approach to the problem of refractory peptic ulceration. Pharmacology 46: 281-288, 1993.
54. Senay, E.C. and R.L. Levine. Synergism between cold and restraint for rapid production of stress ulcer in rats. Proc. Soc. Exp. Biol. Med. 124: 1221-1231, 1967.
55. Sedlak, J. and R.H. Lindsay. Estimation of total protein bound and nonprotein sulfhydryl group in tissue with Ellman's reagents. Anal. Biochem. 25: 192-205, 1968.
56. Shay, H. The simple goes the uniform production of gastric ulceration in rat. Gastroenterology 5: 43-61, 1945.
57. Sun, S.B., T. Matsumoto and H. Yamada. Effects of a polysaccharide fraction from the roots of Bupleurum folcatum L. on experimental gastric ulcer models in rats and mice. J. Pharm. Pharmacol. 43: 699-704, 1991.
58. Stuart, M. The Encyclopedia of Herbs and Herbalism. Orbis Publishing, London, 1979, p. 230.
59. Szabo, S., J.S. Trier and P.W. Frankel. Sulfhydryl compounds may mediate gastric cytoprotection. Science 214: 202-220, 1981.
60. Szabo, S. and P. Vattay. Experimental gastric and duodenal ulcers. Advances in pathogenesis. Gastroenterol. Clin. North Am. 19: 67-85, 1990.
61. Terano, A., H. Hiraishi, S. Ota, J. Shiga and T. Sugimoto. Role of superoxide and hydroxyl radicals in rat gastric mucosal injury induced by ethanol. Gastroenterol. Jpn. 24: 488-493, 1989.
62. Utley, H.G., F. Bernheim and P. Hochstein. Effect of sulfhydryl reagents on peroxidation in microsomes. Arch. Biochem. Biophys. 118: 29-32, 1967.
63. Vagi, E., E. Rapavi, M. Hadolin, K. Vasarhelyine Peredi, A. Balazs, A. Blazovics and B. Simandi. Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents. J. Agric. Food Chem. 53: 17-21, 2005.
64. Valcavi, U., R. Caponi, A. Brambilla, F. Palmira and R. Fuwagali. Gastric anti-secretory, anti-ulcer and cytoprotective properties 9-hydroxy-19,20-bis-nor-prostanoic acid in experimental animals. Arzneim. Forsch. 32: 657-663, 1982.
65. Wallace, J. Mechanisms of protection and healing: Current knowledge and future research. Am. J. Med. 110: 19S-22S, 2001.
66. Watanabe, K. Some pharmacological factors involved in formation and prevention of stress ulcers in rats. Chem. Pharm. Bull. 14: 101-107, 1966.
67. Whittle, B.J. Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology 80: 94-98, 1981.