Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor α homo-dimerization

Biochemical and Biophysical Research Communications

Volumn 430, Issue 1, 2013, Pages 400-405

  Oh, Yohan ^a   Chung, Kwang Chul ^a  

^a Yonsei University   (South Korea)

Author keywords

ER ; Estrogen signaling; Receptor dimerization; Repressor; ZNF131

Indexed keywords

ESTROGEN RECEPTOR ALPHA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 131;

ARTICLE; BREAST CANCER; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SUMOYLATION; TRANSACTIVATION;

CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; ESTROGEN RECEPTOR ALPHA; ESTROGENS; HEK293 CELLS; HUMANS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84872411500     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.11.031     Document Type: Article

References (26)

1. Nilsson S., Makela S., Treuter E., Tujague M., Thomsen J., Andersson G., Enmark E., Pettersson K., Warner M., Gustafsson J.A. Mechanisms of estrogen action. Physiol. Rev. 2001, 81:1535-1565.
2. Deroo B.J., Korach K.S. Estrogen receptors and human disease. J. Clin. Invest. 2006, 116:561-570.
3. Hayashi S.I., Eguchi H., Tanimoto K., Yoshida T., Omoto Y., Inoue A., Yoshida N., Yamaguchi Y. The expression and function of estrogen receptor alpha and beta in human breast cancer and its clinical application. Endocr. Relat. Cancer 2003, 10:193-202.
4. Osborne C.K., Schiff R., Fuqua S.A., Shou J. Estrogen receptor: current understanding of its activation and modulation. Clin. Cancer Res. 2001, 7:4338s-4342s. discussion 4411s-4412s.
5. Paech K., Webb P., Kuiper G.G., Nilsson S., Gustafsson J., Kushner P.J., Scanlan T.S. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 1997, 277:1508-1510.
6. Heldring N., Pike A., Andersson S., Matthews J., Cheng G., Hartman J., Tujague M., Strom A., Treuter E., Warner M., Gustafsson J.A. Estrogen receptors: how do they signal and what are their targets?. Physiol. Rev. 2007, 87:905-931.
7. Dobrzycka K.M., Townson S.M., Jiang S., Oesterreich S. Estrogen receptor corepressors: a role in human breast cancer?. Endocr. Relat. Cancer 2003, 10:517-536.
8. Chen D., Pace P.E., Coombes R.C., Ali S. Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization. Mol. Cell. Biol. 1999, 19:1002-1015.
9. Tamrazi A., Carlson K.E., Daniels J.R., Hurth K.M., Katzenellenbogen J.A. Estrogen receptor dimerization: ligand binding regulates dimer affinity and dimer dissociation rate. Mol. Endocrinol. 2002, 16:2706-2719.
10. Lavinsky R.M., Jepsen K., Heinzel T., Torchia J., Mullen T.M., Schiff R., Del-Rio A.L., Ricote M., Ngo S., Gemsch J., Hilsenbeck S.G., Osborne C.K., Glass C.K., Rosenfeld M.G., Rose D.W. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc. Natl. Acad. Sci. USA 1998, 95:2920-2925.
11. Smith C.L., Nawaz Z., O'Malley B.W. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol. Endocrinol. 1997, 11:657-666.
12. Johansson L., Thomsen J.S., Damdimopoulos A.E., Spyrou G., Gustafsson J.A., Treuter E. The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta. J. Biol. Chem. 1999, 274:345-353.
13. Hu Y.C., Shyr C.R., Che W., Mu X.M., Kim E., Chang C. Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor. J. Biol. Chem. 2002, 277:33571-33579.
14. Singh R.R., Barnes C.J., Talukder A.H., Fuqua S.A., Kumar R. Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein. Cancer Res. 2005, 65:10594-10601.
15. Tommerup N., Vissing H. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Genomics 1995, 27:259-264.
16. Trappe R., Buddenberg P., Uedelhoven J., Glaser B., Buck A., Engel W., Burfeind P. The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. Biochem. Biophys. Res. Commun. 2002, 296:319-327.
17. Donaldson N.S., Daniel Y., Kelly K.F., Graham M., Daniel J.M. Nuclear trafficking of the POZ-ZF protein Znf131. Biochim. Biophys. Acta 2007, 1773:546-555.
18. Huynh K.D., Bardwell V.J. The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene 1998, 17:2473-2484.
19. Han X., Guo J., Deng W., Zhang C., Du P., Shi T., Ma D. High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. BMC Genomics 2008, 9:476.
20. Oh Y., Chung K.C. Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling. J. Biol. Chem. 2012, 287:17517-17529.
21. King W.J., Greene G.L. Monoclonal antibodies localize estrogen receptor in the nuclei of target cells. Nature 1984, 307:745-747.
22. Welshons W.V., Cormier E.M., Wolf M.F., Williams P.O., Jordan V.C. Estrogen receptor distribution in enucleated breast cancer cell lines. Endocrinology 1988, 122:2379-2386.
23. Htun H., Holth L.T., Walker D., Davie J.R., Hager G.L. Direct visualization of the human estrogen receptor alpha reveals a role for ligand in the nuclear distribution of the receptor. Mol. Biol. Cell 1999, 10:471-486.
24. Katzenellenbogen B.S., Kendra K.L., Norman M.J., Berthois Y. Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens. Cancer Res. 1987, 47:4355-4360.
25. Bardwell V.J., Treisman R. The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 1994, 8:1664-1677.
26. McKenna N.J., Lanz R.B., O'Malley B.W. Nuclear receptor coregulators: cellular and molecular biology. Endocr. Rev. 1999, 20:321-344.