Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 383, Issue 2, 2011, Pages 149-158

  Santin, José Roberto ^a   Lemos, Marivane ^a   Klein Júnior, Luiz Carlos ^a   Machado, Isabel Daufenback ^a   Costa, Philipe ^a   De Oliveira, Ana Paula ^a   Tilia, Crislaine ^a   De Souza, Juliana Paula ^a   De Sousa, João Paulo Barreto ^b   Bastos, Jairo Kenupp ^b   De Andrade, Sérgio Faloni ^a  

^a UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antiulcerogenic activity; Eugenol; Gastroprotection; Syzygium aromaticum; Ulcer

Indexed keywords

ALCOHOL; CARBENOXOLONE; CARYOPHYLLENE; CIMETIDINE; CLOVE OIL; ESSENTIAL OIL; EUGENOL; HYDROCHLORIC ACID; INDOMETACIN; NITRIC OXIDE; OMEPRAZOLE; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIULCER ACTIVITY; ARTICLE; CLOVE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; FLOWER; MALE; NONHUMAN; PYLORUS LIGATION; RAT; STOMACH CONTENT; STOMACH JUICE; STOMACH MUCUS; STOMACH PH; STOMACH PROTECTION; STOMACH SECRETION; STOMACH ULCER;

ACUTE TOXICITY TESTS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; DISEASE MODELS, ANIMAL; ETHANOL; EUGENIA; EUGENOL; FLOWERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GASTRIC MUCOSA; OILS, VOLATILE; PLANT OILS; RATS; RATS, WISTAR; STOMACH ULCER;

EID: 79954447874     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-010-0582-x     Document Type: Article

References (39)

1. Adams RP (2001) Identification of essential oil components by gas chromatography quadupole mass spectroscopy. Allured Pub Corp, Carol Stream
2. Alonso JR (1998) Tratado de fitomedicina-bases clínicas y farmacológicas. ISIS, Buenos Aires
3. Andrade SF, Antoniolli D, Comunello E, Cardoso LGV, Carvalho JCT, Bastos JK (2006) Antiulcerogenic activity of crude extract, fractions and populnoic acid isolated from Austroplenckia populnea (Celastraceae). Z Naturforsch C 61:329-333 (Pubitemid 44073422)
4. Babu TH, Manjulatha K, Kumar GS, Hymavathi A, Tiwari AK, Purohit M, Rao JM, Babu KS (2010) Gastroprotective flavonoid constituents from Oroxylum indicum Vent. Bioorg Med Chem Lett 20:117-120
5. Barbastefano V, Cola M, Luiz-Ferreira A, Farias-Silva E, Hiruma-Lima CA, Rinaldo D, Vilegas W, Brito ARMS (2007) Vernonia polyanthes as a new source of antiulcer drugs. Fitoterapia 178:545-551 (Pubitemid 47628888)
6. Capasso R, Pinto L, Vuotto ML, Di Carlo G (2000) Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage. Fitoterapia 71: S131-S137 (Pubitemid 30621706)
7. Chan FK, Leung WK (2002) Peptic ulcer disease. Lancet 360:933-941
8. Cruz GL (1979) Dicionario das plantas úteis no Brasil. Civilização Brasileira SA. Rio de Janeiro, pp. 110-123
9. Domaracky M, Rehak P, Juhas S, Koppel J (2007) Effects of selected plant essential oils on the growth and development of mouse preimplantation embryos in vivo. Physiol Res 56:97-104
10. Esteves I, Rodrigues IR, Cardoso LGV, Santos LS, Sertia JAA, Perazzo FF, Lima LM, Schneedorf JM, Bastos JK, Carvalho JCT (2005) Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw. J Ethnopharmacol 101:191-196 (Pubitemid 41265621)
11. Ghelardini C, Galeotti N, Mannelli LDC, Mazzanti BA (2001) Local anaesthetic activity of beta-caryophyllene. Farmaco 56:387-389
12. Gurib-Fakim A (2006) Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med 27:1-93 (Pubitemid 41790645)
13. Hiruma-Lima CA, Gracioso JS, Bighetti EJB, Grassi-Kassisse DM, Nunes DS, Brito ARMS (2002) Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa. Phytomedicine 9:523-529
14. Hiruma-Lima CA, Santos LC, Kushima H, Pellizzon CH, Silveira GG, Vasconcelos PCP, Vilegas W, Souza Brito ARM (2006) Qualea grandiflora, a Brazilian "Cerrado" medicinal plant presents an important antiulcer activity. J Ethonopharmacol 104:207-214 (Pubitemid 43234106)
15. Kim HM, Lee EH, Hong SH, Song HJ, Shin MK, Kim SH, Shin TY (1998) Effects of Syzygium aromaticum extract on immediate hypersensitivity in rats. J Ethnopharmacol 60:125-131 (Pubitemid 28143722)
16. Kim EH, Kim HK, Ahn YJ (2003) Acaricidal activity of clove bud oil compounds against Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari; Pyroglyphidae). J Agr Food Chem 51:885-889
17. Kiroshita M, Tsunehisa N, Tamaki H (1995) Effect of combination of ecabet sodium and cimetidine on experimentally induced gastriclesions and gastric-mucosal resistance to ulcerogenic agents in rats. Biol Pharm Bull 18:223-226
18. Klein Jr LC, Gandolfi RB, Santin JR, Lemos M, Cechinel-Filho V, Andrade SF (2010) Antiulcerogenic activity of extract, fractions, and some compounds obtained from Polygala cyparissias St. Hillaire & Moquin (Poligalaceae). Naunyn-Schmiedeberg's Arch Pharmacol 381:121-126
19. Klopell FC, Lemos M, Sousa JPB, Comunello E, Maistro EL, Bastos JK, Andrade SF, Klopell FC, Lemos M, Sousa JPB, Comunello E, Maistro EL, Bastos JK, Andrade SF (2007) Nerolidol, an antiulcer constituent from the essential oil of Baccharis dracunculifolia DC (Asteraceae). Z Naturforsch 62 c: 537-542 (Pubitemid 47403761)
20. Lakshimi V, Singh N, Shrivastva S, Mishra SK, Dharmani P, Palit G (2009) Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats. Phytomedicine 17:569-574
21. Marotta F, Tajiri H, Safran P, Fesce E, Ideo G (1999) Ethanol-related gastric mucosal damage: evidence of a free radical-mediated mechanism and beneficial effect of oral supplementation with bionormalizer, a novel natural antioxidant. Digestion 60:538-543 (Pubitemid 29495662)
22. Massignani JJ, Lemos M, Maistro EL, Schaphauser HP, Jorge RF, Sousa JPB, Bastos JK, Andrade SF (2009) Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats. Phytother Res 23:11355-1360
23. Matsuda H, Li Y, Yoshikawa M (1999) Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulphydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sci 65: L27-L32
24. Mishra RK, Singh SH (2008) Safety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in mice. Food Chem Toxicol 46:3333-3338
25. Moreira F (1978) As plantas Curam. Hermus Liv. Ed. Ltda, São Paulo
26. Morimoto Y, Shimohara K, Oshima S, Sukamoro T (1991) Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terprenone and cimetidina. Jpn J Pharmacol 57:495-505
27. Muruganandan S, Srivastava K, Chandra S, Tandan SK, Lal J, Raviprakash V (2001) Anti-inflammatory activity of Syzygium cumini bark. Fitoterapia 72:369-375 (Pubitemid 32515293)
28. Nwafor PA, Okwuasaba FK, Binda LG (2000) Antidiarrhoel and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats. J Ethnopharmacol 72:421-427
29. OECD (2001) Guideline for testing of chemicals. Guidance no. 420. Fixed dose procedure, Adopted December 17, 2001. Disponible in http://iccvam.niehs. nih.gov/SuppDocs/FedDocs/OECD/OECD GL420.pdf
30. Rodrigues TG, Fernandes Jr A, Sousa JPB, Bastos JK, Sforcin JM (2009) In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages. Molecules 23:319-326
31. Rothenstein AS, Booman KA, Dorsky J, Kohrman KA, Schwoeppe EA, Sedlak RI, Steltenkamp RJ (1983) Eugenol and clove leaf oil. A survey of consumer patch-test sensitization. Food Chem Toxicol 21:727-733 (Pubitemid 14216183)
32. Santin JR, Lemos M, Klein Jr LC, Niero R, Andrade SF (2010) Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models. J Ethnopharmacol 130:334-339
33. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol 5:43-61
34. Sun SB, Matsumoto T, Yamada H (1991) Effects of a polysaccharide fraction from the roots of Bupleurum folcatum L. on experimental gastric ulcer models in rats and mice. J Pharm Pharmacol 43:699-704
35. Szabo S, Vattay P (1990) Experimental gastric and duodenal ulcers. Gastroenterol Clin North Am 19:67-85
36. Tulassay Z, Herszényi L (2010) Gastric mucosal defense and cytoprotection. Best Pract Res Clin Gastroenterol 24:99-108
37. Ulrich-Merzenich G, Zeitler H, Jobst D, Panek D, Vetter H, Wagner H (2007) Application of the "-Omic-" technologies in phytomedicine. Phytomedicine 14:70-82
38. Wagner H (2006) Multitarget therapy-the future of treatment for more than just functional dyspepsia. Phytomedicine 13:122-129 (Pubitemid 44816466)
39. Zanatta F, Gandolfi RB, Lemos M, Ticona JC, Gimenez A, Clasen BK, Cechinel-Filho V, Andrade SF (2009) Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae). Chem-Biol Interact 180:312-317