메뉴 건너뛰기




Volumn 52, Issue 5, 2012, Pages 774-782

Inibição seletiva da ciclo-oxigenase-2: Riscos e benefícios

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84872412907     PISSN: 04825004     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0482-50042012000500011     Document Type: Review
Times cited : (11)

References (68)
  • 1
    • 0242410368 scopus 로고    scopus 로고
    • Lost productive time and cost due to common pain conditions in the US workforce
    • Stewart WF, Ricci JA, Chee E, Morganstein D, Lipton R. Lost productive time and cost due to common pain conditions in the US workforce. JAMA 2003; 290(18):2443-54.
    • (2003) JAMA , vol.290 , Issue.18 , pp. 2443-2454
    • Stewart, W.F.1    Ricci, J.A.2    Chee, E.3    Morganstein, D.4    Lipton, R.5
  • 2
    • 84872374150 scopus 로고    scopus 로고
    • Editora de publicações científi cas LTDA
    • DEF 2008/2009 - Dicionário de especialidades farmacêuticas
    • a ed. Rio de Janeiro, 2008.
    • (2008) a ed. Rio de Janeiro
  • 4
    • 33644870565 scopus 로고    scopus 로고
    • COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-infl ammatory drugs
    • Mitchell JA, Warner TD. COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-infl ammatory drugs. Nat Rev Drug Discov 2006; 5(1):75-86.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.1 , pp. 75-86
    • Mitchell, J.A.1    Warner, T.D.2
  • 5
    • 0030962702 scopus 로고    scopus 로고
    • Nonsteroidal Antiinfl ammatory drugs are associated with both upper and lower gastrointestinal bleeding
    • Wilcox CM, Alexander LN, Cotsonis GA, Clark WS. Nonsteroidal Antiinfl ammatory drugs are associated with both upper and lower gastrointestinal bleeding. Dig Dis Sci 1997; 42(5):990-7.
    • (1997) Dig Dis Sci , vol.42 , Issue.5 , pp. 990-997
    • Wilcox, C.M.1    Alexander, L.N.2    Cotsonis, G.A.3    Clark, W.S.4
  • 6
    • 0027146692 scopus 로고
    • Selectivity of nonsteroidal antiinfl ammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
    • Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinfl ammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 1993; 90(24):11693-7.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.24 , pp. 11693-11697
    • Mitchell, J.A.1    Akarasereenont, P.2    Thiemermann, C.3    Flower, R.J.4    Vane, J.R.5
  • 7
    • 33744950115 scopus 로고    scopus 로고
    • Essential fatty acids: biochemistry, physiology and pathology
    • Das UN. Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J 2006; 1(4):420-39.
    • (2006) Biotechnol J , vol.1 , Issue.4 , pp. 420-439
    • Das, U.N.1
  • 8
    • 65249119361 scopus 로고    scopus 로고
    • Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation
    • Shimizu T. Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu Rev Pharmacol Toxicol 2009; 49:123-50.
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 123-150
    • Shimizu, T.1
  • 10
    • 0017770145 scopus 로고
    • Role of prostaglandin-mediated vasodilatation in infl ammation
    • Williams TJ, Peck MJ. Role of prostaglandin-mediated vasodilatation in infl ammation. Nature 1977; 270(5637):530-2.
    • (1977) Nature , vol.270 , Issue.5637 , pp. 530-532
    • Williams, T.J.1    Peck, M.J.2
  • 11
    • 0015505169 scopus 로고
    • Prostaglandins, aspirin-like drugs and analgesia
    • Ferreira SH. Prostaglandins, aspirin-like drugs and analgesia. Nat New Biol 1972; 240(102):200-3.
    • (1972) Nat New Biol , vol.240 , Issue.102 , pp. 200-203
    • Ferreira, S.H.1
  • 12
    • 0034931501 scopus 로고    scopus 로고
    • Genetic and pharmacological analysis of prostanoid receptor function
    • Narumiya S, FitzGerald GA. Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest 2001; 108(1):25-30.
    • (2001) J Clin Invest , vol.108 , Issue.1 , pp. 25-30
    • Narumiya, S.1    FitzGerald, G.A.2
  • 13
    • 0015511847 scopus 로고
    • Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetaminophenol)
    • Flower RJ, Vane JR. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetaminophenol). Nature 1972; 240(5381):410-1.
    • (1972) Nature , vol.240 , Issue.5381 , pp. 410-411
    • Flower, R.J.1    Vane, J.R.2
  • 14
    • 0037108979 scopus 로고    scopus 로고
    • COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression
    • Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA 2002; 99(21):13926-31.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.21 , pp. 13926-13931
    • Chandrasekharan, N.V.1    Dai, H.2    Roos, K.L.3    Evanson, N.K.4    Tomsik, J.5    Elton, T.S.6
  • 15
    • 31044441042 scopus 로고    scopus 로고
    • Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities
    • Grosser T, Fries S, FitzGerald GA. Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest 2006; 116(1):4-15.
    • (2006) J Clin Invest , vol.116 , Issue.1 , pp. 4-15
    • Grosser, T.1    Fries, S.2    FitzGerald, G.A.3
  • 19
    • 0035833502 scopus 로고    scopus 로고
    • The coxibs, selective inhibitors of ciclooxygenase-2
    • FitzGerald GA, Patrono C. The coxibs, selective inhibitors of ciclooxygenase-2. N Engl J Med 2001; 345(6):433-42.
    • (2001) N Engl J Med , vol.345 , Issue.6 , pp. 433-442
    • FitzGerald, G.A.1    Patrono, C.2
  • 20
    • 27444432244 scopus 로고    scopus 로고
    • COX-2 chronology
    • Hawkey CJ. COX-2 chronology. Gut 2005; 54(11):1509-14.
    • (2005) Gut , vol.54 , Issue.11 , pp. 1509-1514
    • Hawkey, C.J.1
  • 21
    • 77951909982 scopus 로고    scopus 로고
    • Emotion recollected in tranquility: lessons learned from the COX-2 saga
    • Grosser T, Yu Y, Fitzgerald GA. Emotion recollected in tranquility: lessons learned from the COX-2 saga. Annu Rev Med 2010; 61:17-33.
    • (2010) Annu Rev Med , vol.61 , pp. 17-33
    • Grosser, T.1    Yu, Y.2    Fitzgerald, G.A.3
  • 22
    • 63749128221 scopus 로고    scopus 로고
    • Low-dose aspirin, coxibs, and other NSAIDS: a clinical mosaic emerges
    • Patrono C, Baigert C. Low-dose aspirin, coxibs, and other NSAIDS: a clinical mosaic emerges. Mol Interv 2009; 9(1):31-9.
    • (2009) Mol Interv , vol.9 , Issue.1 , pp. 31-39
    • Patrono, C.1    Baigert, C.2
  • 23
    • 77953988074 scopus 로고    scopus 로고
    • Use of nonsteroidal anti-infl amatory drugs in patients with cardiovascular disease: a cautionary tale
    • Amer M, Bead VR, Bathon J, Blumenthal RS, Edwards DN. Use of nonsteroidal anti-infl amatory drugs in patients with cardiovascular disease: a cautionary tale. Cardiol Rev 2010; 18(4):204-12.
    • (2010) Cardiol Rev , vol.18 , Issue.4 , pp. 204-212
    • Amer, M.1    Bead, V.R.2    Bathon, J.3    Blumenthal, R.S.4    Edwards, D.N.5
  • 24
    • 34848895746 scopus 로고    scopus 로고
    • Drug insight: cyclo-oxygenase-2 inhibitors - a critical appraisal
    • Hinz B, Renner B, Brune K. Drug insight: cyclo-oxygenase-2 inhibitors - a critical appraisal. Nat Clin Pract Rheumatol 2007; 3(10):552-60.
    • (2007) Nat Clin Pract Rheumatol , vol.3 , Issue.10 , pp. 552-560
    • Hinz, B.1    Renner, B.2    Brune, K.3
  • 26
    • 73649122841 scopus 로고    scopus 로고
    • Do COX-2 inhibitors raise blood pressure more than nonselective NSAIDs and placebo? An update meta-analysis
    • Chan CC, Reid CM, Aw TJ, Liew D, Haas SJ, Krum H. Do COX-2 inhibitors raise blood pressure more than nonselective NSAIDs and placebo? An update meta-analysis. J Hipertens 2009; 27(12):2332-41.
    • (2009) J Hipertens , vol.27 , Issue.12 , pp. 2332-2341
    • Chan, C.C.1    Reid, C.M.2    Aw, T.J.3    Liew, D.4    Haas, S.J.5    Krum, H.6
  • 27
    • 33646349493 scopus 로고    scopus 로고
    • The use of COX-2 inhibitors for acute dental pain: A second look
    • Huber MA, Terezhalmy GT. The use of COX-2 inhibitors for acute dental pain: A second look. J Am Dent Assoc 2006; 137(4):480-7.
    • (2006) J Am Dent Assoc , vol.137 , Issue.4 , pp. 480-487
    • Huber, M.A.1    Terezhalmy, G.T.2
  • 28
    • 43049168656 scopus 로고    scopus 로고
    • Clinical use and pharmacological properties of selective COX-2 inhibitors
    • Shi S, Klotz U. Clinical use and pharmacological properties of selective COX-2 inhibitors. Eur J Clin Pharmacol 2008; 64(3):233-52.
    • (2008) Eur J Clin Pharmacol , vol.64 , Issue.3 , pp. 233-252
    • Shi, S.1    Klotz, U.2
  • 29
    • 6044274282 scopus 로고    scopus 로고
    • Coxibs and cardiovascular disease
    • FitzGerald GA. Coxibs and cardiovascular disease. N Engl J Med. 2004; 351(17):1709-11.
    • (2004) N Engl J Med , vol.351 , Issue.17 , pp. 1709-1711
    • FitzGerald, G.A.1
  • 30
    • 9944234075 scopus 로고    scopus 로고
    • Vioxx, the implosion of Merck, and aftershocks at the FDA
    • Horton R. Vioxx, the implosion of Merck, and aftershocks at the FDA. Lancet. 2004; 364(9450):1995-6.
    • (2004) Lancet , vol.364 , Issue.9450 , pp. 1995-1996
    • Horton, R.1
  • 31
    • 65949114862 scopus 로고    scopus 로고
    • Iatrogenic effects of COX-2 inhibitors in the US population: findings from the Medical Expenditure Panel Survey
    • Vaithianathan R, Hockey PM, Moore TJ, Bates DW. Iatrogenic effects of COX-2 inhibitors in the US population: findings from the Medical Expenditure Panel Survey. Drug Saf 2009; 32(4):335-3.
    • (2009) Drug Saf , vol.32 , Issue.4 , pp. 335-343
    • Vaithianathan, R.1    Hockey, P.M.2    Moore, T.J.3    Bates, D.W.4
  • 32
    • 6044267892 scopus 로고    scopus 로고
    • Failing the public health - rofecoxib, Merck, and the FDA
    • Topol EJ. Failing the public health - rofecoxib, Merck, and the FDA. N Engl J Med 2004; 351(17):1707-9.
    • (2004) N Engl J Med , vol.351 , Issue.17 , pp. 1707-1709
    • Topol, E.J.1
  • 33
    • 0001175594 scopus 로고    scopus 로고
    • Specifi c inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen
    • Lanza FL, Rack MF, Simon TJ, Quan H, Bolognese JA, Hoover ME et al. Specifi c inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen. Aliment Pharmacol Ther 1999; 13(6):761-7.
    • (1999) Aliment Pharmacol Ther , vol.13 , Issue.6 , pp. 761-767
    • Lanza, F.L.1    Rack, M.F.2    Simon, T.J.3    Quan, H.4    Bolognese, J.A.5    Hoover, M.E.6
  • 34
    • 0033601079 scopus 로고    scopus 로고
    • Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs
    • Langman MJ, Jensen DM, Watson DJ, Harper SE, Zhao PL, Quan H et al. Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. JAMA 1999; 282(20):1929-33.
    • (1999) JAMA , vol.282 , Issue.20 , pp. 1929-1933
    • Langman, M.J.1    Jensen, D.M.2    Watson, D.J.3    Harper, S.E.4    Zhao, P.L.5    Quan, H.6
  • 35
    • 0036794967 scopus 로고    scopus 로고
    • Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis
    • Sikes DH, Agrawal NM, Zhao WW, Kent JD, Recker DP, Verburg KM. Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. Eur J Gastroenterol Hepatol 2002; 14(10):1101-11.
    • (2002) Eur J Gastroenterol Hepatol , vol.14 , Issue.10 , pp. 1101-1111
    • Sikes, D.H.1    Agrawal, N.M.2    Zhao, W.W.3    Kent, J.D.4    Recker, D.P.5    Verburg, K.M.6
  • 36
    • 0033601089 scopus 로고    scopus 로고
    • Anti-infl ammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial
    • Simon LS, Weaver AL, Graham DY, Kivitz AJ, Lipsky PE, Hubbard RC et al. Anti-infl ammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. JAMA 1999; 282(20):1921-8.
    • (1999) JAMA , vol.282 , Issue.20 , pp. 1921-1928
    • Simon, L.S.1    Weaver, A.L.2    Graham, D.Y.3    Kivitz, A.J.4    Lipsky, P.E.5    Hubbard, R.C.6
  • 37
    • 0032948948 scopus 로고    scopus 로고
    • Effects of specifi c inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids
    • Catella-Lawson F, McAdam B, Morrison BW, Kapoor S, Kujubu D, Antes L et al. Effects of specifi c inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. J Pharmacol Exp Ther 1999; 289(2):735-41.
    • (1999) J Pharmacol Exp Ther , vol.289 , Issue.2 , pp. 735-741
    • Catella-Lawson, F.1    McAdam, B.2    Morrison, B.W.3    Kapoor, S.4    Kujubu, D.5    Antes, L.6
  • 38
    • 0033524421 scopus 로고    scopus 로고
    • Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2
    • McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, FitzGerald GA. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci USA 1999; 96(1):272-7.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.1 , pp. 272-277
    • McAdam, B.F.1    Catella-Lawson, F.2    Mardini, I.A.3    Kapoor, S.4    Lawson, J.A.5    FitzGerald, G.A.6
  • 39
    • 0034707105 scopus 로고    scopus 로고
    • Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis
    • Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis R et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med 2000; 343(21):1520-8.
    • (2000) VIGOR Study Group. N Engl J Med , vol.343 , Issue.21 , pp. 1520-1528
    • Bombardier, C.1    Laine, L.2    Reicin, A.3    Shapiro, D.4    Burgos-Vargas, R.5    Davis, R.6
  • 41
    • 77955250524 scopus 로고    scopus 로고
    • Incidence and possible risk factors for clinical upper gastrointestinal events in patients taking selective cyclooxygenase-2 inhibitors: a prospective, observational, cohort study in Taiwan
    • Hsiang KW, Chen TS, Lin HY, Luo JC, Lu CL, Lin HC et al. Incidence and possible risk factors for clinical upper gastrointestinal events in patients taking selective cyclooxygenase-2 inhibitors: a prospective, observational, cohort study in Taiwan. Clin Ther 2010; 32(7):1294-303.
    • (2010) Clin Ther , vol.32 , Issue.7 , pp. 1294-1303
    • Hsiang, K.W.1    Chen, T.S.2    Lin, H.Y.3    Luo, J.C.4    Lu, C.L.5    Lin, H.C.6
  • 42
    • 12444258696 scopus 로고    scopus 로고
    • National trends in cyclooxygenase-2 inhibitor use since market release
    • Dai C, Stafford RS, Alexander GC. National trends in cyclooxygenase-2 inhibitor use since market release. Arch Intern Med 2005; 165(2):171-7.
    • (2005) Arch Intern Med , vol.165 , Issue.2 , pp. 171-177
    • Dai, C.1    Stafford, R.S.2    Alexander, G.C.3
  • 44
    • 0037134011 scopus 로고    scopus 로고
    • Role of prostacyclin in the cardiovascular response to thromboxane A2
    • Cheng Y, Austin SC, Rocca B, Koller BH, Coffman TM, Grosser T et al. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science. 2002; 296(5567):539-41.
    • (2002) Science , vol.296 , Issue.5567 , pp. 539-541
    • Cheng, Y.1    Austin, S.C.2    Rocca, B.3    Koller, B.H.4    Coffman, T.M.5    Grosser, T.6
  • 45
    • 0036049144 scopus 로고    scopus 로고
    • Human prostacyclin receptor
    • Smyth EM, FitzGerald GA. Human prostacyclin receptor. Vitam Horm 2002; 65:149-65.
    • (2002) Vitam Horm , vol.65 , pp. 149-165
    • Smyth, E.M.1    FitzGerald, G.A.2
  • 46
    • 0026800837 scopus 로고
    • Prevention of serious cardiac events by low-dose aspirin in patients with silent myocardial ischaemia The Research Group on Instability in Coronary Artery Disease in Southeast Sweden
    • Nyman I, Larsson H, Wallentin L. Prevention of serious cardiac events by low-dose aspirin in patients with silent myocardial ischaemia. The Research Group on Instability in Coronary Artery Disease in Southeast Sweden. Lancet 1992; 340(8818):497-501.
    • (1992) Lancet , vol.340 , Issue.8818 , pp. 497-501
    • Nyman, I.1    Larsson, H.2    Wallentin, L.3
  • 48
    • 33749859179 scopus 로고    scopus 로고
    • The pharmacology of selective inhibition of COX-2
    • Grosser T. The pharmacology of selective inhibition of COX-2. Thromb Haemost 2006; 96(4):393-400.
    • (2006) Thromb Haemost , vol.96 , Issue.4 , pp. 393-400
    • Grosser, T.1
  • 49
    • 30044436433 scopus 로고    scopus 로고
    • Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2
    • Fries S, Grosser T, Price TS, Lawson JA, Kapoor S, DeMarco S et al. Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. Gastroenterology 2006; 130(1):55-64.
    • (2006) Gastroenterology , vol.130 , Issue.1 , pp. 55-64
    • Fries, S.1    Grosser, T.2    Price, T.S.3    Lawson, J.A.4    Kapoor, S.5    DeMarco, S.6
  • 50
    • 34548812006 scopus 로고    scopus 로고
    • Lohmann CH et al Osteoblast response to fl uid induced shear depends on substrate microarchitecture and varies with time
    • Schwartz Z, Denison TA, Bannister SR, Cochran DL, Liu YH, Lohmann CH et al. Osteoblast response to fl uid induced shear depends on substrate microarchitecture and varies with time. J Biomed Mater Res. 2007; 83(1):20-32.
    • (2007) J Biomed Mater Res , vol.83 , Issue.1 , pp. 20-32
    • Schwartz, Z.1    Denison, T.A.2    Bannister, S.R.3    Cochran, D.L.4    Liu, Y.H.5
  • 51
    • 0036738406 scopus 로고    scopus 로고
    • Transcriptional and posttranscriptional regulation of cyclooxygenase-2 expression by fluid shear stress in vascular endothelial cells
    • Inoue H, Taba Y, Miwa Y, Yokota C, Miyagi M, Sasaguri T. Transcriptional and posttranscriptional regulation of cyclooxygenase-2 expression by fluid shear stress in vascular endothelial cells. Arterioscler Thromb Vasc Biol 2002; 22(9):1415-20.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , Issue.9 , pp. 1415-1420
    • Inoue, H.1    Taba, Y.2    Miwa, Y.3    Yokota, C.4    Miyagi, M.5    Sasaguri, T.6
  • 52
    • 0029790770 scopus 로고    scopus 로고
    • Identifi cation of vascular endothelial genes differentially responsive to fl uid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress
    • Topper JN, Cai J, Falb D, Gimbrone MA. Identifi cation of vascular endothelial genes differentially responsive to fl uid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci USA 1996; 93(19):10417-22.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.19 , pp. 10417-10422
    • Topper, J.N.1    Cai, J.2    Falb, D.3    Gimbrone, M.A.4
  • 53
    • 0033015661 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages
    • Baker CS, Hall RJ, Evans TJ, Pomerance A, Maclouf J, Creminon C et al. Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages. Arterioscler Thromb Vasc Biol 1999; 19(3):646-55.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , Issue.3 , pp. 646-655
    • Baker, C.S.1    Hall, R.J.2    Evans, T.J.3    Pomerance, A.4    Maclouf, J.5    Creminon, C.6
  • 54
    • 0032833967 scopus 로고    scopus 로고
    • Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions
    • Schönbeck U, Sukhowa GK, Graber P, Coulter S, Libby P. Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions. Am J Pathol 1999; 155(4):1281-91.
    • (1999) Am J Pathol , vol.155 , Issue.4 , pp. 1281-1291
    • Schönbeck, U.1    Sukhowa, G.K.2    Graber, P.3    Coulter, S.4    Libby, P.5
  • 55
    • 0033841366 scopus 로고    scopus 로고
    • Expression of cyclo-oxygenase-2 in human atherosclerotic carotid arteries
    • Stemme V, Swedenborg J, Claesson H, Hansson GK. Expression of cyclo-oxygenase-2 in human atherosclerotic carotid arteries. Eur J Vasc Endovasc Surg 2000; 20(2):146-52.
    • (2000) Eur J Vasc Endovasc Surg , vol.20 , Issue.2 , pp. 146-152
    • Stemme, V.1    Swedenborg, J.2    Claesson, H.3    Hansson, G.K.4
  • 56
    • 0021269059 scopus 로고
    • Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation
    • FitzGerald GA, Smith B, Pedersen AK, Brash AR. Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. N Engl J Med 1984; 310(17):1065-8.
    • (1984) N Engl J Med , vol.310 , Issue.17 , pp. 1065-1068
    • FitzGerald, G.A.1    Smith, B.2    Pedersen, A.K.3    Brash, A.R.4
  • 57
    • 0021943699 scopus 로고
    • Endogenous biosynthesis of prostacyclin during cardiac catheterization and angiography in man
    • Roy L, Knapp HR, Robertson RM, FitzGerald GA. Endogenous biosynthesis of prostacyclin during cardiac catheterization and angiography in man. Circulation 1985; 71(3):434-40.
    • (1985) Circulation , vol.71 , Issue.3 , pp. 434-440
    • Roy, L.1    Knapp, H.R.2    Robertson, R.M.3    FitzGerald, G.A.4
  • 58
    • 0034702914 scopus 로고    scopus 로고
    • Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis
    • Belton O, Byrne D, Kearney D, Leahy A, Fitzgerald DJ. Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis. Circulation 2000; 102(8):840-5.
    • (2000) Circulation , vol.102 , Issue.8 , pp. 840-845
    • Belton, O.1    Byrne, D.2    Kearney, D.3    Leahy, A.4    Fitzgerald, D.J.5
  • 59
    • 0034946873 scopus 로고    scopus 로고
    • Cyclooxygenaseselective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs
    • Patrono C, Patrignani P, García Rodríguez LA. Cyclooxygenaseselective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs. J Clin Invest 2001; 108(1):7-13.
    • (2001) J Clin Invest , vol.108 , Issue.1 , pp. 7-13
    • Patrono, C.1    Patrignani, P.2    García Rodríguez, L.A.3
  • 61
    • 84872401728 scopus 로고    scopus 로고
    • US Food and Drug Administration. Alert for healthcare professionals: non-selective non-steroidal anti-infl ammatory drugs (NASIDs)
    • US Food and Drug Administration. Alert for healthcare professionals: non-selective non-steroidal anti-infl ammatory drugs (NASIDs). Available from: http://www.fda.gov /cder/drug/InfoSheets/HCP/ NS_NSAIDsHCP.htm.
  • 62
    • 33749339372 scopus 로고    scopus 로고
    • Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2
    • McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA 2006; 296(13):1633-44.
    • (2006) JAMA , vol.296 , Issue.13 , pp. 1633-1644
    • McGettigan, P.1    Henry, D.2
  • 63
    • 33750944984 scopus 로고    scopus 로고
    • Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomized comparison
    • Cannon CP, Curtis SP, FitzGerald GA, Krum H, Kaur A, Bolognese JA et al. Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomized comparison. Lancet 2006; 368(9549):1771-81.
    • (2006) Lancet , vol.368 , Issue.9549 , pp. 1771-1781
    • Cannon, C.P.1    Curtis, S.P.2    FitzGerald, G.A.3    Krum, H.4    Kaur, A.5    Bolognese, J.A.6
  • 64
    • 14844337012 scopus 로고    scopus 로고
    • Meta-analysis of cyclooxygenase-2 inhibitors and their effects on blood pressure
    • Aw TJ, Haas SJ, Liew D, Krum H. Meta-analysis of cyclooxygenase-2 inhibitors and their effects on blood pressure. Arch Intern Med 2005; 165(5):490-6.
    • (2005) Arch Intern Med , vol.165 , Issue.5 , pp. 490-496
    • Aw, T.J.1    Haas, S.J.2    Liew, D.3    Krum, H.4
  • 65
    • 43549090186 scopus 로고    scopus 로고
    • Physiological regulation of prostaglandins in the kidney
    • Hao CM, Breyer MD. Physiological regulation of prostaglandins in the kidney. Annu Rev Physiol 2008; 70:357-77.
    • (2008) Annu Rev Physiol , vol.70 , pp. 357-377
    • Hao, C.M.1    Breyer, M.D.2
  • 66
    • 44049106055 scopus 로고    scopus 로고
    • Comparative inhibitory activity of etoricoxib, celecoxib, and diclofenac on COX-2 versus COX-1 in healthy subjects
    • Schwartz JI, Dallob AL, Larson PJ, Laterza OF, Miller J, Royalty KM et al. Comparative inhibitory activity of etoricoxib, celecoxib, and diclofenac on COX-2 versus COX-1 in healthy subjects. J Clin Pharmacol 2008; 48(6):745-54.
    • (2008) J Clin Pharmacol , vol.48 , Issue.6 , pp. 745-754
    • Schwartz, J.I.1    Dallob, A.L.2    Larson, P.J.3    Laterza, O.F.4    Miller, J.5    Royalty, K.M.6
  • 68
    • 2142695733 scopus 로고    scopus 로고
    • Cicloxygenases: new forms, new inhibitors, and lessons froms the clinic
    • Warner TD, Mitchell JA. Cicloxygenases: new forms, new inhibitors, and lessons froms the clinic. The FASEB Journal 2004; 18(7):790-804.
    • (2004) The FASEB Journal , vol.18 , Issue.7 , pp. 790-804
    • Warner, T.D.1    Mitchell, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.