Alpha-2 adrenergic and opioid receptor-mediated gastroprotection

Journal of Physiology Paris

Volumn 94, Issue 2, 2000, Pages 117-121

  Gyires, Klara ^a   Müllner, Katalin ^a   Fürst, Suzanna ^a   Rónai, Andras Z ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Alpha 2B adrenoceptors; Clonidine; Gastroprotection; Opioid receptors

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; MALE; NONHUMAN; RAT; STOMACH PROTECTION; STOMACH ULCER;

EID: 0342803589     PISSN: 09284257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4257(00)00151-0     Document Type: Conference Paper

References (33)

1. Ali B.H., Bashir A.A. The effect of some alpha-2 adrenoceptor agonists and antagonists on gastrointestinal transit in mice: influence of morphine, castor oil and glucose. Clin. Exp. Pharmacol. Physiol. 20:1993;11-16.
2. Bencsics A., Elenkov I.J., Vizi E.S. α2 -, α2A-, α2B/2C-, adrenoceptor subtype antagonists prevent lipopolysacharide-induced fever response in rabbits. Brain Res. 705:1995;302-306.
3. Bhandare P.N., Rataboli P.V., D'Souza R.S.D. Dual action of clonidine on ethanol-induced gastric lesions: is the imidazol-preferring receptor involved? Eur. J. Pharmacol. 199:1991;243-245.
4. 2-Adrenoceptors-mediated inhibitory and excitatory effects of detomidine on gastric acid secretion. J. Pharm. Phamacol. 42:1988;685-688.
5. 2-adrenoceptor subtypes involved in the modulation of gastric acid secretion. Eur. J. Pharmacol. 278:1995;179-182.
6. Blaxall H., Murphy T.J., Baker J.C., Ray C., Bylund D.B. Characterisation of the alpha-2C adrenergic receptor subtype in the opossum kidney and in the OK cell line. J. Pharmacol. Exp. Ther. 259:1991;323-329.
7. 2-adrenoceptors. Pharmacological and molecular biological evidence converge. Trends Pharmacol. Sci. 9:1988;356-361.
8. Cheng H.C., Gleason E.M., Nathan B.A., Lachmann P.J., Woodward J.K. Effects of clonidine on gastric acid secretion in the rat. J. Pharmacol. Exp. Ther. 217:1981;121-126.
9. Del Soldato P. Gastric lesion-preventing or potentiating action of clonidine in rats. Jpn. J. Pharmacol. 1986;257-279.
10. Del Tacca M., Soldani G., Bernardini C., Martinotti E., Impicciatore M. Pharmacological studies on the mechanism underlying the inhibitory and excitatory effect of clonidine on gastric acid secretion. Eur. J. Pharmacol. 81:1982;255-262.
11. Del Tacca M., Tadini P., Blandizzi C., Bernardini M.C. Excitatory and inhibitory effect of clonidine on isolated guinea pig small intestine. Pharmacol. Res. Commun. 20:1988;673-684.
12. DiJoseph J.F., Eash J.R., Mir N.G. Gastric anti-secretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity. J. Pharmacol. Exp. Ther. 241:1987;97-102.
13. Farsang C., Ramirez-Gonzalez M.D., Mucci L., Kunos G. Possible role of an endogenous opiate in the cardiovascular effects of central alpha adrenoceptor stimulation in spontaneously hypertensive rats. J. Pharm. Exp. Ther. 214:1980;203-214.
14. Giersbergen P.L.M., De Jong W. Antagonism by naltrexone of the hypotension and bradycardia induced by α-methyldopa in conscious normotensive rats. J. Pharm. Exp. Ther. 244:1987;341-347.
15. Giersbergen P.L.M., Wiegant M.V., De Jong W. Possible involvement of beta endorphin (1-31) and dynorphin (1-13) in the central hypotensive mechanism of action of alpha methyldopa. Neuroendocrinology. 49:1989;71-79.
16. Gold M.S., Redmond D.E., Kleber H.D. Clonidine blocks acute withdrawal symptoms. Lancet. 11:1978;599-602.
17. Gyires K. Morphine inhibits the ethanol-induced gastric damage in rats. Arch. Int. Pharmacodyn. 36:1990;170-181.
18. Gyires K. The role of endogenous nitric oxide in the gastroprotective action of morphine. Eur. J. Pharmacol. 255:1994;33-37.
19. Gyires K. Analysis of adrenoceptor and related receptor-mediated gastric cytoprotection. Mózsik Gy, Nagy L, Pár A, Rainsford K.D. Cell injury and protection in the gastrointestinal tract. 1997;83-91 Kluwer Academic Publisher, Dordrecht, Boston, London.
20. 2-adrenoceptors against NSAID-induced gastric mucosal damage. Inflammopharmacology. 4:1996;173-180.
21. Gyires K., Rónai A.Z., Tóth G., Darula Z.S., Fürst S. Analysis of the role of delta opioid receptors in gastroprotection in the rat. Life Sci. 60:1997;1337-1347.
22. Gyires K. Correlation between opioid and presynaptic alpha-2 adrenergic receptors in gastroprotection. Dig. Dis. Sci. 42:1997;197.
23. Hamilton T.C., Longman D.S. A comparison of the cardiovascular and sedative actions of the α-adrenoceptor agonist FLA-136 and clonidine in the rat. Br. J. Pharmacol. 75:1982;13-21.
24. Kaess H., Von Mikuliez-Rodecki J. The influence of 2-(2. 6-dichloro-phenylamino)-2-imidazoline hydrochloride (Catapressan) on the function of the stomach and pancreas. Eur. J. Clin. Pharmacol. 3:1971;97-101.
25. Kunchandy J., Khanna S., Kulkarni S.K. Effect of alpha2 agonists clonidine, guanfacine and B-HT 920 on gastric acid secretion and ulcers in rats. Arch. Int. Pharmacodyn. 275:1985;123-138.
26. Kulkarini S.K., Mehta A.K. P1-purinoreceptor antagonism by clonidine in the rat coecum. Life Sci. 34:1984;2273-2277.
27. Remaury A., Paris H. The insulin-secreting cell line, RINm5F, expresses an alpha-2D adrenoceptor and nonadrenergic idazoxan-binding sites. J. Pharmacol. Exp. Ther. 260:1992;417-426.
28. Nakamura M., Ferreira S.H. Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin-like substances. Eur. J. Pharmacol. 146:1988;223-228.
29. Noble E.P., Wurtman R.J., Axelrod J. A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain. Life Sci. 6:1967;281-291.
30. Schnur P., Espinoza M., Flores R., Ortiz S., Vallejos S., Wainwright M. Blocking naloxone-precipitated withdrawal in rats and hamsters. Pharmacol. Biochem. Behav. 43:1992;1093-1098.
31. Vizi E.S., Harsing L.G. Jr., Gaal J., Kapocsi J., Bernath J., Somogyi G.T. CH-38083, a selective, potent antagonist of alpha-2 adrenoceptors. J. Pharmacol. Exp. Ther. 238:1986;701-706.
32. Ramirez-Gonzalez M.D., Tchakarov L., Garcia M.R., Kunos G. β-endorphin acting on the brainstem is involved in the antihypertensive action of clonidine and α-methyldopa in rats. Circ. Res. 53:1983;150-157.
33. Pascaud X., Roger A., Genton M., Roze C. Further support for the central origin of the gastric anti-secretory properties of clonidine in conscious rats. Eur. J. Pharmacol. 86:1983;247-257.